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Anaphylactoid Reaction Induced by Administration Dirofilaria immitis Extracts  

Lee, Jee-young (College of Veterinary Medicine, Chungnam National University)
Song, Kun-ho (College of Veterinary Medicine, Chungnam National University)
Kwon, Hyun-ju (College of Veterinary Medicine, Chungnam National University)
Kim, Myung-cheol (College of Veterinary Medicine, Chungnam National University)
Yun, Hyo-in (College of Veterinary Medicine, Chungnam National University)
Kim, Duek-hwan (College of Veterinary Medicine, Chungnam National University)
Publication Information
Korean Journal of Veterinary Research / v.43, no.3, 2003 , pp. 507-516 More about this Journal
Abstract
This study was performed to clarify the induction possibility of anaphylactoid reactions by the administration with the heartworm extracts, and, if any, to elucidate different virulences in terms of the protein concentrdtions and sexes of Dirofilaria immitis. Twenty three clinically healthy D. immitis-free adult dogs were used in the present study. The experimental animals were divided into 5 groups. Group A (5 heads) was administered with an female heartworm extract containing 0.1 g/dl protein concentration. Group B (4 heads) was administered with an male heartworm extract containing 0.1g/dl protein concentration. Group C (5 heads) was administered with an female heartworm extract containing 0.2 g/dl protein concentration. Group D (4 heads) was administered with an male heartworm extract containing 0.2 g/dl protein concentration. Group E (5 heads) was administered with an female heartworm extract containing 0.4 g/dl protein concentration. The changes of clinical symptoms and vital signs (body temperature, heart rate and respiration rate) were examined before and 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours and 24 hours after injection with the extracts, respectively. In addition, the changes of hematological values (RBC, PCV and total leukocytes counts), serum chemical values (ALP and CK) were determined. It was considered that heartworm extract could induce anaphylactoid reaction and adult female heartworm extract was more affective than those of adult male heartworm extract in the changes of clinical symptoms, vital signs, hematological values and serum chemical values.
Keywords
heartworm; anaphylactoid reaction; clinical symptom; hematology; biochemistry;
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