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Effects of Soy Bread on Cardiovascular Risk Factor, Inflammation and Oxidative Stress in Women With Active Rheumatoid Arthritis: A Randomized Double-Blind Controlled Trial

  • Afsaneh Sayyaf;Ehsan Ghaedi;Fatemeh Haidari;Elham Rajaei;Kambiz Ahmadi-engali;Bijan Helli
    • Clinical Nutrition Research
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    • v.13 no.1
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    • pp.22-32
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    • 2024
  • Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder with widespread synovitis. Isoflavones, the main active component of soy, have been reported to have potent anti-inflammatory effects; the previous RA animal models showed the promising effect of soy supplementation. We aimed to evaluate the effect of soy bread on inflammatory markers and lipid profiles in RA patients. The present study was designed as a randomized controlled trial. RA patients were randomly allocated to obtain soy bread (n = 22) or placebo bread (n = 22) for 8 weeks. Fasting serum levels of lipid profile, total antioxidant capacity (TAC), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and DAS28 were checked. Findings showed that there were no significant differences between the two groups in physical activity and dietary intake at the beginning of the study and the end of the study. There were no significant differences between the two groups in measured lipid profile markers, including high-density lipoprotein, low-density lipoprotein, total cholesterol, triglyceride, and very low-density lipoprotein, at the end of the trial. In addition, TAC and CRP also were not significant at the end of the trial between the 2 groups (0.66 and 0.12, respectively). However, the serum levels of TNF-α reduced significantly in the soy bread group at the end of the intervention (p < 0.000) and compared with the control group (p < 0.019). Soy bread consumption only decreased circulating TNF-α serum concentration. Other outcome measures were not changed following supplementation. Future long-term, well-designed studies are needed to confirm these findings.

Model for end-stage liver disease-3.0 vs. model for end-stage liver disease-sodium: mortality prediction in Korea

  • Jeong Han Kim;Yong Joon Cho;Won Hyeok Choe;So Young Kwon;Byung-Chul Yoo
    • The Korean journal of internal medicine
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    • v.39 no.2
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    • pp.248-260
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    • 2024
  • Background/Aims: The model for end-stage liver disease (MELD) serves as an indicator for short-term mortality among patients diagnosed with liver cirrhosis (LC) and is used to prioritize patients for liver transplantation. In 2021, the updated version of MELD, MELD-3.0, was introduced to improve the accuracy of the mortality prediction of MELD. Therefore, this study aimed to compare the efficacy of MELD 3.0 and MELD-Na in predicting mortality among Korean patients with LC. Methods: A retrospective review was conducted using the medical records of patients diagnosed with LC who were admitted to Konkuk University Hospital From 2011 to 2021. The study calculated the predictive values of MELD-Na and MELD-3.0 for 3- and 6-months mortality using the area under the receiver operating curve (AUROC) and compared the results using the DeLong test. Results: Of the 3,034 patients enrolled in the study, 339 (11.2%) died within 3 months and 421 (14.4%) died within 6 months. The AUROCs values for predicting 3 months mortality were 0.846 for MELD-Na and 0.851 for MELD-3.0. The corresponding AUROC values for predicting 6 months mortality were 0.843 for MELD-Na and 0.848 for MELD-3.0. MELD-3.0 exhibited better discrimination ability than MELD-Na for both 3 (p = 0.03) and 6 months mortality (p = 0.01). Conclusions: Our study found a significant difference between the performance of MELD-3.0 and MELD-Na in Korean patients with LC.

Performance Analysis of Deep Learning-based Normalization According to Input-output Structure and Neural Network Model (입출력구조와 신경망 모델에 따른 딥러닝 기반 정규화 기법의 성능 분석)

  • Changsoo Ryu;Geunhwan Kim
    • Journal of Korea Society of Industrial Information Systems
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    • v.29 no.4
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    • pp.13-24
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    • 2024
  • In this paper, we analyzed the performance of normalization according to various neural network models and input-output structures. For the analysis, a simulation-based dataset for noise environments with homogeneous and up to three interfering signals was used. As a result, the end-to-end structure that directly outputs noise variance showed superior performance when using a 1-D convolutional neural network and BiLSTM model, and was analyzed to be particularly robust against interference signals. This is because the 1-D convolutional neural network and bidirectional long short-term memory models have stronger inductive bias than the multilayer perceptron and transformer models. The analysis of this paper are expected to be used as a useful reference for future research on deep learning-based normalization.

A study on compositions of listed terms in 2011 elementary mathematics curriculum in Korea (우리나라 2011 초등수학 교육과정 등재용어의 조성에 관한 연구)

  • Park, Kyo-Sik;Kwon, Seo-Kil
    • Journal of Educational Research in Mathematics
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    • v.22 no.3
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    • pp.429-444
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    • 2012
  • As one of the trials for a systematic approach to mathematics terms which occupies an important place in teaching and learning mathematics, compositions of listed terms in 2011 elementary mathematics curriculum in Korea are discussed in this study. To this end, listed terms are classified in view of three points and looked for their characteristics, from which implications are found out for elementary mathematics teaching and learning First of all classifications into grade-group and domain-specific terms, then into newly coined terms and terms from everyday life, and then into korean terms and chinese character terms and english terms are attempted. Next, terms with a kernel and terms without a kernel are distinguished, and in this process, term-sets are presented. Finally, object terms, operation terms, relationship terms, measure terms, conditions terms, graphics terms, name terms are classified. Based on these results, the following implications for elementary mathematics teaching and learning are suggested. First, it should be considered that many of the listed terms in 2011 curriculum are newly coined and chinese character terms. Second, the interconnections between terms should be considered. Third, a variety of roles and functions of the terms should be considered.

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A Study on the Public Library Policies of Local Governments: Focusing on the Long-Term Planning and Organizations (지방자치단체의 공공도서관 정책 분석 - 중장기 계획과 담당 조직을 중심으로 -)

  • Jang, Ji-Suk;Song, Kyoeng-Jin;Lee, Jin-Woo;Cha, Mi-Kyeong
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.21 no.2
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    • pp.15-28
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    • 2010
  • The purpose of this study was to investigate how local governments implement and enforce library policies for their regional libraries to provide benefits to their community residents. To this end, this study analyzed public library polices of regional governments in Korea with their long-term and annual plans. According to the results almost regional governments included plans for public libraries in their long-term plans, however, organizations exclusively responsible for libraries were very rare. Main components of the policy mostly related with establishing public libraries. In addition, creating and supporting a small library, a library of building workforce capacity planning librarians, library cooperation system, whether to target the entire city reading promotion policies were included in the policy.

Short-term Changes of Community Structure of Phytoplankton in Summer Around Namhae Island of Korea (여름철 남해도 연안 식물플랑크톤 군집 구조의 단기 변화)

  • Im, Wol Ae;Gang, Chang Geun;Kim, Suk Yang;Lee, Sam Geun;Kim, Hak Gyun;Jeong, Ik Gyo
    • ALGAE
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    • v.18 no.1
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    • pp.49-58
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    • 2003
  • The short-term dynamics of the summer phytoplankton community structure were investigated in coastal waters around Namhae Island, the Southern Sea of Korea. The study was based on a comprehensive survey constituting 39 collections from 13 stations on July 18-22, August 1-2, 14-16 and 27-30, respectively. The community structure was analysed using cluster analysis and important environmental correlates of the assemblage structure were identified with canonical correspondence analysis (CCA). Water temperature, salinity, NO₂, NO₃, NH₄, PO₄, chlorophyll a and transparency were measured as physico-chemical environmental factors which may be associated with the phytoplankton community structure. Variations of salinity and concentrations of NO₃ and chlorophyll a were not significant. In addition to warmer water temperature, concentrations of NO₂, NO₄and PO₄ decreased at the beginning of August. And transparency was deeper and water column became very unstable after the middle of August. A wide taxonomic diversity was encountered during the survey, including a total of 121 taxa which was composed of 72 diatoms, 48 dinoflagellates and 1 euglenoid species. Cluster analysis showed that the Phytoplankton community could be divided into 4 distinct groups, indicating rapid changes of the community in the short course of this survey. These phytoplankton groups also showed distinctive dispersion patterns in 2-dimensional canonical space, indicating distinct groupings for stations at each survey. Dominant taxa of diatoms (Chaetoceros curvisetus, Chaetoceros spp., Leptocylindrus danicus, Leptocylindrus mediteraneus, Skeletonema costanum, and Pseudo-nitzschia pungen) clustered in region of CCA space corresponding to stations surveyed at the middle of July. Dominant taxa of dinoflagellates were tightly associated with stations surveyed at the middle (Karenia breve) and end (Cochlodinium polykrikoides and Polykrikos schwartzii) of August. The CCA also showed that the phytoplankton community compositions were highly associated with water temperature, transparency, NO₂, NH₄ and PO₄, suggesting that gradients in physical and nutrient conditions affect short-term changes in phytoplankton composition.

Long Term Feeding Effects of Dietary Dehulled Soybean Meal as a Fish Meal Replacer in Growing Olive Flounder Paralichthys olivaceus

  • Kim, Young Chul;Yoo, Gwang Yeol;Wang, Xiaojie;Lee, Seunghyung;Shin, In Soo;Bai, Sungchul C.
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.6
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    • pp.868-872
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    • 2008
  • This experiment was conducted to evaluate the long term effects of dehulled soybean meal (DHSM) as fish meal (FM) replacer in the diet for olive flounder, Paralichthys olivaceus, for 42 wk at a commercial fish farm. The four experimental diets were MP (moist pellet based on raw fish), $DHSM_0$ (fish meal based dry pellet), $DHSM_{30}$ (30% fish meal was replaced by DHSM) and COMD (commercial dry pellet). Fish were fed one of the four diets containing 50% crude protein and 16.7 kJ available energy/kg diet for 42 wk. Fish averaging $3.20{\pm}0.04g$ ($mean{\pm}SD$) were initially distributed to each tank as a group of 6,000 fish reared in a flow-through system. At the end of the experiment, average body weight of fish was $315{\pm}9.3g$ ($mean{\pm}SD$) ). Weight gain (WG) and feed efficiency (FE) of fish fed MP, DHSM0 and DHSM30 showed no significant difference among the diet treatments. However, WG and FE of fish fed MP were significantly higher than those of fish fed COMD (p<0.05). Specific growth rate (SGR), protein efficiency ratio (PER) and survival of fish fed all diets were not significantly different among the dietary treatments. Therefore, these results indicate that DHSM could replace up to 30% white fish meal with amino acid supplementation in olive flounder diets for long-term feeding practice at the commercial farm.

Evaluation of the Structural Behavior Characteristics and Long Term Durability for Transition Track Systems in Railway Bridge Deck Ends (철도교량 단부 전환부 궤도시스템의 구조적 거동특성 및 장기 내구성능 분석)

  • Lee, Kwangdo;Jeong, Incheol;Choi, Jungyoul;Park, Yonggul
    • Journal of the Korean Society for Railway
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    • v.17 no.4
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    • pp.260-269
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    • 2014
  • Transition tracks are an alternative for enhancing the long-term serviceability and durability of concrete track components in railway bridges. The goal of this paper is to investigate the structural behavior for transition track systems of railway bridge deck ends. In this study, the structural behavior of transition tracks such as the variations in static, dynamic, and fatigue behaviors and dynamic properties (natural frequency and damping ratio) are assessed and compared through performing loading tests and finite element analyses using actual vehicle impact loadings. As a result, it is found that the structural behavior of the transition track system is expected to satisfy the actual vehicle impact loading, and the variation in the neutral axis and dynamic characteristics are not affected by the fatigue loading. Therefore, it is inferred that the structural capacity and long-term durability of the transition track system is proven.

A Study on Worker Exposure to Ethylene Oxide in Central Supply Sterilizing Room of Hospital (일부 종합병원 중앙공급실에서의 Ethylene Oxide 노출에 관한 연구)

  • Seo, Sang Ok;Paik, Nam Won
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.5 no.1
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    • pp.68-86
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    • 1995
  • This study was conducted at five Ethylene Oxide(EO) sterilizing processes in hospitals located in Seoul from August 8 to August 30, 1994. The main purposes of this study were to assess the TWA(Time Weighted Average) and short term exposures to EO and to evaluate factors affecting EO concentrations in sterilizing room. Results are summarized as follows. 1. The TWA concentrations of the sterilizing operators ranged from <0.005ppm to 3.04ppm and those of two sterilizing rooms out of five exceeded 1ppm, the Korean and ACGIH standards. 2. When the door of the sterilizer is opened at the end of the sterilization cycle, the short term concentrations of operators ranged from <0.005ppm to 11.4ppm, and those of three sterilizing room out of five exceeded 5ppm, the ACGIH short term exposure limit(STEL). The short term concentrations of area samples ranged from 0.24ppm to 49.2ppm and those of four sterilizing room out of five exceeded 5ppm. 3. Factors affecting EO exposure level were aeration type, the location of storage site for sterilized item, amount of gas, use period of sterilizer(p<0.005). 4. Following recommendations are suggested to minimize exposure to EO. The use of EO gas should be reduced by using another available sterilization methods, and the sterilizers and gas tank storage site should be isolated from, other work areas. Combination of local and general ventilation system should be installed. Metal carts or baskets for sterilization load should be used, and work environment and medical monitoring should be performed regularly.

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LSTM(Long Short-Term Memory)-Based Abnormal Behavior Recognition Using AlphaPose (AlphaPose를 활용한 LSTM(Long Short-Term Memory) 기반 이상행동인식)

  • Bae, Hyun-Jae;Jang, Gyu-Jin;Kim, Young-Hun;Kim, Jin-Pyung
    • KIPS Transactions on Software and Data Engineering
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    • v.10 no.5
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    • pp.187-194
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    • 2021
  • A person's behavioral recognition is the recognition of what a person does according to joint movements. To this end, we utilize computer vision tasks that are utilized in image processing. Human behavior recognition is a safety accident response service that combines deep learning and CCTV, and can be applied within the safety management site. Existing studies are relatively lacking in behavioral recognition studies through human joint keypoint extraction by utilizing deep learning. There were also problems that were difficult to manage workers continuously and systematically at safety management sites. In this paper, to address these problems, we propose a method to recognize risk behavior using only joint keypoints and joint motion information. AlphaPose, one of the pose estimation methods, was used to extract joint keypoints in the body part. The extracted joint keypoints were sequentially entered into the Long Short-Term Memory (LSTM) model to be learned with continuous data. After checking the behavioral recognition accuracy, it was confirmed that the accuracy of the "Lying Down" behavioral recognition results was high.