• Clinical and Experimental Reproductive Medicine
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• v.40 no.4
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• pp.163-168
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• 2013

Objective: Preimplantation genetic diagnosis (PGD) is an assisted reproductive technique for couples carrying genetic risks. Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy, with a prevalence rate of 1/2,500. In this study, we report on our experience with PGD cycles performed for CMT types 1A and 2F. Methods: Before clinical PGD, we assessed the amplification rate and allele drop-out (ADO) rate of multiplex fluorescent polymerase chain reaction (PCR) followed by fragment analysis or sequencing using single lymphocytes. We performed six cycles of PGD for CMT1A and one cycle for CMT2F. Results: Two duplex and two triplex protocols were developed according to the available markers for each CMT1A couple. Depending on the PCR protocols, the amplification rates and ADO rates ranged from 90.0% to 98.3% and 0.0% to 11.1%, respectively. For CMT2F, the amplification rates and ADO rates were 93.3% and 4.8%, respectively. In case of CMT1A, 60 out of 63 embryos (95.2%) were diagnosed and 13 out of 21 unaffected embryos were transferred in five cycles. Two pregnancies were achieved and three babies were delivered without any complications. In the case of CMT2F, a total of eight embryos were analyzed and diagnosed. Seven embryos were diagnosed as unaffected and four embryos were transferred, resulting in a twin pregnancy. Two healthy babies were delivered. Conclusion: This is the first report of successful pregnancy and delivery after specific PGD for CMT disease in Korea. Our PGD procedure could provide healthy babies to couples with a high risk of transmitting genetic diseases.

• Nuclear Engineering and Technology
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• v.47 no.6
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• pp.712-718
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• 2015

Cast duplex stainless steels are susceptible to thermal aging during long-term service at temperatures ranging from $280^{\circ}C$ to $450^{\circ}C$. To analyze the effect of thermal aging on leak-before-break (LBB) behavior, three-dimensional finite element analysis models were built for circumferentially cracked pipes. Based on the elasticeplastic fracture mechanics theory, the detectable leakage crack length calculation and J-integral stability assessment diagram approach were carried out under different bending moments. The LBB curves and LBB assessment diagrams for unaged and thermally aged pipes were constructed. The results show that the detectable leakage crack length for thermally aged pipes increases with increasing bending moments, whereas the critical crack length decreases. The ligament instability line and critical crack length line for thermally aged pipes move downward and to the left, respectively, and unsafe LBB assessment results will be produced if thermal aging is not considered. If the applied bending moment is increased, the degree of safety decreases in the LBB assessment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11A
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• pp.909-917
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• 2009

In this paper, we proposed and implemented the method to efficiently generate TDD synchronization signal and the digital circuit for the RF repeater which can eliminate the shadow region in the wireless communication field using the time division duplex (TDD) method. After detecting the TDD signal from the transmitted or received RF signal, the detected TDD signal is fed to the RF repeater for the normal operation. The proposed technique detects the envelop of the downlink signal and amplifies the detected envelop, and then restores the degraded envelop with the proposed digital filtering method. Finally the restored envelop is manipulated to the TDD synchronization signal. Our focus on the proposed algorithm is to develop it with simple feature and low cost but robust performance. The proposed scheme was implemented to the integrated system which has both RF and digital circuit and tested under the same condition with the commercial WiBro service.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.4 no.1
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• pp.7-13
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• 2005

In this paper, we propose the time synchronization module on fiber optic repeater to use optic line delay for obtaining time synchronization between up-link and down-link, in the 2.3 GHz WiBro network using TDD/OFDM (Time Division Duplex/Orthogonal Frequency Division Multiplexing) Generally, when we use fiber optic repeater to remove the shade area, it occurs transmission delay which is caused by optic transmission between RAS (Radio Access Station) and fiber optic repeater and inner delay of fiber optic repeater. Because the WiBro system is adopting a TOO method and there exists the difference of switching time which is caused by these delay between up-link and down-link, it occurs ISI (Inter Symbol Interference), ICI (Inter Carrier Interference). These interference results in the reduction of the coverage. And the inconsistency between Up-Link and Down-Link switching time maybe gives rise to the interruption of communication. In order to prevent these cases, we propose synchronization module using analog optic line delay as the one of synchronizing up-link and down-link. And we propose the consideration factor for the designing time synchronization module and the feature of optic line of analog method. The measurement result of optic line time synchronization module of structure proposed is as follows, the delay error of $0.5{\mu}g$ and the insertion loss value below maximum 4.5dB in range of $0{\sim}40{\mu}s$. These results fully meet the specification of WiBro System.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.11a
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• pp.467-474
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• 1999

In this paper, Fault tolerant digital governor, using duplex I/O module and triplex CPU module and also 2 out of 3 voting algorithm and adding self diagnostic ability, is designed to realize ceaseless controlling and to improve the reliability of control system. The processor module of the system(SIDG-3000) is developed based on MC68EC040 32 Bit of Motorola, which guaranteed high quality of the module ,and SRAM for data also SRAM for command are separated. The process module also includes inter process communication function and power back up function (SRAM for back-up). System reliability is estimated by using the model of Markov process. The reliability of triplex system in mission time can be improved about 1.8 times in reliability 86%. 2.8 times in 95 %, 6 times in 99 % compared with a single control system. Designed digital governor system is applied after modelling of the steam turbine generator system of Buk-Cheju Thermal Power Plant. Simulation is carried out to prove the effectiveness of the designed digital governor system

• Genomics & Informatics
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• v.13 no.2
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• pp.45-52
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• 2015

Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro RNAs (miRNAs). Argonaute (AGO) protein is a protein family that binds to the miRNAs and mRNA complex where a strong binding affinity is crucial for its RNA silencing function. By understanding pattern recognition between the miRNAs-mRNA complex and its binding affinity with AGO protein, one can decipher the regulation of a particular gene and develop suitable siRNA for the same in disease condition. In the current work, HOXA9 gene has been selected from literature, whose deregulation is well-established in acute myeloid leukemia. Four miRNAs (mir-145, mir-126, let-7a, and mir-196b) have been selected to target mRNA of HOXA9 (NCBI accession No. NM_152739.3). The binding interaction between mRNAs and mRNA of HOXA9 gene was studied computationally. From result, it was observed mir-145 has highest affinity for HOXA9 gene. Furthermore, the interaction between miRNAs-mRNA duplex of all chosen miRNAs are docked with AGO protein (PDB ID: 3F73, chain A) to study their interaction at molecular level through an in silico approach. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding of AGO-assisted miRNA based gene silencing mechanism in HOXA9 gene associated in acute myeloid leukemia computationally.

• Journal of Broadcast Engineering
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• v.24 no.6
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• pp.1143-1151
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• 2019

In this paper, we propose a wireless transmission scheme that maximizes transmission efficiency per frequency bandwidth in a single carrier modulation scheme. The proposed scheme employs a decision directed channel tracking technique to remove both pilot signal and the guard interval signal between symbols in frames. It performs a raised cosine pulse shaping function with an roll-off factor of 0.05. In addition, 2×2 multiple input and multiple output using two polarized antennas is applied and both equalization and signal separation are performed in the frequency domain. The wireless modem with this technology confirms that the transmission speed of up to 63.3Mbps is achieved under the 5MHz frequency bandwidth

• Proceedings of the Korea Contents Association Conference
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• 2008.05a
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• pp.51-55
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• 2008

Request High-Images, High-quality, duplex transmission, BcN Voice telephone, Broadcast, Data internet service came to be all possible and demolished original communication service area. Also, The quality is guaranteed stablely to new business and ISP the requirement comes to become a multicasting quality guarantee mechanism which there is the reliability for a information communication and High-quality multimedia service. Like this, a multicast mechanism to be guaranteed must become air control End-to-End QoS for a service supply, a transmission delay a packet loss or requirement which the user requests guarantee and multicast Path-NET which there is the reliability must be provided. Therefor, we proposed IP base multicast new join the present the multicast mechanism of Probing packet foundation which there is the efficiently a linking acceptance, we used ns-2 simulator for the performance evaluation of the proposed.

• Journal of Satellite, Information and Communications
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• v.6 no.2
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• pp.20-25
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• 2011

The authors have proposed novel TDD-CDMA systems with Pre-Rake transmit diversity schemes (system 1 and system 2) using multiple transmit antennas in [2] and have also evaluated the system performance through the theoretical analysis and computer simulation. However, the performance of system 2 which transmit a signal using all antennas has not been evaluated for multi-user environment. Therefore in this paper, we analyze the performance of system 2 for multi-user environment and compare the performance with that of the already proposed system 1 which chooses only one antenna. From the numerical results, it is found that system 2 outperforms system 1 as the number of users increases while system 1 outperforms system 2 at a small number of users. Therefore in order to achieve the best system performance, the Pre-Rake transmit diversity type should be selected at the base station according to the number of users.

• Korean Institute of Interior Design Journal
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• v.21 no.5
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• pp.264-271
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• 2012

As changed population structure variously, population decrease is one of the important problem in present urbanization. It resulted decline of the medium-large size housings that increasing of 1-2 person household need the variety of small housing with housing type. This study was researched the Gold-Generation on theme by Gold Miss, Gold Mr. who preferring urban small housings that it analyzed survey of Gold generation who be wanted urban small housing by interior coordination elements. Data to be analyzed that first, Gold Mr. and Miss are preferred two bedroom applied by spatial structure coordination. Especially it is based on the separation between livingroom and bedroom with duplex type which is bathroom formed single unit type(shower/toilet/basin). In interior coordination of spatial elements, Gold Mr. considered the form of kitchen with huge ㄷ type instead of Gold Miss are preferred alpha room or alpha space to use powder room or dress room. Second, In Preference of interior coordination elements, Gold Mr. and Miss are preferred bed-clothes and curtains by fabrics, lighting are hanging and spot lighting, accessories are carpet with rug and porcelains. Color are preferred bright scheme both white and ivory, however preference of furniture is different from Gold Mr. and Gold Miss that Gold Mr. are ordered desk, sofa and shelves but Gold Miss are preferred sofa, bed, and dressing table. It showed between Gold Mr. and Gold Miss are equal needs or differences. It expects the basic research for understanding the interior coordination elements for preference in urban small housing as focused on Gold generation(Gold Miss, Gold Mr.) that they will be applied the interior space on urban small housing.