• Title/Summary/Keyword: eIF5A

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Characteristics of Acupuncture at Chok-Samni(ST36) on Facial Thermographic Change of D.I.T.I. (D.I.T.I.를 이용한 족삼리(ST36)자침이 안면부 절대온도변화에 미치는 영향)

  • Cho Eun Hee;Park Min Cheol;Choi Deok Hwa
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.6
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    • pp.1493-1499
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    • 2003
  • This study was examined for effects of acupuncture of Chok-Samni(ST36) on the facial thermography in health subjects, The volunteers who participating in this study had taken rest for 15 mins in room temperature (19-21 ℃) before the examination and informed them what to prohibit smoking, drinking and administration of drug for the previous day, The thermography of face was taken using Digital Infrared Thermographic Imaging (D.I.T.I. : Dorex, DTI-16UT1, U.S.A.) by time interval of 35 minutes at 15 min before and 20 min after acupuncture stimulation. Thermal temperature of Yangbaek(GB14), Myon-koryo(ST3) and Chichang(ST4) was measured and compared, The results showed that acupuncture of Chok-Samni(ST36) decreased the Absolute difference of temperature between Myon-koryo(ST3) and Chichang(ST4) (p<0,05, Data were represented mean±S,E.M.(n=33)), But, acupuncture of Chok-Samni(ST36) particularly decreased the absolute difference of temperature between Yangbaek(GB14) and Chichang(ST4) and particularly decreased the absolute difference of temperature between Vangbaek(GB14) and Myon-koryo(ST3) (p<0,05, Data were represented mean±S,E.M.(n=33)). Also, it was observed that acupuncture of Chok-Samni(ST36) decreased variety of the color tone of thermographic contour line and decreased thermal distribution. The results showed that acupuncture of Chok-5amni(ST36) significantly decreased the absolute difference of temperature of partial facial surface. Hereafter, study about if acupuncture of Chok-Samni(ST36) significantly decrease the absolute difference of temperature of all the areas of facial surface is requested. Also, continued study of effects of acupuncture of other meridian on the facial thermography is requested.

Characterization of $ET_B$ Receptor-mediated Relaxation in Precontracted Mesenteric Artery from Streptozotocin-induced Diabetic Rats

  • Eom, Yang-Ki;Kim, Koan-Hoi;Rhim, Byung-Yong
    • The Korean Journal of Physiology and Pharmacology
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    • v.9 no.5
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    • pp.305-314
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    • 2005
  • Diabetes mellitus is associated with vascular complications, including an impairment of vascular function and alterations in the reactivity of blood vessels to vasoactive substances in various vasculature. In the present study, the authors have observed endothelin-B ($ET_B$) receptor agonist-induced relaxation in precontracted mesenteric arterial segments from streptozotocin (STZ)-induced diabetic rats, which was not shown from control rats or in other arterial segments from diabetic rats. Accordingly, the goal of this study was to investigate in what way STZ-induced diabetes altered reactivity of the mesenteric arterial bed and to examine the causal relaxation, if any, between this $ET_B$ receptor-mediated relaxation and endothelial paracrine function, especially nitric oxide (NO) production. The relaxation induced by $ET_B$ agonists was not observed in mesenteric arteries without endothelium. The relaxation to $ET_B$ agonists was completely abolished by pretreatment with BQ788, but not by BQ610. $N_{\omega}-nitro-L-arginine$ methyl ester and soluble guanylate cyclase inhibitors, methylene blue or LY83583 significantly attenuated the relaxant responses to $ET_B$ agonists, respectively. When the expression of eNOS and iNOS was evaluated on agarose gel stained with ethidium bromide, the expression of eNOS mRNA in diabetic rats was significantly decreased, but the expression of iNOS was increased compared with control rats. Furthermore, the iNOS-like immunostaining was densely detected in the endothelium and slightly in the arterial smooth muscle of diabetic rats, but not in control rats. These observations suggest that $ET_B$ receptor may not play a role in maintaining mesenteric vascular tone in normal situation. However, the alterations in $ET_B$ receptor sensitivity were found in diabetic rats and lead to the $ET_B$ agonist-induced vasorelaxation, which is closely related to NO production. In the state of increased vascular resistance of diabetic mesenteric vascular bed, enhanced NO production by activation of iNOS could lead to compensatory vasorelaxation to modulate adequate perfusion pressure to splanchnic area.

TPH Removal of Oil-Contaminated Soil by Hot Air Sparging Process (고온 공기분사공정에 의한 유류오염대수층의 TPH 제거)

  • Lee, Jun-Ho;Park, Kap-Song
    • Journal of Korean Society on Water Environment
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    • v.23 no.5
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    • pp.665-675
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    • 2007
  • In-situ Air Sparging (IAS, AS) is a remediation technique in which organic contaminants are volatilized from saturated zone to unsaturated layer. This study focuses on the removal and interaction of Volatile Organic Compounds (VOCs) and $CO_2$, and Total Petroleum Hydrocarbon (TPH) in saturated and unsaturated, and air space zone on the unsaturated soil surface. Soil sparging temperature of hot air has risen to $34.9{\pm}2.7^{\circ}C$ from $23.0{\pm}1.9^{\circ}C$ for 36 days. At the diffusing point, fluid TPH concentrations were reduced to 78.7% of the initial concentration in saturated zone when hot air was sparged. The TPH concentrations were decreased to 66.1% for room temperature air sparging. The amount of VOCs for hot air sparging system, in air space, was approximately 26% larger than constant air sparging system. The amount of $CO_2$ was 4,555 mg (in unsaturated zone) and 4,419 mg (in air space) when hot air was sparged was 3,015 mg (in unsaturated zone) and 3,634 mg (in air space) for room air temperature in the $CO_2$ amount. The removals of VOCs and biodegradable $CO_2$ through the hot air sparging system (modified SVE) were more effective than the room temperature air sparging. The regression equation were $Y=976.4e^{-0.015{\cdot}X}$, $R^2=0.98$ (hot air sparging) and $Y=1055e^{-0.028{\cdot}X}$, $R^2=0.90$ (room temperaure air sparging). Estimated remediation time was approximately 500 days, if final saturated soil TPH concentration was set to 1.2 mg/L application of tail effect.

Evaluation of Pollutant Load Unit Factor for Calculating Pollutants Emission in Aquacultural Farms (양식계 오염원 배출량 산정을 위한 원단위 설정)

  • Park, Jae Hong;Park, Bae Kyoung;Rhew, Doug Hee;Lee, Jae Kwan
    • Journal of Korean Society on Water Environment
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    • v.29 no.5
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    • pp.656-665
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    • 2013
  • This research was conducted to investigate pollutant load unit factor from aquacultural farms. Pollutant load unit factors were investigated on the 13 kinds of fish type, i.e., Trout, Leather Carp, Eel, Carp, Cartfish, Freshwater Eel, Crucian Carp, Colored Carp, Sturgeon, Marsh Snail, Sweetfish, Pond Snail, Eriocheir Sinensis. Water qualities in aquacultural farms were investigated wide range of values by fish type and pollutant items. High BOD and COD values were observed at the Leather Carp (Ponded water system), Cartfish (Ponded water system) and Freshwater Eel (Recirculating System). TOC and DOC values were relatively high at the Freshwater Eel (Recirculating System) and Eriocheir Sinensis (Extensive). Eel (Ponded water system) and Freshwater Eel (Recirculating System) produced high concentrated nutrient pollutants, i.e., T-N, T-P. Pollutant load unit factors are dependent on fish type, aquacultural type, water quality items, etc. If some fishes have similar basic unit values, those could be applied for TMDLs as a group of fish having same pollutant load unit. The water quality concentrations of post treatment facilities' (mainly reservoir tank) effluent were higher than those of fish raising bath because of extracting pollutant from sediment in the reservoir tank. Therefore, it needs to the management and regulations about post treatment facilities.

Effectiveness of the Verif $EYE^{TM}$ machine -vision technology for complying with reducing microbial indicator counts on beef carcasses

  • Lee, Jeong-Ah;Kim, Sa-Hyun;Lee, Sang-Koan;Kim, Gi-Cheol;Oh, Hye-Won;Jung, Tae-Nam;Lee, Yang-Soo;Jung, Chang-Jin;Jang, Won-Hyuck
    • Korean Journal of Veterinary Service
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    • v.30 no.2
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    • pp.191-196
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    • 2007
  • The slaughter process for cattle will inevitably transfer some bacteria onto the carcasses. The goal of food safety programs is to minimize and effectively remove this contamination. This study was attempted by the Verif $EYE^{TM}$ machine-vision technology that might be useful for reducing microbial indicator counts and could reduce the contamination chance of E coli O157:H7 and Salmonella spp on beef carcasses. For the evaluation of the effectiveness of the Verif $EYE^{TM}$ technology, 80 samples were examined by the inspection device over 15 days. On an examination of FDS-positive samples compared to negative controls from the same carcasses, aerobic plate counts were bigger than the negative control samples (5.26 vs 4.60 log). Enterobacteriaceae counts were greater on the positive samples than the corresponding negative control samples (2.07 vs 1.17log). There was a consistent correlation between samples detected by the Verif $EYE^{TM}$ system with detectable counts. For example, 100% of positive samples had detectable APC and 91.2% of positive samples had detectable TCC. Therefore, if areas detected as positive for contamination by the Verif $EYE^{TM}$ system were removed from the carcasses, significant sources of microbial contamination will be reduced for objective compliance with HACCP. This results suggest that the use of Verif $EYE^{TM}$ machine-vision technology might be useful for reducing microbial indicator counts (APC, TCC) and could help reduce the risk of presence of E coJi O157:H7 and Salmonella spp on Beef carcasses.

Effect of Juglandis Semen Herbal Acupuncture on Rat by Glycerol-Induced Acute Renal Failure (호도약침(胡桃藥鍼)이 Glycerol로 유발(誘發)된 급성신부전(急性腎不全) 백서(白鼠)에 미치는 영향(影響))

  • Jung, Hyun-Chol;Kim, Cheol-Hong;Youn, Hyoun-Min;Jang, kyung-Jeon;Ahn, Chang-Beohm;Song, Choon-Ho
    • Korean Journal of Acupuncture
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    • v.22 no.3
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    • pp.105-117
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    • 2005
  • Objective : This study was undertaken to determine if Juglandis Semen herbal acupuncture(Ja) has a protective effect against glycerol-induced acute renal failure in rats. Methods : Rats were dehydrated for 24hr and then injected with 5 ml/kg of 50 % glycerol, one-half of dose in each hindlimb muscle. In experiments for Ja effect, rats received 0.1 ml of Ja extraction in both sides of corresponding $Sh\grave{e}nsh\bar{u}(BL_{23})$ of human body and non-acupuncture points(the root of tail) for 3 days after injection of glycerol. The experimental group were divided into the Normal group, the Control group, the Ja to $Sh\grave{e}nsh\bar{u}(BL_{23})$ group(Ja-AS), the Ja to non-acupuncture points group(Ja-AN). Results : There were significant decrease of urine volume, BUN, fractional glucose excretion, fractional phosphate excretion, total protein level in Ja-AS as compared with the control group. Conclusion : This suggests that Ja-AS could be used in prevention and treatment of acute renal failure. However, the precise mechanisms of Ja protection remain to be determined.

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Individual Exposure Characteristics to Humidifier Disinfectant according to Exposure Classification Groups - Focusing on 4-1 and 4-2 Applicants - (가습기살균제 환경노출 판정등급에 따른 개인 노출 특성 분포 - 4-1차와 4-2차 신청자를 중심으로 -)

  • Lee, Seula;Yoon, Jeonggyo;Ock, Jeongwon;Jo, Eun-Kyung;Ryu, Hyeonsu;Yang, Wonho;Choi, Yoon-Hyeong
    • Journal of Environmental Health Sciences
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    • v.45 no.4
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    • pp.370-380
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    • 2019
  • Objective: This study was performed to investigate the distribution of individual exposure characteristics according to an exposure assessment classification for humidifier disinfectant and to identify the factors that influence assessment classification. Methods: We examined the exposure characteristics of 4,482 subjects who applied for the 4-1 and 4-2 assessments of environmental exposure to humidifier disinfectant conducted by the Korea Environmental Industry & Technology Institute (KEITI). Environmental exposure assessment classification was assessed using the following seven criteria: 1) Distance from humidifier to face; 2) Spray direction; 3) Time used, daytime 4) Time used, during sleep; 5) Time used, cumulative; 6) Exposure intensity; and 7) Cumulative exposure level. Each criteria was then classified as 'high' or low'. When participants answered for more than four criteria, exposure assessment was determined as 'definite,' 'probable,' or 'possible' depending on the ratio of 'high' responses. If participants' responses were inconsistent, exposure assessment was listed as 'unlikely.' If participants answered for less than four criteria, exposure assessment was considered 'indeterminate.' Results: For the exposure assessment classes, definite was assigned to 38.5% (1,725 subjects), probable assigned to 32.9% (1,474 subjects), 25.0% (1,122 subjects) were assigned to as possible, unlikely assigned to 0.1% (3 subjects), and indeterminate assigned to 3.5% (158 subjects). Overall, participants who used 'Oxy Ssakssak New Gaseupgi Dangbun,' 'Aekyung Gaseupgi Mate,' 'Homeplus Gaseupgi Chungjungje,' and 'E-Mart Gaseupgi Salgyunje' totaled 2,996, 557, 176, and 162 subjects, respectively. There was a statistical difference in the type of humidifier disinfectant products between high-exposed and low-exposed participants. Based on the assessment criteria of humidifier disinfectant exposure, subjects were likely to be in the highly exposed classes (definite and probable) when the subjects were exposed 1) for more than ten hours per day and 2) for more than four hours at night 3) when the total cumulative exposure time was higher than the average, 4) when the direction of humidifier spray was toward the face, 5) when the respiratory position was less than 1 meter of distance from the humidifier, 6) when the concentration of indoor contaminants (ug/m3) was higher than the average exposure intensity, and 7) when overall exposure level ($ug/m3^*hr$) was higher than the average exposure level. Conclusion: This study suggests that each exposure assessment criteria was able to appropriately estimate cumulative exposure levels.

Selection framework of representative general circulation models using the selected best bias correction method (최적 편이보정 기법의 선택을 통한 대표 전지구모형의 선정)

  • Song, Young Hoon;Chung, Eun-Sung;Sung, Jang Hyun
    • Journal of Korea Water Resources Association
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    • v.52 no.5
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    • pp.337-347
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    • 2019
  • This study proposes the framework to select the representative general circulation model (GCM) for climate change projection. The grid-based results of GCMs were transformed to all considered meteorological stations using inverse distance weighted (IDW) method and its results were compared to the observed precipitation. Six quantile mapping methods and random forest method were used to correct the bias between GCM's and the observation data. Thus, the empirical quantile which belongs to non-parameteric transformation method was selected as a best bias correction method by comparing the measures of performance indicators. Then, one of the multi-criteria decision techniques, TOPSIS (Technique for Order of Preference by Ideal Solution), was used to find the representative GCM using the performances of four GCMs after the bias correction using empirical quantile method. As a result, GISS-E2-R was the best and followed by MIROC5, CSIRO-Mk3-6-0, and CCSM4. Because these results are limited several GCMs, different results will be expected if more GCM data considered.

The Dose Distribution of Arc therapy for High Energy Electron (고에너지 전자선 진자조사에 의한 선량분포)

  • Chu, S.S.;Kim, G.E.;Suh, C.O.;Park, C.Y.
    • Radiation Oncology Journal
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    • v.1 no.1
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    • pp.29-36
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    • 1983
  • The treatment of tumors along curved surfaces with stationary electron beams using cone collimation may lead to non-uniform dose distributions due to a varying air gap between the cone surface and patient. For large tumors, more than one port may have to be used in irradiation of the chest wall, often leading to regions of high or low dose at the junction of the adjacent ports. Electron-beam arc therapy may elimination many of these fixed port problems. When treating breast tumors with electrons, the energy of the internal mammary port is usually higher than that of the chest wall port. Bolus is used to increase the skin dose or limit the range of the electrons. We invertiaged the effect of various arc beam parameters in the isodose distributions, and combined into a single arc port for adjacent fixed ports of different electron beam eneries. The higher fixed port energy would be used as the arc beam energy while the beam penetration in the lower energy region would be controlled by a proper thickness of bolus. We obtained the results of following: 1. It is more uniform dose distribution of electron to use rotation than stationary irradiation. 2. Increasing isocenter depth on arc irradiation, increased depth of maximum dose, reduction in surface dose and an increasing penetration of the linear portion of the curve. 3. The deeper penetration of the depth dose curve and higher X-ray background for the smaller field sized. 4. If the isocenter depth increase, the field effect is small. 5. The decreasing arc beam penetration with decreasing isocenter depth and the isocenter depth effect appears at a greater depth as the energy increases. 6. The addition of bolus produces a shift in the penetration that is the same for all depths leaving the shape of the curves unchanged. 7. Lead strips 5 mm thick were placed at both ends of the arc to produce a rapid dose drop-off.

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An Adaptive Vehicle Platoon Formation Mechanism for Road Capacity Improvement (도로 용량 증대를 위한 적응적 차량 플라툰 형성 기법)

  • Su, Dongliang;Ahn, Sanghyun
    • KIPS Transactions on Computer and Communication Systems
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    • v.5 no.10
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    • pp.327-330
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    • 2016
  • In the road environment with lots of vehicles, we can increase the number of vehicles on the road (i.e., road capacity) and enhance the comfortability of drivers if vehicles are organized into platoons. In the traditional vehicle platooning mechanisms, a pre-determined set of vehicles are allowed to form a platoon and, among them, a specific vehicle is designated as the platoon leader. In this type of platoon mechanisms, platoon is limited in improving the road capacity because the vehicles allowed to involve into platooning are restricted. Therefore, in this paper, we propose an adaptive platoon formation mechanism that allows any vehicle to be a platoon leader from which a platoon is formed. In the proposed mechanism, a platoon leader is elected based on the relative velocity and location information of neighboring vehicles obtained through the periodic exchange of beacon messages among vehicles. Through the NS-3 based simulations, we show the performance of our proposed mechanism in terms of road capacity improvement.