• Journal of Microbiology and Biotechnology
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• 제18권5호
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• pp.997-1003
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• 2008

Viral safety is a prerequisite for manufacturing clinical antihemophilic factor VIII concentrates from human plasma. With particular regard to the hepatitis A virus (HAV), a terminal dry-heat treatment ($100^{\circ}C$ for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor VIII concentrate. The loss of factor VIII activity during dry-heat treatment was of about 5%. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor VIII compared with those of the factor VIII before dry-heat treatment. The dry-heat-treated factor VIII was stable for up to 24 months at $4^{\circ}C$. The dry-heat treatment after lyophilization was an effective process for inactivating viruses. The HAV, murine encephalomyocarditis virus (EMCV), and human immunodeficiency virus (HIV) were completely inactivated to below detectable levels within 10 min of the dry-heat treatment. Bovine herpes virus (BHV) and bovine viral diarrhea virus (BVDV) were potentially sensitive to the treatment. However porcine parvovirus (PPV) was slightly resistant to the treatment. The log reduction factors achieved during lyophilization and dry-heat treatment were ${\geq}5.55$ for HAV, ${\geq}5.87$ for EMCV, ${\geq}5.15$ for HIV, 6.13 for BHV, 4.46 for BVDV, and 1.90 for PPV. These results indicate that dry-heat treatment improves the virus safety of factor VIII concentrates, without destroying the activity. Moreover, the treatment represents an effective measure for the inactivation of non-lipid-enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권1호
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• pp.19-25
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• 2006

With particular regards to the hepatitis A virus (HAV), a terminal dry-heat treatment ($100^{\circ}C$ for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor IX concentrate. The loss of factor IX activity during dry-heat treatment was of about 3%, as estimated by a clotting assay. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor IX compared with those of the factor IX before dry-heat treatment. The dry-heat-treated factor IX was stable for up to 24 months at $4^{\circ}C$, The dry-heat treatment after lyophilization was an effective process for inactivating viruses. The HAV and murine encephalomyocarditis virus (EMCV) were completely inactivated to below detectable levels within 10 min of the dry-heat treatment. Porcine parvovirus (PPV) and bovine herpes virus (BHV) were potentially sensitive to the treatment. The log reduction factors achieved during lyophilization and dry-heat treatment were ${\ge}5.60$ for HAV, ${\ge}6.08$ for EMCV, 2.64 for PPV, and 3.59 for BHV. These results indicate that dry-heat treatment improves the virus safety of factor IX concentrates, without destroying the activity. Moreover, the treatment represents an effective measure for the inactivation of non-lipid enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment.

• 한국환경과학회지
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• 제32권2호
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• pp.121-130
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• 2023

This study was conducted to investigate changes in seed vigor based on temperature of dry heat and duration treatment of watermelon seeds and examine the effect on percent of emergence and seedling vigor. When the upper limit temperature of dry heat treatment was raised to 80℃, the percent of the germination decreased. Moreover, T₅₀ was delayed as the upper limit temperature of dry heat treatment increased. The higher the upper limit temperature of dry heat treatment and the longer the treatment period, the higher the percentage of abnormal seedlings. The optimum upper limit temperature for dry heat treatment was 72℃, and the treatment period was five days. Seed vigor was better maintained at 30℃, 45℃, and 52℃, followed by stepwise exposure to high temperatures of 72℃, the upper limit of dry heat treatment, rather than dry heat treatment at a high temperature of 72℃ for 5 days from the initial stage of treatment. When the fungicide was added during the dry heat treatment process, the germination percentage decreased and the percent of the abnormal seedling percentage increased. However, the addition of 10 mg/kg fungicide did not significantly reduce seed vigor.

• Journal of Ginseng Research
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• 제16권2호
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• pp.99-104
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• 1992

Korean red ginseng and water extract residue of red ginseng roots were treated with dry heat and incorporated in PDA medium to examine the effect of the materials on induced tolerance against mercury chloride and mycelial growth of Fusarium oxysporum. Ginseng residue was not effective in the inducement of tolerance to mercury chloride regardless of dry heat treatment. However, the heat treatment of ginseng and ginseng residues stimulated the mycelial growth of the fungus. The materials responsible for the detoxification appeared to be water-soluble. The stimulation of the fungal mycelial growth on the media by the heat treatment was highest in the water extract of ginseng. Due to the heat treatment, the mycelial growth was also slightly increased in n-hexane and methanol extracts of ginseng, compared with the ginseng fractions without dry heat treatment.

• Fibers and Polymers
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• 제5권1호
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• pp.19-24
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• 2004

PET yarns textured at different texturing conditions were treated with superheated steam or dry heat at different temperatures for different times. The effects of the treatment conditions on the thermomechanical and structural changes of the yarn were examined by shrinkage, X-ray diffraction and birefringence measurements. With increase in superheated steam temperature, the crystalline orientation factor and birefringence decreased, whereas crystal size increased. Dry heat treatment had a smaller effect on shrinkage and structural properties in comparison with superheated steam treatment. The additional shrinkage after texturing process was investigated. The effect of heat-setting in both media was more significant at $200^{\circ}C$. The time dependence of the properties was not linear.

• 사상체질의학회지
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• 제29권4호
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• pp.376-386
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• 2017

Objectives This case study is about a Taeeumin patient with Parkinson's disease identified as Dry-heat (Joyeol) pattern. In this study, we report significant improvement of motor and non-motor symptoms of this patient after Sasang constitutional medicine treatment. Methods The patient was identified as Taeeumin Dry-heat pattern and treated with Cheongsimyeonja-tang and acupuncture. The Unified Parkinson Disease Rating Scale(UPDRS) was used to assess the overall function of the patient. And the Global Assessment Scale (GAS) was used to assess the change of bradykinesia, tremor and dry mouth after the treatment. Results The UPDRS total score decreased from 145 points to 77 points after 5 weeks treatment. And symptoms of bradykinesia, tremor and dry mouth showed significant improvement in GAS after the treatment. Furthermore, constipation, sleep disturbance, dysuresia and anorexia were reported to be improved after treatment. Conclusions This study shows that Sasang constitutional medicine can be effective treatment for motor and non-motor symptoms caused by Parkinson's disease.

• 사상체질의학회지
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• 제25권4호
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• pp.442-453
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• 2013

Objectives This case study was about a Taeeumin patient with advanced Parkinson's disease diagnosed as Dry-heat symptomatic pattern. In this study, we reported significant improvement of motor and non-motor symptoms of this patient after Sasang constitutional medicine treatment. Methods The patient was diagnosed with Taeeumin Dry-heat symptomatic pattern and treated with Taeeumin's constitutional medications and acupuncture. The primary outcome measure for this study is Unified Parkinson Disease Rating Scale(UPDRS) to assess the overall function of patient. Secondary outcome assessments include Global Assessment Scale(GAS), change of patient's sleep, stool and urine. Results and Conclusions The patient treated with Taeeumin's constitutional medications and acupuncture had reduction in UPDRS (specifically Part II, Part III and Part IV) and GAS of motor symptoms. Furthermore, patient's sleep, stool and urine were reported to be normal after treatment. In conclusion, this study shows that Sasang constitutional medicine can be effective treatment for Taeeumin patient with Advanced Parkinson's disease diagnosed as Dry-heat symptomatic pattern.

• 한국식품과학회지
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• 제52권5호
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• pp.503-509
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• 2020

The present study investigated the effects of dry and moist heat treatments on total phenols, total anthocyanins, and antioxidant activity levels in black chokeberry (Aronia melanocarpa) fruits. Lyophilized chokeberry powder samples were heated in a drying oven at 60, 100, 160, 180, and 200℃ for 20, 40, or 60 min. Finely ground fresh chokeberry fruits were heated in water at 60, 80, and 100℃ for 20 min, and bioactive compound and antioxidant activity levels were measured. The bioactive compounds and antioxidant activity decreased with increasing temperature and treatment duration. Antioxidant activity was preserved at 160℃ or lower without significant loss for dry heating, whereas moist heat treatment increased both bioactive compounds and antioxidant activity with increasing temperature.

• 임산에너지
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• 제21권3호
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• pp.10-17
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• 2002

본 연구는 단소용 대나무 악기재를 효과적으로 건조하기 위하여 열처리 및 몇 가지 스케줄에 의한 건조를 실시하였다. 평균 직경 2.2cm, 길이 60cm정도의 솜대를 이용하였다. 열처리 효과를 평가하기 위하여 무처리 및 열처리재로 구분하였으며 적당한 건조 조건 조사를 위해서 20℃, 65%와 40℃, 40% 그리고 대기상태의 3가지 조건으로 실시하였다. 탄화와 재색의 결함이 발생하지 않는 열처리의 최적 온도 조건은 180℃정도가 적당하였으며 열처리가 할렬의 수와 할렬 크기의 발생을 줄였으며 건조결함을 발생하지 않는 최적의 조건은 온도 20℃, 관계습도 65%이지만 건조를 할 때 기간이 너무 많이 소요되는 단점이 있기 때문에 40℃, 40%에서 건조시키는 것이 더욱 효율적이었다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권8호
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• pp.1105-1111
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• 2010

In order to determine the potential for reduction of nitrite levels and ripening period with heat treatment, the effects of ripening period (1-13 days), nitrite level (45-195 ppm), and heat treatment (30-$90^{\circ}C$) on lipolysis, peroxide, TBA, proteolysis, and residual nitrite values of sucuk were investigated using response surface methodology. The ripening period significantly (p<0.01) increased lipolysis, peroxide, TBA, and proteolysis values and decreased residual nitrite values. The effects of additional nitrite levels were found to significantly affect peroxide and residual nitrite values. Significant amounts of the additional nitrite levels were reduced during processing and on the first day of ripening periods.