• Pediatric Infection and Vaccine
• /
• v.12 no.1
• /
• pp.75-85
• /
• 2005

Purpose : Fungal infection is one of the important causes of morbidity and mortality in patients with hematologic malignancies. Amphotericin B(ABV) and itraconazole(ITZA) have been used as the standard empirical antifungal therapy in neutropenic patients with acute leukemia who have persistent fever that does not respond to antibiotic therapy. ABV is an antifungal drug associated with side effects such as fever and chills, symptoms which may be mediated by pro-inflammatory cytokines such as interleukin-$1{\beta}$(IL-$1{\beta}$) and tumor necrosis factor-${\alpha}$(TNF-${\alpha}$). We assessed modulation of these pro-inflammatory cytokines as well as the anti-inflammatory cytokines(IL-4, IL-1Ra) by ABV and ITZA. Methods : From March 2004 to February 2005, a total of 30 episodes from acute leukemia patients with febrile neutropenia were analyzed for this study. They were randomly allocated to receive intravenous ABV or ITZA for 14 days. Clinical responses were evaluated at the completion of therapy, and cytokine IL-$1{\beta}$, TNF-${\alpha}$, IL-4, and IL-1Ra were measured for determination to know the correlation between two antifungal agents and inflammatory cytokines. Results : Empirical antifungal agents were given to 37 patients(ABV 20, ITZA 17), and 30 patients(ABV 15, ITZA 15) were evaluable for efficacy. White blood cell and absolute neutrophil count in the group treated with ITZA increased early days of treatment, so the duration of neutropenia in ITZA group is shorter. Serum creatinine level is lower in ITZA group than in ABV group but this is not statistically significant. There was no significant difference in response rate between two groups. The IL-$1{\beta}$ was increased in ABV treatment group and the ratio of IL-1Ra/IL-$1{\beta}$ is markedly decreased in ABV treatment group while increased in ITZA group. Conclusion : ITZA and ABV have at least equivalent efficacy as empirical antifungal therapy in neutropenic children with acute leukemia. However ITZA is associated with significantly less toxicity in clinical and molecular aspects.

• Journal of Korea Port Economic Association
• /
• v.34 no.3
• /
• pp.17-52
• /
• 2018

The purpose of this paper is to measure the clustering change and analyze empirical results. Additionally, by using k-means, hierarchical, and mixed models on Asian container ports over the period 2006-2015, the study aims to form a cluster comprising Busan, Incheon, and Gwangyang ports. The models consider the number of cranes, depth, birth length, and total area as inputs and container twenty-foot equivalent units(TEU) as output. Following are the main empirical results. First, ranking order according to the increasing ratio during the 10 years analysis shows that the value for average linkage(AL), mixed ward, rule of thumb(RT)& elbow, ward, and mixed AL are 42.04% up, 35.01% up, 30.47%up, and 23.65% up, respectively. Second, according to the RT and elbow models, the three Korean ports can be clustered with Asian ports in the following manner: Busan Port(Hong Kong, Guangzhou, Qingdao, and Singapore), Incheon Port(Tokyo, Nagoya, Osaka, Manila, and Bangkok), and Gwangyang Port(Gungzhou, Ningbo, Qingdao, and Kasiung). Third, optimal clustering numbers are as follows: AL(6), Mixed Ward(5), RT&elbow(4), Ward(5), and Mixed AL(6). Fourth, empirical clustering results match with those of questionnaire-Busan Port(80%), Incheon Port(17%), and Gwangyang Port(50%). The policy implication is that related parties of Korean seaports should introduce port improvement plans like the benchmarking of clustered seaports.

• Journal of Korea Port Economic Association
• /
• v.37 no.1
• /
• pp.31-70
• /
• 2021

The purpose of this paper is to measure the clustering change and analyze empirical results, and choose the clustering ports for Busan, Incheon, and Gwangyang ports by using Hierarchical clustering(single, complete, average, and centroid), Silhouette, and 2SCE[the Second Stage(Type II) cross-efficiency] matrix clustering models on Asian container ports over the period 2009-2018. The models have chosen number of cranes, depth, birth length, and total area as inputs and container TEU as output. The main empirical results are as follows. First, ranking order according to the efficiency increasing ratio during the 10 years analysis shows Silhouette(0.4052 up), Hierarchical clustering(0.3097 up), and 2SCE(0.1057 up). Second, according to empirical verification of the Silhouette and 2SCE models, 3 Korean ports should be clustered with ports like Busan Port[ Dubai, Hong Kong, and Tanjung Priok], and Incheon Port and Gwangyang Port are required to cluster with most ports. Third, in terms of the ASEAN, it would be good to cluster like Busan (Singapore), Incheon Port (Tanjung Priok, Tanjung Perak, Manila, Tanjung Pelpas, Leam Chanbang, and Bangkok), and Gwangyang Port(Tanjung Priok, Tanjung Perak, Port Kang, Tanjung Pelpas, Leam Chanbang, and Bangkok). Third, Wilcoxon's signed-ranks test of models shows that all P values are significant at an average level of 0.852. It means that the average efficiency figures and ranking orders of the models are matched each other. The policy implication is that port policy makers and port operation managers should select benchmarking ports by introducing the models used in this study into the clustering of ports, compare and analyze the port development and operation plans of their ports, and introduce and implement the parts which required benchmarking quickly.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.20 no.2
• /
• pp.157-167
• /
• 2008

The aeration of an overtopping wave on a vertical structure generated by a plunging wave was investigated through laboratory measurements of void fraction. The overtopping wave occurring after wave breaking becomes multi-phased and turbulent with significant aeration, so that the void fraction of the flow is of importance. In this study, fiber optic reflectometer and bubble image velocimetry were employed to measure the void fraction, velocity, and layer thickness of the overtopping flow. Mean properties were obtained by ensembleand time-averaging the repeated instantaneous void fractions and velocities. The mean void fractions show that the overtopping wave is very high-aerated near the overtopping wave front and relatively low-aerated near the deck surface and rear free surface of the wave. The flow rate and momentum of the overtopping flow estimated using the measured data show that the void ratio is an important parameter to consider in the multiphase flow. From the similarity profiles of the depth-averaged void fraction, velocity, and layer thickness, one-dimensional empirical equations were obtained and used to estimate the flow rate and momentum of the overtopping flow.

• Water for future
• /
• v.26 no.1
• /
• pp.115-124
• /
• 1993

This study is to determine the critical duration of design rainfall and to utilize it for the design of detention pond with pump station. To examine the effect of the duration and temporal distribution of the design rainfall, Huff's quartile method is used for the 9 cases of durations ranging from 20 to 240 minutes with 10 years return period, and the ILLUDAS model is used for runoff analysis. The storage ration which is the ratio of maximum storage amounts to total runoff volume, is introduced to determine the critical duration of design rainfall. The duration which maximizes the storage ratio is adopted as the critical duration. This study is applied to 18 urban drainage watersheds with pump station in Seoul, of which the range of watershed area is $0.24-12.70\textrm{km}^2.$ The result of simulation shows that the duration which maximizes storage ration is 30 and 60 minutes on the whole. It is shown also that the storage ration of 2nd- and 3rd-quartile pattern is larger than that of 1st- and 4th-quartile pattern of temporal distribution. A simplified empirical formula for Seoul area is suggested by using the regression analysis between the maximum storage ration and the peak ratio, and can be utilized for the preliminary design and planning of detention pond with pump station.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.38C no.11
• /
• pp.990-999
• /
• 2013

Previous studies based on the theoretical evidence and based on the empirical data have been constantly revealing related factors affecting visual fatigue in viewing 3D images. however, the measurement data coupled with the factors that affect the viewers to feel fatigue is insufficient. this study research that the viewers feel the visual functional data is based on subjective fatigue such as IPD, AC/A ratio, and the degree of phoria and the effects on variance in these data, is to examine the correlation between these data. based on the average score of subjective fatigue which is $6.00{\pm}3.88$, total fatigue points from 0 up to 6 is classified as a group not appealing for the fatigue and from 7 up to 16, they were classified as the fatigue appealing group. the results showed no difference in satisfaction of the images by each subjective fatigue, IPD and far phoria. AC/A ratio was higher from the fatigue not appealing group, near phoria was higher from the fatigue appealing group. after watching 3D images, the fatigue not appealing group showed a tendency of higher increase of exophoria. correlations appeared in this experiment showed that AC/A ratio and near phoria are closely related to level of subjective fatigue which feel when watching 3D images. when watching 3D images based on two data appear to be able to predict the fatigue, even during content production fatigue reduce the data dimensions to be used as the main basis is expected.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.14 no.1
• /
• pp.2503-2519
• /
• 1972

The studies were carried out to find the cause and the quantitative evaluation of sea dike materials loss which is occured during the period of construction works for the tideland reclamation projects on the west coast of Korea. Major subjects to studies were to establish the typical relationships between the tidal flow and the movement of dike materials, the tidal-flow and the erosion, the dike materials and the ratio of material movement(losses), construction methods and the ratio of materials movement (losses). Based on the above subjects, the studies were made for the purpose of obtain the following informations; (1) Collecting and evaluaing the data of dike material losses due to foundation settlement, from designed existing dikes on the west coast. (2) By the field investigation at A-San Sea Dike, Pyong Taek Project, the Comparison would be made by the relationships between the tide velocity and the movement of dike foundation under the natural conditions and the period of construction so that find out the relationship between the dike materials of foundation situation and settlements. With regard to the dike construction works, it is so difficult to calculate the exact quantity of material losses due to the foundation settlements. The major factors that affect the settlement losses of the dike materials are: (1) Topographical variation (2) Swepting the sectional area of dike by the tide velocity. (3) Dumping riprap to the outerside of dike during the period of construction works. (4) Sectional area losses by the cause of occurence of the new tide channels. (5) material losses by the heavy storms. (6) Consolidation settlement by the foundation weakness. (7) Material losses by the earth materials by tide flow. Most hi호 material losses were occured by the Consolidation settlement due to the foundation weakness, the maximum tide velocities due to decrease the cross sectional area of the gaps and erosion of foundation due to the range of tide, Inner and outerside of dike, or dike material loses due to the tide flow. Final conclusion would be obtained by the continuous measurement of consolidation settlement at the stage of final clusure of the dike. (It is scheduled to close on the end of 1972) However, intermediate conclusion can be introduced as follows: (1) The estimation of material(losses) during the period of construction works for the existing sea-dikes up to date were only empirical. The material losses at the general closure for design was estimated at 10% of the riprap, 20% of the earth materials, and 20% of the riprap, 40% of the earth materials at the final closure of the dike. The final closure estimated double quantity to the general closure, but it is still doubt. (2) The ratio of consolidation settlements was found smaller than the calculated quantity. It can be foreseen that settlement speeds is higher thom the calculated speeds. (3) The movement of dike foundation under the natural conditions were not so depends on the geological conditions of the foundation. (4) When the tide velocities was estimated 100 at the normal tide, it was estimated 125 at the high tide and 55 at the low tide. The tide velocities at the low tide shows apparently lower than the high tide and the higher velocities at the deep water depth.

• Land and Housing Review
• /
• v.3 no.1
• /
• pp.59-68
• /
• 2012

The current land development cost price system is classified as the creating land by construction price and composition changes that occur sporadically in the process of completion at the source of the factors by incurred cost price. Housing for land cost price system is a lack of objectivity which scheme of the such a gap due to the land in accordance construction and incurred cost price system so far. Therefore, in order to increase the objectivity of costing the costing of predictable surprises should be reflected in the process. Under such a background, this study defined the effective differential ratio as the predictable, estimated them for various characteristics of each business district to reflect. For this, set the properties category of five types to attributes and making the complex category and Look-up table. Which result of model validation is showed a high reliability. Therefore, Continuous accumulation of material in the future, when them to reflect the construction cost, will contribute to the bridge the gap the construction cost between incurred them.

• Journal of the Korean Geotechnical Society
• /
• v.34 no.6
• /
• pp.49-59
• /
• 2018

When a tracked vehicle travels off-road, shearing action and ground sinkage occur on the soil-track interface and severely affect tractive performance of the tracked vehicle. Especially, the ground sinkage, which is induced by vehicle's weight (hereinafter referred to as static sinkage) and longitudinal forces in the direction of travel producing slip (hereinafter referred to as slip sinkage), develops soil resistance, directly restricting the tractive performance of an off-road tracked vehicle. Thus, to assess the tractive performance of an off-road tracked vehicle, it is imperative to take both of static sinkage and slip sinkage into consideration. In this research, a series of model track experiments was conducted to investigate the slip sinkage which has not been clarified. Experiment results showed that the slip sinkage increased with increasing the slip ratio, but the increasing rate gradually decreased. Also, the slip sinkage was found to increase as relative density of soil decreased and imposed vertical load increased. From the experiment results, the normalized slip sinkage defined as slip sinkage to static sinkage calculated in the identical condition was investigated, and an empirical equation for the slip sinkage was developed in terms of slip ratio, which allows vehicle operators to predict the slip sinkage in a given soil and operating conditions.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.15 no.5
• /
• pp.537-546
• /
• 2013

Traffic congestion in existing tunnels has increased due to increased traffic volume and enlarged vehicles. Enlarging existing tunnels has advantages over constructing new tunnels by reducing land purchasing costs as well as minimizing natural environment destruction. In fact, many overseas projects for enlarging existing tunnels have been reported. Thus, it appears that the demand on enlarging existing tunnels continues to rise in Korea in near future. Nonetheless, the studies related to the enlarged tunnels have been relatively rare since there have been few tunnel enlargement projects in Korea. In the present study, the tunnel behavior and the stability of rock pillar when enlarging existing parallel tunnels were investigated by performing FE analysis and using existing theory and empirical relationships. Four different enlarging cases, depending on the enlargement types and directions, were examined in the study. According to the results, for the tunnels with the same pillar width after enlarged, the uni-laterally enlarged tunnel indicated 5 to 20% higher crown settlement compared to the bi-laterally enlarged tunnel, and for the tunnel with the narrowest pillar, the highest shotcrete stress was observed. Also, the strength/stress ratio for rock pillar was more than 1.0 for all four enlargement cases, and the Matsuda's method was found to give higher strength/stress ratio by about 50% compared to the Peck's method.