• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.05a
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• pp.281-286
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• 2009

The proposed technique uses cyclic frame structure, where three periods such as beacon period (BP), mesh contention access period (MCAP) and slotted period (SP) are in a data frame. This paper studies on a mechanism to allow communication nodes (6lowpan) in a PAN with different logical channel for global healthcare applications monitoring technology. The proposed super framework structure system has installed 6lowpan sensor nodes to communicate with each other. The basic idea is to time share logical channels to perform 6lowpan sensor node. The concept of 6lowpan sensor node and various biomedical sensors fixed on the patient BAN (Body Area Network) for monitoring health condition. In PAN (hospital area), has fixed gateways that received biomedical data from 6lowpan (patient). Each 6lowpan sensor node (patient) has IP-addresses that would be directly connected to the internet. With the help of IP-address service provider can recognize or analyze patient data from all over the globe by the internet service provider, with specific equipments i.e. cell phone, PDA, note book. The NS-2.33 result shows the performance of data transmission delay and data delivery ratio in the case of hop count in a PAN (Personal Area Networks).

• The Journal of Korea Robotics Society
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• v.16 no.2
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• pp.172-178
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• 2021

The COVID-19 pandemic has been reshaping the world by accelerating non-contact services and technologies in various domains. Hospitals as a healthcare system lie at the center of the dramatic change because of their fundamental roles: medical diagnosis and treatments. Leading experts in health, science, and technologies have predicted that robotics and artificial intelligence (AI) can drive such a hospital transformation. Accordingly, several government-led projects have been developed and started toward smarter hospitals, where robots and AI replace or support healthcare personnel, particularly in the diagnosis and non-surgical treatment procedures. This article inspects the remaining element of healthcare services, i.e., surgical treatment, focusing on evaluating whether or not currently available laparoscopic surgical robotic systems are sufficiently preparing for the era of post-COVID-19 when contactless is the new normal. Challenges and future directions towards an effective, fully non-contact surgery are identified and summarized, including remote surgery assistance, domain-expansion of robotic surgery, and seamless integration with smart operating rooms, followed by emphasis on robot tranining for surgical staff.

• BMB Reports
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• v.56 no.10
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• pp.557-562
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• 2023

Dysregulation of the E3 ubiquitin ligase Parkin has been linked to various human cancers, indicating that Parkin is a tumor suppressor protein. However, the mechanisms of action of Parkin remain unclear to date. Thus, we aimed to elucidate the mechanisms of action of Parkin as a tumor suppressor in human lung and colorectal cancer cells. Results showed that Parkin overexpression reduced the viability of A549 human lung cancer cells by inducing G2/M cell cycle arrest. In addition, Parkin caused DNA damage and ATM (Ataxia telangiectasia mutated) activation, which subsequently led to p53 activation. It also induced the p53-mediated upregulation of p21 and downregulation of cyclin B1. Moreover, Parkin suppressed the proliferation of HCT-15 human colorectal cancer cells by a mechanism similar to that in A549 lung cancer cells. Taken together, our results suggest that the tumor-suppressive effects of Parkin on lung and colorectal cancer cells are mediated by DNA damage/p53 activation/cyclin B1 reduction/cell cycle arrest.

• BMB Reports
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• v.57 no.2
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• pp.104-109
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• 2024

Gefitinib exerts anticancer effects on various types of cancer, such as lung, ovarian, breast, and colon cancers. However, the therapeutic effects of gefitinib on cervical cancer and the underlying mechanisms remain unclear. Thus, this study aimed to explore whether gefitinib can be used to treat cervical cancer and elucidate the underlying mechanisms. Results showed that gefitinib induced a caspase-dependent apoptosis of HeLa cells, which consequently became round and detached from the surface of the culture plate. Gefitinib induced the reorganization of actin cytoskeleton and downregulated the expression of p-FAK, integrin β1 and E-cadherin, which are important in cell-extracellular matrix adhesion and cell-cell interaction, respectively. Moreover, gefitinib hindered cell reattachment and spreading and suppressed interactions between detached cells in suspension, leading to poly (ADP-ribose) polymerase cleavage, a hallmark of apoptosis. It also induced detachment-induced apoptosis (anoikis) in C33A cells, another cervical cancer cell line. Taken together, these results suggest that gefitinib triggers anoikis in cervical cancer cells. Our findings may serve as a basis for broadening the range of anticancer drugs used to treat cervical cancer.

• Journal of The Korea Institute of Healthcare Architecture
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• v.23 no.1
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• pp.15-24
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• 2017

Purpose: Korea is expected to enter an aged society in 2018 and then a super-aged society in early 2025. The country's aging is progressing faster than any other country in the world. However, the foundation of the elderly friendly industry is weak, and measures at the government level are urgently needed. Especially, housing problems of the elderly are one of the most urgent measures to be taken. Korea does not have the minimum residential area standard for the elderly, and the current general minimum residential area standard is based on the survey of the housing situation without scientific evidence. Therefore, both standards need to be revised as soon as possible based on scientific evidence. Methods: The minimum residential area standard has been calculated following Karl H. E. Kroemer's Min or Max design also being called as-single cut and dual cut theory- as the maximum population value and minimum population value theory of Ernest J. McCormick. Therefore there is a need for a formula made using a few key factors, such as corresponding dimension, practical dimension, clearance, spare dimension, integrated dimension. These elements can be defined and used as formulas to calculate minimum residential area standards. Results: Assuming the results of the spatial variability in this study showed that it is possible to raise the standard of living in a terms of sustainable minimum size for the young, old and all residents. Implications: The government should set a minimum residential area standard with scientific grounds and set up a policy improving the life of people who live in an needy residential environment.

• Clinical and Experimental Reproductive Medicine
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• v.37 no.2
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• pp.115-124
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• 2010

Objective: To testify whether the increased peripheral blood natural killer (pbNK) cells fraction and their cytolytic activity could coincide with patient's history of recurrent spontaneous abortion (RSA) and to evaluate these factors are can be valuable diagnostic markers in RSA. Methods: Women with a history of RSA comprised the patient group (n=35). Normal fertile women, who were experienced at least one healthy term birth without history of infertility or recurrent miscarriage, were included as the healthy control group (n=15). The pbNK cells of $CD3^-/CD56^+/CD16^+$ and their cytolytic activities against K562 cells were measured by flow cytometry and the values were compared between study and control groups. Results: Proportions of pbNK cells among peripheral blood monocytes (PBMC) ($14.2{\pm}5.2$ vs. $9.4{\pm}3.7%$, p=0.002, 95% confidence interval [CI], 1.8 to 7.8) was significantly higher in the patient group. The odds ratio of having RSA history was increased as 8.4 folds (59% of sensitivity, 80% of specificity, and 95% CI: 2.0 to 35.8) in patients who showed pbNK cells fraction above 12.1% which was determined as cut-off value by using ROC curve analysis. The cytolytic activities of pbNK cells which measured by three different ratio of effecter pbNK cells to target K562 cells and calculated by the percent of cytolytic K562 cells, were significantly higher in study group than that of control group (in 50:1 ratio, $48.3{\pm}19.0$ vs. $31.3{\pm}11.9%$, p=0.002; in 25:1 ratio, $37.0{\pm}18.1$ vs. $20.2{\pm}9.2%$, p<0.001; in 12.5:1 ratio, $23.5{\pm}12.7$ vs. $12.4{\pm}7.3%$, p=0.001). With the cut-off values of cytolytic activity of pbNK cells as 43.1% (50:1), 26.9% (25:1), and 17.4% (12.5:1) each, the risk of having RSA history was increased by 10.0, 11.4, and 15.0 folds in patients who had increased in each effector of pbNK to target of K562 cells ratio. Conclusion: The analysis of pbNK cells fraction and their cytolytic activity can be valuable diagnostic markers for RSA. We are going to planning the large scaled studies which include the data of obstetric outcomes in subsequent pregnancies to clarify our results of this study.

• Clinical and Experimental Reproductive Medicine
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• v.42 no.2
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• pp.45-50
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• 2015

Objective: Artificial oocyte activation (AOA) is an effective method to avoid total fertilization failure in human in vitro fertilization-embryo transfer (IVF-ET) cycles. AOA performed using a calcium ionophore can induce calcium oscillation in oocytes and initiate the fertilization process. We evaluated the usefulness of AOA with a calcium ionophore in cases of total fertilization failure in previous cycles and in cases of severe male factor infertility patients with non-motile spermatozoa after pentoxifylline (PF) treatment. Methods: The present study describes 29 intracytoplasmic sperm injection (ICSI)-AOA cycles involving male factor infertility at Cheil General Hospital from January 2006 to June 2013. Patients were divided into two groups (control, n=480; AOA, n=29) depending on whether or not AOA using a calcium ionophore (A23187) was performed after testicular sperm extraction-ICSI (TESE-ICSI). The AOA group was further split into subgroups according to sperm motility after PF treatment: i.e., motile sperm-injected (n=12) and non-motile sperm-injected (n=17) groups (total n=29 cycles). Results: The good embryo rate (52.3% vs. 66.9%), pregnancy rate (20.7% vs. 52.1%), and delivery rate (10.3% vs. 40.8%) were lower in the PF/AOA group than in the control group. When evaluating the effects of restoration of sperm motility after PF treatment on clinical outcomes there was no difference in fertilization rate (66.6% vs. 64.7% in non-motile and motile sperm, respectively), pregnancy rate (17.6% vs. 33.3%), or delivery rate (5.9% vs. 16.7%) between the two groups. Conclusion: We suggest that oocyte activation is a useful method to ensure fertilization in TESE-ICSI cycles regardless of restoration of sperm motility after PF treatment. AOA may be useful in selected patients who have a low fertilization rate or total fertilization failure.

• Journal of The Korea Institute of Healthcare Architecture
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• v.1 no.2
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• pp.63-72
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• 1996

A syudy on hospital architecture was as a circulation effective work as most amount and function at the view of nurse, staff until now. The architect do not have a data about planning patient-centered hospital, do not reflect a demand of patient at the planning step. This study arrange what is concept of patient-centered, recently concept of patient-centered hospital is importantly raised, at centering around a ward that a life of patient is the most influenced. This study make clear character of patient-centered hospital at home, the problem and demand of patient through the P.O.E.

• Journal of The Korea Institute of Healthcare Architecture
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• v.1 no.2
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• pp.83-90
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• 1996

The architect do not have a data about planning patient-centered hospital, do not reflect a demand of patient at the planning step. This study arrange what is concept of patient-centered, recently concept of patient-centered hospital is importantly raised, at centering around a ward that a life of patient is the most influenced. This study make clear character of patient-centered hospital at home, the problem and demand of patient through the P.O.E. The concept of patient-centered was disregarde, when the hospital was planned, in spite of being aimed hospital. At home, the shape of ward did not be developed, did not be corresponded with a demand of patient. But now proposition, which is satisfied psychologic, physical, mental demand, should be attempted.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06b
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• pp.41-43
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• 2011

Cyber-Physical Systems are tight integration of computation, networking and physical objects to sense, monitor, and control the physical world. This paper presents a novel architecture that combines two next generation technologies i.e. cyber-physical systems and Cloud computing to develop a ubiquitous healthcare based infrastructure. Through this infrastructure, patients and elderly people get remote assistance, monitoring of their health conditions and medication while living in proximity of home. Consequently, this leads to major cost savings. However, there are various challenges that need to be overcome before building such systems. These challenges include making system real-time responsive, reliability, stability and privacy. Therefore, in this paper, we propose an architecture that deals with these challenges.