• 성인간호학회지
• /
• 제14권4호
• /
• pp.543-553
• /
• 2002

Purpose: The purpose of the study was to compare symptoms, medical therapies, and nursing interventions with terminal cancer patients during the last four weeks of their lives in a hospice unit and general units. Method: For the descriptive survey study, data were collected by reviewing the medical records of 243 patients who died of terminal cancer at K hospital in Seoul. The data was analyzed by using Chi-square test and t-test. Result: The study findings are summarized as follows: There were higher frequencies in physical symptoms of constipation, itching sensation, pain, sleeping disturbance, soreness and dysuria for those patients in the hospice unit than those patient in general units. All emotional symptoms were recorded significantly higher for those patients in the hospice unit than those in general units. Regarding the major medical interventions, pain management was used more significantly for those patients in the hospice unit, but antibiotic therapy and resuscitation were used more significantly for those patients in general units. Conclusion: The hospice unit provided more comprehensive nursing interventions including psychological, spiritual, and family cares as well as physiological care for terminal cancer patients. The facts showed that those patients who would need hospice care in general units should be referred to the hospice unit at an appropriate time.

• 성인간호학회지
• /
• 제12권4호
• /
• pp.666-677
• /
• 2000

The purpose of this study was to identify the needs which were perceived by patients who were received spinal anesthesia for surgery. The subjects consisted of 50 adult patients who were admitted to 2 university hospitals and 2 general hospitals in Pusan city and 1 general hospital in Koje City for surgery under spinal anesthesia. Thirty eight percent of subjects received information about anesthesia before the operation. The instrument for this study was developed by the researcher based on literature and a pretest. Data were collected from December 10, 1999 to February 10, 2000 and were analyzed by content analysis. The results were that there were 533 meaningful statements in the needs of spinal anesthesia patients. The needs of spinal anesthesia patients had 51 items (preoperation (6), induction of anesthesia(5), intraoperation (27), postoperation(13)) and 6 categories (information, emotional welfare, physical welfare, post anesthetic management, control of physical environment, humane treatment). From the results, it can be concluded that: 1. In the pre-operation period, we have to explain anesthesia procedures, adequate position of anesthesia, duration before anesthesia wears off and sensation of paralysis. We have to supply emotional support to relieve anxiety because of anesthesia. 2. In induction of anesthesia, we have to support patient's position for anesthesia, and relieve anxiety so that patients participate in induction of anesthesia well. 3. In intra-operative period, we have to check the level of anesthesia, and keep up a comfortable position for operation and care for physical discomfort such as thirst, nausea, vomiting, dyspnea and to maintain body temperature of the patient. Since the patient is conscious, we have to communicate with the patient to relieve anxiety, maintain privacy, inform the patient of the process of the operation and encourage the surgeon to explain the outcome of the operation. The operating team needs the careful about what they say and to place the instrument well. We have to ventilate the room air and reduce noise. 4. In the post-operative period, we have to explain the purpose and duration of bed rest, complications of anesthesia and care for physical discomfort such as pain, dysuria, headache, backache. Also we have to maintain body temperature of the patient and maintain privacy.

• International Journal of Oral Biology
• /
• 제43권2호
• /
• pp.61-68
• /
• 2018

Codium fragile (Suringar) Hariot is an edible green seaweed that belong to the Codiaceae family and has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria. Methanol extract of codium fragile has anti-oxidant, anti-inflammatory and anti-cancer properties, although the anti-cancer effect on oral cancer has not yet been reported. In this study, we investigated the anti-cancer activity and the mechanism of cell death by methanol extracts of Codium fragile (MeCF) on human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that MeCF inhibits cell viability in a dose-dependent manner, and markedly induced apoptosis, as determined by the MTT assay, Live/Dead assay, and DAPI stain. In addition, MeCF induced the proteolytic cleavage of procaspase -3, -7, -9 and poly(ADP-ribose) polymerase(PARP), and upregulated or downregulated the expression of mitochondrial-apoptosis factor, Bax(pro-apoptotic factor), and Bcl-2(anti-apoptotic factor). Futhermore, MeCF induced a cell cycle arrest at the G1/S phase through suppressing the expression of the cell cycle cascade proteins, p21, CDK4, CyclinD1, and phospho-Rb. Taken together, these results indicated that MeCF inhibits cell growth, and this inhibition is mediated by caspase- and mitochondrial-dependent apoptotic pathways through cell cycle arrest at the G1/S phase in human FaDu hypopharyngeal squamous carcinoma cells. Therefore, methanol extracts of Codium fragile can be provided as a novel chemotherapeutic drug due to its growth inhibition effects and induction of apoptosis in human oral cancer cells.

• 대한한의학방제학회지
• /
• 제24권4호
• /
• pp.259-269
• /
• 2016

Objectives : Phyllostachys Folium is leaves of Phyllostachys nigra var. henesis $S_{TAPF}$. In the East Asian traditional medicine, the herb has been used to treat nasal bleeding, dysuria, epilepsy and etc. The present study was conducted to evaluate the anti-inflammatory effects of the Phyllostachys Folium water extracts (PFE) in vitro and in vivo model. Methods : Cell viability was measured by MTT assay after the treatment of PFE and NO production was monitored by measuring the nitrite content in culture medium. iNOS, COX-2, $I{\kappa}B$, $p-I{\kappa}B{\alpha}$ amd $NF{\kappa}B$ were detected by immunoblot analysis, and levels of cytokine were analyzed by sandwich ELISA kit. Anti-edema effect of PFE was determined in the carrageenan-induced paw edema model in rats. Results : LPS increased NO and cytokines levels compared with control, these increases were attenuated by PFE. In addition, LPS-induced pro-inflammatory proteins such as iNOS, COX-2 were down regulated by PFE. These anti-inflammatory effect of PFE results from inhibition of phosphorylation of $I{\kappa}B$ and translocation of $NF-{\kappa}B$. Conclusion : These results show that PFE has some anti-inflammatory effects which might play a role in gram-negative bacterial infection inflammation and $NF{\kappa}B$ activated diseases.

• 한국임상수의학회지
• /
• 제27권3호
• /
• pp.295-298
• /
• 2010

5살의 중성화된 수컷 풍산 개가 서혜부에 지속적인 출혈 증상으로 내원하였다. 내원 5일 전에 멧돼지에게 공격을 받은 병력을 가지고 있었으며, 양성 요도 조영술에서 막성 요도의 파열과 요도 피부 누공이 있음을 확인 하였다. 수술 중 요도 카테터를 장착하여서 요도와 요도 피부 누공을 확인 하였고, 오줌의 누출로 인해 발생한 괴사 조직과 손상된 조직을 제거 하였다. 요도 카테터를 장착하여 요도 문합술을 실시하였다. 술 후 한달 째 배뇨장애나 혈뇨 증상이 없이, 정상적인 배뇨를 유지하였으며, 수술 후 2 달째 실시한 역행성 양성 요도 조영술에서 요도 협착 소견을 보이지 않았다.

• Childhood Kidney Diseases
• /
• 제16권2호
• /
• pp.146-149
• /
• 2012

평소 건강했던 아이들에서 육안적 혈뇨는 드물게 나타나며, 수신증과 동반된 경우 또한 드물다. 3세 남아가 육안적 혈뇨와 배뇨통을 주소로 내원하였다. 소변검사에서 농뇨, 혈뇨 보였으나 소변 배양 검사에서 균이 배양되지 않았으며, 혈액검사와 신체 검진상에서는 특이 소견 관찰되지 않았다. 초음파 검사상 양쪽 수신증과 함께 방광 벽이 두꺼워진 소견 보였다. 배뇨 요도 방광 조영술상 방광 요관 역류는 관찰되지 않았으나 방광 벽 비후가 심했으며, 방광 용적이 줄어들고 모양이 찌그러져있었다. 진단 후 ceftriaxone을 2주간 치료하였다. 항생제 치료 일주일 후 혈뇨 소실되어 초음파 검사를 다시 시행하였고 양쪽 수신증의 호전과 방광 용적 및 모양이 정상으로 호전됨을 관찰하였다. 환아의 배뇨통 증상도 호전되어 퇴원하였다. 외래 추적 관찰 중에 역류 검사 재 시행하였으며 정상 소견 보였다. 육안적 혈뇨 및 현미경적 혈뇨는 더 이상 관찰되지 않았다. 본 저자들은 육안적 혈뇨를 보인 소아에서 양측성 수신증을 동반한 방광염 1례를 경험하여 보고하는 바이다.

• 동의생리병리학회지
• /
• 제24권2호
• /
• pp.249-257
• /
• 2010

Crataegii Fructus is commonly used as a improving digestion, removing retention of food, promoting blood circulation and resolving blood stasis agent in East Asia. Cadmium (Cd) is widely distributed in the environment due to its use in industry. An exposure to Cd causes dysuria, polyuria, chest pain, hepatic and renal tubular diseases. The liver is the most important target organ when considering Cd-induced toxicity because Cd primarily accumulates in the liver. This study investigated the protective effect of Crataegii Fructus water extract against cadmium ($CdCl_2$, Cd)-induced liver toxicity in H4IIE cells, a rat hepatocyte-derived cell line and in rats. Cell viability was significantly reduced in Cd-treated H4IIE cells in a time and concentration-dependent manner. However, Crataegii Fructus water extract (CFE) protected the cells from Cd-induced cytotoxicity via inhibition of PARP cleavage. To induce acute toxicity in rats, Cd (4 mg/kg body weight) was dissolved in normal saline and intravenously injected into rats. The rats then received either a vehicle or silymarin (as a positive control) or CFE (50, 100 mg/kg/day) for 3 days, and were subsequently exposed to a single injection of Cd. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased by Cd treatment. In contrast, pretreatment with CFE reduced ALT, AST and LDH. In histopathological analysis, CFE reduced the hepatic degenerative regions and the number of degenerative hepatocytes. These are considered as direct evidences that Crataegii Fructus has favorable inhibitory effects on the Cd-intoxicated liver damages. The efficacy of Crataegii Fructus shows slight lower than that of silymarin in the present study.

• 대한한방부인과학회지
• /
• 제31권3호
• /
• pp.109-120
• /
• 2018

Objectives: The purpose of this study is to report the effect of Korean medicine treatments on a chronic pelvic inflammatory disease (CPID). Methods: We treated 2 cases of chronic pelvic inflammatory disease patients with Korean herbal medicine, acupuncture and moxibustion. One patient is a 50 years old woman, who suffered from uterine bleeding, lower abdominal pain, right pelvic pain. She was treated with Gwichuligyeong-tang-gami and Samul-tang-gami. Other patient is a 40 year old woman, who appealed for pain such as pelvic pain, lower abdominal pain, urinary frequancy, dysuria. She was treated with Cheongpochugeo-tang. Both patients are taken acupuncture at Junggeuk (CV3), Gwanwon (CV4), Chagung (CA111), Sameumgyo (SP6), Eumneungcheon (SP9) and moxified at Gwanwon (CV4). Results: After treatments, their symptoms were remarkably improved. Conclusions: This study suggests that Korean medicine treatments have significant effect on reducing symptoms of chronic pelvic inflammatory disease.

• Journal of Korean Biological Nursing Science
• /
• 제18권3호
• /
• pp.127-134
• /
• 2016

Purpose: The purpose of this study was to investigate the physiological index, anxiety and depression by the severity of lower urinary tract symptoms in patients with benign prostatic hyperplasia. Methods: This research was conducted from the 4th to the 27th of May in 2016 on112 patients with benign prostatic hyperplasia. The data were analyzed using a chi-square test, ANOVA, and Pearson Correlation Coefficients. Results: The results demonstrated a difference depending on the dysuria period of each lower urinary tract symptom, marital status, occupation and perceived health state of the patient. The physiological index by lower urinary tract symptoms showed a difference in the maximum flow rate, amount of post-void residual urine and Prostate-Specific Antigen (PSA), and anxiety and depression factors also revealed a difference. Lower urinary tract symptoms showed a positive correlation to the amount of post voided residual urine and PSA, a negative correlation to the maximum flow rate and also indicated a positive correlation to depression. Conclusion: The results of the study belonging to the moderate and severe categories were high when the result was based on the categorization of subjects with benign prostatic hyperplasia with lower urinary tract symptoms. Considering that depression levels increase as the symptom intensifies and the anxiety score is also high with mild symptoms, psychological support intervention is needed when a pattern of benign prostatic hyperplasia appears.

• 사상체질의학회지
• /
• 제25권1호
• /
• pp.62-70
• /
• 2013

Objectives This study reports a case of rectal cancer patient treated with Dokhwaljihwang-tang. Methods The patient's subjective symptoms such as pain, sleeping difficulty, frequent defecation and dysuria were observed and the change of the quality of life(QOL) was evaluated using Functional Assessment of Cancer-Colon (FACT-C). Results After the treatment, symptoms such as pain, sleep disorder, defecation, and urination difficulty ameliorated and the score of the FACT-C improved. Conclusions A rectal cancer patient suffering from adverse consequences from the low anterior resection and the pain induced by the metastases showed the improvement of general condition and the quality of life after treated with Dokhwaljihwang-tang.