• Genomics & Informatics
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• v.17 no.3
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• pp.29.1-29.8
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• 2019

The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide association study that aimed to identify common variants associated with seven diseases. That study combined two control datasets (58C and UK Blood Services) as shared controls. Prior to using the combined controls, the WTCCC performed analyses to show that the genomic content of the control datasets was not significantly different. Recently, the analysis of human leukocyte antigen (HLA) genes has become prevalent due to the development of HLA imputation technology. In this project, we extended the between-control homogeneity analysis of the WTCCC to HLA. We imputed HLA information in the WTCCC control dataset and showed that the HLA content was not significantly different between the two control datasets, suggesting that the combined controls can be used as controls for HLA fine-mapping analysis based on HLA imputation.

• Journal of Korea Society of Industrial Information Systems
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• v.12 no.4
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• pp.97-106
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• 2007

According to the 2004 Sloan Consortium Report, distance education is the fastest growing sector of higher education. This study suggests a research model, based on an e-Learning success model, the relationship of the e-learner's self-regulated learning strategy, computer self-efficacy, and system quality perception of the e-Learning environment. As a result, perceived usefulness, perceived ease of use, and service quality effect on e-learner's satisfaction. In addition to, self-regulated learning strategy based on computer self-efficacy is also important variable regarding e-learner's satisfaction.

• Korean Journal of Biological Psychiatry
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• v.20 no.3
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• pp.104-110
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• 2013

Objectives : The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) ${\varepsilon}4$ on cognitive performance in the community-dwelling elderly individuals with Alzheimer's disease (AD). Methods : The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE ${\varepsilon}4$. Results : The impact of ${\varepsilon}4$ allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033). Conclusions : The APOE ${\varepsilon}4$ allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.

• Journal of Preventive Medicine and Public Health
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• v.36 no.3
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• pp.213-222
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• 2003

Genomic epidemiology is defined as 'an evoking field of inquiring that uses the systematic application of epidemiologic methods are approaches in population-based studies of the impact of human genetic variation on health and disease (Khoury, 1998)'. Most human diseases are caused by the intricate interaction among environmental exposures and genetic susceptibility factors. Susceptibility genes involved in disease pathogenesis are categorized into two groups: high penetrance genes (i.e., BRAC1, RB, etc.) and lour penetranoe genes (i.e., GSTs, Cyps, XRCC1, ets.), and low penetrance susceptibility genes has the higher priority for epidemiological research due to high population attributable risk. In this paper, the summarized results of the association study between single nucleotide polymorphisms (SNPs) and breast cancer in Korea were introduced and the international trends of genomic epidemiology research were reviewed with an emphasis on internee-based case-control and cohort consortium.

• Nuclear Engineering and Technology
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• v.49 no.6
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• pp.1326-1338
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• 2017

The continuous energy Monte Carlo neutron transport code, MC21, was coupled to the CTF subchannel thermal-hydraulics code using a combination of Consortium for Advanced Simulation of Light Water Reactors (CASL) tools and in-house Python scripts. An MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 6 demonstrated good agreement with MC21/COBRA-IE and VERA solutions. The MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 7, Watts Bar Unit 1 at beginning of cycle hot full power equilibrium xenon conditions, is the first published coupled Monte Carlo neutronics/subchannel T-H solution for this problem. MC21/CTF predicted a critical boron concentration of 854.5 ppm, yielding a critical eigenvalue of $0.99994{\pm}6.8E-6$ (95% confidence interval). Excellent agreement with a VERA solution of Problem 7 was also demonstrated for integral and local power and temperature parameters.

• Korean Journal of Optics and Photonics
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• v.12 no.6
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• pp.452-459
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• 2001

ICC profiles of output devices are necessary to solve the problem of color inconsistency between output devices. Therefore, output device manufacturers are offering ICC profiles that encode each model\`s color characteristics according to the specification decided in ICC (International Color Consortium). In this study, a program that can decode data of ICC profile was composed and evaluated the present condition of ICC profile files of domestic CRT monitor. As a result of comparing the ICC profiles of various model\ulcorner selling since 1999 from LG and Samsung companies, it was found that ICC profiles that are made at a similar time are the same regardless of model\`s specification and in some profiles, extraordinary data are saved. Accordingly, it can be said that current ICC profiles are made independently of the real monitor\`s color characteristics. This paper shows how color characteristics of a real monitor are affected by the control of brightness and color temperature, and proposes that the ICC profile has to be made from the data. measured in the optimum brightness state at each color temperature setting.

• The Journal of Society for e-Business Studies
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• v.11 no.1
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• pp.113-126
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• 2006

The scope of e-Commerce process becomes wider as the emphasis on the enterprise collaboration grows. It has expanded from its initial settings of order management or billing processes to cover various collaborative processes in the company's value-chain. In order for those collaborative e-Commerce processes to be successful, corresponding business processes should be fully supported by standard bodies. The RosettaNet consortium, one of the most representative international B2B standard bodies, has steadily provided new PIPs to support those expansions. Since individual RosettaNet PIPs correspond to unit tasks that are executed separately in or between companies, multiple PIPs have to be integrally used to properly handle larger business cases. RosettaNet implementation, however, has suffered from the lack of standard guidelines or deliverables to refer under this multi-PIP environment. In this research, a contents-based document routing system is implemented. By applying this routing system to the RosettaNet e-Logistics program where multi-PIP environment is inevitable, we verified our contents-based document routing system is effective to support multi-PIP environment flexibly.

• Journal of Korean Society for Atmospheric Environment
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• v.18 no.E2
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• pp.79-84
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• 2002

The objective of this study was to investigate the biodegradation of ethylene in an activated carbon biofilter inoculated with immobilized microbial consortium. The biofilter performance was monitored in terms of ethylene removal efficiency and carbon dioxide production. The biofilter was capable of achieving ethylene removal efficiency as much as 100% at a residence time of 14 min and an inlet concentration of 290 ppm. Under the same conditions, carbon dioxide with a concentration of up to 546 ppm was produced. Its was found that carbon dioxide was produced at a rate of 87 mg day$\^$-1/, which corresponded to a volume of 0.05 L day$\^$-1/. During operation with an inlet ethylene of 290 ppm, the maximum elimination capacity of the biofilter was 34 g of C$_2$H$_4$m$\^$-3/ day$\^$-1/. The biofilter could provide an attractive treatment technology for removing ethylene, an extremely volatile and slowly adsorbed compound.

• Proceedings of the Korea Contents Association Conference
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• 2011.05a
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• pp.39-40
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• 2011

온라인 정보자원의 활용이 급속히 증가하면서, 정보자원 이용량에 대한 일관적이고 표준화된 통계 구축의 필요성에 대한 인식이 널리 확산되고 있다. 그러나 대부분의 도서관에서는 정보공급사로부터 이용통계를 수작업으로 수집하고, 정보공급사별로 상이한 통계 보고서를 재가공하여 분석하기에는 많은 어려움이 따른다. 본 논문에서는 전자정보 컨소시엄에 참가하는 개별 도서관을 대신하여 컨소시엄 주관기관에서 각 정보공급사별 이용통계를 자동으로 통합 수집하여 표준화된 포맷으로 구축하고, 이를 다양한 형태와 정보로 재가공하여 서비스 방안을 제안하였다.

• International Commerce and Information Review
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• v.8 no.3
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• pp.121-142
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• 2006

Recently regarding the ownership and proper operational forms of paperless trade infrastructure has become an issue. In this research the structural separation approach, different from the behavioral regulation approach, has been adopted. Following the structural separation, the core e-trade infrastructure which is separated from a vertically integrated provider, can be operated by three different forms such as a private sector; a public sector; finally a consortium among participants. As another option, the separated whole infrastructure including both core and non-core can be operated by a independent private entity. However, this option is not interesting case to us. As the last option, it can be considered that a new wholesale independent company for the separated core-infra can be set up for running. Additionally, three other alternative ways such as accounting separation, division separation, or corporation separation with keeping same ownership are also demonstrated. However the cautious investigation on cost and benefits of vertical separation are strongly recommended by OECD and agrees with the conclusion of this study.