• 제목/요약/키워드: early recurrence

검색결과 486건 처리시간 0.024초

젊은 뇌졸중 환자의 우울감이 재발염려와 건강관련 삶의 질에 미치는 영향 (The Effects of Depression on Fear of Recurrence and Health-related Quality of Life in Young Adults with Stroke)

  • 윤수지;한상호
    • 한국엔터테인먼트산업학회논문지
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    • 제14권4호
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    • pp.371-380
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    • 2020
  • 본 연구는 젊은 뇌졸중 환자의 우울감이 재발염려와 건강관련 삶의 질에 미치는 영향을 파악하고자 실시한 서술적 조사연구로 2018년 7월 24일부터 2018년 11월 22일까지 C도 내 일개 상급종합병원과 J도 내 일개 대학교 병원 신경과 외래를 방문하여 젊은 뇌졸중 환자 240명을 대상으로 조사하였다. 수집된 자료는 SPSS 24.0과 SmartPLS 3.0를 이용하여 통계적인 유의성과 가설검증을 위한 분석을 실시하였다. 우울에 대한 탐색적 요인분석 결과, 죄책감, 정신적 우울, 신체적 우울의 3개의 요인으로 나누어져 추후 분석에 사용되었다. 가설 검증 결과, 우울감 중 죄책감과 정신적 우울이 재발염려에 영향을 미치는 것으로 나타났으며, 정신적 우울이 건강관련 삶의 질에 통계적으로 유의한 영향을 미치는 것으로 나타났다. 또한 재발염려가 건강관련 삶의 질에도 유의한 영향을 미치는 것으로 나타났다. 본 연구 결과를 통해 환자의 죄책감과 정신적 우울 정도를 경감시키기 위한 중재뿐만 아니라 우울감의 조기 사정 및 중재를 통하여 젊은 뇌졸중 환자의 뇌졸중 재발염려를 극복하는 것이 건강관련 삶의 질 향상에 크게 기여할 수 있을 것으로 사료된다.

심근 경색후 심실중격결손: 1례 보고 (Surgical Management of Postinfarction VSD - Report of 1 case -)

  • 윤태진
    • Journal of Chest Surgery
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    • 제24권9호
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    • pp.913-917
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    • 1991
  • Ventricular septal defect complicating myocardial infarction is rare but fatal condition which requires early surgical intervention before end-organ failure ensues from cardiogenic shock. Since the first successful repair by Cooley et al in 1956, surgical skills and strategies were developed and modified to a great extent, and we adopted the new repair technique in our case which stresses that minimal or no part of the infarcted septum and left ventricular wall be resected. This technique obviates the need to resect the infarcted part of the septum and prevents recurrence of an even larger VSD, and provides adequate size and shape of the left ventricle after of transinfarction left ventriculotomy.

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췌장암에서 $^{18}F-FDG$ PET의 임상 이용 (Clinical Application of $^{18}F-FDG$ PET in Pancreas Cancer)

  • 강원준
    • Nuclear Medicine and Molecular Imaging
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    • 제42권sup1호
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    • pp.71-75
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    • 2008
  • The prevalence of pancreas cancer is increasing. Due to difficulty in detecting early stage disease, the prognosis of pancreas cancer is known to be poor. Clinical use of FDG PET in pancreas has been reported. FDG PET showed good performance in diagnosing pancreas cancer, and is expected to be useful in staging and detecting recurrence.

Supratentorial Clear Cell Ependymoma Mimicking Oligodendroglioma : Case Report and Review of the Literature

  • Lee, Byoung-Hun;Kwon, Jeong-Taik;Park, Yong-Sook
    • Journal of Korean Neurosurgical Society
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    • 제50권3호
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    • pp.240-243
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    • 2011
  • Clear cell ependymomas (CCEs) are rare variants of ependymomas. Tumors show anaplastic histological features and behave as an aggressive manner. CCEs have a predilection for extraneural metastases and early recurrence, and they demonstrate characteristic radiographic features. These tumors should be radiologically and pathologically differentiated from oligodendrogliomas. On microscopic examination, CCEs are composed of sheets of cells and resemble oligodendroglioma. However, upon closer examination, the nature of CCEs can be detected earlier, resulting in prompt treatment of the tumor. Although we report only one case, we emphasize the importance of early diagnosis and treatment. Future description of more cases of these rare cancers is necessary to aid in their diagnosis and treatment.

유방암에서 $^{18}F-FDG$ PET의 임상 이용 (Clinical Application of $^{18}F-FDG$ PET in Breast Cancer)

  • 윤준기
    • Nuclear Medicine and Molecular Imaging
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    • 제42권sup1호
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    • pp.76-90
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    • 2008
  • $^{18}F-FDG$ PET in combination with conventional imaging modalities could help avoid unnecessary biopsy for the primary mass, and it also has a high diagnostic accuracy in patients with dense breasts. In the assessment of metastasis, $^{18}F-FDG$ PET was useful to select patients who required sentinel lymph node biopsy and to detect extra-axillary lymph node metastasis and distant metastasis. To increase the sensitivity for osteoblastic bone metastasis, bone scintigraphy should be added. In the detection of recurrence, $^{18}F-FDG$ PET showed a higher diagnostic accuracy than tumor marker or computed tomography, and therefore it can be used in routine breast cancer follow-up. $^{18}F-FDG$ PET has been reported that it correctly predicted the response of neoadjuvant chemotherapy on as early as 8th day of treatment. Therefore, it is useful for the early detect of therapeutic response in advanced breast cancer.

RNA Interference: a Promising Therapy for Gastric Cancer

  • Felipe, Aledson Vitor;Oliveira, Juliana de;Chang, Paula Yun Joo;Moraes, Andrea Aparecida de Fatima Souza;Silva, Tiago Donizetti da;Tucci-Viegas, Vanina Monique;Forones, Nora Manoukian
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권14호
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    • pp.5509-5515
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    • 2014
  • Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantly regulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigenetic approach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanism of RNAi for GC treatment.

Metachronous Liver Metastasis Resulting from Early Gastric Carcinoma after Subtotal Gastrectomy Following Endoscopic Resection: A Case Report

  • Oh, Sung Jin;Suh, Byoung Jo
    • Journal of Gastric Cancer
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    • 제15권2호
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    • pp.139-142
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    • 2015
  • Hepatic metastasis of early gastric cancer (EGC) following subtotal gastrectomy with lymphadenectomy is rare. We report the case of a 61-year-old male patient who was diagnosed with EGC that was initially treated using endoscopic submucosal dissection (ESD) and subsequently underwent laparoscopic subtotal gastrectomy. Histopathological examination of the patient's ESD specimen showed a moderately differentiated tubular adenocarcinoma invading the submucosa without lymphatic invasion. The deep margin of the specimen was positive for adenocarcinoma, and he subsequently underwent laparoscopic distal gastrectomy. The patient developed liver metastasis 15 months after the operation and then underwent liver resection. Histology of the resected specimen confirmed the diagnosis of two foci of metastatic adenocarcinoma originating from stomach cancer. Immunohistochemical analysis of the specimen demonstrated overexpression of human epidermal growth factor receptor 2. The patient was treated with trastuzumab in combination with chemotherapy consisting of capecitabine and cisplatin. Twenty-four months after the operation, the patient remained free of recurrence.

Best Treatments in Borderline Resectable Advanced Pancreatic Cancer

  • Joon Seong Park
    • Journal of Digestive Cancer Research
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    • 제4권2호
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    • pp.88-91
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    • 2016
  • Pancreatic cancer is the lethal disease and the prognosis of pancreatic cancer has remained largely unchanged over the past years. Borderline advanced pancreatic cancer is a biological different from resectable pancreatic cancer due to higher risk of early recurrence because of artery/vein abutment. Therefore this unique subset of pancreatic cancer has a controversial issue with regard to their treatment policy. Some institutes managed borderline advanced pancreatic cancer by up-front neoadhuvant chemotherapy because neoadjuvant chemotherapy provide the opportunity to treat early micro-metastasis with unfavorable tumor biology. But, some institutes try aggressive up-front surgical procedures to provide a chance of long-term survival in highly selected patients. Therefore this unique subset of pancreatic cancer has a controversial issue with regard to their treatment policy. This review address recent treatment trend for patients with borderline advanced pancreatic cancer.

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위암환자의 생활양식, 건강신념 및 건강 통제위 (A study on the life style. locus of control and health belief of gastric cancer patients)

  • 소희영;김현리
    • 지역사회간호학회지
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    • 제10권2호
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    • pp.362-371
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    • 1999
  • This study was conducted to explore the relationship between locus of control and health belief. the life style of gastric cancer patients. The subjects of this study were 40 of the early gastric cancer and 90 of the advanced gastric cancer who first visiting patient to general surgery out patient department of Chungnam University Hospital for operation. The data was collected with structured questionnaire from July. 1998 to Feb. 1999 The tool were Moon's Health Belief Scale and Multiple Locus of Control of Wallston. Wallston, DeVellis. The data was analysed by SAS program using frequency, $X^2$-test, Pearson's correlation coefficient, ANOVA. Scheffe-test, t-test. The results were as follows 1. 30.8% of subjects were early gastric cancer anf 69.2% were advanced gastric cancer. The subject knowing about diagnosis was 83.1%. 16.9% did'nt know about diagnosis. 2. The correlationship between Health belief and Locus of control of subjects was not supported. 3. There was statistically no difference of life style between early and advanced gastric cancer patients. 4. There were statistically significant differences in perceived sensitivity according to weight. educational level. and birth order, in perceived barrier according to educational level. and in perceived severity according to occupation among demographic characteristics of study subjects. From above results. health professional has to educate general population to detect gastric cancer early to improve survival rate because early gastric cancer is high in survival rate, and to prevent recurrence and to maintain continuing healthy status. In the future, gastroscopy also has to expand to detect early. For there was no difference in life style between early and advanced gastric cancer. carcinogen related to diet should be emphasized through education. The perceived benefit among health belief model was not supported in this study therefore further study and comparison between gastric cancer and normal population are needed.

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재발성 자궁경부 편평상피암 환자들에서 Squamous Cell Carcinoma 항원의 유용성 (The Clinical Significance of Follow Up SCC Levels in Patients with Recurrent Squamous Cell Carcinoma of the Cervix)

  • 최영민;박성광;조흥래;이경복;김기태;김주리;손승창
    • Radiation Oncology Journal
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    • 제20권4호
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    • pp.353-358
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    • 2002
  • 목적 : 자궁경부 편평상피암의 치료 후 추적조사 시에 시행하는 혈중 Squamous Cell Carcinoma (SCC) 항원 검사가 재발의 조기 발견에 도움이 되는지 알아보고자 하였다. 대상 및 방법 : 1997년 1월부터 1998년 12월까지 자궁경부 편평상피암으로 방사선치료를 받고 완전 관해 되었다가 재발된 환자들 중에서 재발 시에 SCC 항원 검사가 이루어졌던 20명을 대상으로 하였다. SCC 항원은 환자의 혈청으로부터 면역효소법으로 측정되었고, 2 ng/mL 미만을 정상으로 하였다. 진단, 추적조사, 재발 시의 SCC 항원값을 조사하여, SCC 항원 검사의 재발에 대한 민감도, 재발 양상에 따른 차이, 재발에 대한 증가 시기, 종양의 크기 및 병기와의 관계 등을 조사하였다. 결과 : 재발된 환자 20명 중의 17명에서 SCC 항원이 정상보다 증가되어 SCC 항원의 민감도는 $85\%$였고, 평균은 15.2 ng/mL (중앙값 : 9.5 ng/mL)였다. 재발 부위별로는 국소 재발, 원격전이, 동시에 발생한 경우 등으로 나누어서 SCC 항원을 비교하였으나 차이가 없었다. 재발을 진단하기 전 6개월 내에 SCC 항원이 검사되었던 11명에서 재발전 SCC 항원은 평균이 13.6 ng/mL (중앙값 : 3.6 ng/mL)였고, 7명에서 정상 보다 높았으며, 정상 범위였던 4명 중의 3명에서 1.5 ng/mL 이상으로 증가되는 양상이었다. 재발된 환자들 중에서 진단 시에 SCC 항원이 검사되었던 16명의 환자들에서 병기 Ib, IIa이면서 4 cm 미만이었던 환자들에 비하여 병기 Ib, IIa이면서 4 cm 이상이거나 병기 IIb, III이었던 환자들에서 진단 당시의 SCC 항원값이 높았다. 결론 : 자궁경부 편평상피암 환자들에서 추적조사 SCC 항원 검사는 재발의 조기 발견에 유용하고, 향후 효과적인 구제치료법이 개발되면 임상적인 이득이 더욱 증가될 것으로 생각된다.y 미만과 그 이상인 경우가 $5.1\%$$22.1\%$, 병기 II 이하인 경우와 III 이상인 경우가 $10.5\%$$31.8\%$였다. 다변량분석에서는 icruCREED 만이 유의하였다(0=0.0432). 등급 1 출혈은 자연적으로 소실되거나(3명) $1\~2$개월의 sucralfate 관장으로 멈추었다. 등급 2의 환자 6명은 $1\~2$개월 동안 sucralfate 관장으로 출혈의 빈도와 양이 줄어들었고 이 중 4명은 전기응고술을 추가로 시행하였다. 다른 9명은 전기응고술을 먼저 시행하였다(4명; sucralfate 관장 병행). 모두 $3\~10$개월 내에 정지되었다. 등급 3의 출혈은 잦은 전기응고술과 수혈을 요하였다. 결론 : 본 연구에서 중등도 이상의 직장출혈빈도가 $8.5\%$로 타 문헌에서 보고된 빈도와 유사한 결과였다. 직장에 조사된 총 생물학적 동등선량이 100 Gy 이상인 경우에 직장출혈이 유의하게 증가하므로, 치료계획시 생물학적 동등선량을 고려함으로써 휴유증 감소에 도움이 될 것으로 생각된다. 직장출혈이 발생한 환자에서 조기에 적극적으로 치료를 시행함으로써 출혈로 인한 불편함을 신속하게 해결하고 이로 인한 심리적 불안감을 해소할 수 있으며 나아가 삶의 질 향상에도 도움을 줄 수 있을 것으로 판단된다.절, 복강림프절 그리고 문합부위 등을 모두 포함하는 좀더 넓은 조사면의 치료가 필요할 것으로 사료된다.장암의 국소제어율을 높일 수 있는 치료방법이 개발되어야 할 것으로 사료된다.어율 모두에 유의한 인자는 방사선치료 후 종양반응과 N 병기였다. 결론 : 조기 병기의 성문상부암에서는 통상적인 방사선단독치료로 후두기능을 보존하면서 수술군과 대등한 종양제어율을 보여주었다. 그러나 진행된 병기의 경우에는 수술과 방사선치료의