• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.6
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• pp.531-538
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• 2016

In this paper, we design and fabricate a short range FMCW radar which detects and tracks a moving target in a two-dimensional domain using dual transceiver modules. For the short range radar, we propose a scheme for alternate extraction of the two-dimensional positions using one-dimensional range information from time division transceiver modules, and successfully apply the scheme to the two-dimensional short range radar. Measured results of the targets at 10 m and 30 m are presented as performance demonstration of each transceiver module. Also the performance of the two-dimensional radar is demonstrated using a two-dimensional target map, which uses the range bin corresponding to the frequency resolution, and the effectiveness of the proposed scheme is validated.

• Journal of the Korea Institute of Military Science and Technology
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• v.20 no.3
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• pp.337-344
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• 2017

In this paper, the optical axis alignment(OAA) of an infrared sensor(IRS) using a microwave sensor(MWS) was presented as a method of an axis alignment to minimize the problems that could be caused by the misalignment of the two sensors in the missile including the dual-mode sensor. The azimuth(AZ) and elevation(EL) angles of the two targets used for each sensor test were calculated by using the transformation equation and the test results of the MWS and IRS, and then the proposed OAA was verified by comparing the angles. Furthermore, the validity of the proposed OAA was demonstrated by confirming the abnormality of the OAA through the test results of the electro optical head(EOH) of the IRS which was equipped with a tilt on the missile fuselage.

• Journal of information and communication convergence engineering
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• v.7 no.3
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• pp.366-371
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• 2009

A realization for an accurate position detecting system of a moving target in two dimensional plane using dual line CCDs and photometric interpolation is presented. The system is realized that the infrared LEDs are utilized for lighting source, a target size is recognized by the scanned data from CCD owing to blocking the radiated light path by placing the target between CCD and lighting source, a coordinate on the plane is found by plane trigonometry formed by the moving target and two CCD sensors, and the former scan data is used for the coordinate iteratively and the photometric interpolation is applied to sub-pixel of scanned image. The experimental results show that the experiment results in a success rate about 3 different size targets, 3, 5 and 7mmm on the test plane $210{\times}373mm$. The moving target positioning detected success rate is 93% in 3mm target, 5mm is 95.3%, and 7mm is 95.8% respectively. The photometric interpolation is enhanced to 1.5% in comparison to be unused.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.5
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• pp.831-835
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• 2016

In this paper, a dual-channel feed-forward transimpedance(TIA) array is realized in a standard $0.18-{\mu}m$ CMOS technology which exploits automatic gain control function to provide 40-dB input dynamic range for either detecting targets nearby or sensing imminent danger situations. Compared to the previously reported conventional feed-forward TIA, the proposed automatic-gain-control feed-forward TIA(AFF-TIA) extends the input dynamic range 25 dB wider by employing a 4-level automatic gain control circuit. Measured results demonstrate the linearly varying transimpedance gain of 47 to $72dB{\Omega}$, input dynamic range of 1:100, the bandwidth of $${\geq_-}670MHz$$, the equivalent input referred noise current spectral density of 6.9 pA/${\surd}$HZ, the maximum sensitivity of -26.8 dBm for $10^{-12}BER$, and the power consumption of 27.6 mW from a single 1.8-V supply. The dual-channel chip occupies the area of $1.0{\times}0.73mm^2$ including I/O pads.

• Journal of Integrative Natural Science
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• v.5 no.1
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• pp.22-26
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• 2012

Chemokine receptor antagonists have potential applications in field of drug discovery. Although the chemokine receptors are G-protein-coupled receptors, their cognate ligands are small proteins (8 to 12 kDa), and so inhibiting the ligand/receptor interaction has been challenging. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple sclerosis. Based on their roles in disease, they have been attractive targets for the pharmaceutical industry, targeting both CCR2 and CCR5 could be a useful strategy. Because of the importance of these receptors, providing information regarding the binding site is of prime importance. Herein, we report the comparison of CCR2 of CCR5 binding sites both sequentially as well as structurally. We also urged the importance of crucial residues in the binding site, to facilitate the development of dual antagonists targeting both the receptors. These results could also be useful for the design of novel and potent dual CCR2 and CCR5 antagonists using structure based drug design.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.35 no.5
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• pp.488-493
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• 2022

Generally, diamond-like carbon films (a-C:H, DLC) have been shown to have a low coefficient of friction, a high hardness and a low wear rate. Pd-doped C thin film was fabricated using a dual magnetron sputtering with two targets of graphite and palladium. Graphite target RF power was fixed and palladium target RF power was varied. The structural, physical, and surface properties of the deposited thin film were investigated, and the correlation among these properties was examined. The doping ratio of Pd increased as the RF power increased, and the surface roughness of the thin film decreased somewhat as the RF power increased. In addition, the hardness value of the thin film increased, and the adhesive strength was improved. It was confirmed that the value of the contact angle indicating the surface energy increases as the RF power increases. It was concluded that the increase in RF power contributed to the improvement of the physical properties of Pd-doped C thin film.

• Journal of Periodontal and Implant Science
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• v.53 no.1
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• pp.20-37
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• 2023

Purpose: Our pilot study showed that a 3-dimensional dual drug delivery scaffold (DDDS) loaded with Chinese herbs significantly increased the regenerated bone volume fraction. This study aimed to confirm the synergistic anti-inflammatory and osteogenic preclinical effects of this system. Methods: The targets and pathways of parthenolide and naringin were predicted. Three cell models were used to assess the anti-inflammatory effects of parthenolide and the osteogenic effects of naringin. First, the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) and the bone mineral density (BMD) of surgical defects were measured in a rat model of periodontitis with periodontal fenestration defects. Additionally, the mRNA expression levels of matrix metallopeptidase 9 (MMP9) and alkaline phosphatase (ALP) were measured. Furthermore, the number of inflammatory cells and osteoclasts, as well as the protein expression levels of tumor necrosis factor-alpha (TNF-α) and levels of ALP were determined. Results: Target prediction suggested prostaglandin peroxidase synthase (PTGS2) as a potential target of parthenolide, while cytochrome P450 family 19 subfamily A1 (CYP19A1) and taste 2 receptor member 31 (TAS2R31) were potential targets of naringin. Parthenolide mainly targeted inflammation-related pathways, while naringin participated in steroid hormone synthesis and taste transduction. In vitro experiments revealed significant antiinflammatory effects of parthenolide on RAW264.7 cells, and significant osteogenic effects of naringin on bone marrow mesenchymal stem cells and MC3T3-E1 cells. DDDS loaded with parthenolide and naringin decreased the CEJ-ABC distance and increased BMD and ALP levels in a time-dependent manner. Inflammation was significantly alleviated after 14 days of DDDS treatment. Additionally, after 56 days, the DDDS group exhibited the highest BMD and ALP levels. Conclusions: DDDS loaded with parthenolide and naringin in a rat model achieved significant synergistic anti-inflammatory and osteogenic effects, providing powerful preclinical evidence.

• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.107-114
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• 2023

X-ray fluorescence analysis has been widely used in the field of science and industry because it gives information about elements and their concentrations without destruction of samples. To increase analysis accuracy of fluorescence generated by photons of the transmission-type X-ray tube for mixture and compound samples would be recommend to have strong energy near 10 keV and 20 keV simultaneously. Tungsten of 9.65 keV and molybdenum of 17.48 keV were considered as targets with dual deposition structure for obtaining two strong characteristic X-rays, and the transmission-type X-ray tube was analyzed using Geant4 Monte Carlo simulation. The W-Mo structure resulted in strong characteristic X-ray near 10 keV and 20 keV simultaneously. A structure with Mo-W multilayers of 5 ㎛ thick also gave optimal spectrum. Various material combination and thickness optimization for the dual-structured target can give X-ray spectrum with strong characteristic X-ray of specific energies.

• Fisheries and Aquatic Sciences
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• v.14 no.3
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• pp.218-225
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• 2011

Dual frequency identification sonar (DIDSON) is an imaging sonar that has been used for numerous fisheries investigations in a diverse range of freshwater and marine environments. The main purpose of DIDSON is fish counting, fish sizing, and fish behavioral studies. DIDSON records video-quality data, so processing power for handling the vast amount of data with high speed is a priority. Therefore, a semiautomated analysis of DIDSON data for fish counting, sizing, and fish behavior in Echoview (fisheries acoustic data analysis software) was accomplished using testing data collected on the Rakaia River, New Zealand. Using this data, the methods and algorithms for background noise subtraction, image smoothing, target (fish) detection, and conversion to single targets were precisely illustrated. Verification by visualization identified the resulting targets. As a result, not only fish counts but also fish sizing information such as length, thickness, perimeter, compactness, and orientation were obtained. The alpha-beta fish tracking algorithm was employed to extract the speed, change in depth, and the distributed depth relating to fish behavior. Tail-beat pattern was depicted using the maximum intensity of all beams. This methodology can be used as a template and applied to data from BlueView two-dimensional imaging sonar.

• IMMUNE NETWORK
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• v.24 no.1
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• pp.6.1-6.17
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• 2024

The intricate role of innate type-2 cytokines in immune responses is increasingly acknowledged for its dual nature, encompassing both protective and pathogenic dimensions. Ranging from defense against parasitic infections to contributing to inflammatory diseases like asthma, fibrosis, and obesity, these cytokines intricately engage with various innate immune cells. This review meticulously explores the cellular origins of innate type-2 cytokines and their intricate interactions, shedding light on factors that amplify the innate type-2 response, including TSLP, IL-25, and IL-33. Recent advancements in therapeutic strategies, specifically the utilization of biologics targeting pivotal cytokines (IL-4, IL-5, and IL-13), are discussed, offering insights into both challenges and opportunities. Acknowledging the pivotal role of innate type-2 cytokines in orchestrating immune responses positions them as promising therapeutic targets. The evolving landscape of research and development in this field not only propels immunological knowledge forward but also holds the promise of more effective treatments in the future.