• Title/Summary/Keyword: efficiency of permeation

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Formulation of Liposome for Topical Delivery of Arbutin

  • Wen, Ai-Hua;Choi, Min-Koo;Kim, Dae-Duk
    • Archives of Pharmacal Research
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    • v.29 no.12
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    • pp.1187-1192
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    • 2006
  • The aims of this study were to encapsulate arbutin (AR) in liposome to enhance the skin-whitening activity, and to investigate the effect of liposome formulation on the entrapment efficiency (EE%), skin permeation rate and skin deposition. The liposomes were prepared by a film dispersion method with several different formulations and were separated from the solution by using the gel-filtration method. The physical (size distribution, morphology) and chemical (drug entrapment efficiency, hairless mouse skin permeation and deposition) properties of liposomes were characterized. The entrapment efficiency in all liposome formulations varied between 4.35% and 17.63%, and was dependent on the lipid content. The particle sizes of liposomes were in the range of $179.9{\sim}212.8\;nm$ in all liposome formulations. Although the permeation rate of AR in the liposome formulations decreased compared with AR solution, the deposition amount of AR in the epidermis/dermis layers increased in AR liposomal formulation. These results suggest that liposomal formulation could enhance the skin deposition of hydrophilic skin-whitening agents, thereby enhancing their activities.

Analysis of Injection Efficiency for Cement Grouts by Model Test of Permeation in Soil (지반침투모형시험에 의한 시멘트그라우트의 주입성능 분석)

  • Song, Young-Su;Lim, Heui-Dae;Choi, Dong-Nam
    • Economic and Environmental Geology
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    • v.43 no.2
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    • pp.177-184
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    • 2010
  • When cement grout is used for waterproofing of grounds, important roles are played by fluidity, particle size and bleeding. The most important element which determines their characteristics is the water/cement ratio of grout. Moreover in order to improve the efficiency of soil permeation, micro cement with a smaller average diameter is used in addition to ordinary portland cement. Besides the mixing ratio and cement diameter, the condition of ground is also of fundamental importance in the efficiency of permeation. In order to evaluate grout in terms of permeation ability into ground, we need a field test of grounting, which is cost and time consuming. In this paper we present a laboratory test method in which the suitability and efficiency of grouts are simply and more practically tested. In Korea neither a test standard nor devices are available to simulate grouting in a laboratory. We devised a grout injection equipment in which grouting was reproduced in the same condition with different materials, and suggested a standard for the production of specimens. Our tests revealed that the efficiency of injection increases with the water/cement ratio. We also found that more efficiently injected is the grout with the order of decreasing size; MS8000, micro cement, and ultra fine cements, and colloidal super cement.

해안 지역 농촌지하수 시스템분석 (화성시 매향리 일대)

  • 김윤영;이기철;정형재;박종철
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • 2003.04a
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    • pp.422-425
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    • 2003
  • Many pumping station of Maehang-ri of Hwasung city are established for irrigation water supply, and brine permeation phenomenon is happening thereby. Proposed optimum pumping fluid amount conclusion model that use tidal efficiency and Ghyben-Hertzberg theory so that brine does not permeate in pumping station hereupon and applied this in study area.

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Formulation Design for Skin Permeation of Lincomycin Cream (린코마이신 크림의 피부투과를 위한 처방설계)

  • 김미정;김영일;양재헌
    • YAKHAK HOEJI
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    • v.47 no.3
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    • pp.154-158
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    • 2003
  • Lincomycin, a selective tyrosinase blocker, has been thought to be effective in the treatment of melanogenesis, ephelis, post inflammatory pigmentation, and facial discoloration. In an attempt to develop a transdermal perparation for lincomycin, this study was designed to examine the appropriate contents of various surfactants and ethanol in the cream preparation. Frans type diffusion cell was used to investigate permeation efficiency of the preparation, and lincomycin in the receptor phase was measured by HPLC. After having a 1.5 hrs of leg time, the permeability of lincomycin was rapidly increased by adding surfactants, and varied with different types of surfactants after 10 hrs, the permeability of Brij 56$^{(R)}$ preparation (501.4$\pm$45 $\mu\textrm{g}$/mι) was greater than that either of Labrasol$^{(R)}$ (263.9$\pm$33.7 $\mu\textrm{g}$/mι) or Tween$^{(R)}$20(386.2$\pm$26.7 $\mu\textrm{g}$/mι). Ethanol also increased the permeability of lincomycin.mycin.

Analysis of Permeation Efficiency in Soil for OPC and Non-Pollution MIS Grouts by Laboratory Model Test (실내모형시험을 통한 OPC와 친환경 MIS 그라우트의 지반 침투성능 분석)

  • Ahn, Jung-Ho;Lim, Heui-Dae;Choi, Dong-Nam;Song, Young-Su
    • Economic and Environmental Geology
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    • v.45 no.3
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    • pp.307-315
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    • 2012
  • In this paper, a laboratory model test was conducted to evaluate grouting efficiency of ordinary portland cement(OPC) and micro cement used in MIS(Micro-Injection Process System). For this research, a injection equipment was developed for pressure permeation which can evenly simulate various grouting tests in a laboratory and suggested a standard for the production of the test specimen. Using the injection device, the laboratory injection tests of grouts were prepared with water/cement ratio of 1:1, 2:1, 3:1, 4:1, and 5:1. The analysis of injection test for pressure permeation showed that the efficiency of injection increases linearly as the water/cement ratio increases. Comparison of efficiency of the injection indicates that MIS with a relatively smaller average diameter shows more efficient injection than the OPC. In the low ratio of water/cement as 2:1~1:1, the injection efficiency of OPC was especially poor. Also, a nonlinear grout volume-injection time is represented by a hyperbolic model and grout volume predicted by hyperbolic model was compared with the value measured. From the comparison, it shows that the hyperbolic model has the potential of evaluating the efficiency of grouting.

Deformable Liposomes for Topical Skin Delivery of Arbutin

  • Bian, Shengjie;Choi, Min-Koo;Lin, Hongxia;Zheng, Junmin;Chung, Suk-Jae;Shim, Chang-Koo;Kim, Dae-Duk
    • Journal of Pharmaceutical Investigation
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    • v.36 no.5
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    • pp.299-304
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    • 2006
  • The aim of this study was to investigate the effect of deformable liposomes with sodium cholate on the skin permeation and skin deposition of arbutin, a hydrophilic skin-whitening agent. Various compositions of liposomes were prepared by the extrusion method. Particle size distribution and entrapment efficiency were determined by the laser light scattering and the gel permeation chromatography, respectively. The in vitro rat skin permeation and deposition of arbutin in various skin layers were investigated using the Keshary-Chien diffusion cells at $37^{\circ}C$. The average particle size of the deformable liposomes ranged from 217.4 to 117.4 nm, depending on the composition. The entrapment efficiency was dependent on surfactant concentration and loading dose of arbutin. The permeation rate of 5% arbutin in deformable liposomes was $8.91({\pm}1.33){\mu}g/cm^2/h$, and was not significantly different from 5% arbutin aqueous solution $[9.82({\m}0.86){\mu}g/cm^2/h]$. The deposition of arbutin was $43.34({\pm}12.13)$ and $16.99({\pm}7.83){\mu}g/cm^2$ in stratum corneum layer and epidermis/dermis layer, respectively, after 12 h of permeation study. These results are consistent with several earlier studies for the localization effect of liposomal formulations in stratum corneum, and demonstrated the feasibility of the deformable liposomes as a promising carrier for the skin deposition of hydrophilic skin-whitening compounds.

Increase of Permanent Wave Efficacy and Decrease of Hair Damage by using Enhancer of Permanent Wave Lotion (흡수촉진제를 이용한 펌제의 웨이브 효율 증가 및 모발손상 억제)

  • Song Hee-Ra;Park Myung-Hee
    • Journal of the Korean Society of Costume
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    • v.56 no.4 s.103
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    • pp.124-133
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    • 2006
  • Human hair could be damaged by various physicochemical conditions and treatment. Permanent and decoloring treatment were the most serious factor on hair damage. The new permanent wave lotion containing Permeation enhancers such as Cremophor EL, Transcutol and propylene glycol based on cysteine permanent wave lotion were prepared. Efficiency of permanent wave and hair damage following pH of permanent wave lotion and addition of permeation enhancer were investigated. PH of solution, wave efficiency, loss of protein from hair, morphology of hair by SEM and solubility of alkaline solution were evaluated. The addition of Cremophor EL and Transcutol with ethanol increased permanent wave efficacy and decreased hair damage effectively. They diminished permanent wave lotion's pH and augmented permanent wave lotion's penetration compare to cysteine permanent wave lotion. new permanent wave lotion containing permeation enhancers such as Cremophor EL could be a good candidate for a new permanent wave lotion.

Nano-emulsion Containing Parthenocissus tricuspidata Stem Extracts for Enhanced Skin Permeation and the Antibacterial Activity of the Extracts (피부 흡수 증진을 위한 담쟁이덩굴 줄기 추출물 함유 나노에멀젼 및 이의 항균활성 연구)

  • Jo, Na Rae;Park, Min A;Jeon, So Ha;Park, Soo Nam
    • Microbiology and Biotechnology Letters
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    • v.41 no.3
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    • pp.320-326
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    • 2013
  • In a previous study, we investigated the antioxidative and cellular protective effects of Parthenocissus tricuspidata stem extracts. In this study, we prepared nano-emulsion containing P. tricuspidata stem extract to improve skin permeation. The particle size of the nano-emulsion using the microfluidizer was 302 nm. Its loading efficiency was over 86%. The size distribution of the nano-emulsion took a monodispersed form and the nano-emulsion was more stable than typical emulsion without using microfluidizer during a 2 week period. In vitro skin permeation study of nano-emulsion containing P. tricuspidata stem extracts was carried out using Franz diffusion cell. The 1,3-butylene glycol used as a control group had 32.59% skin permeation efficiency. The skin permeation efficiency of the nano-emulsion was 42.47%. Also, we observed the antibacterial activity of the ethyl acetate fraction on skin flora for prospective applications as a natural antimicrobial. The ethyl acetate fraction had antibacterial activities higher than methyl paraben on Staphylococcus aureus, and Bacillus subtilis. These results indicate that nano-emulsion containing P. tricuspidata stem extracts could possess valued applications in cosmetic formulations for improving skin permeation. Also, based on the antibacterial activities on skin flora, antioxidative and cellular protective effects shown in our previous study, we suggest that P. tricuspidata stem extracts could be used as functional cosmetic materials.

Transdermal Permeation of $[{^3}H]Acyclovir$ Using Niosome (니오솜을 이용한 $[^{3}H]$아시클로버의 경피투과)

  • Park, Sae-Hae;Lee, Soon-Young;Yong, Chul-Soon
    • Journal of Pharmaceutical Investigation
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    • v.28 no.1
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    • pp.43-50
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    • 1998
  • Niosomes are vesicles formed from synthetic non-ionic surfactants, offering an alternative to chemically unstable and expensive liposomes as a drug carrier. Non-ionic surfactant and cholesterol mixture film leads to the formation of vesicular system by hydration with sonication method. The formation of niosome was ascertained by negative staining of TEM. The entrapment efficiency of niosomal suspension was gradually increased with increasing the ratio of cholesterol to surfactant. It was found that the niosome with 6 : 4 (polyoxyethylene 2-cetyl ether: cholesterol) ratio was more stable than those with other ratios. The topical application of acyclovir(ACV) in the treatment of herpes simplex virus type 1(HSV-1) skin disease has a long history. There are an increasing number of reports, however, in which topical ACV therapy is not as effective as oral administration. Lack of efficacy with topical ACV has been hypothesized to reflect the inadequate delivery of drug to the skin. We investigated the permeation of niosome containing $[^{3}H]ACV$ in hairless mouse skin using Franz diffusion cell model. Permeation coefficient(P) of aqueous ACV was $6.7{\times}10^{-4}\;(cm/hr)$ and that of ACV in niosome was $23.4{\times}10^{-4}\;(cm/hr)$, suggesting about 3.5 times increase in the transdermal permeation.

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Transdermal and topical LMWH delivery from ultradeformable and other vesicles: Characterization and in vitro and vivo permeation studies

  • Hyun, Myung-Ja;Park, Jeong-Sook;Kim, Chong-Kook
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.247.2-247.2
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    • 2003
  • To increase skin permeability of LMWH (Low Molecular Weight Heparin), ultradeformable liposomes were developed. Ultradeformable liposomes were developed by Egg phosphatidylcholine (Egg-PC) and edge activator. Entrapment efficiency, vesicle size and zeta potential of vesicles were determined and characterized for deformability and stability. Transepidermal permeation of LMWH was compared to saturated aqueous control in vitro. The steady-state flux and its maximum time were calculated from the flux curves. (omitted)

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