• Title/Summary/Keyword: eIF5A

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Effects of Exercise on the Physiological Changes of Aging Skeletal Muscle (운동이 노화로 인한 골격근의 생리적 변화에 미치는 영향)

  • Song, Ju-Young;Kim, Jin-Sang
    • Physical Therapy Korea
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    • v.5 no.1
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    • pp.63-78
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    • 1998
  • The decrease of muscle power and muscle size between twenties and seventies was about 30% and 40% respectively. The loss of muscle mass by aging resulted in the decrease of muscle power. The loss of muscle mass was due to the decrease of number of Type I fiber and Type II fiber and size of each muscle fiber. The aging skeletal muscle didn't show the loss of glycolysis capacity but showed 20% decrease of the oxidative enzymes and muscle vascularization. The vigorous endurance exercise training with graded intensity played a role in the vascular proliferation, increase of activity of oxidative enzymes and improvement of $VO_2$ max. The graded resistance exercise also played a role in the muscle hypertrophy and increase of muscle power, if it performed with adequate intensity and period. The exercise adaptation of aging skeletal muscle prevented it from sarcopenia, provided the activity of daily living with great effect and provided the aging related disease, that is Type II diabetes mellitus, arteriosclerosis, hypertension, osteoporosis and obesity, with great effect.

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A study on the Effective Use of Environmental Information System in Korea - focused on the accuracy of raw data - (환경정보체계 구축의 효과적 이용 - 원자료의 정확성을 중심으로 -)

  • 이규석
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 1998.11a
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    • pp.34-36
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    • 1998
  • In Korea, the initial installation of GIS requires lots of cost, time, and human efforts, If the accuracy of GIS data does not meet the certain standard for use, the system may not work as expected. So, it needs to be investigated for the accuracy of raw data. However, there is little study for the accuracy of raw data in Korea. Therefore, the purpose of this study is to review the data accuracy of raw data - geologic map, 1:5,000 and 1:25,000 scale topographic map, forest stand map, degree of green naturality(DGN) map, and detailed survey data of DGN map - for fulfilling the expected use in Korea. After this study, some errors in data were surveyed and following conclusions were derived. (1) There is a lack of data, e. g, wildlife habitat map. (2) Some data are misinterpreted depending on the location in the geologic map. (3) Some data are not updated after change of topography in the topographic map. (4) Some data are not edited properly in the forest stand map. (4) DGN classification system does not reflect the characteristic of Korean vegetation community. So, it needs to be refined and restructured.

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An Enhanced Investment Priority Decision of Facilities Considering Reliability of Distribution Networks

  • Choi Jung-Hwan;Park Chang-Ho;Kim Kwang-Ho;Jang Sung-Il
    • KIEE International Transactions on Power Engineering
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    • v.5A no.3
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    • pp.260-268
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    • 2005
  • This paper proposes an improved investment pnonty decision method of facilities considering the reliability of distribution networks. The proposed method decides an investment order of the facilities combining, by fuzzy rules, the investment priority decision by KEPCO and that by reliability evaluation indices. The reliability evaluation indices are SAIFI (System Average Interruption Frequency Index) and SAIDI (System Average Interruption Duration Index). The reliability analysis method of distribution networks applied in this paper utilizes the analytic method, where the used reliability data is the historical data of KEPCO. Particularly, we assumed that the failure rate increases as the equipment ages. To verify the performance of the proposed method, we applied it with the planned projects to reinforce the weak electrical facilities in KEPCO in 2004. The evaluation result showed that, under a limited budget, the reliability of KEPCO in the Busan region using the proposed method could be enhanced if used rather than the conventional method typically in place. Therefore, the results verify that the proposed method can be efficiently used in the actual priorities method for investing in the electrical facilities.

Physicochemical Properties of Liquid Infant Formula Stored at Different Temperatures

  • Seo, Chan Won;Hong, Shik;Shin, Yong Kook;Kang, Shin Ho
    • Food Science of Animal Resources
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    • v.38 no.5
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    • pp.995-1007
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    • 2018
  • Changes in the physicochemical properties of ready-to-feed liquid infant formula (LIF) stored at different temperatures (10, 20, 30, and $40^{\circ}C$) for 6 mon, focusing on 5-hydroxymethylfurfural (HMF) content, color, pH, fat globule size distribution, and rheological properties were determined. The HMF content increased with storage time, and LIF stored at $40^{\circ}C$ had a higher HMF content than that of LIF stored at $10^{\circ}C$. The lightness ($L^*$) decreased while redness ($a^*$) and yellowness ($b^*$) increased with increasing HMF content. The fat globule size and pH of LIF stored at $10^{\circ}C$ did not change. However, in the case of LIF stored at $30^{\circ}C$ and $40^{\circ}C$, the fat globule size increased and the pH decreased during storage for 6 mon. LIF stored at $40^{\circ}C$ had a higher apparent viscosity (${\eta}_{a,10}$) than that of LIF stored at $10^{\circ}C$, and the shear-thinning behavior of LIF stored at higher temperature was stronger than that of LIF stored at low temperature. The physicochemical changes of LIF during storage were accelerated by Maillard reaction (MR) at higher storage temperatures. Therefore, even if LIF is aseptically manufactured, we recommend that sterilized LIF should be stored at low temperature in order to minimize quality changes during storage.

The Accuracy of Hysterosalpingography for Evaluating Female Infertility (불임 검사시 자궁난관 조영술의 진단 정확도)

  • Park, Joon Cheol;Kim, Jong In;Rhee, Jeong Ho
    • Clinical and Experimental Reproductive Medicine
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    • v.32 no.3
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    • pp.223-230
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    • 2005
  • Objective: This study was performed to evaluate the accuracy of hysterosalpingography (HSG) for evaluating female infertility patients by comparison with hysteroscopic and laparoscopic examination. Methods and Material: Total 219 infertile patients were retrospectively analyzed between January 1, 2002 and December 31, 2003. Ninety seven patients (44.3%) were primary infertility, 122 patients (55.7%) were secondary infertility. We performed hysteroscopic and laparoscopic examination on next cycle when HSG revealed any abnormal finding, and 3~6 cycles later if HSG was normal. Results: The accuracy of HSG was 65.2% compared with hysteroscopic examination (sensitivity 88.4%, specificity 46.4%, false positive rate 53.6%, false negative rate 11.6%). The most common abnormal finding of hysteroscopy was uterine synechia (67.4%) followed by endometrial polyp, uterine anomaly (e.g. uterine septum), endometrial hyperplasia. Compared with laparoscopic examination, the accuracy of HSG was 76.9% (sensitivity 98.9%, specificity 70.6%, +LR 3.36, -LR 0.02). The positive predictive value of normal patent tube was excellent (99.6%) but that of proximal tubal blockage was only 46.7%. The unilateral tubal obstruction of HSG was poor accuracy (+LR 3.85 -LR 0.68) and 70% of those was patent by laparoscopic examination. Laparoscopic examination also revealed that 53% of patients had peritubal adhesion and 37% of patients has additional pelvic findings, especially endometriosis. Among the patients had normal HSG, 53.5% patients with normal ultrasonography was diagnosed endometriosis (25.6% of them had endometriosis stage I-II). Conclusion: Normal HSG shows a high negative predictive value. Nevertheless, the incidence of associated pelvic disease in the normal HSG group is high enough to warrant diagnostic laparoscopy if nonsurgical treatment is unsuccessful. Because HSG has poor accuracy in predicting distal tubal blockage and peritubal adhesion, and poor positive predictive value of proximal tubal blockage, laparoscopic examination could be considered in abnormal HSG group.

A Study on Selecting Model for Small and Medium Management Innovative Manufacturers (경영혁신형 중.소 제조기업 선정 모형에 관한 연구)

  • You, Yen-Yoo;Roh, Jae-Whak
    • The Journal of Society for e-Business Studies
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    • v.15 no.2
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    • pp.55-75
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    • 2010
  • The primary purposes of this study are to find a proper model for government's selections of Mainbiz and present what are the better weights of the current indexes. We prepared three sets of models:first one using original 10 variables; second one using 9principally composed variables; third one using 7 principally composed variables. Among 3 models, the last one had higher explanation power than the other two models. Therefore, if index weights are adjusted according to the third newly developed model, the credibility in evaluating and selecting Mainbiz will be improved. When transforming the index weights and running the analysis, 5 variables(organization process, marketing management, management process, production-facility states, the level of forecasting) have more direct influences than other 4 variables(innovation strategies, knowledge management, achieving level, operational level) on selecting Main-biz.

Anaphylactoid Reaction Induced by Administration Dirofilaria immitis Extracts (개 심장사상충 추출액 투여에 의한 Anaphylactoid Reaction)

  • Lee, Jee-young;Song, Kun-ho;Kwon, Hyun-ju;Kim, Myung-cheol;Yun, Hyo-in;Kim, Duek-hwan
    • Korean Journal of Veterinary Research
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    • v.43 no.3
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    • pp.507-516
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    • 2003
  • This study was performed to clarify the induction possibility of anaphylactoid reactions by the administration with the heartworm extracts, and, if any, to elucidate different virulences in terms of the protein concentrdtions and sexes of Dirofilaria immitis. Twenty three clinically healthy D. immitis-free adult dogs were used in the present study. The experimental animals were divided into 5 groups. Group A (5 heads) was administered with an female heartworm extract containing 0.1 g/dl protein concentration. Group B (4 heads) was administered with an male heartworm extract containing 0.1g/dl protein concentration. Group C (5 heads) was administered with an female heartworm extract containing 0.2 g/dl protein concentration. Group D (4 heads) was administered with an male heartworm extract containing 0.2 g/dl protein concentration. Group E (5 heads) was administered with an female heartworm extract containing 0.4 g/dl protein concentration. The changes of clinical symptoms and vital signs (body temperature, heart rate and respiration rate) were examined before and 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours and 24 hours after injection with the extracts, respectively. In addition, the changes of hematological values (RBC, PCV and total leukocytes counts), serum chemical values (ALP and CK) were determined. It was considered that heartworm extract could induce anaphylactoid reaction and adult female heartworm extract was more affective than those of adult male heartworm extract in the changes of clinical symptoms, vital signs, hematological values and serum chemical values.

Neuroprotective effects of Extract of Broccoli, Cultivated in Desalinated Magma Seawater, on neuron-like SH-SY5Y cells (제주도 탈염 용암해수 재배로 제조한 브로콜리 추출물의 신경 세포 보호 효과)

  • Rhee, Jin Seol;Jang, Youn Bi;Choi, Ge Sun;Choung, Jai Jun;Kang, Seung Woo
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.3
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    • pp.448-462
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    • 2020
  • Dietary nutrition is a critical lifestyle factor that can reduce the risk of future cognitive impairments caused by dementia. Accumulating evidence suggests that dietary supplementation with Sulforaphane may help the prevention of cognitive impairments and dementia. Thus, Sulforaphane-enriched broccoli extract would hold promise to improve cognitive impairments of dementia patients. Here, we have used broccoli extracts, prepared from broccoli cultivated in Magma Seawater, to test if the broccoli extracts can be dietary supplement to improve cognitive impairments. Magma Seawater originated from Jeju Island, Korea is unique in terms of containing high concentrations of usable minerals (Zinc, Vanadium and Germanium etc.). Broccoli, grown in Magma Seawater, would contain Sulforaphane and the extra amount of usable minerals. The chemical compositions of the broccoli extracts were analyzed using LC-Q-orbitrap to detect Sulforaphane and Glucoraphanin. Analysis method based on HPLC was developed for measurement of sulforaphane levels in the broccoli extracts. We have tested if the broccoli extracts have anti-apoptotic and anti-inflammatory effects on neuron-like SH-SY5Y cells. In addition, we examined if the broccoli extracts are able to upregulate expression of synaptic plasticity-associated proteins (BDNF and phospho-CREB) and to inhibit acetylcholine esterase (AchE) activity. We have shown that the broccoli extracts inhibited the apoptotic pathway and inflammatory responses. Finally, we present evidence showing that AchE activity was inhibited by the broccoli extracts, but expression of BDNF and phospho-CREB was upregulated. Taken together, these findings suggest that the broccoli extracts from Magma Seawater-grown broccoli would be a good source of dietary nutrition to improve cognitive impairments in the future.

Resistance to Air Flow through Fruits and Vegetables in Bulk (산물퇴적 청과물의 송풍저항 특성)

  • 윤홍선;조영길;박판규;박경규
    • Journal of Biosystems Engineering
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    • v.20 no.4
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    • pp.333-342
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    • 1995
  • The resistance to air flow through fruits and vegetables in bulk was an important consideration in the design of the pressure cooling system. The amount of resistance to air flow through produce in bulk normally depended upon air flow rate, stacking depth, porosity, stacking patterns and shape and site of product. But, there was not enough information relating the effects of those factors on air flow resistance. The objectives of this study were to investigate the effect of stacking depth, stacking patterns, porosity and airflow rate on airflow resistance and to develop a statistical model to predict static pressure drop across the produce bed as a function of air flow rate, stacking depth, bed porosity, and product size. Mandarins and tomatoes were used in the experiment. The airflow rate were in the range of 0.1~1.0 ㎥/s.$m^2$, the porosity were in the range of 0.25~0.45, the depth were in the range of 0.3~0.9m and the equivalent diameters were 5.3cm and 6.3cm for mandarins, and 6.5cm and 8.5cm for tomatoes. Three methods of stacking arrangement were used i.e. cubic, square staggered, and staggered stacking arrangement. The results were summarized as follows. 1. The pressure drops across produce bed increased in proportion to stacking depth and superficial air velocity and decreased in proportion to porosity. 2. The increasing rates of pressure drop according to stacking patterns with the increase of superficial air velocity were different one another. The staggered stacking arrangement produced the highest increasing rate and the cubic stacking arrangement produced the lowest increasing rate. But it could be assumed that the stacking patterns had not influenced greatly on pressure drops if it was of equal porosity. 3. The statistical models to predict the pressure drop across produce bed as a function of superficial air velocity, stacking depth, porosity, and product diameter were developed from these experiments.

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Fruit Wall Anatomy of Ocotea (Lauraceae)

  • Heo, Kweon
    • Korean Journal of Plant Resources
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    • v.9 no.3
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    • pp.298-304
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    • 1996
  • The fruit wall anatomy of Ocotea was investigated on the basis of 14 species within the genus to contribute to a better understanding of specific relationships and homogeneity of genus. The species have a similar mature fruit wall structure, but diUerences among the species are found with respect to whether or not sdc.nchyma cells are present in the mesocarp. if present, whether or not they are present in particular positions and forms. Comparisons with species studied suggested that at least a few groups of species can be distinguished in Ocotea. They arc divided into five groups on the basis of anatomical structures. i.e., group 1) O. atrriensis, O. cujumari, O. helicterifolia, O. rubra and O. schomburgkiana; group 2) O. aeiphylla, O. javitensis, and O. sp. [Werff et ai. 12676]; group 3) O. tonduzii: group 4) O. foetens, O. quixos, and O. veraguensis; and group 5) O. floribunda and O. nitida. These various variations in Ocntea were also discussed to invite its respective systematic revisions. By the comparisons with species, on the other hand, it suggested that the specialized species are evolved from non-specialized species.

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