• The Journal of Korean Academy of Sensory Integration
• /
• v.13 no.2
• /
• pp.75-84
• /
• 2015

Objective : The aim of this study was to provide mechanism information of a link between arousal and sensory modulation to increase understanding of neurophysiological study. Subject : Optimal arousal state of a child is an important issue in sensory integration therapy. Limbic system and reticular formation are related to sensory modulation by sensory input. Sensory inputs processes from reticular formation to cortex via ascending reticular activation system for moderate arousal. A lot of neurotransmitters such as cholinergic neurons and monoamin neurons help this processes. Mechanism of arousal was measured by functions of central nervous system (CNS) and autonomic nervous system (ANS) using objective tools such as an electroencephalogram (EEG) and electrodermal responses. Functions of CNS and ANS showed differences between normal children and children with disabilities. Optimal sensory input using sensory integration therapy for children with disabilities helps to act reticular formation, limbic system, and cortex and to maintain appropriate arousal. Conclusion : Such quantitative studies by using neurophysiological methods provide evidence for sensory integration therapy.

• Biomolecules & Therapeutics
• /
• v.25 no.6
• /
• pp.586-592
• /
• 2017

Sinomenium acutum has been long used in the preparations of traditional medicine in Japan, China and Korea for the treatment of various disorders including rheumatism, fever, pulmonary diseases and mood disorders. Recently, it was reported that Sinomenium acutum, has sedative and anxiolytic effects mediated by GABA-ergic systems. These experiments were performed to investigate whether sinomenine (SIN), an alkaloid derived from Sinomenium acutum enhances pentobarbital-induced sleep via ${\gamma}$-aminobutyric acid (GABA)-ergic systems, and modulates sleep architecture in mice. Oral administration of SIN (40 mg/kg) markedly reduced spontaneous locomotor activity, similar to diazepam (a benzodiazepine agonist) in mice. SIN shortened sleep latency, and increased total sleep time in a dose-dependent manner when co-administrated with pentobarbital (42 mg/kg, i.p.). SIN also increased the number of sleeping mice and total sleep time by concomitant administration with the sub-hypnotic dosage of pentobarbital (28 mg/kg, i.p.). SIN reduced the number of sleep-wake cycles, and increased total sleep time and non-rapid eye movement (NREM) sleep. In addition, SIN also increased chloride influx in the primary cultured hypothalamic neuronal cells. Furthermore, protein overexpression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptor subunits by western blot were found, being activated by SIN. In conclusion, SIN augments pentobarbital-induced sleeping behaviors through $GABA_A$-ergic systems, and increased NREM sleep. It could be a candidate for the treatment of insomnia.

• Natural Product Sciences
• /
• v.21 no.3
• /
• pp.219-225
• /
• 2015

In the previous experiments, we reported that ethanol extract of Gastrodiae Rhizoma, the dried tuber of Gastrodia ElataBlume (Orchidaceae) increased pentobarbital-induced sleeping behaviors. These experiments were undertaken to know whether 4-hydroxybenzaldehyde (4-HBD), is one of the major compounds of Gastrodiae Rhizoma increases pentobarbital-induced sleeping behaviors and changes sleep architectures via activating GABA_A-ergic systems in rodents. 4-HBD decreased locomotor activity in mice. 4-HBD increased total sleep time, and decreased of sleep onset by pentobarbital (28 mg/kg and 40 mg/kg). 4-HBD showed synergistic effects with muscimol (a GABA_A receptor agonist), shortening sleep onset and enhancing sleep time on pentobarbital-induced sleeping behaviors. On the other hand, 4-HBD (200 mg/kg, p.o.) itself significantly inhibited the counts of sleepwake cycles, and prolonged total sleep time and non-rapid eye movement (NREM) in rats. Moreover, 4-HBD increased intracellular Cl⁻ levels in the primary cultured cerebellar cells. The protein levels of glutamic acid decarboxylase (GAD) and GABA_A receptors subunits were over-expressed by 4-HBD. Consequently, these results demonstrate that 4-HBD increased NREM sleep as well as sleeping behaviors via the activation of GABA_A-ergic systems in rodents.

• Science of Emotion and Sensibility
• /
• v.4 no.2
• /
• pp.79-88
• /
• 2001

The objectives of this study were to investigate the relationship of sound parameters with subjective sensation and physiological responses, and to figure out the interrelationship between the subjective sensation and physiological responses. Sound parameters calculated were LPT, ΔL, Δf, loudness[Z], and sharpness[Z]. Subjective sensation was evaluated in 7 aspects(soft-hard, loud-quiet, pleasant-unpleasant, sharp-dull, clear-obscure, rough-smooth, high-low) by thirty participants. We acquired physiological responses when each fabric sound was presented to 10 participants. Physiological signals obtained in this study were electroencephalogram(EEG), pulse volume(PV), skin conductance level(SCL), and LF/HF of heart rate variability. The larger the values of loudness[Z] and LPT, the louder and the rougher the subjective sensation of the perceived fabric sound. Also, the larger the values of loudness[Z] and LPT, the harder, the duller, and the less pleasant. As LPT increased, PV decreased. Loudness[Z] increased in proportion to SCL and so did sharpness[Z] to LF/HF. As the sound perceived to be quieter and clearer, the relative power of slow alpha rose. As the sound perceived to be more pleasant and smoother, PV rose.

• Science of Emotion and Sensibility
• /
• v.8 no.4
• /
• pp.321-332
• /
• 2005

This study is about the effect on the user's cognitive stress by font size when they read on PDA (Personal Digital Assistant). The evaluation was done through both subjective evaluation and physiological one, which is brain wave test, while the research and analysis were focused on the relationship between the user's cognitive stress and font, size. The two final results were found out as follows. 1) Font sizes, which were tested, were 8, 10, 12, 14, and 16points. Among theses, font size 14 was the least stressful for the users. while the most stressful size was found out 8 points. 2) The cerebral cortex reaction according to the font size activated occipital lobe, parietal lobe of occipital visual area. Here we could come to a very important conclusion that the smaller font size on mobile information appliances mate users the more stressed.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.30 no.3
• /
• pp.149-157
• /
• 2018

In this research, the psychological and physiological reactions of the driver were measured during winter to evaluate thermal comfort. The experiment was conducted using 3 different cases which are hot air heating, warm-wire seat heating and hot air & warm-wire seat heater operating simultaneously. With regard to psychological reaction, the warm-wire heating mode was the most preferred. The reason is that it is dry in other cases. With regard to EEG response, thermal comfort increased by 37% in warm air mode heating. In addition, when the warm-wire heating mode and the hot air & warm-wire heating mode were simultaneously operated, the thermal comfort continuously increased by between 17% and 20% for 20 minutes after boarding. Under the change of the autonomic nervous system, the thermal stress level increased by 23% after 15 minutes on board in the hot air heating mode and decreased continuously by 13% during the warm-wire seat heating mode. We recommended the hot air heating mode is only used for a short time to raise the inside temperature during the early boarding period and that warm-wire seat heating mode be actively utilized.

• Journal of Korean Society of Forest Science
• /
• v.98 no.1
• /
• pp.88-93
• /
• 2009

The overall purpose of this study was to figure out psycho-physiological variations in human bodies according to observing visual images of forests. To collect data, the authors employed 9 views each in three different environments such as cities, forests, and landscape which combines a forest with water. The experiment was conducted by showing total 27 images to 30 visitors to measure the subjects' changes of alpha waves of EEG(electroencephalogram). As measures of psychological impact of the views, PRS(Perceived Restorativeness Scale) and PANAS(Positive and Negative Affect Schedule) were used. The results of the data analyses indicated that the views of landscape with a forest and water influenced most highly on subjects' psycho-physiological responses.

• Archives of design research
• /
• v.15 no.3
• /
• pp.249-258
• /
• 2002

This study is about the effect on the user's cognitive stress by font size when they read on PDA(Personal Digital Assistant). The evaluation was done through both subjective evaluation and physiological one, which is brain wave test, while the research and analysis were focused on the relationship between the user's cognitive stress and font size. The two final results were found out as follows. 1) Font sizes, which were tested, were 8, 10, 12, 14, and 16 points. Among theses, font size 14 was the least stressful for the users, while the most stressful size was found out 8 points. 2) The cerebral cortex reaction according to the font size activated occipital lobe, parietal lobe of occipital visual area. Here we could come to a very Important conclusion that the smaller font size on mobile information appliances made users the more stressed.

• The Journal of the Society of Stroke on Korean Medicine
• /
• v.23 no.1
• /
• pp.55-64
• /
• 2022

Nonconvulsive Status Epilepticus(NCSE) refers to continuous epileptic condition with altered mental status and behavioral symptoms, but without convulsive movement at least 10 minutes. In Salzburg criteria, well known as the diagnostic criteria of NCSE, it is diagnosed with clinical symptoms, electroencephalogram (EEG), and effects before and after the use of antiepileptic drugs (AEDs). Commonly being used to treat NCSE, AEDs are likely to have adverse effects. In the present case, a 85-year-old female NCSE patient complaining delirium underwent combined Korean medical treatment by acupuncture and herbal medicine for 13 days. The effect of treatment was assessed with delirium scales including Delirium Rating Scale-Revised-98(DRS-R-98) and Assessment Test for Delirium & Cognitive Impairment(4AT) per 2 days. After the treatment, both DRS-R-98 and 4AT scores decreased, and orientation and mental status of patient improved. This case report suggests that Korean medical treatment might be an effective option without side for those NCSE patients complaining delirium.

• Journal of People, Plants, and Environment
• /
• v.22 no.2
• /
• pp.127-143
• /
• 2019

This study investigates the color stimuli of two varieties of foliage plants by extracting electroencephalogram, electrocardiogram and physiology activity data from 30 participants in their 50s or older. Changes in the physiological activity of subjects against six color stimuli were examined. The stimulus to real green plants 'Silver Queen' was set as the control group, and was compared with other groups including the stimulus to real 'Angel' plants and four stimuli to artificial colors (two color images and color schemes of the same green and red plants). Compared to the five groups, the relative theta power spectrum (RT) and the ratio of alpha to high beta (RAHB) increased in the subjects exposed to real green plants. This result demonstrates that the green plant ('Silver Queen') increases the stability, relaxation, and internal concentration of subjects in a proper state of awakening. The result of this experiment showed a statistically significant difference in the level of RT when subjects were exposed to the groups of real green and red plants. This finding indicates that the green plant increases internal concentration more than the red plant. RT and the relative low beta power spectrum (RLB) in the groups of natural colors were higher than the groups of artificial colors when subjects focused their mind on the two types of real plants. However, the level of relative mid beta power spectrum (RMB), ratio of SMR to theta (RST), ratio of mid beta to theta (RMT), relative high beta power spectrum (RHB), and spectral edge frequency 95% were higher when subjects were exposed to the photos and colors scheme of plants than when they were exposed to real plants. The subjects experienced more "comfortable" emotions when they were looking at plants with green colors. Overall, it is recommended to use the natural colors of real plants in places where which stability and relaxation are required. On the contrary, the artificial colors of plants such as their photos and color schemes are useful in places where a high level of concentration is required in a short period of time.