• Proceedings of the Optical Society of Korea Conference
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• 2005.02a
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• pp.120-121
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• 2005

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.82-83
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• 2006

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.06a
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• pp.525-526
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• 2007

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.84-85
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• 2003

The process of drug development has seen major changes over the last two decades with the movement away from standard small molecule drug discovery programs, through computer-assisted drug design methodologies towards biotechnologically derived products. The aim of duplication of endogenously active materials to be administered exogenously has enormous impact on development practices and evaluation of safety.(omitted)

• Proceedings of the Korean Society of Laser Processing Conference
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• 2004.10a
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• pp.14-17
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• 2004

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.29-29
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• 2022

• Neonatal Medicine
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• v.16 no.1
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• pp.76-80
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• 2009

A male baby with intrauterine growth retardation had a short neck, small hands and feet, hypospadia, both grade I hydronephrosis, type II atrial septal defect, and moderate valvular pulmonary stenosis. The routine chromosome and banding analyses revealed a 46,XY,rec(8)del(8)(p21)dup(8) (q24.1)inv(8)(p21q24.1)pat chromosome constitution. His mother has normal chromosomes, but the father had 46,XY,inv(8)(p21q24.n Also his uncle had an inv(8) chromosome constitution. We used lymphocytes and examined 40 mitotic cells. All mitotic cells showed deletion of 8p21-->pter and duplication of 8q24.1 -->qter. Because Sp21 involves secretion of macrophage and lymphocyte against cancer cells, long-term follow-up for cancer will be needed.

• Toxicological Research
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• v.17
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• pp.289-292
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• 2001

Gene targeting allows precise, predetermined changes to be made in a chosen gene in the mouse genome. To date, targeting has been used most often for generation of animals completely lacking the product of a gene of interest. Models of essential hypertension have been produced by mutated genes relating renin angiotensin system. The most significant contribution to understanding the genetic etiology of essential hypertension is probably the demonstration that discrete alterations in the expression of a variety of different genes can individually cause changes in the blood pressures of mice, even when the mice have all their compensatory mechanisms intact. These effects are readily detected in animals having moderate decreases in gene function due to heterozygosity for gene disruptions or modest increases due to gene duplication. As a species the mouse is highly resistant to atherosclerosis. However. through induced mutations it has been possible to develop lines oj mice that are deficient in apolipoprotein E, a ligand important in lipoprotein clearance, develop atherosclerotic lesions resembling those observed in humans. The atherosclerotic lesions in apoE-deficient mice have been well characterized, and they resemble human lesions in their sites of predilection and progression to the fibroproliferative stage. Other promising models are mice that are deficient in the low-density lipoprotein receptor. Considerable work still remains to be done in dissecting out in a rigorous manner the effects of alterations in single genes on the induction or progression of atherosclerosis and on the control of blood pressures. Perhaps even more exciting is the opportunity now becoming available to breed animals in which the effects oj precise differences in more than one gene can be studied in combination.

• Journal of the Korean Operations Research and Management Science Society
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• v.23 no.4
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• pp.87-96
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• 1998

Using the concept of cellular manufacturing systems(CMS) in job shop manufacturing system is one of the most innovative approaches to improving plant productivity. However. several constraints in machine duplication cost, machining capability, cell space capacity, intercell moves and exceptional elements(EEs) are main problems that prevent achieving the goal of maintaining an ideal CMS environment. Minimizing intercell part traffics and EEs are the main objective of the cell formation problem because it is a critical point that improving production efficiency. Because the intercell moves could be changed according to the sequence of operation, it should be considered in assigning parts and machines to machine ceil. This paper presents a method that eliminates EEs under the constraints of machine duplication cost and ceil space capacity attaining two goals of minimizing machine duplications and minimizing intercell moves simultaneously. Developing an algorithm that calculates the machine duplications by cell-machine incidence matrix and part-machine Incidence matrix, and calculates the exact intercell moves considering the sequence of operation. Based on the number of machine duplications and exact intercell moves, the goal programming model which satisfying minimum machine duplications and minimum intercell moves is developed. A linear programming model is suggested that could calculates more effectively without damaging optimal solution. A numerical example is provided to illustrate these methods.

• Journal of KIISE:Databases
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• v.27 no.2
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• pp.256-268
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• 2000

Multi-way spatial join is a nested expression of two or more spatial joins. It costs much to process multi-way spatial join, but there have not still reported the scheme of parallel processing of multi-way spatial join. In this paper, parallel processing of multi-way spatial join consists of parallel multi-way spatial filter and parallel spatial refinement. Parallel spatial refinement is executed by the following two steps. The first is the generation of a graph used for reducing duplication of both spatial objects and spatial operations from pairs candidate object table that are the results of multi-way spatial filter. The second is the parallel spatial refinement using that graph. Refinement using the graph is proved to be more efficient than the others. In task creation for parallel refinement, minimum duplication partitioning of the Spatial_Obicct_On_Node graph shows best performance.