• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.5 no.1
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• pp.62-67
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• 2002

Purpose: The aim of this study was to investigate the age of onset and the prevalence of lactose malabsorption in early childhood in Korea. Methods: We conducted a study of lactose malabsorption by breath hydrogen test in healthy children aged between 25~96 months old. Standard lactose loading (2 g lactose/kg, maximum 40g) test was done in 129 children and cow's milk (10 mL/kg) loading in 126 children followed by breath sampling of 60 and 120 minutes after the loading. An increase above baseline of 20 ppm or more was used as a criteria for positive responses. Results: The prevalence of lactose malabsorption was 7% in 25~36 months old, 19% in 37~48 months old, 35% in 49~60 months old, 55% in 61~72 months old, 82% in 72~84 months old, 80% in 85~96 months old children. Only 1% of the children showed positive result in breath hydrogen test after the cow's milk challenge. Conclusion: The prevalence of lactose malabsorption was increased between 37 months and 60 months of age, reached to adult level of prevalence after 72 months of age. When physiological dose of lactose was used as the challenge, the number of lactose malabsorbers become clinically insignificant.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.48-51
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• 2004

This paper is to study the response of flat plate slab-column connections consisting of various types of shear reinforcement and steel plate subjected to gravity loadings, mainly punching shear forces using the non-destructive testing, spectral analysis of surface waves and structural experiments. The base specimen failed due to punching shear generated from the gravity. The three other types of slab shear reinforcement and steel plate showed effective in resisting punching shear for these types of connections under gravity loading. This study has focused in evaluating the velocity response of a Surface wave during the early age as the poured concrete specimens have been hardened, the possibility of damage detection in the slab-column connection and the relationship between the punching shear forces and the surface wave velocities under the condition that the punching shear forces had gradually increased until the flat plate slab in slab-column connection had been failed.

• Steel and Composite Structures
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• v.6 no.2
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• pp.123-138
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• 2006

This paper proposes a model for the analysis of the construction sequences of steel-concrete composite decks in which the slab is cast-in-situ for segments. The model accounts for early age shrinkage, such as thermal and endogenous shrinkage, drying shrinkage, tensile creep effects and the complex sequences of loading due to pouring of the different slab segments. The evolution of the structure is caught by suitably defining the constitutive relationships of the concrete and the steel reinforcements. The numerical solution is obtained by means of a step-by-step procedure and the finite element method. The proposed model is then applied to a composite deck in order to show its potential.

• Journal of the Korean Society of Visualization
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• v.21 no.3
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• pp.39-48
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• 2023

In this study, we investigate the effects of slots installed on the tip of a rotor blade on aerodynamic characteristics. The slots weaken the strength and spatial coherence of the tip vortex at early vortex age and accelerate the dissipation of the generated tip vortex. Accordingly, the turbulence intensity of the rotor wake is reduced at both near and far wake, which leads to a reduction in broadband noise. Tonal noise is also reduced by mitigation of tip vortices, but tonal noise reduction is limited to a narrower range of azimuths than broadband noise due to the extinction of tip vortices. In addition, slots reduce both mean thrust and thrust fluctuations. Reduction in thrust fluctuations leads to a reduction in blade loading noise, resulting in a reduction in tonal noise.

• Structural Engineering and Mechanics
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• v.69 no.1
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• pp.1-10
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• 2019

In the construction of flat plate slabs, which are widely used for tall buildings but have relatively low flexural stiffness, serviceability problems such as excessive deflections and cracks are of great concern. To prevent excessive deflections at service load levels, current design codes require the minimum slab thickness, but the requirement could be unconservative because it is independent on loading and elastic modulus of concrete, both of which have significant effects on slab deflections. In the present study, to investigate the effects of the construction load of shored slabs, reduced flexural stiffness and moment distribution of early-age slabs, and creep and shrinkage of concrete on immediate and time-dependent deflections, numerical analysis was performed using the previously developed numerical models. A parametric study was performed for various design and construction conditions of practical ranges, and a new minimum permissible thickness of flat plate slabs was proposed satisfying the serviceability requirement for deflection. The proposed minimum slab thickness was compared with current design code provisions and numerical analysis results, and it agreed well with the numerical analysis results.

• Journal of Periodontal and Implant Science
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• v.37 no.2
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• pp.165-180
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• 2007

Dental Implants have been proved to be successful prosthetic modality in edentulous patients for 10 years. However, there are few reports on the survival of implant according to location in molar regions. The purpose of this study was to evaluate the $4{\sim}5$ years' cumulative survival rate and the cause of failure of dental implants in different locations for maxillary and mandibular molars. Among the implants placed in molar regions in Gwangju Mir Dental Hospital from Jan. 2001 to Jun. 2002, 473 implants from 166 patients(age range; $26{\sim}75$) were followed and evaluated retrospectively for the causes of failure. We included 417 implants in 126 periodontally compromised patients, 56 implants in 40 periodontal healthy patients, and 205 maxillary and 268 mandibular molar implants. Implant survival rates by various subject factors, surgical factors, fixture factors, and prosthetic factors at each location were compared using Chi-square test and Kaplan-Meier cumulative survival analysis was done for follow-up(FU) periods. The overall failure rate at 5 years was 1O.2%(subject level) and 5.5%(implant level). The overall survival rates of implants during the FU periods were 94.5% with 91.3% in maxillary first molar, 91.1% in maxillary second molar, 99.2% in mandibular first molar and 94,8% in mandibular second molar regions. The survival rates differed significantly between both jaws and among different implant locations(p<0.05), whereas the survival rates of functionally loaded implants were similar in different locations. The survival rates were not different according to gender, age, previous periodontal status, surgery stage, bone graft type, or the prosthetic type. The overall survival rate was low in dental implant of too wide diameter(${\geq}5.75$ mm) and the survival rate was significantly lower for wider implant diameter(p

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.1
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• pp.1-12
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• 2018

Purpose: Disorders of organic acid metabolism have various clinical manifestations and it may be life-threatening. The prognoses of affected children are dependent on early diagnosis and treatment. We report this study to find out detection rate of referred samples, clinical manifestations and age distribution after introduction of neonatal screening test using tandem mass spectrometry in Hallym University Chuncheon Sacred Heart Hospital during 8 years and 9 months. Methods: The 2,794 patients referred from Jan. 2007 to Sep. 2015 were divided into four groups according to age. We conducted organic acid analysis of urine samples of patients and analyzed clinical manifestations and distributions of age at the diagnosis. For patients with ambiguous results, reanalysis of urine organic acid after diet restriction, protein loading and restriction, has been done. Results: A total of 626 patients with 20 disorders were diagnosed. Mitochondrial disorders (482 patients) were the most common diagnosis, followed by ketolytic defects (67), 3-hydroxyisobutyric aciduria (32), EPEMA syndrome (8), 3-methylcrotonyl glycinuria (7), glutaric aciduria type II (6) and type I (4), methylmalonic aciduria (3), isovaleric aciduria (3) and medium chain acyl-CoA dehydrogenase deficiency (3). Conclusion: As neonatal screening test using tandem mass spectrometry is increasingly common and medical environment is changed, detection rate of disorders of organic acid metabolism in this study has decreased compared to previous report. Because the deterioration can be prevented by early diagnosis and treatment, many pediatricians have to pay special attention to possibility of the disorders and make an effort for early diagnosis in clinical setting.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4835-4837
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• 2012

Objectives: To evaluate residual disease in uterine cervical cancer patients treated with teletherapy using combined high dose rate Cobalt-60 brachytherapy. Materials and Methods: A retrospective study of uterine cervical cancer patients, FIGO stages IB-IVB (International Federation of Gynecologists and Obstetricians recommendations), treated by radiotherapy alone between April 1986 and December 1988 was conducted and the outcomes analysed. The patients were treated using teletherapy 50 Gy/25 fractions, five fractions per week to the whole pelvis together with HDR Cobalt -60 afterloading brachytherapy of 850 cGy/fraction, weekly to point A for 2 fractions. Results: The study covered 141 patients with uterine cervical cancer. The mean age was 50.0 years with a range of 30-78 years. The mean tumor size was 4.1 cm in diameter (range 1-8 cm). Mean follow - up time was 2.94 years (range 1 month-6.92 years). The overall incidence of residual locoregional disease was 3.5%. Residual disease, according to stage IIB, IIIB and IVA was present in 2.78%, 3.37% and 50.0%. It was noted that there was no evidence of residual disease in stage IB and IIA cases. Conclusion: Combined teletherapy along with high dose rate Cobalt -60 brachytherapy of 850 cGy/fraction, weekly to point A for 2 fractions resulted in overall 3.5% residual disease and a 96.5% complete response. The proposed recommendation for improving outcome is initiation of measurements for early detection of disease.

• International Journal of Highway Engineering
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• v.11 no.1
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• pp.247-256
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• 2009

This research was conducted to analyze the behavior of PTCP (Post-Tensioned prestressed Concrete Pavement) under tensioning by performing field tests when the experimental PTCP slab was being constructed. The displacements in the slab under the environmental loading and tensioning were measured using temperature measurement sensors and displacement transducers. Tensioning was performed three times and appropriateness of tensioning could be determined by investigating the relationship between temperature and displacement, behavior of transverse crack, and daily change in displacement. The results of this study showed that under the first tensioning at very early age, large displacements were observed only near the joints because of the friction between slab and underlying layer and concrete inelasticity. Under consecutive tensioning, displacements were clearly observed all over the slab, but still affected by the friction. In addition, appropriate tensioning ensured the one-slab behavior of the PTCP slab even though cracks existed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.9 no.2
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• pp.237-246
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• 1998

Objectives and Methods：This study investigated clinical characteristics, treatment modality, outcome of 57 children and adolescent inpatients(male 53, female 4) who were diagnosed as pervasive developmental disorder(PDD) by DSM-Ⅳ criteria recent five years. Results：1) The mean age at admission was $96{\pm}28.2$ months, and the mean age at which they first visited treatment facility was $52{\pm}26.6$ months. The mean hospitalization period was $43.7{\pm}31.3$ days. 2) Diagnosis：Twenty-seven(47.4%) of subjects met DSM-Ⅳ criteria for PDD NOS. Fifteen (26.3%) met for autistic disorder, nine(15.8%) met for Asperger's syndrome, and two(3.5%) met for childhood disintegrative disorder. 3) Comorbid diagnosis：The most common comorbid dignosis was attention deficit hyperactivity disorder(23.8%). 4) IQ test：IQ test for twenty-eight subjects was possible. The Average of the subjects was $70{\pm}27.5$. Fifteen(53.6%) of the subjects were approximate or under 70. 5) Neurology Abnormality：EEG findings of eleven(21.2%) subjects were abnormal, brain CT or MRI findings of eight subjects(21.6%) were abnormal. 6) Family Hx：Depressive disorder were found in Eight mothers(14%). Familial loading was found in twenty families(35.1%), and familial loading of PDD was found in three(5.3%). Conclusion：The most important thing for the management of PDD is early detection and early treatment. To do so, multidisciplinary team approach should be emphasized.