• 제목/요약/키워드: drug

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EFFICACY EVALUATION OF THE WHITENING COSMETICS USING IN VITRO TYROSINASE INHIBITION ASSAY

  • Lee, J. P.;Kim, Y. O.;J. Y. Jang;K. H. Son;S. J. Yang;Lee, K. S.;Kim, W. H.;J. T. Hong;Park, S. S.
    • 대한화장품학회:학술대회논문집
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    • 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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    • pp.479-479
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    • 2003
  • We investigated the tyrosinase inhibitory effect using whitening materials such as arbutin, ethyl ascorbyl ether, glabridin, kojic acid, magnesium ascorbyl phosphate and ascorbic acid. Tyrosinase inhibition rate were determined varying the enzyme concentration, reaction time, reaction temperature and pH. The optimal conditions to measure the inhibitory efficacy were as follows. : enzyme concentration 1,500 or 2,000IU/mL, reaction time 15min(for the enzyme concentration 1,500 IU/mL) and l0min(for the enzyme concentration 2,000IU/mL), reation temperature 42$^{\circ}C$, pH 6.5. Under these conditions $IC_{50}$/ of arbutin, ethyl ascorbyl ether, glabridin, kojic acid, magnesium ascorbyl phosphate and ascorbic acid were calculated. In the case of magnesium ascorbyl phosphate, the inhibitory effect of tyrosinase was very low and the $IC_{50}$/ of magnesium ascorbyl phosphate could not be calculated. Other five materials showed good inhibitory effect of tyrosinase and can be used for the whitening materials.

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DEVELOPMENT OF ANALYYICAL METHOD OF DMDM HYDANTOIN, SORBIC ACID, PHENOXY ETHANOL IN COSMETICS

  • K. H. Son;Kim, Y. O.;J. Y. Jang;Lee, J. P.;S. J. Yang;Lee, K. S.;W. J. Yang;Kim, C. K.;Park, S. S.
    • 대한화장품학회:학술대회논문집
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    • 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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    • pp.527-527
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    • 2003
  • A high-performance liquid chromatographic method for the simultaneous quantitative analysis of DMDM hydantoin, sorbic acid, phenoxy ethanol in cosmetics was studied by using a X-terra C$\sub$18/ column and 0.75mM KH$_2$PO$_4$ in 0.85% sulfuric acid and methanol mixture(7:3) at 214nm. Calibration curves were found to be linear in the 20-100 $\mu\textrm{g}$/mL range (DMDM hydantoin), 50-250 $\mu\textrm{g}$/mL range (sorbic acid) and 10-50 $\mu\textrm{g}$/mL range (phenoxy ethanol). The result of recovery test were 96.6% ∼ 104.2%. This HPLC method can be applied quality control of cosmetics.

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서방정으로부터의 약물 용출에 대한 고분자-약물 상호작용의 영향 (Effects of Polymer-Drug Interactions on Drug Release from Sustained Release Tablets)

  • 김행자;이승진
    • Journal of Pharmaceutical Investigation
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    • 제26권2호
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    • pp.119-124
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    • 1996
  • To develop oral controlled release dosage forms, ionic interactions between polymers and drugs were evaluated. Hydroxypropylmethyl cellulose and carboxymethylene were used as model nonionic and ionic polymers, respectively. 5-fluorouracil, propranolol-HCl and sodium salicylate were selected as model nonionic, cationic and anionic, respectively. Polymer-drug mixtures were compressed into tablets and drug release kinetics from these tablets were determined. Drug release from the tablets made of the nonionic polymer was not affected by the charge of drugs, rather, was regulated by the solubility of drugs in different pH releasing media. However, drug release kinetics were significantly affected when drug-polymer ionic interactions exist. Enhanced drug release was observed from anionic drug-anionic polymer tablets due to ionic repulsion, whereas drug release was retarded in cationic drug-anionic polymer tablets owing to ionic attractive force. Therefore, the results suggested that the polymer-drug interactions are important factors in designing controlled release dosage forms.

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CV Safety & Future Generation COX-2 inhibitors

  • Shin, Song-Seok;Byun, Young-Joo;Lim, Kyung-Min;Choi, Jin-Kyu;Lee, Ki-Wha;Moh, Joo-Hyun;Kim, Jin-Kwan;Jeong, Yeon-Su;Kim, Ji-Young;Choi, Young-Hoon;Koh, Hyun-Ju;Park, Young-Ho;Oh, Young-Im
    • 대한약학회:학술대회논문집
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    • 대한약학회 2005년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.67-68
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    • 2005
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약물 정보 문서 임베딩을 이용한 딥러닝 기반 약물 간 상호작용 예측 (Prediction of Drug-Drug Interaction Based on Deep Learning Using Drug Information Document Embedding)

  • 정선우;유선용
    • 한국정보통신학회:학술대회논문집
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    • 한국정보통신학회 2022년도 춘계학술대회
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    • pp.276-278
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    • 2022
  • 모든 약물은 신체 내에서 특정한 작용을 하며, 많은 경우 합병증 또는 기존 약물치료 중 새롭게 발생하는 증상에 의해 약물이 혼용되는 경우가 발생한다. 이런 경우 신체 내에서 예상치 못한 상호작용이 발생할 수 있다. 따라서 약물 간 상호작용을 예측하는 것은 안전한 약물 사용을 위해 매우 중요한 과제이다. 본 연구에서는 다중 약물 사용 시 발생 가능한 약물 간 상호작용 예측을 위해 약물 정보 문서를 이용해 학습시키는 딥러닝 기반의 예측 모델을 제안한다. 약물 정보 문서는 DrugBank 데이터를 이용해 약물의 작용 기전, 독성, 표적 등 여러 속성을 결합해 생성되었으며, 두 약물 문서가 한 쌍으로 묶여 딥러닝 기반 예측 모델에 입력으로 사용되고 해당 모델은 두 약물 간 상호작용을 출력한다. 해당 연구는 임베딩 방법이나 데이터 전처리 방법 등 다양한 조건의 변화에 따른 실험 결과의 차이를 분석하여 차후 새로운 약물쌍 간 상호작용을 예측하는 데에 활용이 가능하다.

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Multi-class, Multi-residue Analysis of 59 Veterinary Drugs in Livestock Products for Screening and Quantification Using Liquid Chromatography-tandem Mass Spectrometry

  • Yu Ra Kim;Sun Young Park;Tae Ho Lee;Ji Young Kim;Jang-Duck Choi;Guiim Moon
    • 한국환경농학회지
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    • 제41권4호
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    • pp.288-309
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    • 2022
  • BACKGROUND: The objective of this study was to develop a comprehensive and simple method for the simultaneous determination of 59 veterinary drug residues in livestock products for safety management. METHODS AND RESULTS: For sample preparation, we used a modified liquid extraction method, according to which the sample was extracted with 80% acetonitrile followed by incubation at -20℃ for 30 min. After centrifugation, an aliquot of the extract was evaporated to dryness at 40℃ and analyzed using liquid chromatography combined with tandem mass spectrometry. The method was validated at three concentration levels for beef, pork, chicken, egg, and milk in accordance with the Codex Alimentarius Commission/Guidelines 71-2009. Quantitative analysis was performed using a matrix-matched calibration. As a results, at least 52 (77.6%) out of 66 compounds showed the proper method validation results in terms of both recovery of the target compound and coefficient of variation required by Codex guidelines in livestock products. The limit of quantitation of the method ranged from 0.2 to 1119.6 ng g-1 for all matrices. CONCLUSION(S): This method was accurate, effective, and comprehensive for 59 veterinary drugs determination in livestock products, and can be used to investigate veterinary drugs from different chemical families for safety management in livestock products.

약물남용 청소년의 주관적 경험에 관한 연구 (A Study On Subjective Experience Of Drug Abuse Adolescent)

  • 김미희
    • 대한간호학회지
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    • 제30권1호
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    • pp.7-17
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    • 2000
  • The purpose of this study is to affect health improvement of adolescent, to understand behavioral causes follow adolescent's drug abuse, to understand recovery and rehabilitaton process of adolescent drug abuser. The data are collected through open questionnaire and interview of 25 adolescents from the experienced drug abuse 16 students(male 8, female 8) in two vocational high schools and admissing adolescents 9 person in Alcohol-Drug Addiction Care Centre in Seoul from June 28th to August 31st, 1994. The collected data are arranged and explained through categorizing method stated contents about motives, causes, experiences and effected behaviors for using the drugs of drug abuser adolescents. DRUG USING MOTIVATION They are almost first son and daughter in their family. In their conversation person, male converses to their mother well, but female does not converse to their parents include family. Both groups respond positively to companionship and attitude to other, but negatively to self-confidence and actualizing attitude. They hope always peace of family and want to do their best for their life. In school group, hard and difficult things are school life and family problems, also using the drugs for resolving the them. About drug using behaviors, male responds to bad habbit and shamfull, but female is unconcerned with drug using attitude. The first background of drug using, male gets to use because of curiosity and to be induced from friends or seniors, but female gets to use for feminine beauty(thin body) and escape from reality. Used the drugs, male uses frequently Bond, Butane-Gas among inhalation materials and also marijuana, but female uses various diuretics. The times of drug using, both groups repond to use during the chaging of emotion or filling with stress. The place of drug using, both groups take drugs in vacant houses or in the mountain. The frequency of drug using, they use almost once in a day and they use mostly alone or drug user in friends. Experienced mental changing after drug using, which is fantasy, ecstasy, anxiety and suicidal feeling, and experienced physical changing after drug using, which is elevating sense, headach, abdominal pain, dyspnea and chaging of skin colour and reddish. They coincide with inconvenience feeling due to drug using. RECOVERY AND REHABILITATION PROCESS OF DRUG USING ADOLESCENTS The reason for reforming drug using behavior and attitude, both groups respond to reforming for oneself and social life. The difficult things during the stop to using drugs, all of them responed to family problems, friends problems and temptation and impulse. As for stop to using drug, they need good advise, understandable attitude and family love. But they do not need to be stigmatized, scolding, over protect and ridicule of friends. Also they entreat continuous understanding, advise, concern and the method for resolving stress. For the friends to want to use the drug, they will talk about the stories of their personal experiences and for the friends to stop to using the drug, they will consider for them how to stop. From the theses results, drug users understand personal problems due to drug using, and consider about why to stop and how to stop. Also drug users need to resolve the family problems, personal problems, stress and temptations or impulses. Accordingly this paper suggests that drug users in adolescents need understandable and acceptable atitudes, loving and tenderness, continuous advice and concern, and hopes for life.

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의약품 등 기준 및 시험방법(제 3개정) 소개 (Revision of The Korean Pharmceutical Codex, The Third Edition)

  • 최명신;양지선;유태무;김인규;김혜수;이선희;장승엽;조정희;이수정;김영림;김미정;김은정;이종필;김도훈;백경민;김희성;박상애;강인호;김은경
    • Journal of Pharmaceutical Investigation
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    • 제35권3호
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    • pp.201-205
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    • 2005
  • The aim of publishing the Korean Pharmaceutical Codex is to update and set specification of essential drugs for humane health. In accordance with speedy development of new drugs and improvement of science and technology, the need of revision of drug specification through the ICH guidelines and discussions between regulatory agency and pharmaceutical industry for the quality assurance of safer and efficient drugs is getting higher. The first edition of Korean Pharmaceutical Codex was published in 1983. Now, the third revision of the Codex is prepared because of the revision of domestic and foreign Pharmacopeias, changes of drug control environment, improvement of science and technology and so on. The aim of 3th edition is to improve the quality of essential drugs through the setting of the required specifications and discussions between the regulatory agency and pharmaceutical industry.

주사제의 실용량시험법에 관한 조사 (Tests for Volume of Injections in Containers)

  • 최명희;박승희;최보경;강찬순;이석호;김길수
    • Journal of Pharmaceutical Investigation
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    • 제30권3호
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    • pp.223-228
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    • 2000
  • Testing the volume of injection in container is to ensure that the nominal content of a container can be administered to the patient. The method to test the volume of injection in container is described in European Pharmacopeia (EP) and United States Pharmacopeia (USP). However there is no method to test the volume of injection in Korean Pharmacopeia (KP). So we surveyed the method practiced by 53 pharmaceutical companies in Korea by a questionnaire and tested commercially available injections by discharged volume. As the result, we agreed with the International Conference on Harmonization (ICH) test method for discharged volume. It was suggested that the ICH test method for discharged volume of injection in container would be adopted.

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