• Journal of Ginseng Research
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• 제44권2호
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• pp.267-273
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• 2020

Background: Continuous exposure to high temperatures can lead to heat stress. This stress response alters the expression of multiple genes and can contribute to the onset of various diseases. In particular, heat stress induces oxidative stress by increasing the production of reactive oxygen species. The liver is an essential organ that plays a variety of roles, such as detoxification and protein synthesis. Therefore, it is important to protect the liver from oxidative stress caused by heat stress. Korean ginseng has a variety of beneficial biological properties, and our previous studies showed that it provides an effective defense against heat stress. Methods: We investigated the ability of Korean Red Ginseng and Korean black ginseng extracts (JP5 and BG1) to protect against heat stress using a rat model. We then confirmed the active ingredients and mechanism of action using a cell-based model. Results: Heat stress significantly increased gene and protein expression of oxidative stress-related factors such as catalase and SOD2, but treatment with JP5 (Korean Red Ginseng extract) and BG1 (Korean black ginseng extract) abolished this response in both liver tissue and HepG2 cells. In addition, JP5 and BG1 inhibited the expression of inflammatory proteins such as p-NF-κB and tumor necrosis factor alpha-α. In particular, JP5 and BG1 decreased the expression of components of the NLRP3 inflammasome, a key inflammatory signaling factor. Thus, JP5 and BG1 inhibited both oxidative stress and inflammation. Conclusions: JP5 and BG1 protect against oxidative stress and inflammation induced by heat stress and help maintain liver function by preventing liver damage.

• 대한기계학회논문집A
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• 제27권5호
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• pp.724-733
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• 2003

Fatigue design rules for welds in the ASME Boiler and Pressure Vessels Code are based on the use of Fatigue Strength Reduction Factors(FSRF) against a code specified fatigue design curve generated from smooth base metal specimens without the presence of welds. Similarly, stress intensification factors that are used in the ASME B3l.1 Piping Code are based on component S-N curves with a reference fatigue strength based on straight pipe girth welds. But the determination of either the FSRF or stress intensification factor requires extensive fatigue testing to take into account the stress concentration effects associated with various types of component geometry, weld configuration and loading conditions. As the fatigue behavior of welded joints is being better understood, it has been generally accepted that the difference in fatigue lives from one type of weld to another is dominated by the difference in stress concentration. However, general finite element procedures are currently not available for effective determination of such stress concentration effects. In this paper, a mesh-insensitive structural stress method is used to re-evaluate the S-N test data, and then more effective method is proposed for pressure vessel and piping fatigue design.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.1458-1465
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• 2010

A lot of dredging and reclaming projects are recently under way in Korea for the efficient use of limiting land space. Saemanguem area is special case of reclaiming by dredged soil. In case of a confined disposal of dredged soils by a pump dredger, generally coarse grained soils are separated from fines with dropping at the near part of the pump dredger. This kind of seperation of fine contents could be a factor of liquefaction by earthquake. In Korea, recently, earthquakes with magnitude of 3.0 or higher are distinctively increasing in 1990. In this study, cyclic shear characterics of Saemanguem Dredged sand depending on fine content were analyzed. A series of undrained cyclic triaxial test with cyclic stress ratio ($\sigma_d/{2\sigma_{{\upsilon}c}}'$) were performed on both isotropic consolidated specimen and sand with fine contents of 0%, 5%, 15%, 30%, 40% under the effective vertical stress of 100kPa and 50% and 60%, 70% of relative density for fine content of 0%, respectively. In the test results, cyclic shear strength increased by increasing of cyclic stress ratio($\sigma_d/{2\sigma_{{\upsilon}c}}'$) with increasing the relative density at the same number of cyclic under the effective confining pressure of 100kPa. It is almost highest the double amplitude(DA) 1%, 3%, 5%, 7.5% and 10% at fine content of 15% between Cyclic stress ratio($\sigma_d/{2\sigma_{{\upsilon}c}}'$) value at cyclic number five and fine content. Number of cyclic is 30 under the effective vertical stress of 100kPa, 70% of relative density for fine content of 15%. when the cyclic stress ratio at each relative density was compared at cyclic number five, the double amplitude(DA) 1%, 3%, 5%, 7.5% and 10%, and the pore-pressure ratio (${\Delta}u/{\sigma'}_c$) 0.95 value were compared; under the relative density of 70% and the effective confining pressure of 100kPa. The pore-pressure ratio (${\Delta}u/{\sigma'}_c$) 0.95 value showed a similar trend to the double amplitude (DA) 5% line.

• 한국안전학회지
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• 제12권2호
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• pp.17-21
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• 1997

The fatigue crack propagation rate has so far been measured by the effective stress intensity factor range Δ K/sub eff/. But no research has been done to study how much the crack opening ratio influences the expectation of the fatigue crack propagation. Therefore, this paper evaluates of the crack opening ratio on the fatigue crack propagation life by using the method of parameter sensitivity study. Summarizing the result ; ( 1 ) When the crack opening ratio U' is high, the effect of U' gets larger than any other except for the material factor m. But when U' is low, the effect is also diminished. Therefore, the selection of the lowest value possible is desirable in the evaluation of life. (2) When the value of the material factor m is high, the effect of crack opening ratio U' is increased, at the same time the effect of the other parameters also increased wholly. The effect of material factor m itself on life is high, but in case the material factor m is high, that the effect of each parameter on life get higher is unique. In designing, better attention to the material selection should be drawn. (3) In case the stress ratio R gets smaller, the effect of crack opening ratio U' is unchangeable. But the effect of R itself remarkably decreases, and the effect of material factor m somewhat decreases.

• 한국자동차공학회논문집
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• 제6권5호
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• pp.20-27
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• 1998

According as the member of the automobile body structure have been thinned their thickness and have become high strength, each part of the body structure has been put more severe stress condition. And, because fatigue strength of the spot welded lap joint is influenced by its geometrical and mechanical factors, welding condition and etc., there needs a quantitative and systematic evaluation method for them. In this study, by considering nugget edge of the spot weld part of the IB-type spot welded lap joint under tension-shear load to the ligament crack. fatigue strength of various IB-type spot welded lap joints was estimated with the stress intensity factor(S.I.F.) KIII which is fracture mechanical parameter. We could find that fatigue strength evaluation of the IB-type spot welded lap joints by KIII is more effective than the maximum principal stress ($\sigma$1max) at edge of the spot weld obtained from FEM analysis.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 추계 학술발표회
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• pp.71-78
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• 2010

The stability analysis of unsaturated infinite slope under rainfall-induced infiltration condition was performed using the generalized effective stress that unifies both saturated and unsaturated condition recently proposed by Lu and Likos(2004, 2006). The Soil-Water Characteristic Curve (SWCC) of the sand with the relative density of 75% was first measured for both drying and wetting processes. The Hydraulic Conductivity Function (HCF) and Suction Stress Characteristic Curve (SSCC) were subsequently estimated. Also, under the rainfall-induced infiltration condition transient seepage analysis of unsaturated infinite slope was performed using the finite element program, SEEP/W. Based on these results, the stability of unsaturated infinite slope under rainfall-induced infiltration condition was examined considering the suction stress. According to the results, the negative pore water pressure and water content within the soil changed with time due to the infiltration. Also, the variation of those caused the variation of suction stress and then the factor of safety of slope changed consequently during the rainfall period.

• 시큐리티연구
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• 제22호
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• pp.1-14
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• 2010

본 연구는 서울, 경기지역 소재 경호업체 종사자를 대상으로 직무형태의 하위요인인 근무경력과 직무유형과 스트레스 수준에 따른 생리학적 변화를 비교, 분석한 결과 다음과 같은 결론을 얻었다. 1. 근무경력에 따라 체지방률은 단기간일수록 낮고, 장기간일수록 젖산수준은 높다. 2. 직무유형에 따라 체지방률은 현장직일수록 낮고, 젖산과 스트레스 수준은 현장직일수록 높다. 결론적으로, 경호업 종사자의 효율적이고 건강측면에서의 관리를 위해서는 장기근속과 사무직 종사자의 지속적인 신체활동 수행이 필요하고, 현장직 종사자는 신체적, 정신적 스트레스 감소를 위한 휴식 및 안정이 요구되어진다.

• Journal of Mechanical Science and Technology
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• 제16권5호
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• pp.599-608
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• 2002

Finite element analysis for the stress intensity factor (SIF) at the skin/stiffener structure with inclined central crack repaired by composite stiffened panels is developed. A numerical investigation was conducted to characterize the fracture behavior and crack growth behavior at the inclined crack. In order to investigate the crack growth direction, maximum tangential stress (MTS) criterion are used. Also, this paper is to study the performance of the effective bonded composite patch repair of a plate containing an inclined central through-crack. The main objective of this research is the validation of the inclined crack patching design. In this paper, the reduction of stress intensity factors at the crack-tip and prediction of crack growth direction are determined to evaluate the effects of various non-dimensional design parameter including; composite patch thickness and stiffener distance. We report the results of finite element analysis on the stiffener locations and crack slant angles and discuss them in this paper. The research on cracked structure subjected to mixed mode loading is accomplished and concludes that more work using a different approaches is necessary. The authors hope the present study will aid those who are responsible for the repair of damaged aircraft structures and also provide general repair guidelines.

• Journal of Welding and Joining
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• 제13권2호
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• pp.96-105
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• 1995

본 연구에서는 종래의 미소피로균열 성장속도 해석방법에 대한 수정안을 제시하고 수정 후의 방 법에 의해서 계산한 값들과 S4SC 탄소강에 대한 Nisitani와 Goto의 실험결과를 비교하여 계산한 값과 실험데이터 사이에 양호한 일치가 있음을 보였다. 이미 제시된 피로균열성장속도 식에는 하한계수준과 피로한도를 연관시키는 재료상수와 탄소성 거동에 대한 수정 및 균열닫힘효과를 나타내는 방법이 포함되어 있다. 본 연구에서 행한 수정중의 하나는 기하학적인 상수대신에 퍼만(Forman)의 탄성응력 강도계수 범위식을 이용하는 것이고, 다른 하나는 균열이 성장함에 따라 편심형단면으로 되면서 모멘트에 기인해 발생되는 굽힘효과를 고려하는 것이다. 이 방 법을 수명예측에 사용하면 용접구조물은 물론 기계구조물의 보다 정확한 수명예측이 가능할 것 이다.

• International Journal of Concrete Structures and Materials
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• 제18권3E호
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• pp.191-198
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• 2006

The objective of this study is to examine fracture characteristics of concrete at early ages, i.g. critical stress intensity factor, critical crack-tip opening displacement, fracture energy, and bilinear softening curve based on the concepts of effective-elastic crack model and cohesive crack model. A wedge splitting test for Mode I was performed on cubic wedge specimens with a notch at the edge. By experimenting with various strengths and ages, load-crack mouth opening curves were obtained, and the results were analyzed by linear elastic fracture mechanics and FEM(finite element method). The results from the test and analysis showed that critical stress intensity factor and facture energy increased while critical crack-tip opening displacement decreased with concrete aging from 1 day to 28 days. Four parameters of bilinear softening curve from 1 day to 28 days were obtained from a numerical analysis. The obtained fracture parameters and bilinear softening curves at early ages from this study are to be used as a fracture criterion and an input data for the finite element analysis of concrete at early ages.