• Clinical and Experimental Pediatrics
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• v.57 no.1
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• pp.1-18
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• 2014

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells and many cellular organelles. These include diseases of the nervous system (e.g., generalized epilepsy with febrile seizures plus, familial hemiplegic migraine, episodic ataxia, and hyperkalemic and hypokalemic periodic paralysis), the cardiovascular system (e.g., long QT syndrome, short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia), the respiratory system (e.g., cystic fibrosis), the endocrine system (e.g., neonatal diabetes mellitus, familial hyperinsulinemic hypoglycemia, thyrotoxic hypokalemic periodic paralysis, and familial hyperaldosteronism), the urinary system (e.g., Bartter syndrome, nephrogenic diabetes insipidus, autosomal-dominant polycystic kidney disease, and hypomagnesemia with secondary hypocalcemia), and the immune system (e.g., myasthenia gravis, neuromyelitis optica, Isaac syndrome, and anti-NMDA [N-methyl-D-aspartate] receptor encephalitis). The field of channelopathies is expanding rapidly, as is the utility of molecular-genetic and electrophysiological studies. This review provides a brief overview and update of channelopathies, with a focus on recent advances in the pathophysiological mechanisms that may help clinicians better understand, diagnose, and develop treatments for these diseases.

• Proceedings of the CALSEC Conference
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• 2001.08a
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• pp.503-510
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• 2001

Q+-reader, an E-Book reader system for XML based contents is introduced. The system is developed for the embedded platform, called Q+, which targets for the digital home electronics systems. The system supports XML contents and CSS based styling as described in Open e-Book standard. The system renders the e-book contents for users, so the contents are secured for a proper use. This will found an essential part of business infra for electronic books with copyright protection. The system was developed in Java language to be used in various platforms, and has an open architecture to be reusable for other standards as well.

• Steel and Composite Structures
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• v.19 no.6
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• pp.1483-1499
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• 2015

With the improvement of the quality of construction materials and the development of construction technologies, large-scale long-span steel frame buildings have been built recently. The P.E.B system using tapered members is being employed as an economically-efficient long-span structure owing to its advantage of being able to distribute stress appropriately depending on the size of sectional areas of members. However, in December 2005 and in February 2014, P.E.B buildings collapsed due to sudden loads such as snow loads and wind gusts. In this study, the design and construction of the P.E.B system in Korea were analyzed and its structural safety was evaluated using the finite element analysis program to suggest how to improve the P.E.B system in order to promote the efficient and rational application of the system.

• Journal of Korean Society for Quality Management
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• v.31 no.2
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• pp.98-116
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• 2003

The objective in this paper is to develope the e-Supply Chain Management System and applied for the Manufacturing. A Manufacturing that is consider to be world class recognize that its ability to complete in the marketplace depends on developing e-SCM System that is properly align with its mission of serving the customer. This paper investigated the relationship between e-SCM and performance in manufacturing. A stratified random sample was collected from the Federation of Korea Industries. Conclusively, e-SCM is important factor between source factors (environmental dynamic, Leadership) and manufacturing performance. e-SCM is significantly related to Quality, Flexibility, Delivery, and Cost.

• Journal of the Korea Society of Computer and Information
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• v.17 no.11
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• pp.125-132
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• 2012

In recent years, a variety of learning content construction utilizing the smart phone is coming. In this paper, we investigate on overall trends and movements in e-learning performance at University. And system developed a e-learning platform consisting of smart phone portal, learning management system(LMS), and learning content management system(LCMS). Throughout the experiment, each of the components of the e-learning were implemented. LMS was implemented more efficiently using a user profile evaluation system for qualification.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.3
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• pp.612-619
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• 2011

Satellite navigation system such as GPS is becoming more important infrastructure for positioning, navigation and timing. But satellite navigation system is vulnerable to interferences because of the low received power, complementary navigation system such as eLoran is needed. In order to develop eLoran/GPS navigation system, integrated eLoran/GPS navigation algorithm is necessary. In this paper, new integrated eLoran/GPS navigation algorithm is proposed. It combines the position domain integration and the range domain integration to get accurate position with less computational burden. Also an eLoran/GPS evaluation platform is designed and performance evaluation of the proposed algorithm using the evaluation platform is given. The proposed algorithm gives an accuracy of the range domain integration with a computational load of the position domain integration.

• International Journal of Contents
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• v.17 no.2
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• pp.41-47
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• 2021

The coronavirus pandemic has brought about dramatic changes in education, evidenced most clearly by the increase in e-learning. Thus, to identify how learners' attitudes toward e-learning are affected by diverse factors, this study examined the effects of perceived system quality and usefulness, the self-management of learning, and self-efficacy. A total of 236 college students participated in the survey. Multiple regression analysis was performed to test the study's proposed hypotheses. The study findings suggested that learners' attitudes toward e-learning are positively influenced by perceived e-learning usefulness, self-management of learning, and self-efficacy. However, the perceived system quality had no influence and no statistical significance.

• Journal of Intelligence and Information Systems
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• v.9 no.2
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• pp.121-133
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• 2003

Due to the rapid growth of Internet, means of communication with customers in a traditional customer support environment such as telephone calls are being replaced by mainly e-mail in a Web-based customer support system. Although such a Web-based support is efficient and promises potential benefits for firms, including reduced transaction costs, reduced time, and high quality of support, there are some difficulties associated with responding to many types of customer's inbound e-mails appropriately. As many types of e-mail are received, considerable attention is being paid to methods for increasing the efficiency of managing and responding e-mails. This research proposes an intelligent system for managing customer's inbound e-mails in organizations by applying case based reasoning technique for responding to various customers' inbound e-mails more effectively. In this approach, a case is represented as a frame-typed data structure corresponding to an inbound e-mail, keywords, and its reply e-mail. In the retrieval procedure, keywords and affinity set is developed to index a case, and then the case is represented as a vector, a case vector. Also, cosines value is calculated to measure the similarity between a new inbound e-mail and the cases in the case base. In the adaptation procedure, we provide several adaptation strategies to adapt and modify the retrieved case. The strategies guide to make an outbound e-mail using product databases, databases for customer support, etc. Additionally, the Web-based system architecture is proposed to implement our methodology. The proposed methodology and system will be helpful for developing more efficient Web-based customer support.

• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.714-720
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• 2012

With the help of information technology, it is the most important to collect clinical data correctly in clinical trials. For this, recently, in many pharmaceutical companies and Clinical Research Organizations (CRO) have tried to adopt an Electronic Case Report Form (eCRF) system. The eCRF system is a computerized system designed for collecting and managing clinical data in clinical trials. Although the eCRF is recognized as a significant system for clinical trials, until now there are no widely useable, due to the huge effort and expense at the initiatory stage of adopting eCRF system. In this study, we inquired the use of eCRF system developed for clinical trial at Korea Institute of Oriental Medicine. Especially, we focused on the time required for entering clinical data into the eCRF, hours of use, and the number of queries according to the time flow.

• The KIPS Transactions:PartD
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• v.10D no.1
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• pp.85-100
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• 2003

Today's computing system has expanded its application to business trade and distributed work transactions using the Internet. As the demand for more flexible, adaptable, extensible, and robust web-based enterprise, these application development has been gradually expanded based on reusable, independent, and portable components. Component Based Development (CBD) works by developing and evolving software from selected reusable software components and then assembling them within appropriate software architecture. However, it requires an increase in cost to build new components as well as the necessary effort to develop of the business requirement these components. Standardized component models are required as well from the perspective of systems in order to support rapid and exact component information transmission on the web. In this paper, we describe the e-Business Component Development with agent for rapid application development on the web that correspond to the demands of users in the business domain. We design and implement the specifications of e-business components by combining these demands. In order to improve the agent register and retrieval, we propose the intelligent search and register agents, which can conduct more precise searching and specializing for components. The system enables the locating of user's frequently used components through an agent involving register and retrieval, as well as rapid procedures for registers The e-BCOS (e-Business Component System) is the agent system for the user to register distributed components and to search for components Information. The e-BCOS increases reusability through the e-business component development of distributed components in the business domain. For the share and delivery, specification with XML is acceptable to user's variable order e-BCOS Includes the effective investment, timeliness, reliability, efficiency, and maintenance effort by with agent.