• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.28 no.2
• /
• pp.130-142
• /
• 2015

Objective : The purpose of this case study is to report the effectiveness of Sihochunggan-tang gagambang in respect of liver meridian wind-heat or liver-heat on 7 seborrheic dermatitis patients who were in high stress and had unhealthy dietary habit. Methods : VAS (Visual Analogue Scale) score was used to check the prognosis of 7 seborrheic dermatitis patients, who have been treated with Sihochunggan-tang gagambang and acupuncture. Results : VAS score decreased as a result of Sihochunggan-tang gagambang treatment in 7 patients. Conclusion : Sihochunggan-tang gagambang can be effective treatment for the high stress and unhealthy diet related seborrheic dermatitis when diagnosed as liver meridian wind-heat or liver-heat

• The Journal of Internal Korean Medicine
• /
• v.42 no.5
• /
• pp.1160-1172
• /
• 2021

Objectives: This study examined cases of patients with palpitations treated with Gami-ondam-tang. Methods: The patients were treated with Gami-ondam-tang and changes in their symptoms were assessed using a self-reported numeral rating scale (NRS) score. Results: Following treatment, the patients' palpitations and accompanying symptoms (e.g., insomnia, hot flushes, dyspepsia, and depression) improved. The study investigated 14 first occurrences and 10 subsequent recurrences. In the subsequent recurrent cases, compared to the first occurrence cases, the symptoms according to the NRS score were not severe, and the treatment period was shorter. Conclusions: The results showed that Gami-ondam-tang is effective for treating palpitations and accompanying symptoms.

• Communications for Statistical Applications and Methods
• /
• v.30 no.1
• /
• pp.1-19
• /
• 2023

Observational data with missing or incomplete data are common in biomedical research. Multiple imputation is an effective approach to handle missing data with the ability to decrease bias while increasing statistical power and efficiency. In recent years propensity score (PS) matching has been increasingly used in observational studies to estimate treatment effect as it can reduce confounding due to measured baseline covariates. In this paper, we describe in detail approaches to competing risk analysis in the setting of incomplete observational data when using PS matching. First, we used multiple imputation to impute several missing variables simultaneously, then conducted propensity-score matching to match statin-exposed patients with those unexposed. Afterwards, we assessed the effect of statin exposure on the risk of heart failure-related hospitalizations or emergency visits by estimating both relative and absolute effects. Collectively, we provided a general methodological framework to assess treatment effect in incomplete observational data. In addition, we presented a practical approach to produce overall cumulative incidence function (CIF) based on estimates from multiple imputed and PS-matched samples.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.30 no.3
• /
• pp.220-230
• /
• 2017

Objectives : The purpose of this study is to report the efficacy of using oriental medical treatment with Melonix Calyx Vomiting Therapy for Cholinergic urticaria patient. Methods : We experienced one case of Cholinergic urticaria patient treated with oriental medical treatment and Melonix Calyx Vomiting Therapy(MCVT). MCVT is traditional treatment, which induces vomiting by eating Melonix Calyx powder with water. To evaluate the results of this treatment, we measured the decrease of pruritus, number of wheals, redness. Decrease of pruritus, number of wheals was assessed by Urticaria Activity Score(UAS) and quality of life was assessed by Chronic urticaria quality of life questionnaire(CU-Q2oL). Results : UAS decreased from 6 to 0, and severity score of redness decreased from 3 to 0. CU-Q2oL score decreased from 78 to 23. Conclusions : This study suggests that using MCVT with oriental medical treatment is effective on Cholinergic urticaria.

• Journal of Acupuncture Research
• /
• v.33 no.2
• /
• pp.189-200
• /
• 2016

Objectives : The purpose of this study is to report the clinical effect of Korean medical treatment on spinal cord infarction. Methods : We treated a patient who was diagnosed with spinal cord infarction. We used acupuncture, bee venom pharmacopuncture, herbal medicine, moxibustion and physical therapy. We evaluated the patient through Manual Muscle Testing (MMT) and International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) score. Results : MMT grade improved grade from 1 to 5 and ISNCSCI score increased from 2 to 14. Conclusion : According to these results, this report suggests that Korean medical treatment could be effective for spinal cord infarction.

• Tuberculosis and Respiratory Diseases
• /
• v.86 no.3
• /
• pp.234-244
• /
• 2023

Background: Effective treatment of fluoroquinolone-resistant multidrug-resistant tuberculosis (FQr-MDR-TB) is difficult because of the limited number of available core anti-TB drugs and high rates of resistance to anti-TB drugs other than FQs. However, few studies have examined anti-TB drugs that are effective in treating patients with FQr-MDR-TB in a real-world setting. Methods: The impact of anti-TB drug use on treatment outcomes in patients with pulmonary FQr-MDR-TB was retrospectively evaluated using a nationwide integrated TB database (Korean Tuberculosis and Post-Tuberculosis). Data from 2011 to 2017 were included. Results: The study population consisted of 1,082 patients with FQr-MDR-TB. The overall treatment outcomes were as follows: treatment success (69.7%), death (13.7%), lost to follow-up or not evaluated (12.8%), and treatment failure (3.9%). On a propensity-score-matched multivariate logistic regression analysis, the use of bedaquiline (BDQ), linezolid (LZD), levofloxacin (LFX), cycloserine (CS), ethambutol (EMB), pyrazinamide, kanamycin (KM), prothionamide (PTO), and para-aminosalicylic acid against susceptible strains increased the treatment success rate (vs. unfavorable outcomes). The use of LFX, CS, EMB, and PTO against susceptible strains decreased the mortality (vs. treatment success). Conclusion: A therapeutic regimen guided by drug-susceptibility testing can improve the treatment of patients with pulmonary FQr-MDR-TB. In addition to core anti-TB drugs, such as BDQ and LZD, treatment of susceptible strains with later-generation FQs and KM may be beneficial for FQr-MDR-TB patients with limited treatment options.

• Journal of Oriental Neuropsychiatry
• /
• v.20 no.3
• /
• pp.297-307
• /
• 2009

Objectives : Insomnia, depression and anxiety disorder are widespread in elderly patients. Mood disorder and insomnia share complex theoretical and clinical relationships. We investigated if traditional Korean medical treatment and breathing meditation are effective in patient with insomnia, depression and anxiety disorder. Methods : We treated one patient with traditional Korean medical treatment such as accupuncture, herb-medication, moxa and breathing meditation Results : After Treatment, the chief complaint and accompanying symptoms were improved, and the score of BAI, SADS, BDI, PSQI, IQ were decresed. Conclusions : According to this study traditional Korean medical treatment is effective for the cure of insomnia, depression and anxiety disorder and breathing meditation forifies the traditional Korean medical treatment.

• The Korean Journal of Pain
• /
• v.25 no.1
• /
• pp.28-32
• /
• 2012

Background: Primary hyperhidrosis is a disorder of excessive sweating, which shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oral glycopyrrolate is one of the treatments available. There are a few published studies on the use of glycopyrrolate given orally in the treatment of hyperhidrosis. Methods: Thies is study was a review of case notes in a series of 36 patients with primary hyperhidrosis. We made a comparison between the Keller's scale score of a pre-glycopyrrolate medication group and the Keller's scale score f a post-glycopyrrolate medication group. The Milanez de Campos score, Short Form_36 (SF-36) score, Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the two groups. Results: In the post-glycopyrrolate medication group, there were declines in Keller's scale, and Milanez de Campos scale score and BAI score (P < 0.001). In addition, there were increases in SF_36 score in the post-glycopyrrolate medication group (P = 0.03) However, no changes were seen in, BDI score and ANS score in the post-glycopyrrolate medication group (P < 0.001). Conclusions: Glycopyrrolate is an effective initial method of treating primary hyperhidrosis that, reduces anxiety and improve patients' quality of life.

• Journal of Oriental Neuropsychiatry
• /
• v.20 no.2
• /
• pp.177-186
• /
• 2009

Objectives : We investigated if korean traditional treatment and psychotherapy is effective in patients with depression and menopausal symptoms. Methods : We treated two patients with typical korean traditional medical treatment( Acupuncture, Giungoroen therapy(至言高論療法), Moxibustion ) and progressive muscle relaxation. Results : After treatment, the chief complaint and accompanying symptoms were subsided and improved. BDI score and Kupperman's index were decreased. Conclusions : We may conclude that korean traditional treatment and psychotherapy is effective in patients with depression and menopausal symptoms.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.17 no.1
• /
• pp.31-36
• /
• 2014

Purpose: Infliximab (IFX) is considered safe and effective for the treatment of ulcerative colitis (UC) in both adults and children. The aim of this study was to evaluate the short- and long-term clinical course of IFX in Korean children with UC. Methods: Pediatric patients with UC who had received IFX infusions between November 2007 and May 2013 at Samsung Medical Center were retrospectively investigated. The clinical efficacy of IFX treatment was evaluated at 8 weeks (short term) and 54 weeks (long term) after the initiation of IFX treatment using the Pediatric Ulcerative Colitis Activity Index (PUCAI). The degree of response to IFX treatment was defined as complete response (PUCAI score=0), partial response (decrement of PUCAI score${\geq}20$ points), and non-response (decrement of PUCAI score <20 points). Adverse events associated with IFX treatment were also investigated. Results: Eleven pediatric patients with moderate to severe UC had received IFX. The remission rate after IFX treatment was 46% (5/11) and 82% (9/11) at 8 weeks and 54 weeks after IFX treatment, respectively. All patients who were steroid-dependent before treatment with IFX achieved remission at 54 weeks and were able to stop treatment with corticosteroids, while all steroid-refractory patients failed to achieve remission at 54 weeks after treatment with IFX. Conclusion: Response to IFX treatment after 8 weeks may predict a favorable long-term response to IFX treatment in Korean pediatric UC patients.