• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.5
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• pp.1239-1244
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• 2013

In the field of clinical medicine and research, the analysis of such as protein and DNA at the molecular level and even at the cell level are necessary for disease diagnosis and treatment. In many cases, a real time image of samples is needed for the accurate analysis and manipulation of samples since experimental samples are degenerated with time. In this research, a three-dimensional fluorescence microscope device was developed for taking images of protein and DNA inside a single cell and the server-client based image analysis system was made for an integrated management of the real-time images taken from the microscope device. The system consists of a fluorescent measurement device, the associated software and a client program on smartphone. The developed system allows doctors or experimental managers to receive and look at the real-time experimental images taken from the samples of patients anywhere in the emergency, to analyze results and to instantly diagnose the disease and to transfer the results to the patients. As a result, the system is able to be utilized in the implementation of ubiquitous health as well.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.3
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• pp.1245-1251
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• 2013

The aim of this study is to identify characteristics of 2D:4D according to type of handedness. Data was collected from October, 4th, 2010 to April, 30th, 2012. After handedness assessment, 2nd and 4th finger length were measured by vernier calipers. This study showed remarkable gender difference of 2D:4D in left hand for left handers and right hand for right handers, However, there was no significant difference according to type of handedness in each gender. The correlation between left and right 2D:4D in males right handedness was higher than that of male left handedness, otherwise, in case of female, that of left handedness was higher than that of right handedness. The results of this study suggest that the 2D:4D of left handedness does not differ from that of right handedness, however, gender difference and correlation between left and right 2D:4D show different characteristics according to handedness.

• Pediatric Infection and Vaccine
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• v.22 no.3
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• pp.131-135
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• 2015

Since April 2012, more than 1,600 laboratory-confirmed human infections with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been reported, occurring primarily in countries in the Arabian Peninsula; the majority in Saudi Arabia. The MERS outbreak in Korea, which began in May 2015 through the importation of a single case who had recently traveled to Bahrain, the United Arab Emirates, Saudi Arabia, and Qatar. As of November 28th, 186 secondary and tertiary cases had been reported; 38 deaths, mainly associated with underlying chronic illnesses, were reported. One case was exported to China and has been recorded as the first MERS case in China. Thirty-seven confirmed cases were associated with the index case, who was hospitalized from May 15 to May 17. Emergency room at one of the nation's largest hospitals had been affected by hospital-to-hospital and intra-hospital transmissions of MERS-CoV, resulting in an outbreak of 90 infected patients. The vast majority of 186 confirmed cases are linked to a single transmission chain associated with health facilities. The median age of patients is 55 years, with a range of 16 to 87 years. The majority (61%) of patients are men. Twenty-five (14%) of the cases involve healthcare workers. The overall median incubation period was six days, but it was four days for secondary cases and six days for tertiary cases. There has been no evidence of airborne transmission and sustained human-to-human transmission in communities. Intensified public health measures, including contact tracing, quarantine and isolation of all contacts and suspected cases, and infection prevention and control have brought the MERS-CoV under control in Korea. Since 4 July no new cases have been reported.

• Journal of Genetic Medicine
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• v.11 no.2
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• pp.74-78
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• 2014

Sotos syndrome (SS, OMIM 117550) is characterized by prenatal and postnatal overgrowth with multiple congenital anomalies. However, there have been few cases of growth retardation caused by renal failure from infancy. We report a case of dysplasia of the bilateral kidneys with renal failure and poor postnatal growth. A 2-month-old boy visited the emergency room owing to poor oral intake and abdominal distension. He was born at the gestational age of 38 weeks with a birth weight of 4,180 g. After birth, he had feeding difficulty and abdominal distension. Upon physical examination, his height and weight were in less than the 3rd percentile, while his head circumference was in the 50th percentile on the growth curve. He also showed a broad and protruding forehead and high hairline. Blood laboratory tests showed severe azotemia; emergent hemodialysis was needed. Abdominal ultrasonography revealed bilateral renal dysplasia with multiple cysts and diffuse bladder wall thickening. A posterior urethral valve was suggested based on vesicoureterography and abdominal magnetic resonance findings. Results of a colon study to rule out congenital megacolon did not reveal any specific findings. The conventional karyotype of the patient was 46, XY. Array comparative genomic hybridization study revealed a chromosome 5q35 microdeletion including the NSD1 gene, based on which SS was diagnosed. We describe a case of SS presenting with end stage renal disease due to posterior urethral valve. The typical somatic overgrowth of SS in the postnatal period was not observed due to chronic renal failure that started in the neonatal period.

• Proceedings of the KAIS Fall Conference
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• 2011.12a
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• pp.163-165
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• 2011

본 연구에서는 해부학강의에 있어 혼합강의의 적용가능성을 평가하였다. 2007~2009년 매 1학기동안 강원대학교 의과대학 간호학과 학생(n=143)을 대상으로 해부학강의를 가상강의 9회, 면대면 강의 3회, 사체해부실습 2회로 구성된 혼합강의로 실시한 후 설문을 통해 자기평가요인(만족도, 난이도, 흥미도, 유용성, 평가의 적절성, 학업성취도, 운영의 적절성, 이론실습연계성), 학업성취별 자기평가요인, 자기평가요인간의 상관관계를 분석하였다. 자기평가요인의 난이도는 평균$2.96{\pm}0.63$점으로 전반적인 강의수준은 적절했던 것으로 나타났고 나머지 모든 요소들은 평균 3.82~4.21점 사이로 평가되어 간호학과에서 해부학강의를 위한 혼합강의의 적용이 매우 긍정적인 것으로 나타났다. 학기종료 후 화보한 최종성적을 기준으로 세 그룹(상위, 중위, 하위)으로 나누어 자기평가요인과의 관계를 분석한 결과, 모든 요소에서 통계적으로 유의하지 않았다(p>0.05). 자기평가요인 간의 상관관계는 난이도와 전공연계성의 유용성(r=0.300, p<0.0003),혼합강의의 유용성(r=0.210, p<0.0137), 평가의 적절성(r=0.323, p<0.0001), 이론실습연계성(r=0.216 0.0097)이 높을수록 상관성을 보였다, 만족도, 전공연계성의 유용성, 혼합강의의 유용성, 이론실습연계성에서는 학업성취도를 제외한 모든 요소에서, 흥미도는 난이도와 학업성취도를 제외한 모든 요소에서 유의성 있게 높은 상관성을 보였다. 하지만 학업성취도에서는 평가의 적절성을 제외한 다른 요소에서는 연관성을 보이지 않아 성적과 관련해 영향을 미치는 요소가 없다는 것으로 판단되어지며 본 연구를 위해 도입된 강의구성이 해부학의 균형 있는 학업성취를 유도할 수 있는 수업방식이라 판단되었다. 결론적으로 본 연구를 통해 해부학강의에 있어 혼합강의의 우수한 교육효과를 알 수 있었고, 간호학과만이 아닌 최근 급증하고 있는 의료-보건계열의 다양한 전공자를 위한 적용, 확대로 해부학지식의 질적 향상과 강의수요에 비해 부족한 해부학 전공 교수진들의 교육 부담을 경감할 수 있는 효과적인 교수법으로 활용가치가 있다고 사료된다.

• Archives of Craniofacial Surgery
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• v.12 no.2
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• pp.107-110
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• 2011

Purpose: There have been few case reports regarding treatment plans for long-term, neglected scalp defects and calvarial defects with subdural abscess. The purpose of this case report is to present our experience with a free latissimus dorsi musculocutaneous flap for scalp and calvarial defects and to discuss flap options in comparison with a literature review. Methods: A 60-year-old man who fell down from a four-story-height that resulted in a craniotomy in 1979; he visited our outpatient clinic for a chronic, purulent scalp and calvarial defects with unidentified artificial bone. The artificial bone was removed by a neurosurgeon and reconstructed with a free latissimus dorsi musculocutaneous flap. The deep temporal artery was used as a recipient artery. The postoperative flap status was excellent until the 6th day post-operation when the patient experienced a seizure, and an arterial insufficiency occurred at the flap probably due to an arterial spasm. Emergency exploration with arterial re-anastomosis was performed and the flap status was stabilized. Results: Complete wound healing was achieved after 3 weeks without infectious and systemic postoperative complications. During the 6 month follow-up period, there were no complications. Conclusion: We suggest the latissimus dorsi myocutaneous free flap as a good treatment option for a chronic, purulent, complicated scalp with calvarial defect, as a well as treatment for an acute traumatic defect.

• Journal of Trauma and Injury
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• v.28 no.2
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• pp.55-59
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• 2015

Purpose: To compare clinical and radiographic outcomes of between two and three Kirschner wire(K-wire) intramedullary fixation for fractures in the neck of the metacarpal bone. Methods: A single institutional retrospective review identified 28 cases of metacarpal fractures between March 2010 and August 2014. Each of the cases met the inclusion criteria for closed, extra-articular fractures of the neck of the metacarpal bone. The patient groups were divided by the number of K-wire. Outcomes were compared for range of motion of the metacarpophalangeal joint, radiographic parameters, and period until union. Results: The fractures were treated with either 2 Kirschner wire fixation (n=10) or 3 Kirschner wire fixation (n=18). The active range of motion of metacarpophalangeal joint and radiographic result showed no statistically significant difference between the two groups. The mean union period was 5.9 weeks. However, four cases suffered distal head perforation in 2 K-wire fixation group and one case in 3 K-wire fixation group. Conclusion: Multiple retrograde intramedullary Kirschner wire fixation is a good treatment of choice for fractures in the neck of the metacarpal bone. To prevent metacarpal head perforation, it is preferred to use three K-wires than two K-wires.

• Korean Journal of Biological Psychiatry
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• v.27 no.2
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• pp.42-57
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• 2020

Electroconvulsive therapy (ECT) is indicated for various mental disorders (e.g., major depressive disorder, schizophrenia, and bipolar disorder) and the behavioral and psychological symptoms of dementia in elderly patients. Furthermore, ECT is a useful first-line treatment in emergency and crisis situations such as suicide risk, violent behavior, catatonia, and food refusal, which are more frequent in elderly patients. ECT is also effective in the treatment of the motor symptoms of neurological disorders, such as Parkinson's disease and Huntington's disease. Due to the high risk of various physical diseases, the comorbid physical conditions of elderly patients should be individually controlled to optimize ECT treatment. Compared to young adults, in elderly patients the seizure threshold is higher, the seizure duration is shorter, and the anesthetic dose is lower. On the contrary, the response rate in the elderly is both faster and higher. Considering potential cognitive decline and the prevention of further deterioration of cognitive function in elderly patients, in the absence of significant comorbidities, twice weekly sessions and right unilateral electrode placement with a lower seizure threshold and less cognitive effect are preferred to bilateral electrode placement, which has a high risk of adverse cognitive effects. After an acute course of ECT, continuation and maintenance of ECT, combined with prescription of therapeutic drugs, may prevent possible relapse or recurrence of mental disorders. In conclusion, ECT can be used to treat mental disorders in elderly adults, with safety and effectiveness comparable to that in young adults.

• Journal of Trauma and Injury
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• v.32 no.1
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• pp.8-16
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• 2019

Purpose: The Essential Surgical Procedures in Trauma (ESPIT) course was developed as a model to teach necessary surgical procedures to trauma physicians. Its goals are to improve knowledge, self-confidence, and technical competence. Methods: The ESPIT course consisted of five lectures and a porcine lab operative experience. The ESPIT course has been run seven times between February 2014 and April 2016. ESPIT participants completed a questionnaire to assess self-efficacy regarding essential surgical procedures in trauma before and immediately after taking the ESPIT course. Sixty-three participants who completed both pre- and post-course questionnaires on self-efficacy were enrolled in this study. Results: The overall post-ESPIT mean self-efficacy score was higher than the pre-ESPIT mean self-efficacy score ($8.3{\pm}1.30$ and $4.5{\pm}2.13$, respectively) (p<0.001). Self-efficacy was significantly improved after the ESPIT course in general surgeons (p<0.001), thoracic and cardiovascular surgeons (p<0.001), emergency medicine doctors, and others (neurosurgeons, orthopedic surgeons) (p<0.001). The differences in self-efficacy score according to career stage (<1 year, 1-3 years, 3-5 years, and >5 years) were also statistically significant (p<0.001). Conclusions: The data of the ESPIT participants indicated that they felt that the ESPIT course improved their self-efficacy with regard to essential surgical procedures in trauma. The ESPIT course may be an effective strategy for teaching surgical procedures, thus promoting better management of traumatic injuries.

• Journal of the Korea Convergence Society
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• v.10 no.10
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• pp.231-240
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• 2019

For the development of school meals, this study was designed to identify the status of middle school students who eat eco-friendly school meals with a view to converging on their awareness, interest, and operational satisfaction. The results of the survey of 468 K middle school students in Gwangju were all based on a significant level of p.Validated at 05. There were achievements in the recognition of students' awareness, interest, and operational satisfaction contributing to the improvement of school meal satisfaction, but there were also limitations in the operation of eco-friendly school meals, such as various family composition and budget expansion, and not the entire school. If the disclosure of data on future results is expanded to the whole, it could be used as a valuable resource for improving school meal satisfaction and developing school meals.