• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.29 no.2
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• pp.31-38
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• 2023

Background: The aim of this study was to compare the effects of taping techniques on menstrual pain, body temperature, and menstrual symptoms in women of reproductive age. Methods: This study targeted 40 female students enrolled at G university with menstrual pain rated above 5 on the visual analog scale (VAS). The participants were randomly assigned to four groups: the Kinesio taping, spiral taping, non-steroidal anti-inflammatory drug, and control groups. The intervention was applied one day after the onset of menstruation, and menstrual pain, menstrual symptoms, and body temperature were measured before the intervention and 24 hours after the intervention application. We measured menstrual pain using the VAS. Additionally, we evaluated menstrual symptoms using the menstruation symptom scale and measured body temperature of the abdomen and feet using digital infrared thermal imaging. Results: After the intervention, all three experimental groups showed significant improvement in menstrual pain and menstrual symptoms compared to the control group, and there was no significant difference among the three groups. After applying Kinesio taping, there was a slight decrease in the temperature difference between the abdomen and feet, but no statistically significant difference was observed. Conclusion: The results of this study demonstrated that kisesio and spiral taping have similar effects as with anti-inflammatory medication in relieving menstrual pain and menstrual symptoms. Taping can be considered as an effective method to replace medications in order to alleviate menstrual pain.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.3
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• pp.275-284
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• 2024

Worldwide, cardiovascular disease is the main cause of death, which accordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to control high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, because of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181-0.72) and (-13.4 to -6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters using triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formulations is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.

• Tuberculosis and Respiratory Diseases
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• v.86 no.1
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• pp.1-13
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• 2023

Lung cancer ranks first in cancer mortality in Korea and cancer incidence in Korean men. More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. Cytotoxic agents, targeted therapy, and immune checkpoint inhibitors are used in chemotherapy according to the biopsy and genetic test results. Among chemotherapy, the one that has developed rapidly is targeted therapy. The National Comprehensive Cancer Network (NCCN) guidelines have been updated recently for targeted therapy of multiple gene mutations, and targeted therapy is used not only for chemotherapy but also for adjuvant therapy. While previously targeted therapies have been developed for common genetic mutations, recently targeted therapies have been developed to overcome uncommon mutations or drug resistance that have occurred since previous targeted therapy. Therefore, this study describes recent, rapidly developing targeted therapies.

• Molecules and Cells
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• v.42 no.3
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• pp.237-244
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• 2019

Understanding the mechanisms of cancer drug resistance is a critical challenge in cancer therapy. For many cancer drugs, various resistance mechanisms have been identified such as target alteration, alternative signaling pathways, epithelial-mesenchymal transition, and epigenetic modulation. Resistance may arise via multiple mechanisms even for a single drug, making it necessary to investigate multiple independent models for comprehensive understanding and therapeutic application. In particular, we hypothesize that different resistance processes result in distinct gene expression changes. Here, we present a web-based database, CDRgator (Cancer Drug Resistance navigator) for comparative analysis of gene expression signatures of cancer drug resistance. Resistance signatures were extracted from two different types of datasets. First, resistance signatures were extracted from transcriptomic profiles of cancer cells or patient samples and their resistance-induced counterparts for >30 cancer drugs. Second, drug resistance group signatures were also extracted from two large-scale drug sensitivity datasets representing ~1,000 cancer cell lines. All the datasets are available for download, and are conveniently accessible based on drug class and cancer type, along with analytic features such as clustering analysis, multidimensional scaling, and pathway analysis. CDRgator allows meta-analysis of independent resistance models for more comprehensive understanding of drug-resistance mechanisms that is difficult to accomplish with individual datasets alone (database URL: http://cdrgator.ewha.ac.kr).

• YAKHAK HOEJI
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• v.48 no.6
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• pp.335-344
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• 2004

Interleukin-2 (IL-2), a glycoprotein mainly secreted by CD4+ T helper Iymphocytes, has been developed to use recombinant cytokine to augment the immune response against cancer since IL-2 not only stimulates T Iymphocytes but also enhances natural killer (NK) cell activity. In order to evaluate the immunological safety of recombinant mouse IL-2 (rmIL-2) in cancer therapy, renal cell carcinoma was established in the flank by s.c. injection of renca cell line. Tumor-bearing BALB/c mice were treated with I.p. injections with $2{\times}10^5$ Lu rmIL-2. Even though the tumor size was diminished, there were not significant recovery of body and relative lymphoid organ weights including thymic atrophy in rmIL-2 immunotherapy. Distribution ratios of T cell subsets in thymus were analysed using flow cytometry. Without regard to dosage of rmIL-2, the ratio of CD3+CD4-CD8- T cells was increased in accordance with survival of solid tumor but that of CD4+CD8+ T cells was decreased dramatically. Emergence of autoantibodies (ANA, anti-dsDNA, and anti-histone) in blood was measured after rmIL-2 treatment. The results showed that the levels of ANA and anti-dsDNA did not significantly changed, but the level of anti-histone was increased significantly owing to rmIL-2 therapy. These results indicate rmIL-2 immunotherapy is to induce the autoimmune potential, and the anti-histone measurement as a biomarker of autoimmunity is useful in cancer immunotherapy.

• Journal of Acupuncture Research
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• v.18 no.3
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• pp.154-170
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• 2001

Objective : To broaden understanding about acupuncture and moxibustion therapy on AIDS and to promote base studies and clinical trials Materials and Methods : Analysis was given to more than 30 literatures including acupuncture and moxibustion therapy on AIDS-related sites explored by internet search engine named NAVER from Nov., 2000 to Feb. 20th, 2001 Results : 1. Acupuncture and moxibustion played great role as a complementary therapy in enabling AIDS patients to keep their antiretroviral therapy by enhancing immune system, ameliorating AIDS-related symptoms and side effect of antiretroviral drug 2. Acupuncture and moxibustion therapy had a broad spectrum indication from systemic or local signs of AIDS patients to signs of antiretroviral drug-related side effect 3. Contraindication of acupuncture and moxibustion therapy against AIDS patients include abstraction and moxibustion on the skin lesion, because of their easy exposure to inflammation 4. AIDS patients were regarded as the state of KI-HE(氣虛), EUM-HE(陰虛), YEOL-DOK(熱毒) in general 5. BO-KI(補氣), BO-HYUL(補血), BO-EUM(補陰), CHEONG-YEOL-HAE-DOK(淸熱解毒) were shown as a principle of acupuncture and moxibustion therapy for AIDS patients 6. Principle of selecting acupoints for AIDS patients had characteristics of enhancing immune system, detoxicating detrimental agents and relieving each AIDS related symptom appropriately 7. Acupuncture on 合谷(HAPKOK, LI4), 內關(NAE-GWAN, P6), 足三里(CHOK-SAMNI, S36) were applied to the early stage of AIDS in order to enhance immune system. Acupuncture on 血海(HYOLHAE, SP10), 三陰交(SAMUMGYO, SP6), (KOHWANG, B43) were applied to the intermediate stage of AIDS so as to enhance immune system and eliminate YEOL-DOK(熱毒) in blood. Moxibustion on 湧泉(YONGCHON, K1), 足三里(CHOK-SAMNI, S36) were applied to the late stage owing to enhance immune system more. Conclusion : The efficacy of acupuncture and moxibustion therapy on AIDS has been acknowledged to the world, moreover, it is proved to be significant as a complementary therapy on AIDS patients. Thus, more control group studies of the efficacy of acupuncture and moxibustion therapy on AIDS and clinical trials are considered to be necessary.

• The Journal of Korean Physical Therapy
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• v.10 no.1
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• pp.139-148
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• 1998

The purpose of this study was to investigate the actual condition of physical therapy for leprosy patients of invalide home in Korea. The subjects were 928 leprosy patients who answered for the questionnaires kindly and lived in invalide homes such as An-Dong & San-Chung. The questionnaires survey was carried out from July to August 1997. The results of this study were as follows : 1. $67.6\%$ of the subjects said that they were knowing of physical therapy. 2. $88.4\%$ of the subjects who had been served physical therapy said that they were satisfied with it. 3. Between no physical therapy service group and physical therapy service group, treatment of pain was done in a different way. In physical therapy service group, for example, physical therapy treatment was most frequently used. But in no physical therapy service group, drug treatment was most frequently used. 4. The majority of the subjects responded that physical therapy was needed. 5. Each group expressed different kinds of difficulties with regard to physical therapy. No physical therapy service group, on the one hand, found it very difficult to visit physical therapy rooms. Physical therapy service group, on the other hand, complained of not having sufficient physical therapy appliance. 6. The situation of disability and disease was much worse in no physical therapy service group than in physical therapy service group. Especially, in case of low back pain and joint pain, no physical therapy service group complained of than suffering from these pains twice as often as physical therapy service group.

• Annals of Clinical Neurophysiology
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• v.23 no.1
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• pp.29-34
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• 2021

New therapeutics in neurology are expanding at an unprecedented pace. In addition to the classic enzyme-replacement therapies, monoclonal antibodies are increasingly being used to modulate autoimmunity. RNA therapeutics are an emerging class, together with gene and cell therapies. The nomenclature of international nonproprietary names helps us to recognize these new drugs according to their class and function. Suffixes denote major categories of the drug, while infixes provide additional information such as the source and target.

• CELLMED
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• v.13 no.9
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• pp.37.1-37.5
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• 2023

Objective: Case report of improvement in joint pain and gum bleeding in a breast cancer patient using OCNT. Methods: A Korean woman in her 60s was diagnosed with breast cancer. After being diagnosed with stage 2 breast cancer, her quality of life has greatly deteriorated due to the side effects of the drugs administered. Results: Improved joint pain and bleeding gums after OCNT Conclusion: The application of OCNT to patients with above problem can help improve symptoms.

• Journal of the Korean Society of Radiology
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• v.81 no.1
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• pp.58-69
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• 2020

In this study, we evaluated the technical characteristics and usefulness of diffusion-weighted magnetic resonance imaging for discrimination between benign and malignant vertebral fractures, for detection and differentiation of multiple myeloma or metastases, and for response monitoring in malignant vertebral lesions after anticancer drug therapy or radiation therapy.