• 한국식품과학회지
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• 제34권5호
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• pp.885-888
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• 2002

본 연구의 목적은 우리나라의 식품으로 인한 알레르기 발생 빈도를 파악하며 주 알레르기 원인 식품을 파악하는 것이다. 삼성서울병원에 알레르기 증상으로 1998년 5월부터 2001년 8월까지 방문한 환자의 혈청 특이 IgE 항체를 대상 식품에 대해 CAP 시스템을 이용하여 조사하였다. 총 9054건의 CAP 검사가 난백, 난황, 우유, ${\alpha}-lactalbumin,\;{\beta}-lactoglobulin$, 카세인, 밀, 쌀, 메밀, 대두, 복숭아, 게, 새우, 돼지고기, 쇠고기, 닭고기, 참치, 연어, 고등어 및 혼합식품에 대해 1707명의 방문자를 중심으로 이루어졌다. 조사 결과 CAP 수치가 +2(0.7 U/mL) 이상인 값을 양성으로 판단하였으며 CAP 검사결과 11.3% (1022/9054건)가 양성이었다. 각 알레르기 원인 식품별로는 난백이 336건, 우유가 266건, 난황이 95건, 대두가 76건 ${\alpha}-lactalbumin$ 이 69건, 카세인이 61건, ${\beta}-lactoglobulin$이 58건, 메밀이 39건, 밀이 12건, 쇠고기 3건, 게 2건, 쌀, 새우, 돼지고기, 닭고기, 고등어 가 각각 1건, 복숭아, 참치, 연어 혼합식품이 각각 0건이었다. 우리나라에서 제일 많은 5대 알레르기 원인 식품으로 계란, 우유, 대두, 메밀 및 밀이 확인되었으며 환자 1인당 평균 2가지의 알레르기 원인 식품을 갖고 있는 것으로 확인되었다.

• 동의생리병리학회지
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• 제17권1호
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• pp.123-129
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• 2003

Experimental studies were done to research the dinical effects of Juglandis Semen aqua-acupuncture and acupuncture(BL 13) on the anti-allergic response. anaphylaxis provoked by the compound 48/80, delayed type hypersensitivity response to picryl chloride and SASC and inflammation response to egg albumin. The following results have been obtained: Juglandis Semen aqua-acupuncture and acupuncture(BL13) group were increased the survival rate in compound48/80 induced systemic anaphylactic reaction. Picryl chloride induced contact dermatitis and delayed type hypersensitivity in SRBC challenged mouse were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture (BL13) group. Inflammation response - WBC, CRP and Nitric Oxide in egg albumin induced allergic rat were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture(BL13) group. According to the above results, Semen aqua-acupuncture and acupuncture(BL13) both depress the allergy reaction.

• Journal of Nutrition and Health
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• 제42권6호
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• pp.523-535
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• 2009

본 연구는 알레르기 유발에 영향을 미치는 요인과 식품 알레르기 빈도 및 그 원인 식품을 조사하기 위하여 다양한 연령의 알레르기 환자 62명과 정상인 69명을 대상으로 2008년 8$\sim$9월 2개월 동안 설문조사를 실시하였다. 설문지의 조사항목으로는 일반사항, 알레르기 환자에 대한 일반사항, 생활습관, 식습관 및 식품 알레르기의 발생 빈도가 높은 식품에 대한 섭취 빈도에 대하여 분석하였다. 그 결과는 다음과 같다. 1) 일반사항 조사 결과 알레르기 환자군이 정상군에 비해서 가정의 한 달 평균 수입이 높은 것으로 나타났고, 알레르기 환자군이 정상군에 비해 애완동물을 많이 보유하고 있었으며 (p < 0.05), 알레르기 환자군이 정상군보다 식물을 더 많이 키우고 있는 것으로 나타났다 (p < 0.05). 2) 알레르기 환자의 알레르기 질환양상에 대한 조사결과, 복합적인 증상과 두개 이상의 알레르기를 경험한 환자가 많았고, 알레르기 유발 요인으로는 집먼지 진드기와 식품의 비율이 높게 나타났으며, 계절과는 상관없이 알레르기 증상이 나타나는 환자가 많았다. 또한 알레르기 가족력이 있는 환자가 많았으며 (66.1%), 최선의 예방방법은 주위 환경을 깨끗이 하여야 한다고 생각하는 환자가 가장 많았다 (45.2%). 3) 생활습관 조사결과, 운동 빈도는 두 군간 차이가 없었으며 음주 빈도는 알레르기 환자군이 정상군에 비해 유의적으로 높게 나타났다 (p < 0.01). 4) 식습관은 알레르기 환자군이 정상군에 비해 결식의 비율이 높고, 간식을 많이 섭취하고 있는 것으로 나타났다 (p < 0.05). 5) 식품 알레르기의 발생 빈도가 높은 식품에 대한 섭취 빈도를 살펴보면, 알레르기 환자군이 정상군 보다 계란 (p < 0.05), 돼지고기 (p < 0.001), 호두 (p < 0.05), 양파 (p < 0.05), 참치 (p < 0.05), 조개류 (p < 0.05), 키위 (p < 0.05), 인스턴트식품 (p < 0.05)의 섭취빈도가 유의적으로 높은 것으로 나타났다.

• 대한의생명과학회지
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• 제19권4호
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• pp.315-329
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• 2013

This study was conducted to evaluate the distribution, frequency, sensitization rate, and types of specific allergen in allergic patients. We analyzed allergens of 12,882 allergic patient's serum referred for Medical Laboratory using MAST Allergy Screen Test (Inhalation/food panel) from April, 2010 to March, 2011. Allergen reactivity were not detected in 833/12,882 (6.5%) allergic patients and the other allergic patients had two or more types of allergens of food and inhalant, respectively. In the distribution of the allergen food 73.4% (9,450/12,882 patients) was much higher than the pollen 26.6% (3,432/12,882 patients). The sensitization rate to each allergen showed garlic 26.7%, egg white 21.5% of food allergens, mugwort 24.9%, ragweed short 19.6% of pollen allergens, Candida albicans 10.5%, Alternaria spp. 7.9% of fungus allergens, and showed high sensitized rate to Dermatophagoides farinae 90.2%, Dermatophagoides pteronyssinus 77.8%, house dust 57% of indoor allergens, respectively. The specific allergens of food allergen, fungus allergen, and indoor allergen were more frequent in young child than adult, but pollen allergens were frequent in adult than young child. In seasonal distribution, the food allergen were frequent in summer and autumn, the pollen allergen in autumn, fungus allergen in spring and in winter, and indoor allergen in autumn and in winter. In conclusion, the mite of Dermatophagoides farinae and Dermatophagoides pteronyssinus, and house dust showed the highest sensitization rate in specific allergen of allergic patients. The allergens showed difference feature according to the age, region, and types of allergen.

• Journal of Nutrition and Health
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• 제54권6호
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• pp.664-678
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• 2021

본 연구에서는 제주지역 일부 만 6세 이하 미취학 아동의 부모를 대상으로 아동의 식품알레르기 유병률 및 관리, 부모의 식품알레르기 관련 지식도와 양육 부담의 현황을 식품알레르기 유무에 따라 분석하였으며, 그 결과는 다음과 같다. 조사대상자 총 387명으로 남아가 51.4%, 여아가 48.6%이었고, 그 중 식품알레르기를 경험한 아동은 16.8% (남아: 58.5%, 여아: 41.5%)로 조사되었다. 식품알레르기를 경험한 아동 중 실제로 의사로부터 식품알레르기 진단을 받은 아동 44.6%로 나타났다. 식품알레르기를 경험한 아동의 주된 증상으로는 구토, 설사, 기침, 복통, 쌕쌕 거림과 호흡곤란 순으로 나타났으며, 원인 식품으로는 난류가 가장 높은 빈도로 나타났고, 우유, 갑각류, 땅콩 및 콩류, 밀, 쇠고기 등이 뒤를 이었다. 또한 식품알레르기를 경험한 전체 아동의 부모 중 15.4%만이 대체식품을 사용한다고 조사되어 대부분의 부모가 대체식품을 사용하지 않는 것으로 조사되었다. 식품알레르기를 경험한 아동의 부모에서 식품알레르기로 인한 양육 부담은 정서적 고충이 일상생활의 제약에 비해 더 큰 것으로 나타났으며, 부모의 식품알레르기 관련 지식도는 식품알레르기 경험 유무에 따라 유의적인 차이를 보였다. 즉, 조사대상자의 식품알레르기 관련 지식과 식품알레르기 관련 교육 및 상담 참여경험 (보건소 또는 병원)비율과 의지가 식품알레르기 경험이 없는 아동의 부모보다 높아, 자녀의 식품알레르기에 대한 관심과 동시에 그에 따른 양육 부담 및 근심 정도가 높게 나타났다. 이상의 연구결과를 토대로 살펴볼 때, 미취학 아동 부모를 대상으로 한 식품알레르기의 예방과 대처방안 및 대체식품을 이용한 영양관리 등 수요자의 니즈-맞춤형 영양교육과 상담을 위한 체계적인 교육 자료의 개발이 필요하며, 학부모의 접근성을 고려한 교육 및 상담 장소를 적극적으로 활용하는 방안이 모색되어야 할 것으로 사료된다.

• Food Science and Biotechnology
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• 제14권3호
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• pp.355-357
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• 2005

This study evaluated the binding abilities of rabbit anti-ovalbumin (OVA) immunoglobulin G (IgG) and egg-allergic patient IgE on gamma-irradiated OVA during proteolysis using pepsin and trypsin. The concentrations of both the intact and the irradiated OVAs decreased during proteolysis when detected with IgG However, when detected by patient IgE the concentration of the intact OVA decreased up to 30 min after the trypsin treatment and increased thereafter. Irradiated OVA detected by patient IgE showed a lower initial concentration (0.16%) than that of the intact OVA, and this reduced concentration was maintained stably. The results indicate that irradiation, rather than enzymatic treatment, could reduce the binding of the irradiated and enzyme-treated OVA. Therefore, gamma irradiation has potential as an effective method to reduce OVA-induced allergy and may enhance the safety of egg-allergic individuals.

• 대한지역사회영양학회지
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• 제10권3호
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• pp.264-270
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• 2005

Breastfeeding has been known as the best feeding practice to prevent allergies including atopic dermatitis (AD) However, the benefit on the prevention of allergic disease is still controversial. The objectives of this study were to examine the rate of sensitization to the protein of eggs, cow's milk and soy in exclusively breastfed infants and to evaluate antigen-antibody reaction between breast milk and serum of AD infant. Data on feeding and food hypersensitivity were obtained for 62 AD infants (32 male, 30 female) aged < 6 month who had visited Samsung Medical Center from September 2001 to May 2003. Food hypersensitivity was determined by measuring specific IgE to egg, cow's milk and soy. Specific IgE levels > 0.7 kU/L by CAP assay (Pharmacia, Uppsala, Sweden) were considered positive. The rates of sensitization in breastfed infants were $41.9\%$ (26/62) to egg, $30.6\%$ (19/62) to milk and $18.0\%$ (11/62) to soy. Immunoblotting analyses were performed using breast milk with the matched serum of seven AD infants (4 male/3 female). Binding patterns of AD infant's IgE to breast milk extract showed visible specific band for immunoglobulin, especially in case of a lactating mother who did not completely restricted ingestion of egg, milk and soy. These results indicate that sensitization to food allergen develops via breast milk feeding. Breast milk feeding should be recommended in infants at risk of developing allergic disease, but maternal intake of highly allergenic food might be restricted for prevention and treatment of food allergy among the babies with AD.

• Toxicological Research
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• 제17권
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• pp.197-199
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• 2001

Enhancement of antigen-specific IgE is a hallmark of allergic hyperresponsiveness, therefore it is necessary to adopt or develop a highly sensitive and specific assay for determination of allergen-specific IgE levels in vivo. In this presentation, we introduce an ELISA (enzyme linked immunosorbent assay) system developed to measure the levels of chicken egg ovalbumin (OVA)-specific IgE in serum. The ELISA method uses a commercially available purified rat anti-mouse IgE as a capture Ab and biotinylated OVA as a detection reagent. Avidin-peroxidase with its substrate is used for color development resulting in optical density measurement at 405 nm. The ELISA system produces a highly sensitive dose-response relation-ship between optical density levels and the dilution titer of the OVA-IgE standard serum but no cross-reaction with unrelated IgE or IgG. It is believed that the system is an Efficient tool to delineate an adjuvant effect of environmental pollutants on development of asthmatic and atopic responses.

• International Journal of Contents
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• 제14권3호
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• pp.39-45
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• 2018

Purpose: Food Allergen Immunotherapy (Oral) is a form of immunotherapy administered to patients who are allergic to foods such as egg, milk, and peanut. The food allergen is orally administered to the patient in an escalating dose for desensitization or tolerance development. The safety and effectiveness of the therapy were assessed using a systematic literature review and meta-analysis. Methods: For a literature search, 8 national databases and a number of international databases including Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library were used; and 13 articles (all from international databases) were selected. The target of Food Allergen Immunotherapy (Oral) included patients with food allergy, and the intervention was food allergen immunotherapy without limiting the food type. The safety and effectiveness of Food Allergen Immunotherapy (Oral) were assessed by reviewing all the articles reporting on the therapy. The control group received standard therapies including aversion therapy, no treatment, anti-histamine treatment, and placebo. Safety was assessed through the incidence of complication and emergency medication. Effectiveness was assessed based on therapy success rate, symptomatic improvement, and quality of life. Results: Although Food Allergen Immunotherapy (Oral) was shown to have successful desensitization in patients with food allergy, the safety of the technique has not yet reached an acceptable level; the possible reason is due to the high rate of complication and frequency of emergency medication. Also, each study employed varying protocols while relying on a small number of participants and a short monitoring period. Conclusion: The results of assessment suggest that the level of evidence from current literature review is low and further research is necessitated for the verification of the safety and effectiveness of the therapy (Grade of Recommendation: A; Level of Technology: II-b).

• Korean Journal of Acupuncture
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• 제20권3호
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• pp.81-90
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• 2003

Objectives : This experimental research has been done to study the effects of herbal-acupuncture with Juglandis Semen on the anti-allergic reaction. Methods : ICR mice were injected intraperioneally with compound 48/80 to induce the immediately type hypersensitivity (anaphylaxis). ICR mice were sensitized by PC and SRBC to induce the delayed type hypersensitivity. Sprage-Dawley rats were injected subcutaneously with egg albumin to measure the WBC. ICR mice and Sprage-Dawley rats were injected with Juglandis Semen herbal-acupuncture for the anti-allergic reaction test. Results : 1. In the restraint effect of systemic anaphylactic reaction, the mortality of mice decreased 20% each before 10 minutes and after 5 minutes. 2. In the contact dermatitis induced by PC, both Treat Ⅰand Treat Ⅱ group showed significant(p<0.01, p<0.05) decrease in comparison with the Control group, and also Treat Ⅲ group showed significance(p<0.005). 3. In the delayed type hypersensitivity in mice challenged by SRBC, Treat Ⅰ group showed significant(p<0.05) decrease in comparison with the Control group, and there was significance(p<0.05, p<0.05) in Treat Ⅲ and Treat Ⅳ group. 4. The change of the WBC in allergic rats induced by egg albumin showed significant(p<0.01, p<0.05, p<0.05) decrease in Treat Ⅰ, Treat Ⅱ and Treat Ⅲ group. Conclusions : The restraint effects of Juglandis Semen herbal-acupuncture on the anti-allergic reaction showed significance statistically. And also allergic group treated with $BL_{17}$ acupuncture (Treat Ⅲ group) showed same results.