• 제목/요약/키워드: eIF5A

검색결과 925건 처리시간 0.03초

CONFIRMATION OF THE EXOPLANET AROUND β GEM FROM THE RV OBSERVATIONS USING BOES

  • Ran, In-Woo;Lee, Byeong-Cheol;Kim, Kang-Min;Mkrtichian, D.E.
    • 천문학회지
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    • 제41권3호
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    • pp.59-64
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    • 2008
  • To detect exoplanets and study pulsation of K giant stars, we have observed precise RV (radial velocity) of about 55 early K giant (K0 - K4) stars brighter than V = 5 magnitude since 2003 by using BOES, a high resolution Echelle spectrograph attached to the 1.8 m telescope at BOAO (Bohyunsan Optical Astronomy Observatory). We detected periodic RV variation of KO III star $\beta$ Gem (HD 62509) with a period $P\;=\;596.6\;{\pm}\;2.3$ days and a semi-amplitude $K\;=\;44.8\;{\pm}\;0.7\;ms^{-1}$. If we adopt 1.7 $M_{\odot}$ for the mass of $\beta$ Gem, this yields the minimum mass of the companion m sin i = 2.64 $M_{Jupiter}$. Our results agree well with Hatzes et al. (2006) and Reffert et al. (2006), and confirm their discovery of a planetary object around $\beta$ Gem. We also confirmed about 192 minutes short period stellar oscillation found by Hatzes and Zechmeister (2007). This is the first report of exoplanet detection using BOES and demonstrates that the RV observation using BOES is accurate and stable enough to detect exoplanets around bright K giant stars.

악성코드의 위협과 대응책 (Threats and countermeasures of malware)

  • 임동열
    • 중소기업융합학회논문지
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    • 제5권1호
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    • pp.13-18
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    • 2015
  • 악성코드란 해커가 악의적인 목적을 위하여 작성이 되어있는 실행 가능한 코드의 통칭으로써 자기복제 능력과 감염 대상 유무에 따라 바이러스, 웜, 트로이목마 등으로 분류된다. 주로 웹페이지 검색이나 P2P사용, 셰어웨어를 사용 할 때 등, 이런 상황에서 침투가 많이 발생이 되고 있다. 악성코드로 공격을 당하게 되면 이메일이 자동으로 발송이 된다거나, 시스템 성능 저하, 개인 정보 유출 등의 피해를 입게 된다. 이번에 악성코드를 소개 하면서 악성코드에 관련된 내용들을 설명하고 대응책을 알아본다. 그리고 향후 연구방향에 대해서도 생각해본다.

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On the Multicast Capacity of Wireless Ad Hoc Networks with Network Coding

  • Wang, Zheng;Karande, Shirish S.;Sadjadpour, Hamid R.;Garcia-Luna-Aceves, J.J.
    • Journal of Communications and Networks
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    • 제13권5호
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    • pp.525-535
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    • 2011
  • In this paper, we study the contribution of network coding (NC) in improving the multicast capacity of random wireless ad hoc networks when nodes are endowed with multi-packet transmission (MPT) and multi-packet reception (MPR) capabilities. We show that a per session throughput capacity of ${\Theta}$(nT$^3$(n)) can be achieved as a tight bound when each session contains a constant number of sinks where n is the total number of nodes and T(n) is the transmission range. Surprisingly, an identical order capacity can be achieved when nodes have only MPR and MPT capabilities. This result proves that NC does not contribute to the order capacity of multicast traffic in wireless ad hoc networks when MPR and MPT are used in the network. The result is in sharp contrast to the general belief (conjecture) that NC improves the order capacity of multicast. Furthermore, if the communication range is selected to guarantee the connectivity in the network, i.e., ${\Omega}$($\sqrt{log\;n/n}$)=T(n) = O(log log n / log n), then the combination of MPR and MPT achieves a throughput capacity of ${\Theta}$(log$^{\frac{3}{2}}$ n/$\sqrt{n}$) which provides an order capacity gain of ${\Theta}$(log$^2$ n) compared to the point-to-point multicast capacity with the same number of destinations.

ON ERDŐS CHAINS IN THE PLANE

  • Passant, Jonathan
    • 대한수학회보
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    • 제58권5호
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    • pp.1279-1300
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    • 2021
  • Let P be a finite point set in ℝ2 with the set of distance n-chains defined as ∆n(P) = {(|p1 - p2|, |p2 - p3|, …, |pn - pn+1|) : pi ∈ P}. We show that for 2 ⩽ n = O|P|(1) we have ${\mid}{\Delta}_n(P){\mid}{\gtrsim}{\frac{{\mid}P{\mid}^n}{{\log}^{\frac{13}{2}(n-1)}{\mid}P{\mid}}}$. Our argument uses the energy construction of Elekes and a general version of Rudnev's rich-line bound implicit in [28], which allows one to iterate efficiently on intersecting nested subsets of Guth-Katz lines. Let G is a simple connected graph on m = O(1) vertices with m ⩾ 2. Define the graph-distance set ∆G(P) as ∆G(P) = {(|pi - pj|){i,j}∈E(G) : pi, pj ∈ P}. Combining with results of Guth and Katz [17] and Rudnev [28] with the above, if G has a Hamiltonian path we have ${\mid}{\Delta}_G(P){\mid}{\gtrsim}{\frac{{\mid}P{\mid}^{m-1}}{\text{polylog}{\mid}P{\mid}}}$.

Can a nanofluid enhance the critical heat flux if the recirculating coolant contains debris?

  • Han, Jihoon;Nam, Giju;Kim, Hyungdae
    • Nuclear Engineering and Technology
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    • 제54권5호
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    • pp.1845-1850
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    • 2022
  • In-vessel corium retention (IVR) during external reactor vessel cooling (ERVC) is a key severe accident management strategy adopted in advanced nuclear power plants. The injection of nanofluids has been regarded as a means of enhancing CHF when using the IVR-ERVC strategy to safeguard high-power nuclear reactors. However, a critical practical concern is that various types of debris flowing from the contaminant sump during operation of an ERVC system might degrade CHF enhancement by nanofluids. Our objective here was to experimentally assess the viability of nanofluid use to enhance CHF in practical ERVC contexts (e.g., when fluids contain various types of debris). The types and characteristics of debris expected during IVR-ERVC were examined. We performed pool boiling CHF experiments using nanofluids containing these types of debris. Notably, we found that debris did not cause any degradation of the CHF enhancement characteristics of nanofluids. The nanoparticles are approximately 1000-fold smaller than the debris particles; the number of nanoparticles in the same volume fraction is 1 billion-fold greater. Nanofluids increase CHF via porous deposition of nanosized particles on the boiling surface; this is not hindered by extremely large debris particles.

조화가진된 밀폐계 음장에서의 능동소음제어 (I) 컴퓨터 시물레이션 (The Active Noise Control in Harmonic Enclosed Sound Fields (I) Computer Simulation)

  • 오재응;이태연;김흥섭;신준
    • 대한기계학회논문집
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    • 제17권5호
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    • pp.1054-1065
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    • 1993
  • 본 연구에서는 정상상태의 단일 주파수에서의 임의의 음압분포로 조화가진되 는 3차원 정방형 밀폐계 음장의 경우에 대한 능동제어를 시도함으로써 사무실과 같은 실내 공간에 대한 능동적 소음저감의 응용 가능성을 검토하고자 하였다. 또한 변환기 의 위치선정을 위하여 상태공간 모드 모델의 모드 근사화에 따른 계수행렬의 요소를 평가함으로써 가제어성과 가광측성을 만족하는 최적한 변환기 (부가음원, 마이크로폰) 의 위치를 선정하였다. 밀폐계 내부의 음압을 저감시키는 목적함수로는 전체 시간평 균 음향 포텐셜에너지를 사용하였으며 폐공간의 음압변동을 이론적으로 규명함으로써 부가적인 음원의 복소세기를 적절히 선정하여 이 음향 포텐셜 에너지의 양을 최소화 시킬 수 있음을 보였다.

체질처방 결정요인 확인을 위한 연구설계 (Research Design for the Verification of Constitutional Prescription Determinants)

  • 진희정;김상혁;백영화;장은수;유종향;이시우
    • 사상체질의학회지
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    • 제27권2호
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    • pp.222-230
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    • 2015
  • Objectives The purpose of this study is to design a research to find clinical factors involved in the decision-making process for determining the constitutional prescription based on prospective clinical data. Methods We have created a draft of the case report form. Therefore, seven constitutional experts was interviewed for additional items to be important used to determine the constitutional prescription in clinic. Interviews were done from December 2012 to March 2014, experts per person 2-3 times, took time of about 120 minutes per interview. Since then, we developed the final case report form through the expert meeting. At the same time, the developing the electronic case report form (eCRF) and the protocol to collect constitutional treatment cases was also discussed. Results & Conclusions The items of the case report form were subject general, lifestyle, health measurement, record of expert, prescription and evaluation after medication. The part of the clinical symptoms of the record of expert allowed to be recorded in the 5-point scale for the collection of quantitative data as much as possible. Assuming a re-visit of the patient, if necessary, twice the recording were to be possible. At the same time, the eCRF and the protocol to collect constitutional treatment cases were also developed. In this study, it will be able to more objectively standardize the medical decision making process that the experts of constitutional prescription decision. As a result, it will be possible to provide the standardized constitutional medical services.

Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress

  • Kim, Tae Jin;Pyun, Do Hyeon;Kim, Myeong Jun;Jeong, Ji Hoon;Abd El-Aty, A.M.;Jung, Tae Woo
    • Journal of Ginseng Research
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    • 제46권3호
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    • pp.444-453
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    • 2022
  • Background: Compound K (CK) is among the protopanaxadiol (PPD)-type ginsenoside group, which produces multiple pharmacological effects. Herein, we examined the effects of CK on muscle atrophy under hyperlipidemic conditions along with its pro-myogenic effects. Further, the molecular pathways underlying the effects of CK on skeletal muscle have been justified. Methods: C2C12 myotubes were treated with palmitate and CK. C2C12 myoblasts were differentiated using CK for 4-5 days. For the in vivo experiments, CK was administered to mice fed on a high-fat diet for 8 weeks. The protein expression levels were analyzed using western blotting analysis. Target protein suppression was performed using small interfering (si) RNA transfection. Histological examination was performed using Jenner-Giemsa and H&E staining techniques. Results: CK treatment attenuated ER stress markers, such as eIF2a phosphorylation and CHOP expression and impaired myotube formation in palmitate-treated C2C12 myotubes and skeletal muscle of mice fed on HFD. CK treatment augmented AMPK along with autophagy markers in skeletal muscle cells in vitro and in vivo experiments. AMPK siRNA or 3-MA, an autophagy inhibitor, abrogated the impacts of CK in C2C12 myotubes. CK treatment augmented p38 and Akt phosphorylation, leading to an enhancement of C2C12 myogenesis. However, AMPK siRNA abolished the effects of CK in C2C12 myoblasts. Conclusion: These findings denote that CK prevents lipid-induced skeletal muscle apoptosis via AMPK/autophagy-mediated attenuation of ER stress and induction of myoblast differentiation. Therefore, we may suggest the use of CK as a potential therapeutic approach for treating muscle-wasting conditions associated with obesity.

아산시 지표미생물의 분포와 Escherichia coli의 항생제 내성에 관한 연구 (A Study of Antimicrobial Resistance in Escherichia coli and the Distribution of Indicator Microorganisms in Asan City)

  • 이근열;김근하;권문주;권혁구;김연희;이장훈
    • 한국환경보건학회지
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    • 제36권3호
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    • pp.229-235
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    • 2010
  • Efforts to evaluate water pollution using indicator microorganisms have been underway for decades, and driven by research on water purity control applications, water quality criteria are growing more and more strict. Furthermore, recent reports indicate that high concentrations of antibiotics are not absorbed, and are present in excrement from animals and humans dosed with unnecessarily high levels of antibiotics. This has emerged as very important issue from the standpoint of being an ecological and health hazard. In this study, water pollution was analyzed through physicochemical and microbiological means, and antibiotic resistance in indicator microorganisms was assessed. In physicochemical analysis, biochemical oxygen demand (BOD)$_5$ and chemical oxygen demand (COD)$_{Mn}$ evaluation showed that pollution by organisms was highest at the G1 location with a high human population, and the DP location which has many livestock-containing households. The indicator organism levels at the G1 location were: Total Coliforms (1205 colony forming units (CFU)/100 ml), Fecal Coliforms (270 CFU/100 ml), Escherichia coli (253 CFU/100 ml) and Fecal Streptococci (210 CFU/100 ml), while for the DP location levels were: Total Coliforms (1480 CFU/100 ml), Fecal Coliforms (438 CFU/100 ml), E. coli (560 CFU/100 ml), and Fecal Streptococci (348 CFU/100 ml). Levels of fecal indicator microorganisms such as Fecal Coliforms, E. coli and Fecal Streptococci were high at all locations in the fall (the period after the rainy season), and the yearly distribution was similar between these organisms. If the number of livestock-containing households was high, almost all strains of E. coli (as distinct from the other indicator organisms) showed resistance to antibiotics, with the degree of resistance varying between areas. E. coli strains from the OY area in particular, which has a high population density, showed strong resistance to AM10 and Va30. While strong antibiotic resistance was observed overall at the DP and OY locations, no resistance was observed at the EB location.

A new method to predict the critical incidence angle for buildings under near-fault motions

  • Sebastiani, Paolo E.;Liberatore, Laura;Lucchini, Andrea;Mollaioli, Fabrizio
    • Structural Engineering and Mechanics
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    • 제68권5호
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    • pp.575-589
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    • 2018
  • It is well known that the incidence angle of seismic excitation has an influence on the structural response of buildings, and this effect can be more significant in the case of near-fault signals. However, current seismic codes do not include detailed requirements regarding the direction of application of the seismic action and they have only recently introduced specific provisions about near-fault earthquakes. Thus, engineers have the task of evaluating all the relevant directions or the most critical conditions case by case, in order to avoid underestimating structural demand. To facilitate the identification of the most critical incidence angle, this paper presents a procedure which makes use of a two-degree of freedom model for representing a building. The proposed procedure makes it possible to avoid the extensive computational effort of multiple dynamic analyses with varying angles of incidence of ground motion excitation, which is required if a spatial multi-degree of freedom model is used for representing a building. The procedure is validated through the analysis of two case studies consisting of an eight- and a six-storey reinforced concrete frame building, selected as representative of existing structures located in Italy. A set of 124 near-fault ground motion records oriented along 8 incidence angles, varying from 0 to 180 degrees, with increments of 22.5 degrees, is used to excite the structures. Comparisons between the results obtained with detailed models of the two structures and the proposed procedure are used to show the accuracy of the latter in the prediction of the most critical angle of seismic incidence.