• The Korean Journal of Physiology and Pharmacology
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• 제20권5호
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• pp.477-485
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• 2016

CG200745 is a novel inhibitor of histone deacetylases (HDACs), initially developed for treatment of various hematological and solid cancers. Because it is water-soluble, it can be administered orally. We hypothesized that the HDAC inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in deoxycorticosterone acetate (DOCA)-induced hypertensive rats. For establishment of hypertension, 40 mg/kg of DOCA was subcutaneously injected four times weekly into Sprague-Dawley rats. All the rats used in this study including those in the sham group had been unilaterally nephrectomized and allowed free access to drinking water containing 1% NaCl. Systolic blood pressure was measured by the tail-cuff method. Blood chemistry including sodium, potassium, glucose, triglyceride, and cholesterol levels was analyzed. Sections of the heart were visualized after trichrome and hematoxylin and eosin stain. The expression of hypertrophic genes such as atrial natriuretic peptide A (Nppa) and atrial natriuretic peptide B (Nppb) in addition to fibrotic genes such as Collagen-1, Collagen-3, connective tissue growth factor (Ctgf), and Fibronectin were measured by quantitative real-time PCR (qRT-PCR). Injection of DOCA increased systolic blood pressure, heart weight, and cardiac fibrosis, which was attenuated by CG200745. Neither DOCA nor CG200745 affected body weight, vascular contraction and relaxation responses, and blood chemistry. Injection of DOCA increased expression of both hypertrophic and fibrotic genes, which was abrogated by CG200745. These results indicate that CG200745 attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats.

• 한국산학기술학회논문지
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• 제12권7호
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• pp.2975-2981
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• 2011

본 논문에서는 얼굴 영상 처리와 음성 신호처리를 적용하여 오미자차가 인체 장기에 효과가 있는 차인지 그리고 있다면 어느 장기에 효용이 있는지에 대한 분석 방법을 제안하고자 한다. 이를 위해 우선 영상처리를 통해 오미자차를 섭취하기 전과 후의 얼굴 영상에서 우측 뺨 영역의 색상 변화를 비교 분석하였다. 아울러 오미자차 효능에 대해 보다 많은 사실 확보를 위해 성대 진동 및 음성 에너지의 크기를 분석하는 음성분석 실험을 수행하였다. 실험 결과 오미자차 섭취에 의해 폐의 기능이 원활해지면서 성대 진동 및 에너지 크기가 안정적으로 변했으며 오른쪽 뺨 부위의 b값이 증가하는 현상이 나타났다.

• 한국물환경학회지
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• 제20권3호
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• pp.215-222
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• 2004

The sewages produced from small villages, rural community, drinking water reservation area and park which doesn't have sewage piping system can be caused a serious water pollution at the restricted areas. The objective of this research was to suggest an economical and effective sewage treatment method by investigating the removal of the organics, nitrogen, and phosphorus in the multi-soil-layering reactor. Soil, natural zeolite, and iron slag were used as a supporting media of multi-soil-layering in this research. The purpose of natural zeolite addition was to maintain the consistent ammonium exchange capacity by providing a sequential environment, and that of iron slag addition was to remove phosphorus by adsorption. Continuous experiment of lab-scale single-soil-layering (S-1), multi-soil-layering (S-2), and mixed-soil-layering (S-3) methods were studied to compare and optimize three different types of the reactors. The organic removal efficiencies showed more than 90% in all three reactors. While S-1 and S-3 reactors showed about T-N removal of 31%, 45%, respectively, the average T-N removal efficiency of the S-2 reactor represented an 87%. In conclusion, that results suggest that the multi-soil-layering reactor could be effectively utilized as a plant for treatment of small village sewage.

• Journal of Nutrition and Health
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• 제26권9호
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• pp.1129-1137
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• 1993

This study was carried out to analyze the effects of dietary and life-style factors on the prevalence of depression in Korea. Epidemiologic data from a nation-wide sample of 2,000 adults who were selected with the stratified random sampling method in Korea were interviewed by trained interviewers. Data were presented on the CES-D, a 20-items self-report depression symptom scale developed by the Center for Epidemiologic Studies in U.S.A. The prevalence of depression among all the respondents was 13.5%, with 13.1% in urban samples and 15.5% in rural samples. The prevalence was higher in females(15.3%) than in males(11.7%). There were highly marked differences in the prevalence of depression by sex(p<0.05), age(p<0.0001), education(p<0.001) and income(p<0.01). Respondents of 60 years and over group, the less educated group(below elementary school graduated), and the less income group(less than 400,000 won/month) reported the highest rate of depression. However subjects' occupation and residence had little relation with the prevalence of depression. Drinking and smoking habit appeared to be highly associated with depression in females(p<0.0001) but not in males. The prevalence of depression and eating behavior were highly related(p<0.005). Male respondents below 20 years, 20-29, and 60 years and over depressed group reported significantly lower energy and protein intakes compared to that of the normal group. However, in the female respondents 20-29 years and 60 years and over depressed groups showed the significantly lower energy and protein intakes compared to those of the normal groups(p<0.05), it can be concluded that the various ecological factors such as epidemiological, dietary, and health factors may affect the prevalence of depression among Korean.

• Nutrition Research and Practice
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• 제9권5호
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• pp.503-510
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• 2015

BACKGROUND/OBJECTIVES: Increased serum homocysteine (Hcy) levels have been reported to be related to the occurrence of cardio- and cerebrovascular diseases. High serum Hcy levels are also related to the development of secondary stroke and all-cause mortality. The purpose of this study was to investigate the prevalence of high serum homocysteine level and relating factors, and the change over the 10 month period post-stroke. SUBJECTS/METHODS: Consecutive stroke patients who were admitted to the Asan Medical Center were enrolled. Ten months after the onset of stroke, an interview with a structured questionnaire was performed and blood samples were obtained for the biochemical parameters. Nutritional status was determined using the mini nutritional assessment (MNA) score and dietary nutrient intakes were also obtained using a 24 hour recall method. RESULTS: Out of 203 patients, 84% were malnourished or at risk of malnutrition, and 26% had high homocysteine levels at 10 months post-stroke. Using logistic regression, the factors related with high homocysteine levels at 10 months post-stroke included heavy alcohol consumption (P = 0.020), low MNA scores (P = 0.026), low serum vitamin $B_{12}$ (P = 0.021) and low serum folate levels (P = 0.003). Of the 156 patients who had normal homocysteine levels at admission, 36 patients developed hyperhomocysteinemia 10 months post-stroke, which was related to heavy alcohol consumption (P = 0.013). Persistent hyperhomocysteinemia, observed in 22 patients (11%), was related to male sex (P = 0.031), old age (P = 0.042), low vitamin $B_6$ intake (P = 0.029), and heavy alcohol consumption (P = 0.013). CONCLUSION: Hyperhomocysteinemia is common in post-stroke, and is related to malnutrition, heavy alcohol drinking and low serum level of folate and vitamin $B_{12}$. Strategies to prevent or manage high homocysteine levels should consider these factors.

• Advances in nano research
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• 제5권2호
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• pp.127-140
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• 2017

Metal nanoparticles have been intensively studied within the past decade. Nano-sized materials have been an important subject in basic and applied sciences. Zinc oxide nanoparticles have received considerable attention due to their unique antibacterial, antifungal, and UV filtering properties, high catalytic and photochemical activity. In this study, microbiological aspects of scale formation in PVC pipelines bacteria and fungi were isolated. In the emerging issue of increased multi-resistant properties in water borne pathogens, zinc oxide (ZnO) nanoparticle are being used increasingly as antimicrobial agents. Thus, the minimum bactericidal concentration (MBC) and minimum fungal concentration of ZnO nanoparticles towards pathogens microbe were examined in this study. The results obtained suggested that ZnO nanoparticles exhibit a good anti fungal activity than bactericidal effect towards all pathogens tested in in-vitro disc diffusion method (170 ppm, 100 ppm and 30 ppm). ZnO nanoparticles can be a potential antimicrobial agent due to its low cost of production and high effectiveness in antimicrobial properties, which may find wide applications in various industries to address safety issues. Stable ZnO nanoparticles were prepared and their shape and size distribution characterized by Dynamic light scattering (35.7 nm) and transmission electron microscopic TEM study for morphology identification (20 nm), UV-visible spectroscopy (230 nm), X-ray diffraction (FWHM of more intense peak corresponding to 101 planes located at $36.33^{\circ}$ using Scherrer's formula), FT-IR (Amines, Alcohols, Carbonyl and Nitrate ions), Zeta potential (-28.8). The antimicrobial activity of ZnO nanoparticles was investigated against Bacteria and Fungi present in drinking water PVC pipelines biofilm. In these tests, Muller Hinton agar plates were used and ZnO nanoparticles of various concentrations were supplemented in solid medium.

• 여성건강간호학회지
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• 제6권1호
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• pp.82-95
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• 2000

The purpose of this study is to provide a basis to recognize the health behaviors of middle-aged women that are constructive to a healthy life style. Data were collected from interview of questionnaires completed by 208 middle-aged women living in Incheon from November 1 to 30, 1999. The questionnaires used in this study were obtained from publications on health-related topics shown in literature review. These topics included : health concept, diseases, use of tobacco, alcohol, caffeine, drug, exercise and diet, cause of stress and stress management. The data were analyzed by descriptive statistics using the SPSS program. The results of this study were as follows. 1. Middle-aged women though of concept of health as a doing daily living pattern(48.1%). 2. 49.5% of the middle-aged women had illness or disease, which included gastritis, arthritis, anemia, hypertension, indigestion and allergies. 3. 1.4% of the middle-aged women smoked cigarettes. Most of them began to smoke due to stress. 4. 42.3% of the middle-aged women drink alcohol. Most of them began drinking due to peer pressure. 5. 28.8% of the middle-aged women consumed caffeine-containing products 5-7 times per week. 6. 55.3% of the middle-aged women took drugs. Most of the drugs were digestant and analgesics. 7. 21.2% of the middle-aged women exercised more than 2 times per week. 8. Most of causes of stress were economic difficulties and sickness. The method of stress management were enduring and sleeping.

• 한국물환경학회지
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• 제37권4호
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• pp.275-285
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• 2021

Algal bloom is an important issue in maintaining the safety of the drinking water supply system. Fast detection and classification of algae images are essential for the management of algal blooms. Conventional visual identification using a microscope is a labor-intensive and time-consuming method that often requires several hours to several days in order to obtain analysis results from field water samples. In recent decades, various deep learning algorithms have been developed and widely used in object detection studies. YOLO is a state-of-the-art deep learning algorithm. In this study the third version of the YOLO algorithm, namely, YOLOv3, was used to develop an algae image detection model. YOLOv3 is one of the most representative one-stage object detection algorithms with faster inference time, which is an important benefit of YOLO. A total of 1,114 algae images for 30 genera collected by microscope were used to develop the YOLOv3 algae image detection model. The algae images were divided into four groups with five, 10, 20, and 30 genera for training and testing the model. The mean average precision (mAP) was 81, 70, 52, and 41 for data sets with five, 10, 20, and 30 genera, respectively. The precision was higher than 0.8 for all four image groups. These results show the practical applicability of the deep learning algorithm, YOLOv3, for algae image detection.

• 대한한방내과학회지
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• 제42권5호
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• pp.949-957
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• 2021

Objective: This study aimed to report a case of alcoholic liver disease with jaundice that was improved with Korean medicine treatment. Methods: A patient who developed jaundice due to continuous drinking was treated with herbal medicine, acupuncture, moxibustion, and cupping. Blood tests were performed to measure the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (γ-GTP), total bilirubin, albumin, and total protein; AST/ALT ratio; and mean corpuscular volume (MCV). Jaundice parameters were subjectively recorded at 3-day intervals. Results: After treatment, the AST, ALT, ALP, γ-GTP, and total bilirubin levels; MCV; and jaundice were decreased. Conclusion: Korean medicine treatment appeared to be an effective method for alcoholic liver disease with jaundice.

• 임상이비인후과
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• 제29권2호
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• pp.182-189
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• 2018

Background and Objectives : There were few literatures about the relationship between upper airway disorders and cardiovascular risk factors such as hypertension, although an association between impaired lower respiratory function and cardiovascular alterations was often reported. Our purpose was to assess the relationships between chronic sinusitis and hypertension. Materials and Methods : Three hundred subjects with bilateral chronic sinusitis who underwent functional endoscopic sinus surgery between 2015and 2017 were evaluated. Six hundred forty subjects without any nasal diseases were enrolled as a control group. Blood pressure and body mass index (BMI) were measured using a standardized method, and subjects were asked about current use of any antihypertensive medication, history of diabetes, smoking and alcohol drinking habits.Sinusitis group was assessed by nasal endoscopic examination, paranasal sinus CT scan and allergy test. Results : Average systolic and diastolic blood pressures were statistically significantly higher in subjects with sinusitis than control group. Chronic rhinosinusitis was associated with a 1.415-fold (95% confidence interval 1.053-1.930) increased hazard of hypertension after multivariate adjustment. Conclusions : These results suggest that sinusitis is associated with high blood pressure. Therefore patients with sinusitis may need special attention for blood pressure control. Further studies need to be performed to elucidate the pathogenesis behind such associations.