• 약학회지
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• 제57권3호
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• pp.226-233
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• 2013

Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an analytical procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Ministry of Food and Drug Safety (MFDS). The analytical method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with commercially available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC.

• 한국의류산업학회지
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• 제18권4호
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• pp.520-530
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• 2016

This research aims to propose an ergonomic design process for hip protector based on previous studies, existing products, multidisciplinary experts opinion, and wearing test. The elderly are more likely to suffer a hip fracture when they fall due to their physical changes in skeletal form, muscle quantity, bone density, and joint movement. A hip protector is an effective product to prevent hip fractures in the elderly but it also has a problem in that it is uncomfortable. Therefore there is a high chance that it won't be able to prevent hip fractures properly. Since the comfort of a hip protector is one of the most critical elements in preventing a hip fracture, we need to keep improving the hip protector for mobility and usability. Based on the previous studies and limitations of current hip protector products, we need to come up with an optimal design for the Korean elderly. First, knowledge has to be built relating to the ergonomic design of the hip protector considering body shape and size analysis using 3D-scan data, and biomechanical analysis on hip fracture. Second, we need to develop a design process including hip protector pattern design, and wearing evaluation with virtual system. Third, we suggest to reevaluate and verify the design procedure from impact evaluation using testing simulator, virtual evaluation of impact, to wearing comfort and usability evaluation. This design process presented in this study would be expected to contribute to the development of ergonomic hip protector which is suitable for the Korean elderly.

• 생약학회지
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• 제31권2호
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• pp.130-141
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• 2000

The dried roots of Rehmannia glutinosa (RG) have been used in the traditional medicine for treatment of diabetes, fever and dysuria, etc. In order to investigate the quality evaluation of the dried roots of RG, we conducted the physico-chemical and biological evaluation method. The amount of catalpol from commercial samples is very diverse about $0.00{\sim}3.89%$ by using HPLC method, because it is easily decomposed by processing of RG. So, we should try to identify the correlation with the contents of catalpol and biological activities of RG. We chose 3 samples which were a wide difference of catalpol contents between each sample (Sample-I; 3.4%, Sample-II; 2.8%, Sample-III; 0.05%). Sample-I and Sample-II were found to be more effective than Sample-III on the DPPH free radical scavenging effect and inhibitory effect on $H_2O_2-catalyzed$ lipid peroxidation in rat liver in vitro. And, Sample-I and Sample-II exhibited more significant effects than Sample-III on accelerating actions of the small and large intestinal transport, and diuretic action in mice. So, it is suggested that the quantitative determination of catalpol should be required for the tandardization of the dried roots of RG.

• 한국식품조리과학회지
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• 제16권6호
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• pp.584-592
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• 2000

Standard recipes of various Korean soups for cook/chill system were developed to provide foodservice managers in kindergarten with more effective management system. Three kinds of soup, Miyuck-gook (Korean sea mustard soup), Soup of beef and radish and Chige of beef and soybean paste (Korean thick soup made of beef and soybean paste) were selected as menu items in this study, and the standard recipes for these soups were developed through sensory evaluation, and microbiological analyses were performed to assure the quality of soup. The microbial counts of the soups which were chilled at 0-3$^{\circ}C$ and stored for 10 days in refrigerator were as follows: Aerobic bacteria were not detected in Miyuck-gook; however, those in Soup of beef and radish were 0.00-1.32${\pm}$0.28 log CFU/g and those in Chige of beef and soybean paste were 3.36${\pm}$0.10- 4.67${\pm}$0.08 log CFU/g. Coliform bacteria were not detected in any soups. All the items of sensory evaluation showed no significant differences between the first and third day of storage, except the flavor, tenderness, chewiness, feeling after swallowing of Soup of Beef and Radish and color of Chige of Beef and Soybean Paste. Overall acceptability scores of chilled stored foods in the first and third day were 6.40:t0.83 and 6.07 :to.46 in Miyuck-gook, 6.93 ${\pm}$0.80 and 6.27${\pm}$1.16 in Soup of beef and radish, and 6.40${\pm}$1.40 and 6.07${\pm}$1.44 in Chige of beef and soybean paste, respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7409-7414
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• 2015

Loop-mediated isothermal amplification (LAMP) developed by Notomi et al. (2000) has made it possible to amplify DNA with high specificity, efficiency and rapidity under isothermal conditions. The ultimate products of LAMP are stem-loop structures with several inverted repeats of the target sequence and cauliflower-like patterns with multiple loops shaped by annealing between every other inverted repeats of the amplified target in the similar strand. Because the amplification process in LAMP is achieved by using four to six distinct primers, it is expected to amplify the target region with high selectivity. However, evaluation of reaction accuracy or quantitative inspection make it necessary to append other procedures to scrutinize the amplified products. Hitherto, various techniques such as turbidity assessment in the reaction vessel, post-reaction agarose gel electrophoresis, use of intercalating fluorescent dyes, real-time turbidimetry, addition of cationic polymers to the reaction mixture, polyacrylamide gel-based microchambers, lateral flow dipsticks, fluorescence resonance energy transfer (FRET), enzyme-linked immunosorbent assays and nanoparticle-based colorimetric tests have been utilized for this purpose. In this paper, we reviewed the best-known techniques for evaluation of LAMP amplicons and their applications in molecular biology beside their advantages and deficiencies. Regarding the properties of each technique, the development of innovative prompt, cost-effective and precise molecular detection methods for application in the broad field of cancer research may be feasible.

• 전자공학회논문지
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• 제50권10호
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• pp.13-20
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• 2013

SEAMCAT(Spectrum Engineering Advanced Monte Carlo Analysis Tool)은 통신 시스템 간에 발생할 수 있는 간섭 영향을 분석하는 도구로서 현재 널리 사용되고 있다. 이전 논문 [9]에 따르면 기존의 SEAMCAT에 ITU-R P.526 경로 손실 모델을 추가하여 지표 고도 정보를 반영한 간섭 분석 연구를 수행한 바가 있다. 이때 간섭 분석 대상 지역을 보여주기 위하여 구글 맵에 기반한 지형 디스플레이 기능도 함께 추가하였다. 하지만 구글 맵은 2차원 지도 형태로 실제 지형의 형태를 보여주지 않기 때문에 사용자가 해당 지역의 지표 고도 변화 등의 지형 특성을 파악하는데 효과적이지 않았다. 본 논문에서는 이를 개선하기 위해 3차원으로 지형을 보여주는 구글 어스(Google Earth)의 API 기능을 활용하여 입체적으로 지형을 보여주면서 부가적으로 분석 대상 통신 시스템의 위치 표시, 위치에 따른 전계 강도나 간섭 강도의 변화, 음영 지역 표시, 가시 분석을 함께 표시할 수 있는 기능을 SEAMCAT에 추가하였으며, 이를 사용한 간섭 분석 사례를 제시하였다.

• 대한기계학회논문집A
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• 제39권6호
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• pp.575-581
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• 2015

드릴비트는 암반에 직접적으로 타격력과 회전력을 전달함으로써 연속적으로 암반을 파쇄, 분쇄하는 천공기의 핵심 구성요소이다. 일정한 속도로 회전하는 동시에 회전축 방향으로 타격하며 암반을 파쇄하기 때문에 암반 파쇄효율을 높이기 위해서는 드릴비트의 배열 최적설계가 필요하다. 그러므로 본 연구에서는 버튼배열 최적화를 수행하기 위한 선행연구로써 버튼배열의 성능을 정량적으로 평가할 수 있는 방법에 대한 연구를 수행하였다. 버튼의 중복타격 면적, 비 타격 면적, 천공편향 모멘트와 같은 평가지표를 활용하여 버튼배열의 파쇄 효율성을 평가하였으며, 더불어 제안된 평가방법을 활용하여 기존 드릴비트 버튼배열의 파쇄 효율성을 검토함으로써 제안한 배열성능 평가방법의 적합성을 확인하였다.

• 대한간호
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• 제31권5호
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• pp.53-64
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• 1992

A nurse is give much weight in the professions of hospital.The effective achievement of a goal of hospital organization needs to get nurses to contribute the structure positively through the rational personnel management of the nurses.The operation of performance rating system is necessary to improve because the nurses hold negative opinions about the resonable management of that system in most Korean hospitals.Therefore, the prupose of this research was to suggest an efficient method to solve the problem in connection with the management of nurses performance rating system.The results of the study are summarized as follows.1. As the performance rating implies the evaluation of employee's functional accomplishment and ability, and essential condition of the job was surveyed according to the job analysis of nursing activities and nurse position.That is to say, Nusrses' performances and capability is estimated in comparision with the condition of the job. 2. It is required adequacy for evaluation factors in performance rating.That is, $\circled1$ as for those who work in psychiatry or newborn baby room they should be appraied in terms of different factors from those applicable to whom work in a general staffs. $\circled2$ Evaluation factors should be concrete so that the quality and quantity of work and the potential ability of them can be correctly appraised. 3. In order to realize the object of perfamance rating system, the training on chief nurses are quite important. Also, careful practices and continuous supplementary training are required before the system is introduced.First of all, the appropriate evaluation can be mad by continuing to record the rating objects every day for the purpose of obtaining the objectivity of rating. 4. In course of transfering of the position and training, the induction of self-rating system and presentation of self-description is required to supplement functionally the performance rating system. 5. For the efficiency of nurses' performance rating system, the results of performance rating system must be reflected in promotion, allocation and training course, which makes the nurses have the motives and the organization accomplish the goal of modern nursing through its activation.

• 실천공학교육논문지
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• 제6권1호
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• pp.57-64
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• 2014

한국기술교육대학교(이하 한기대)는 학부교육과 전일제 근무를 병행하는 기업 연계형 장기실습제도(IPP)를 마련하여 2012년 8월부터 12월까지 시범사업을 운영하였고, 2013년 봄부터 본 사업을 추진하였다. 또한 IPP 프로그램의 실효성을 평가하고 프로그램 운영체계 및 과정에 대한 개선방안을 찾기 위해 Kirkpatrick의 4단계 평가모형에 기반 하여 IPP 성과평가모형을 개발하였다. 본 연구는 IPP 성과평가모형을 2013년 본 사업에 적용하여 참여학생들을 대상으로 기업체 파견 전과 후에 실시한 설문조사 결과를 분석하여 IPP 프로그램의 효과성을 평가하고, 향후 평가체계의 개선방향을 모색하고자 하였다. 설문조사 분석결과에 따르면, IPP 프로그램이 학생들의 비전공역량과 직업에 대한 태도를 개선하는데 어느 정도 효과적이었고, 학생들의 기업체 및 업무에 대한 만족도가 매우 높았던 반면, 전공역량과 IPP에 대한 인식 측면에서는 의미 있는 향상이 발견되지 않았다. 이러한 분석결과에 기반 하여 한기대 IPP 프로그램의 개선방향을 제시하였다.

• KIEAE Journal
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• 제17권3호
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• pp.5-13
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• 2017

Purpose: Various studies have been performed to address the issue of increased energy use by buildings. In particular, research on complex envelopes that combines diverse envelope element techniques is currently in progress in the building sector. The present study aimed to develop an awning system using a light shelf, and to verify its validity through performance evaluation. Method: In the present study, a testbed was established for the performance evaluation of the awning system using a light shelf, and the uniformity ratio and lighting energy consumption were compared and analyzed relative to those with no awning and light shelf installation (Case 1), awning installation (Case 2), and light shelf installation (Case 3). Result: 1) In the present study, an awning system using a light shelf (Case 4) where an opening is made on the awning screen and natural light can be introduced through the light shelf located at the bottom was developed. 2) The optimum standard for Case 4 obtained through the performance evaluation was a 0.6m lighting length and a 2m extension length at a light shelf angle of $30^{\circ}$. 3) Case 4 with the optimum standard had a 5.5% lower uniformity ratio than Case 2, but had a higher uniformity ratio than Case 1 and Case 3. 4) Case 4 with the optimum standard showed 13.3%, 44.6%, and 0%~8.7% lighting energy reductions compared to Case 1, Case 2, and Case 3, respectively. 5) Based on the above results, Case 4 suggested in the present study was found to be effective for indoor light environment improvement and lighting energy reduction.