• Asian-Australasian Journal of Animal Sciences
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• v.21 no.5
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• pp.640-647
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• 2008

Breed differences in adult animals are determined during fetal development. If interventions are to be developed that influence growth of muscle and fat, it is important to know at which time during gestation breed differences appear and are fixed. The objective of this study was to characterize fetal development in cattle of different breeds. Pregnant cows of 4 cattle breeds with different growth impetus and muscularity were slaughtered under normal processing conditions and the fetuses were removed. German Angus, a typical beef cattle; Galloway, a smaller, environmentally resistant beef type; Holstein Friesian, a dairy type; and Belgian Blue, an extreme type for muscle growth were used. Fetuses of each breed were investigated at 3, 6, and 9 mo of gestation. Fetuses were weighed and dissected into carcass, organs, and muscles. Body fat weight was obtained using the Soxhlet extraction method. Fetal weight increased most rapidly in the third trimester of gestation mainly due to the accelerated muscle and fat deposition. The organ weight to body weight (BW) ratios decreased and the muscle and fat weight to BW ratios increased. At 3 mo of gestation, Galloway fetuses had the significantly smallest BW, half-carcass weight, leg weight, organ weight, muscle weight and shortest leg length. In contrast, Holstein fetuses had the significantly greatest BW, liver, kidney, and lung weights and significantly longest leg length among the 4 breeds, but no differences between Holstein Friesian and Belgian Blue were detected in half-carcass and leg weight. Indeed, Belgian Blue fetuses had the significantly greatest half-carcass weight, leg weight, and muscle weight at 9 mo of gestation, and Galloway had a significantly greater body fat to BW ratio than Holstein Friesian and Belgian Blue. These differences were not evident at 3 and 6 mo of gestation. These data show that the profound increase of tissue and organ weights occurred in later gestation in cattle fetuses even though breed differences were evident as early as 3 mo of gestation. Depending on the tissue of interest, impacting fetal growth likely needs to occur early in gestation before the appearance of breed-specific differences.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.3
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• pp.266-272
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• 2017

In this study, it was simulated and analyzed the evacuation safety to identify the cadets' evacuation time by using maritimeEXODUS which is applied IMO MSC.1/Circ.1238 theory as well as the trim and heel which are the major factor of reducing the ship evacuation speed. In addition, this study carried out a simulation through the special program for fire analysis - FDS (Fire Dynamics Simulator) in order to find the effective evacuation time, i.e. life survival time. Particularly, this study did comparative analysis of the influence on the survival of cadets based on the collected simulation data by fire size and sort. As a result of the analysis, It was analyzed the Evacuation Allowable Limit Temperature $60^{\circ}C$ and resulted that there is no influence in evacuation by temperature. As a result of the analysis on visibility evacuation limit 5 m, it was found that the only one evacuation rallying point could not meet the evacuation safety. However, it derived the perfect evacuation safety under the condition of two rallying points available on wood fire. In case of Kerosene, it was satisfied the evacuation safety if the heeling was under $10^{\circ}$. Moreover, it could not meet the evacuation safety by evacuating through upper deck although there were two evacuation rallying points. When it was set by the lifeboat descending maximum angle-$20^{\circ}heel$ and $10^{\circ}trim$ which was described in SOLAS regulation, it was simulated that the wood fire having two evacuation rallying points in the center of the ship satisfied the evacuation safety.

• KSBB Journal
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• v.13 no.5
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• pp.502-510
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• 1998

Stabilization of antibody, which is specific to Salmonella typhimurium antigens, present in dry states on membranes was accomplished, and its shelf-life, i.e., duration for maintaining minimum 90% of the initial activity, under optimal conditions was determined. To prepare two major components of an immuno-strip, the antibody was not only immobilized on nitrocellulose membrane surfaces but also placed within the pores of glass fiber membrane after conjugating it with old colloids as signal generator. Among potential stabilizers of the immuno-components, a disaccharide, trehalose, showed a significant protection effect of immunoglobulin structure from thermal energy. Optimal concentrations of trehalose for the respective component were significantly different (8-fold higher for the antibody-gold conjugate than for the immobilized antibody), which probably resulted from distinct densities and configurations of antibody present on the membranes. An additional requirement for the gold conjugate was freeze-drying of this substance such that the conjugate can be readily resolubilized upon contact with aqueous medium. By using the components prepared under optimal conditions, immuno-strips were constructed and exposed to thermal energy. Signals with less than 10% decrease in the intensity were maintained for approximately 21 days at 60$^{\circ}C$. Compared to previous reports, this result represented a 2-year shelf-life at room temperature. it was, however, two times longer if determined from thermal acceleration tests based on the theory of inactivation rate of protein. Such discrepancy between the two estimates could be mainly attributed to errors in accurately controlling temperatures and also to changes in the physical properties of membranes due to a high thermal energy.

• International Journal of Highway Engineering
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• v.7 no.1 s.23
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• pp.1-9
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• 2005

This is a basic research for producing hot-mix recycled asphalt mixtures and suggesting methods for solving quality problems, if any. Various mixing methods are introduced to mate aging evenly between old and virgin aggregates and to improve aging conditions. Gel-permeation chromatography(GPC) analysis was performed to evaluate aging of binders coated on coarse aggregates and a matrix separately. Round-shaped aggregates(13m gravel) were used in manufacturing mixtures for analysis of aging levels in recycled mixtures. It was found out that there was significant difference in aging levels between the binder coated on RAP's coarse aggregates and on virgin aggregates in a recycled mixture. The difference in the aging level was reduced by modifying mixing method(RAP and virgin binders were mixed first and then virgin aggregates were introduced). Among A to E mixing methods studied, the D was turned out to be the best.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.3
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• pp.84-107
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• 2011

Purposes : The purpose of present study is to detect the effects of ointment contained Takrisodok-Eum on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 44 patients who visited Semyung Oriental Medical Center from April 27th, 2011 to September 20th, 2011 were included in the study. In this study, the patients were treated with Takrisodok-Eum (experimental group) and positive control group. For 8 weeks of gross examination, hematological examination and instrumental asessment were made before and after the study to examine how well the products for experimental group with those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in experimental group. 2. In the secondary endpoint index of skin hydration, both the experimental group and the control group showed statistical significance. 3. In the secondary endpoint index of TEWL, the experimental group showed greater statistical significance than the control group. 4. In the secondary endpoint index of skin pH, skin pH showed a statistically significant decline in both the control group and the experimental group within the normal range. 5. In the secondary endpoint index of Total IgE, Eosinophil count, IL-10, IL-13, both the experimental group and the control group showed no statistical significance. 6. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination, vital sign check were conducted; both control group and experimental group showed no abnormal level. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that Takrisodok-Eum should be effective for the Atopic dermatitis.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.5
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• pp.679-692
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• 2006

The carbonyl compounds in the atmosphere belong to one of the regulatory pollutants for the malodor control designated by the Korean Ministry of Environment(KMOE). In the present study, the emission concentration levels of carbonyl compounds were measured along with a number of criteria odor pollutants from a total of 47 individual companies(June 2004 to January 2005). The results of our study showed that a number of carbonyl compounds(such as formaldehyde, acetaldehyde, acetone, and butyraldehyde) maintained significantly high mean concentrations of 298 to 372 ppb. In contrast, other carbonyl compounds were low enough with the mean valves of 0.54 to 19.1 ppb. It was found that except for such industries as metal production or leather processing, their emissions were generally quite significant. If the measured values were evaluated in terms of malodor intensity, butyraldehyde appeared to be the most significant contributor to the malodor release. According to the measurements made in strong source areas, it can be concluded that several carbonyl compounds(acetaldehyde, propionaldehyde, butyraldehyde, isovaleraldehyde, and valeraldehyde) are useful enough to diagnose malodor release from those source areas. It should also be addressed that a number of carbonyl compounds added newly as the result of malodor control legislation were not sensitive enough to diagnose malodor release from such sources.

• Journal of Information Processing Systems
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• v.10 no.1
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• pp.145-161
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• 2014

Recently, many large organizations have multiple data sources (MDS') distributed over different branches of an interstate company. Local patterns analysis has become an effective strategy for MDS mining in national and international organizations. It consists of mining different datasets in order to obtain frequent patterns, which are forwarded to a centralized place for global pattern analysis. Various synthesizing models [2,3,4,5,6,7,8,26] have been proposed to build global patterns from the forwarded patterns. It is desired that the synthesized rules from such forwarded patterns must closely match with the mono-mining results (i.e., the results that would be obtained if all of the databases are put together and mining has been done). When the pattern is present in the site, but fails to satisfy the minimum support threshold value, it is not allowed to take part in the pattern synthesizing process. Therefore, this process can lose some interesting patterns, which can help the decider to make the right decision. In such situations we propose the application of a probabilistic model in the synthesizing process. An adequate choice for a probabilistic model can improve the quality of patterns that have been discovered. In this paper, we perform a comprehensive study on various probabilistic models that can be applied in the synthesizing process and we choose and improve one of them that works to ameliorate the synthesizing results. Finally, some experiments are presented in public database in order to improve the efficiency of our proposed synthesizing method.

• Journal of Digestive Cancer Research
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• v.4 no.1
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• pp.36-38
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• 2016

Biliary tract cancer, a relatively rare disease, is usually found in an unresectable stage. Weekly cisplatin plus gemcitabine has been applied as a standard first-line therapy for advanced biliary tract cancer, but almost up to 3-5% patients experience drug induced renal impairment. Many anticancer medication guidelines recommend drug adjustment when kidneys are damaged, but weekly cisplatin is somewhat low dose so that there is a controversy on reducing the dose. And it is known that the cumulative dose of cisplatin is the most important factor contributing to renal impairment. Therefore, clinicians face troubles whether or not to maintain the chemotherapy. Here, we reported a patient whose renal function (eGFR) had been decreased as the number of chemotherapy increased, so her chemotherapy should be stopped. Since we held the chemotherapy on her, the disease progressed aggressively. Weekly cisplatin regimen is just 25 mg/m², so it may be meaningless to reduce this dose, and it is well known that cumulative dose of cisplatin is the most important factor contributing to renal impairment, it is better not to use cisplatin anymore. Therefore, we recommend that if the patient responds well to weekly cisplatin plus gemcitabine regimen, it would be beneficial to use gemcitabine alone.

• Journal of Dental Rehabilitation and Applied Science
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• v.18 no.3
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• pp.145-155
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• 2002

The results of the present feasibility study are summarized as follows, 1. The three unit bridge of knitted material and UD fibre reinforcement has both the rigidity and the strength against a vertical occlusal load of 75N. 2. Stress concentration at the junctional area between the bridge and the abutments, i.e. between the pontic and the knitted caps was observed. In the case of the bridge with reinforcement straps, it was partly shown that the concentration problem could be improved by simply increasing the fillet size at the area. Further refining in the surface of the junctional area will be needed to ensure a further improvement in the stress distribution. This will require some trade off in the level of the stress and the available space. A parametric study will help to decide the appropriate size of the fillet. 3. Design refinement is a must to improve the stress distribution and realize the most favourable shape in terms of fabrication. The current straight bar with a constant cross section area can be redesigned to a tapered shape. The curve from the dental arch should also be placed on the pontic design. In accordance with design refinement, the resistance of the bridge frame to other load cases should be evaluated. 4. Although not included in the present feasibility study, it is estimated that bridges of the anterior teeth can be made strong enough with the knitted material without further reinforcement using unidirectional materials. In this regard, a feasibility study on design concepts and stress analysis for 3, 4, 5 unit bridge is suggested. 5. Two types of bridge were analysed in terms of fatigue. The safe life design concept, i.e. fatigue design concept, looks reasonable for the bridge where if cracks should form and propagate there is virtually nothing a dentist to do. The bridge must be designed so that no crack will be initiated during the life span. In the case of crowns, however, if constructed with composite resin with knitted materials, it might be possible to repair them, which in general is impossible for crowns of PFM or of metal. Therefore for composite resin crowns, a damage tolerance design concept can be applied and reasonably higher operational stresses can be allowed. In this case, of course, a periodic inspection program should be established in parallel. 6. Parts of future works in terms of structural viewpoint which need to be addressed are summarized as the following: 1) To develop processing technology to accommodate design concepts; 2) More realistic modelling of the bridge and analysis-geometry and loading condition. Thickness variation in the knitted material, taper in the pontic, design for anterior tooth bridge, the effect of combined loads, etc, will need to be included; 3) To develop appropriate design concepts and design goals for the fibre composite FPD aiming at taking the best advantage of knitted materials, including the damage tolerance design concept; 4) To develop testing method and perform test such as static ultimate load test, fatigue test, repair test, etc, as necessary.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.10B
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• pp.946-961
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• 2008

This study aims to provide guidelines on future policy for restructuring the scheme of aid programs associated with If small and medium-sized enterprises (i.e. SME) in Korea. For this purpose, we investigate an empirical dataset of recent aid programs deployed by Ministry of Information and Communication (i.e. MIC) for the last four years First, it is examined that the programs are practiced in accordance with their own policy objective by comparing matching samples between two groups such as program beneficiary and non-beneficiary companies. Second, positioning transition of programs within a same category is visualized in terms of two business portfolio analysis matrices. Third, an affiliation network matrix of (he programs is newly developed and then we attempt to analyze the programs relationship by the application of multidimensional scaling method to the affiliation network matrix. The empirical dataset is composed of two different kinds of corporate datasets. One is a corporate dataset of 8,994 beneficiary companies that are aided by MIC during the year of '03-'06. The other is also a corporate dataset of 18,354 non-beneficiary companies that have no records of the program supports during the years at all. Particularly, the matching samples of non-beneficiary companies are prepared in order to have comparable corporate age years (i.e. CAY) against beneficiary companies' CAY. Results show that; 1) up-to-date, the programs are properly assigned to IT SME conforming to their own policy objective; 2) however, as the year goes on, the following two distinct positioning transitions are revealed such as (1) both CAY and corporate sales (i.e. SAL) are increased simultaneously, (2) ratio of intangible assets (i.e. RIA) is decreased and ratio of operating gain to revenue (i.e. ROR) is increased. Hence, the role of the programs gets weakened with regard to providing seed money to technology innovation-typed IT SME so that a managerial adjustment of the programs is required consequently; 3) even though the model adequacy is not satisfactory through the analysis of multidimensional scaling method, the relationship of indirect-typed programs can relatively be stronger than that of direct-typed programs.