• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7473-7482
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• 2013

The G-protein coupled receptor 87 (GPR87) is a recently discovered orphan GPCR which means that the search of their endogenous ligands has been a novel challenge. GPR87 has been shown to be overexpressed in squamous cell carcinomas (SCCs) or adenocarcinomas in lungs and bladder. The 3D structure of GPR87 was here modeled using two templates (2VT4 and 2ZIY) by a threading method. Functional assignment of GPR87 by SVM revealed that along with transporter activity, various novel functions were predicted. The 3D structure was further validated by comparison with structural features of the templates through Verify-3D, ProSA and ERRAT for determining correct stereochemical parameters. The resulting model was evaluated by Ramachandran plot and good 3D structure compatibility was evidenced by DOPE score. Molecular dynamics simulation and solvation of protein were studied through explicit spherical boundaries with a harmonic restraint membrane water system. A DRY-motif (Asp-Arg-Tyr sequence) was found at the end of transmembrane helix3, where GPCR binds and thus activation of signals is transduced. In a search for better inhibitors of GPR87, in silico modification of some substrate ligands was carried out to form polar interactions with Arg115 and Lys296. Thus, this study provides early insights into the structure of a major drug target for SCCs.

• Journal of the Korean Society of Hazard Mitigation
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• v.2 no.3 s.6
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• pp.101-108
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• 2002

There exist many construction joints in segmentally constructed bridge girders. It is required coupling of tendons or overlapping of tendons to introduce continuous prestress through several spans of bridges. Even though tendon coupling method is easier to use in practice, some cracking problems around construction joints have been reported and complicated stress states around construction joints in PSC girders is not clearly investigated. The purpose of this paper is to investigate in detail the complicated longitudinal stress distributions around the construction joints in prestressed concrete girders with tendon couplers. To this end, a comprehensive experimental program has been set up and a series of specimens have been tested to identify the effects of tendon coupling and segmental construction of bridge sections. The present study indicates that the longitudinal stress distributions of PSC girders with tendon couplers are quite different from those of PSC girders without tendon couplers. The longitudinal compressive stresses introduced by prestressing are greatly reduced around coupled joints according to tendon coupling ratios.

• International Journal of Safety
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• v.11 no.2
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• pp.29-37
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• 2012

Since most construction workers comprehend information on work through sight, the importance of safety signs are increasing by the day. In Korea, due to the sharp economic progress and the higher standard of the workforce, since the end of 1980, each year the number of foreign workers entering the country who working simple technical jobs have increased this condition. This study researched safety signs, which are the final accident prevention measures at the workplace. Based on the study, comprehension of the standard safety signs of the Occupational Safety and Health Act (OSHA) was lacking at a level of 2.5. Also, the perception level of the Industry Public Safety Law (38%) was very low. And, it was found that sex and experience or non-experience in safety training was not an issue in the level of understanding. However, when satisfying the standards of the Occupational Safety and Health Act and changing the safety signs, the level of understanding went up to 3.49 and the perception level was increased significantly to 70%. Thus, it is concluded that, since the foreign workers are mainly from non-English speaking countries and because the workers of Korea are not familiar with English, in order to provide proper safety information, there must first of all be simplistic and concise pictograms. This will provide needed information and must be coupled with simple English words that can give additional information to the worker and be effective in helping him understand and perceive the safety sign. Also, it has been determined that the existing forms of safety signs and their effectiveness in industry accident prevention must be reassessed.

• Journal of the Korean Ceramic Society
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• v.39 no.2
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• pp.171-177
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• 2002

In this study, the vertical aligned carbon nanotubes was synthesized by DC bias-assisted Inductively Coupled Plasma Hot-Filament Chemical Vapor Deposition (ICPHFCVD). The substrate used CNTs growth was Ni(300 ${\AA}$)/Cr(200 ${\AA}$)-deposited one on glass by RF magnetron sputtering. R-F, DC bias and filament power during the growth process were 150 W, 80 W, 7∼8 A, respectively. The grown CNTs showed hollow structure and multi-wall CNTs. The top of grown CNT was found to Ni-tip that the CNT end showed to metaltip. The graphitization and field emission properties of grown was better than grown CNTs by ICPCVD. The turn-on voltage of CNT grown by DC bias-assisted ICPHFCVD showed about 3 V/${\mu}m$.

• Archives of Plastic Surgery
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• v.44 no.2
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• pp.117-123
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• 2017

Background Upper extremity soft tissue defects with complete circumferential involvement are not common. Coupled with the unique anatomy of the upper extremity, the underlying etiology of such circumferential soft tissue defects represent additional reconstructive challenges that require treatment to be tailored to both the patient and the wound. The aim of this study is to review the various options for soft tissue reconstruction of complete circumferential defects in the upper extremity. Methods A literature review of PubMed and MEDLINE up to December 2016 was performed. The current study focuses on forearm and arm defects from the level at or proximal to the wrist and were assessed based on Tajima's classification (J Trauma 1974). Data reviewed for analysis included patient demographics, causality, defect size, reconstructive technique(s) employed, and postoperative follow-up and functional outcomes (when available). Results In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 14 unique articles were identified for a total of 50 patients (mean=28.1 years). Underlying etiologies varied from extensive thermal or electrical burns to high impact trauma leading to degloving or avulsion, crush injuries, or even occur iatrogenically after tumor extirpation or extensive debridement. Treatment options ranged from the application of negative pressure wound dressings to the opposite end of the spectrum in hand transplantation. Conclusions With the evolution of reconstructive techniques over time, the extent of functional and aesthetic rehabilitation of these complex upper extremity injuries has also improved. The proposed management algorithm comprehensively addresses the inherent challenges associated with these complex cases.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.4 no.2 s.7
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• pp.81-87
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• 2005

In this paper, a VCDRO(Voltage Control Dielectirc Resonator Oscillator) for signal source of doppler radar system is designed and fabricated. The proposed VCDRO is made with new tuning mechanism using CPW line. The coplanar waveguide of $\lambda_{g}$/2 in length with varactor diode is placed on the metallization side under the dielectric resonator and coupled to it. Tuning varactor diode is mounted at one end of the CPW. The proposed circuit tuned by a CPW allows one more varactor diode to be mounted on the optimized CPW, where a greater sensitivity of frequency tuning is needed. With varying the biasing voltage for the varactor diode from 0 V to 15 V, output frequency tuning of 12 MHz is obtained. The PLDRO exhibits output power of 16.5 dBm with phase noise in the phase locked state characteristic of -115 dBc/Hz at 100 Hz, -105 dBc/Hz at the 10 kHz, and -102 dBc/Hz at 1 Hz offset from 10.525 GHz , respectively.

• Composites Research
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• v.13 no.5
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• pp.1-9
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• 2000

An intensity-based optical fiber vibration sensor is applied to monitor the structural vibration and detect impact locations on a plate. Optical fiber vibration sensor is constructed by placing two cleaved fiber end, one of which is cantilevered in a hollow glass tube. The movement of the cantilevered section lags behind the rest of the sensor in response to an applied vibration and the amount of light coupled between the two fibers is thereby modulated. For vibration sensing, optical fiber vibration sensor is mounted on the carbon fiber composite beam and its response is investigated to free and forced vibration. In impact location detection, four optical fiber vibration sensors whose location is predetermined are placed at chosen positions and the different arrival times of impact-generated vibration signal are recorded by an FFT analyzer. Impact location can be calculated from these time delays. Experimental results show that optical fiber vibration sensor signals coincide with gap sensor in vibration sensing. The precise location of impact can be detected on an acrylate plate.

• Journal of Korean Society of Disaster and Security
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• v.7 no.1
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• pp.17-25
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• 2014

Due to the recent climate change impact, natural disasters occur due to sea surface rising, typhoon attacks, flash floods, local heavy rainfalls, landslides, and coastal area erosion, continuing to cause human and property damage. These impacts, coupled with urbanization and industrialization activities, are turning the previously safe areas into disaster-vulnerable areas, increasing human and economic damage. This paper aimed to prepare measures designed to minimize human damage in natural disaster vulnerable parts of South Korea in summer. Toward that end, how vulnerable areas were managed and what the damage was like were studied. Also, cases of human damage and statistics there of were reviewed and analyzed, relevant problems were derived, and thus structural and non-structural measures designed to minimize human damage were presented.

• Explosives and Blasting
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• v.15 no.3
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• pp.14-19
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• 1997

Koreans have emphasized education as the primary means to reconstruct our country means to reconstruct our country after two catastrophic events-the Japanese occupation and the Korean War(1950-1953). A Strong belief- in education coupled with sheer deter-mination spurred the period of industrial and eeonomic development that started in the early 1970-'s. The "can-do" attitude of the general public was matched and aided by small S & T communities. Scientists and engineers provided the neeessary expertise to manufacture goods and process the many raw materials imported from overseas. After nearly three decades of reconst-ructing our completely devastated country, Korea has become a modern, cosmo-politan, fast-paced and dynamic country. In order to further increaser our manufac- turing capabilities and double the per-capita income by the beginning of the 21st century, we must improve productivitiy and encourage creatitivity in all sectors of our country. The S & T community's efforts in research and development. education, and interna-tional cooperation will be invaluable in determining our direction and reaching these goals. The general public is eager to peacefully unite our foreign powers since 1945. Toward that end. members of the S & T community are willing to coope-rate with our north Korean counterparts in all areas of S & T with the exception of defense related endeavors. Establi-shing scientific ties with north Korea will result in mutual economic benefit and greater regional stability in East Asia. In particular. scientists and manu-facturers in each province are eager to initiate cordial and professional relation-ships with north Korea in the hopes of securing these benefits. The Korean Federation of Science and Technology Societies(KOFST) has played an important role both in developing S & T policies, and in gostering the frowty of S & T societies. A non-governmental umbrella organization composed of over 251 professional societies, KOFST facili-tates the transfer of research outcomes and technology from research institutions to the various industries. KOFST also seeks to increase cooperation between the countries of the Pacific Rim. As evidence of that, we have pursued joint research and industrial ventures with China. Established projects include those on environmental conditions in the Yellow Sea, and improvement of aircraft manufacturing, telecommunica-tion equipment, and agricultural produ-cts. Increased cooperation between the Pacific Rim countries, particularly in S & T, would foster social and economic development for the region as a whole.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.12 no.1
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• pp.37-43
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• 2014

A parametric sensitivity to the annual exposure dose rate to the farming exposure group has been deterministically carried out for three principal elements identified in the near-field of the pyroprocessed waste repository system as a series study of Part 1 of the coupled paper with the same title. Credit time for both metal and ceramic containers, annual nuclide release rete and the degree of loss of bentonite buffer around the container are selected and investigated deterministically for important nuclides. To this end the A-KRS has been assessed and then compared among each other with the normal, the worst, and the best case scenarios associated with their extreme values these elements could have. All the elements are shown to be sensitive to the results as was in Part 1. Methodology studied through this study and the results are expected to make a good feedback to the repository design.