• Title/Summary/Keyword: dynamic mechanical properties.

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Enhanced Transdermal Delivery of Drug Compounds Using Scalable and Deformable Ethosomes (에토좀 입자크기와 멤브레인 특성 조절을 통한 약물의 경피흡수능 향상)

  • An, Eun-Jung;Shim, Jong-Won;Choi, Jang-Won;Kim, Jin-Woong;Park, Won-Seok;Kim, Han-Kon;Park, Ki-Dong;Han, Sung-Sik
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.36 no.2
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    • pp.105-113
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    • 2010
  • This study introduces a flexible approach to enhance skin permeation by using ethosomes with deformable lipid membranes as well as controllable sizes. To demonstrate this, a set of ethosomes encapsulating an anti-hair loss ingredient, Triaminodil$^{TM}$, as a model drug, were fabricated with varying their size, which was achieved by solely applying the different level of mechanical energy, while maintaining their chemical composition. After characterization of the ethosomes with dynamic light scattering, transmission electron microscopy, and deformability measurements, it was found that their membrane deformability depended on the particle size. Moreover, studies on in vitro skin permeation and murine anagen induction allowed us to figure out that the membrane deformability of ethosomes essentially affects delivery efficiency of Triaminodil$^{TM}$ through the skin. It was noticeable in our study that there existed an optimum particle size that can not only maximize the delivery of the drug through the skin, but also increase its actual dermatological activity. These findings offer a useful basis for understanding how ethosomes should be designed to improve delivery efficiency of encapsulated drugs therein in the aspects of changing their length scales and membrane properties.

A Study on Creep Effect of Synthetic Fiber Rope Mooring System on Motion Response of Vessel and Tension of Mooring Line (섬유로프 계류시스템의 크리프 효과가 부유체의 운동응답 및 계류선의 장력 변화에 미치는 영향에 관한 연구)

  • Park, Sung Min;Lee, Seung Jae;Kang, Soo Won
    • Journal of the Society of Naval Architects of Korea
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    • v.54 no.2
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    • pp.151-160
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    • 2017
  • Growing demand and rapid development of the synthetic fiber rope in mooring system have taken place since it has been used in deep water platform lately. Unlike a chain mooring, synthetic fiber rope composed of lightweight materials such as Polyester(polyethylene terephthalate), HMPE(high modulus polyethylene) and Aramid(aromatic polyamide). Non-linear stiffness and another failure mode are distinct characteristics of synthetic fiber rope when compared to mooring chain. When these ropes are exposed to environmental load for a long time, the length of rope will be increased permanently. This is called 'the creep phenomenon'. Due to the phenomenon, The initial characteristics of mooring systems would be changed because the length and stiffness of the rope have been changed as time goes on. The changed characteristics of fiber rope cause different mooring tension and vessel offset compared to the initial design condition. Commercial mooring analysis software that widely used in industries is unable to take into account this phenomenon automatically. Even though the American Petroleum Institute (API) or other classification rules present some standard or criteria with respect to length and stiffness of a mooring line, simulation guide considers the mechanical properties that is not mentioned in such rules. In this paper, the effect of creep phenomenon in the fiber rope mooring system under specific environment condition is investigated. Desiged mooring system for a Mobile Offshore Drilling Unit(MODU) with HMPE rope which has the highest creep is analyzed in a time domain in order to investigate the effects creep phenomenon to vessel offset and mooring tension. We have developed a new procedure to an analysis of mooring system reflecting the creep phenomenon and it is validated through a time domain simulation using non-linear mooring analysis software, OrcaFlex. The result shows that the creep phenomenon should be considered in analysis procedure because it affects the length and stiffness of synthetic fiber rope in case of high water temperature and permanent mooring system.

Effect of Polypropylene Fiber on the Freeze-Thaw Damage of Mortar (모르타르의 동결융해 피해에 미치는 폴리프로필렌 섬유의 영향)

  • Yoo, Jae-Chul;Kim, Gyu-Yong;Lee, Sang-Kyu;Hwang, Eui-Chul;Nam, Jeong-Soo
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.7 no.4
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    • pp.438-444
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    • 2019
  • In this study, the effect of polypropylene fiber on the freeze-thaw damage of mortar was evaluated experimentally. The effects of the reinforcing of polypropylene fiber on the compressive and bending performance of mortar after 300 cycles of freeze-thaw test were evaluated by comparing the normal mortar and the mortar with polyvinyl alcohol fiber. In addition, the mass loss, relative dynamic elastic modulus, and cumulated pore volume of mortar were measured by each cycle of freeze-thaw test. As a result, it was confirmed that the fiber reinforced mortar, regardless of the fiber type, was effective not only in maintaining the performance of the compressive strength and the bending strength but also suppressing the mass loss after the freeze-thaw test of 300 cycles. Meanwhile, it was confirmed that not only polyvinyl alcohol fibers but also polypropylene fibers can effectively act to suppress the damage of the mortar by freeze-thaw. However, in order to improve the freeze-thaw resistance of mortar mixed with polypropylene fiber, it is necessary to increase the bonding performance with the cement matrix which can be expected from polyvinyl alcohol fiber.

Studies of Annealing Effect on the Properties of the Rigid Polyurethane (열처리에 따른 경질 폴리우레탄의 물성 변화 연구)

  • Kang S. J.;Jung H. C.;Kim W. N.;Lee Y. B.;Choe K. H.;Hong S. H.;Kim S. B.
    • Journal of the Korean Institute of Gas
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    • v.2 no.4
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    • pp.18-24
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    • 1998
  • Polyurethane (PU) synthesized from 4,4'-diphenylmethane diisocyanate having high functionality (f=2.9) and polyester polyol have been investigated by differential scanning calorimeter (DSC), dynamic mechanical thermal analyzer (DMTA), and Fourier transform infrared spectroscope (FT-IR). From the DSC measurement of polyurethane, a single transition temperature ($T_g$) was observed. This result indicates that polyurethanes synthesized in this work have homogeneous network structure due to high functionality of diisocyanate. It was also found that the $T_g$ of polyurethane was increased as hard segment content was increased. The results from DMTA measurement are consistent with DSC results. In order to investigate the effect of thermal annealing on the $T_g$ of polyurethane, the samples were annealed at various annealing conditions. $T_gs$ of polyurethanes were found to increased with annealing temperature. From swelling experiment and FT-IR studies, it was found that the $T_g$ was increased as crosslinking density of polyurethane was increased.

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Free Vibration Analysis of Circular Arches Considering Effects of Midsurface Extension and Rotatory Inertia Using the Method of Differential Quadrature (미분구적법을 이용 중면신장 및 회전관성의 영향을 고려한 원형아치의 고유진동해석)

  • Kang, Ki-Jun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.1
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    • pp.9-17
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    • 2021
  • Curved beams are increasingly used in buildings, vehicles, ships, and aircraft, which has resulted in considerable effort being directed toward developing an accurate method for analyzing the dynamic behavior of such structures. The stability behavior of elastic circular arches has been the subject of a large number of investigations. One of the efficient procedures for the solution of ordinary differential equations or partial differential equations is the differential quadrature method DQM. This method has been applied to a large number of cases to overcome the difficulties of the complex computer algorithms, as well as excessive use of storage due to conditions of non-linear geometries, loadings, or material properties. This study uses DQM to analyze the in-plane vibration of the circular arches considering the effects of midsurface extension and rotatory inertia. Fundamental frequency parameters are calculated for the member with various parameter ratios, boundary conditions, and opening angles. The solutions from DQM are compared with exact solutions or other numerical solutions for cases in which they are available and given to analyze the effects of midsurface extension and rotatory inertia on the frequency parameters of the circular arches.

Development and Application of Cellulose Nanofiber Powder as a Nucleating Agent in Polylactic Acid (나노셀룰로오스 분말 개발과 폴리젖산 내 핵제 적용 연구)

  • Sanghyeon Ju;Ajeong Lee;Youngeun Shin;Teahoon Park
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.29 no.1
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    • pp.51-57
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    • 2023
  • Because of the global pollution caused by plastic disposal, demand for eco-friendly transformation in the packaging industry is increased. As part of that, the utilization of polylactic acid (PLA) as a food packaging material is increased. However, it is necessary to improve the crystallinity of PLA by adding nucleating agents or to improve the modulus by adding fillers because of the excessive brittleness of the PLA matrix. Thus, the cellulose nanofiber (CNF) was fabricated and dried to obtain a powder form and applied to the CNF/PLA nanocomposite. The effect of CNF on the morphological, thermal, rheological, and dynamic mechanical properties of the composite was analyzed. We can confirm the impregnated CNF particle in the PLA matrix through the field emission scanning electron microscope (FE-SEM). Differential scanning calorimetry (DSC) analysis showed that the crystallinity of not annealed CNF/PLA nanocomposite was increased approximately 2 and 4 times in the 1st and 2nd cycle, respectively, with the shift to lower temperature of cold crystallization temperature (Tcc) in the 2nd cycle. Moreover, the crystallinity of annealed CNF/PLA nanocomposite increased by 13.4%, and shifted Tcc was confirmed.

Interfacial and Durability Evaluation of Jute and Hemp Fiber/Polypropylene Composites Using Micromechanical Test and Acoustic Emission (미세역학적시험법과 음향방출을 이용한 Jute 및 Hemp 섬유/폴리프로필렌 복합재료의 내구성 및 계면 평가)

  • Kim, Pyung-Gee;Jang, Jung-Hoon;Kim, Sung-Ju;Hwang, Byung-Sun;Park, Joung-Man
    • Composites Research
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    • v.20 no.3
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    • pp.55-62
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    • 2007
  • Interfacial evaluation and durability of Jute and Hemp fibers/polypropylene (PP) composites were investigated. Moisture content of various treated conditions were measured by thermogravimetic analyzer (TGA). After boiling water test, mechanical properties and IFSS between Jute, Hemp fibers and PP matrix decreased. On the other hand, work of adhesion increased due to swelled fibril by water. Surface energies of Jute and Hemp fibers before and after boiling water test were obtained using dynamic contact angle measurement. IFSS was not always consistent with thermodynamic work of adhesion. In boiling water case, since Jute and Hemp fibers could be swelled by water, surface area and moisture infiltration space increased. Environmental effect on microfailure modes of Jute or Hemp fibers and Jute or Hemp fibers/PP composites were obtained by observing via optical microscope and by monitoring acoustic emission (AE) events and their AE parameters. After boiling water test, unlike Hemp fiber, microfailure process of Jute fiber could occur due to low tensile strength by swelled fibril. In addition, AE events occurred more and AE amplitude and energy became lower than those of before boiling water test.

A Comparative Study on the Electrophysiological Properties of Medial and Lateral Spinoreticular Tract Cells in Cats (고양이의 내측 및 외측 척수망상로 세포의 전기생리학적 비교연구)

  • Lee, Suk-Ho;Jun, Jae-Yeol;Park, Choon-Ok;Goo, Yong-Sook;Kim, Jun;Sung, Ho-Kyung
    • The Korean Journal of Physiology
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    • v.24 no.1
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    • pp.181-194
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    • 1990
  • Antidromically activated spinoreticular tract (SRT) cell units in the lumbosacral enlargement of ${\alpha}-chloralose$ anesthetized cats were classified as medial and lateral SRT units according to the location of their axonal termination. Identified SRT units were tested fer antidromic conduction velocity, laterality of their axonal projection, the location in spinal gray, peripheral receptive field, the response pattern to graded mechanichal stimulation and the responsiveness to $A{\delta}$ and C volley of the peripheral nerve. 1) The 59% of 34 medial SRT units were recorded in ipsilateral side to the antidromic stimulation site, but 60% of the 47 lateral SRT units projected to contralateral side. 2) Most of the medial SRT cells and rostral ventrolateral medulla (RVLM)-projecting lateral SRT cells were recorded in lamina VII & VIII. The LRN (lateral reticular nucleus)-projecting SRT cells, however, distributed through all the laminae except superficial ones (I & II). 3) The identified SRT units were classified as low theshold (LT), deep, high threshold (HT), wide dynamic range (WDR) cells, based on the response patterns to graded mechanical stimuli. The proportion of SRT units which receive noxious input was 37.5%, 25% and 75% in the medial, LRN-projecting and RVLM SRT group, respectively. 4) There was no significant difference in the mean conduction velocities between the 3 groups. But the deep cells had significantly higher velocity than that of the HT cells. The above results show that the peripheral inputs to the SRT units are different in the 3 groups: medial, LRN & RVLM SRT group. Especially in case of the SRT cells projecting to RVLM which is a probable candidate fur the integration center of various pressor reflexes such as somatosympathetic reflex, the noxious informations occupy higher proportion of input to them than in other groups. Therefore the noxious information transmitted through the lateral SRT destined for RVLM is expected to play a role in somatosymapthetic reflex.

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