• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제26권2호
• /
• pp.63-69
• /
• 2020

Purpose: The purpose of this study is to identify the neuro architecture items and detailed elements that can be considered for each detailed space in the future medical space design development through the development of a checklist of neuro architecture elements that can be utilized in medical space design. Methods:: This study first develops the neuro architecture element through theoretical research and prepares the basic plan for the checklist through consultation with the employees of the design company in which the researcher works. Finally, a checklist was developed through a survey of nine experts, including designers, hospital staff, and professors. Results: The result of this study 1) The neuro architecture component was developed in seven categories: light, color, sound, air, image, nature, ergonomic furniture and equipment. 2) Specifically, it consists of 49 elements including 7 light elements, 7 color elements, 5 sound elements, 4 air elements, 11 image elements, 6 elements in nature, 9 elements in ergonomic furniture and equipment. It was. 3) Although each of the detailed elements is more preferred according to the space, in general, all the elements should be considered in the context of the hospital space design. Implications: The checklist on the neuro architecture element will enable the development of the most faithful design as an efficient and useful tool for applying the neuro architecture philosophy that considers human beings in hospital design and pursues healing and happiness.

• 한국통신학회논문지
• /
• 제32권4B호
• /
• pp.200-207
• /
• 2007

최근에 인터넷에서는 많은 Peer-to-Peer (P2P) 시스템이 등장하여 자료 공유가 활발히 이루어지고 있다. P2P 시스템은 자가 형성, 자가 치료, 분산처리와 같은 특징을 지니고 있어, 그러한 특징을 공유하는 애드혹 환경에서도 적절한 응용 프로그램으로 인식되고 있다. 본 논문은 가장 널리 사용되는 P2P 시스템중의 하나인 Gnutella를 애드혹 망에서 보다 효율적으로 동작할 수 있도록 개선하여 시스템 수명 연장, 오버헤드 감소, 향상된 성능을 제공하는 것을 목적으로 한다. 이를 위해 계층적 피어를 사용하는 Gnutella 방식에 계량값을 이용한 울트라피어 선택방안, 능동적 울트라피어 정보제공 방안 등을 도입하였다. 모의실험 결과, 본 논문에서 제안한 방안은 Gnutella 보다 망을 더욱 효율적으로 사용함으로써 검색 성공률을 높이고, 응답시간을 줄였으며, 오버헤드 측면에서도 훨씬 좋은 결과를 보였다. 또한 애드혹 망 및 P2P 시스템의 지속시간에 영향을 미칠 수 있는 노드들의 잔여 에너지양을 높일 수 있었다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제40권
• /
• pp.34.1-34.8
• /
• 2018

Background: Radiation therapy is widely employed in the treatment of head and neck cancer. Adverse effects of therapeutic irradiation include delayed bone healing after dental extraction or impaired bone regeneration at the irradiated bony defect. Development of a reliable experimental model may be beneficial to study tissue regeneration in the irradiated field. The current study aimed to develop a relevant animal model of post-radiation cranial bone defect. Methods: A lead shielding block was designed for selective external irradiation of the mouse calvaria. Critical-size calvarial defect was created 2 weeks after the irradiation. The defect was filled with a collagen scaffold, with or without incorporation of bone morphogenetic protein 2 (BMP-2) (1 ㎍/ml). The non-irradiated mice treated with or without BMP-2-included scaffold served as control. Four weeks after the surgery, the specimens were harvested and the degree of bone formation was evaluated by histological and radiographical examinations. Results: BMP-2-treated scaffold yielded significant bone regeneration in the mice calvarial defects. However, a single fraction of external irradiation was observed to eliminate the bone regeneration capacity of the BMP-2-incorporated scaffold without influencing the survival of the animals. Conclusion: The current study established an efficient model for post-radiation cranial bone regeneration and can be applied for evaluating the robust bone formation system using various chemokines or agents in unfavorable, demanding radiation-related bone defect models.

• Journal of Periodontal and Implant Science
• /
• 제52권1호
• /
• pp.54-64
• /
• 2022

Purpose: This in vitro study was conducted to evaluate the effects of different debridement techniques and conditioning procedures on root surface morphology and blood clot stabilization. Methods: Two debridement techniques (curette [CU] vs. high-speed ultrasound [US]) and 2 conditioning procedures (ethylenediaminetetraacetic acid [EDTA] and phosphoric acid [PA]) were used for the study. Seven experimental groups were tested on root surfaces: 1) no treatment (C); 2) CU; 3) US; 4) CU+EDTA; 5) US+EDTA; 6) CU+PA; and 7) US+PA. Three specimens per group were observed under scanning electron microscopy (SEM) for surface characterization. Additional root slices received a blood drop, and clot formation was graded according to the blood element adhesion index by a single operator. Data were statistically analyzed, using a threshold of P<0.05 for statistical significance. Results: The C group displayed the most irregular surface among the tested groups with the complete absence of blood traces. The highest frequency of blood component adhesion was shown in the CU+EDTA group (P<0.05), while no differences were detected between the CU, US+EDTA, and CU+PA groups (P<0.05), which performed better than the US and US+PA groups (P<0.05). Conclusions: In this SEM analysis, EDTA and conventional manual scaling were the most efficient procedures for enhancing smear layer removal, collagen fiber exposure, and clot stabilization on the root surface. This technique is imperative in periodontal healing and regenerative procedures.

• 한국임상수의학회지
• /
• 제39권6호
• /
• pp.353-359
• /
• 2022

Several suture patterns can be used for cystotomy closure, and a continuous suture pattern is the most commonly used. In this study, the fluid-tight ability and other suitabilities of continuous appositional sutures, such as the simple continuous suture pattern (SC), running suture pattern (RN), and Ford interlocking suture pattern (FI), were compared for cystotomy closure. Cystotomy closure was performed using each suture method in 10 cases of ex vivo swine bladders in each group. Suture time, leakage site, suture length, bursting pressure (BP), bursting volume (BV), and circular bursting wall tension (CBWT) were measured. Suture time and suture length were the shortest in RN and the longest in FI. Leakage occurred in two places: the incision line directly and the hole made by the suture. Leakage occurred through the incision line in 4 bladders of the RN group and 2 bladders of the FI group, but not in the SC group, and in the rest of the bladders, leakage occurred through the suture hole. The values of BP, BV, and CBWT increased in the order of FI, SC, and RN. Suture time and suture length can be considered as factors related to healing and side effects. In this study, leakage through the incision was found in a less appositional area; therefore, leakage through the hole could be considered an indicator of better apposition. Good apposition is one of the conditions required for ideal cystotomy closure. The bursting strength representing the fluid-tight ability can be expressed as the CBWT. RN is expected to be efficient and cause a small degree of foreign body reaction; however, it is expected to be less stable. FI has the greatest fluid-tightness ability, but it has been proposed that side effects due to foreign body reactions most frequently occur in FI. In conclusion, SC, which is expected to have a sufficient degree of fluid-tightness and appropriate recovery, is preferable to other continuous appositional suturing methods for cystotomy closure.

• 구강회복응용과학지
• /
• 제39권1호
• /
• pp.45-51
• /
• 2023

치근단 수술의 성공 여부는 적절한 역충전 재료와 충전 기법을 선택하여 근단부를 밀폐하는 데 달려있다. 역충전 재료는 확실한 밀폐를 제공하고 양호한 치유를 얻기 위하여 여러가지 물리화학적 특성들이 요구되는데 현재까지 MTA는 기존의 재료들이 가지지 못한 전례없는 우수한 장점을 갖추어 역충전 재료의 gold standard로써 사용되어 왔다. 그러나 이러한 MTA도 경화시간이 길고 조작이 어렵다는 단점이 있어 최근에는 이러한 단점을 개선한 premixed putty type bioceramic material이 개발되었다. 또한 이러한 재료를 활용하여 역충전 와동을 효율적으로 충전하기 위한 'Lid technique'이 함께 제안되었다. 본 증례 보고는 치근단 수술에서 premixed putty type material과 Lid technique을 활용한 증례에 대하여 소개하고자 한다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제28권3호
• /
• pp.219-227
• /
• 2024

Bladder cancer remains the 10th most common cancer worldwide. In recent years, metformin has been found to have potential anti-bladder cancer activity while high concentration of IC₅₀ at millimolar level is needed, which could not be reached by regular oral administration route. Thus, higher efficient agent is urgently demanded for clinically treating bladder cancer. Here, by conjugating artesunate to metformin, a novel artesunate-metformin dimer triazine derivative AM2 was designed and synthesized. The inhibitory effect of AM2 on bladder cancer cell line T24 and the mechanism underlying was determined. Anti-tumor activity of AM2 was assessed by MTT, cloning formation and wound healing assays. Decreasing effect of AM2 on lipogenesis was determined by oil red O staining. The protein expressions of Clusterin, SREBP1 and FASN in T24 cells were evaluated by Western blotting. The results show that AM2 significantly inhibited cell proliferation and migration at micromolar level, much higher than parental metformin. AM2 reduced lipogenesis and down-regulated the expressions of Clusterin, SREBP1 and FASN. These results suggest that AM2 inhibits the growth of bladder cancer cells T24 by inhibiting cellular lipogenesis associated with the Clusterin/SREBP1/FASN signaling pathway.

• Journal of Acupuncture Research
• /
• 제21권4호
• /
• pp.135-147
• /
• 2004

Objective: Moxibustion is one of major healing technique in oriental medicine. It has been widely used in many disease. There is an text which suggest moxibustion is more efficient to the situation of han(寒) and heo(虛) than yeal(熱) and sil(實) in Huangdineijing <黃帝內經>. The aim of this study is to research the effect of moxibustion at Shinmun(H7) is different according to cold or heat tendendy man by analyzing the electroencephalogram(EEG). Methods: We classified objects by their cold or heat tendency using questionnare for cold - heat patternization. (12 cold tendency man, 19 heat tendency man) Before and after moxibustion at Shinmun(H7), EEG raw data were measured during 5 minutes. The correlation dimension(D2), the correlation dimension variability rate(${\Delta}D2$), largest lyapunov exponent(L1) and largest lyapunov exponent variability rate(${\Delta}L1$) were calculated. We analyzed D2, ${\Delta}D2$, L1, ${\Delta}L1$ to see the effect of moxibustion at Shinmun(H7) was statistically different according to Cold or Heat tendendy man. Results : Paired t-test showed significant differences between before and after moxibustion at Shinmun(H7) on the Fp2 in D2(p<0.05), on the Fp2, F3 and F4 in ${\Delta}L1$(p<0.05). Student Hest showed significant differences between cold and heat tendendy man on the F3 in ${\Delta}L1$(p<0.05). Conclusion: These results suggest that moxibustion at Shinmun has an effect on stabilizing mind and it is more efficient to the cold tendendy man than the heat tendendy man.

• 한국조경학회지
• /
• 제49권6호
• /
• pp.1-15
• /
• 2021

본 연구는 산림청 소관 법령분석을 통해 법제도에 의해 양성되는 산림전문가를 고찰했다. 특히, 산림관련 법률의 변천과정과 산림전문가를 양성하는 법률을 파악하고, 산림정책 분야에 따른 산림전문 인재 양성에 관한 변화 및 특성을 규명했다. 그 결과, 산림산업 정책에 관한 산림전문가는 임야를 가지고 임업진흥을 위한 임업후계자와 산림산업 발전을 위한 기술능력을 갖춘 산림기술자가 있으며, 목재의 지속가능한 이용을 위한 법률 개정에 따라 목구조기술자, 목재등급평가사, 목재교육전문가를 별도로 양성하는 것으로 나타났다. 산림복지 정책에 관한 산림전문가는 산림에 설치하는 산림문화 휴양시설, 치유의 숲, 산림레포츠시설의 다양한 서비스를 제공하기 위해 전문 교육과정을 이수하는 산림전문가를 양성하는 것으로 밝혀졌으며, 산림복지전문가와 산림레포츠지도사가 있다. 산림복지전문가는 산림교육전문가와 산림치유지도사로 구분되며, 산림교육전문가는 숲해설가, 유아숲지도사, 숲길등산지도사로 구분하고 있다. 산림보호 정책에 관한 산림전문가는 수목원과 정원의 효율적 관리 및 전시를 위한 수목원·정원 전문가와 수목진료를 위한 나무의사와 수목치료기술자를 양성하는 것으로 나타났다. 나무의사와 수목치료기술자는 수목피해 진단 및 치료를 위한 나무병원업을 운영하기 위해 필요한 자격조건으로 밝혀졌다. 따라서 산림청은 임업 진흥 및 산림산업 발전과 수목진료를 위한 기술능력을 갖춘 산림전문가와 산림 내 문화·휴양·치료·보전 등의 시설에서 교육 및 복지 서비스를 제공하는 산림전문가를 양성하는 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권16호
• /
• pp.6813-6823
• /
• 2015

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive of human brain tumors and has a stunning progression with a mean survival of one year from the date of diagnosis. High cell proliferation, angiogenesis and/or necrosis are histopathological features of this cancer, which has no efficient curative therapy. This aggressiveness is associated with particular heterogeneity of the tumor featuring multiple genetic and epigenetic alterations, but also with implications of aberrant signaling driven by growth factors. The transforming growth factor ${\beta}$ ($TGF{\beta}$) superfamily is a large group of structurally related proteins including $TGF{\beta}$ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF). It is involved in important biological functions including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. This superfamily is also considered to impact on cancer biology including that of GBM, with various effects depending on the member. The $TGF{\beta}$ subfamily, in particular, is overexpressed in some GBM types which exhibit aggressive phenotypes. This subfamily impairs anti-cancer immune responses in several ways, including immune cells inhibition and major histocompatibility (MHC) class I and II abolishment. It promotes GBM angiogenesis by inducing angiogenic factors such as vascular endothelial growth factor (VEGF), plasminogen activator inhibitor (PAI-I) and insulinlike growth factor-binding protein 7 (IGFBP7), contributes to GBM progression by inducing metalloproteinases (MMPs), "pro-neoplastic" integrins (${\alpha}v{\beta}3$, ${\alpha}5{\beta}1$) and GBM initiating cells (GICs) as well as inducing a GBM mesenchymal phenotype. Equally, Nodal promotes GICs, induces cancer metabolic switch and supports GBM cell proliferation, but is negatively regulated by Lefty. Activin promotes GBM cell proliferation while GDF yields immune-escape function. On the other hand, BMPs target GICS and induce differentiation and sensitivity to chemotherapy. This multifaceted involvement of this superfamily in GBM necessitates different strategies in anti-cancer therapy. While suppressing the $TGF{\beta}$ subfamily yields advantageous results, enhancing BMPs production is also beneficial.