• The Korean Journal of Physiology and Pharmacology
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• v.17 no.3
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• pp.229-235
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• 2013

Among several animal models of retinitis pigmentosa (RP), the more recently developed rd10 mouse with later onset and slower rate of retinal degeneration than rd1 mouse is a more suitable model for testing therapeutic modalities. We therefore investigated the time course of retinal degeneration in rd10 mice before adopting this model in our interventional studies. Electroretinogram (ERG) recordings were carried out in postnatal weeks (PW) 3~5 rd10 (n=23) and wild-type (wt) mice (n=26). We compared the amplitude and implicit time of the b-wave of ERG records from wt and rd10 mice. Our results showed that b-wave amplitudes in rd10 mice were significantly lower and the implicit time of b-waves in rd10 mice were also significantly slower than that in wt mice ($20{\sim}160{\mu}V$ vs. $350{\sim}480{\mu}V$; 55~75 ms vs. 100~150 ms: p<0.001) through PW3 to PW5. The most drastic changes in ERG amplitudes and latencies were observed during PW3 to PW4. In multichannel recording of rd10 retina in PW2 to PW4.5, we found no significant difference in mean spike frequency, but the frequency of power spectral peak of local field potential at PW3 and PW3.5 is significantly different among other age groups (p<0.05). Histologic examination of rd10 retinae showed significant decrease in thickness of the outer nuclear layer at PW3. TUNEL positive cells were most frequently observed at PW3. From these data, we confirm that in the rd10 mouse, the most precipitous retinal degeneration occurs between PW3~PW4 and that photoreceptor degeneration is complete by PW5.

• Journal of Arbitration Studies
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• v.27 no.3
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• pp.95-107
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• 2017

Mongolian government enacted the Foreign Trade Arbitration Law to modernize the practice of commercial arbitration. Nevertheless, the Foreign Trade Arbitration Trade Law fell short on a number of fronts and arbitration itself remained a distant second option to litigation within Mongolia. Law on Arbitration of 2003 aimed to modernize the Mongolian arbitration framework so that it would mirror the UNCITRAL Model Law on International Commercial Arbitration. At the same time, the Law on Arbitration 2003 made a conscious decision to deviate from international norms with respect to certain aspects in order to accommodate for the unique circumstances and characteristics of Mongolia. For example, unlike its UNCITRAL counterpart, the Law on Arbitration of 2003 did not include an exhaustive list of grounds for refusing the recognition and enforcement of arbitral awards. In that sense, the Law on Arbitration of 2003 was a resounding success and a drastic improvement on the Foreign Trade Arbitration Law. These factors convinced the Mongolian government to once again revise its arbitration law. This process, which started in 2008 with the help of foreign law firms and institutions, ultimately culminated in the Law of Arbitration of 2017. The chief objective of the Law of Arbitration of 2017 was to more closely adhere to preexisting international norms on arbitration such as the Model Law on International Commercial Arbitration, and there is no question that Mongolia has succeeded in doing so. This article thus concludes by explaining some of the noteworthy improvements made by the 2017 revisions, and by noting that Mongolia is now equipped with a truly international legal framework for arbitration.

• Journal of Korean Society of Transportation
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• v.28 no.5
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• pp.155-162
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• 2010

Elderly pedestrians account for more than 30% of all deaths in traffic accident and the number of elderly-related traffic accidents are increasing every year. Considering Korea's quickly aging society, drastic measures must henceforth be taken. Taking notice of the elderly living in and moving around the provinces, this research focused on analyzing the characteristics of elderly pedistrians' traffic accidents on provincial roads and developing an Equivalent Property Damage Only (EPDO) model. The authors collected 720 traffic accident data points from the police agency and developed the EPDO model, weighted differently by light injury, severe injury, and death using Multiple Regression Analysis. As a result, the speed of vehicles is the most influential variable in EPDO, and the shape of the road is significant as well. Therefore, various policies should be established like improving the environmental factors of provincial roads, like expanding speed-reduction treatments and signage, and setting up detours around areas of high elderly concentration.

• Advances in environmental research
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• v.9 no.2
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• pp.97-107
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• 2020

The indiscriminate growth in global population poses a threat to the world in handling and disposal of Municipal solid waste. Rapid urban growth increases the production, consumption and generation of Municipal solid waste which leads to a drastic change in the environment. The methane produced from the Municipal Solid waste accounts for up to 11% global anthropogenic emissions, which is a major cause for global warming. This study reports the methane emission estimation using IPCC default, TNO, LandGEM, EPER and close flux chamber from open dump yards at Perungudi and Kodungaiyur in Chennai, India. The result reveals that the methane emission using close flux chamber was in the range of 8.8 Gg/yr-11.3 Gg/yr and 6.1Gg/yr to 9.1 Gg/yr at Kodungaiyur and Perungudi dump yard respectively. The per capita waste generation was estimated based on waste generation and population. The waste generation potential was projected using linear regression model for the period 2017-2050. The trend of CH₄ emission in the actual field measurement were increased every year, similarly the emission trend also increased in IPCC default method (mass balance approach), EPER Germany (zero order decay model) where as TNO and Land GEM (first order decay model) were decreased. The present study reveals that Kodungaiyur dump yard is more vulnerable to methane emission compared to Perungudi dump yard and has more potential in waste to energy conversion mechanisms than compare to Perungudi dump yard.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.314-314
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• 2023

Extreme climate events can have a large impact on human life by hampering social, environmental, and economic development. Global circulation models (GCMs) are the widely used numerical models to understand the anticipated future climate change. However, different GCMs can project different future climates due to structural differences, varying initial boundary conditions and assumptions about the physical phenomena. The multi-model ensemble (MME) approach can improve the uncertainties associated with the different GCM outcomes. In this study, a comprehensive rating metric was used to select the best-performing GCMs out of 11 CMIP5 and 13 CMIP6 GCMs, according to their skills in terms of four temporal and five spatial performance indices, in replicating the 21 extreme climate indices during the baseline (1975-2017) in South Korea. The MME data were derived by averaging the simulations from all selected GCMs and three top-ranked GCMs. The random forest (RF) algorithm was also used to derive the MME data from the three top-ranked GCMs. The RF-derived MME data of the three top-ranked GCMs showed the highest performance in simulating the baseline extreme climate which was subsequently used to project the future extreme climate indices under both the representative concentration pathway (RCP) and the socioeconomic concentration pathway scenarios (SSP). The extreme cold and warming indices had declining and increasing trends, respectively, and most extreme precipitation indices had increasing trends over the period 2031-2100. Compared to all scenarios, RCP8.5 showed drastic changes in future extreme climate indices. The coasts in the east, south and west had stronger warming than the rest of the country, while mountain areas in the north experienced more extreme cold. While extreme cold climatology gradually declined from north to south, extreme warming climatology continuously grew from coastal to inland and northern mountainous regions. The results showed that the socially, environmentally and agriculturally important regions of South Korea were at increased risk of facing the detrimental impacts of extreme climatology.

• Journal of Technology Innovation
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• v.13 no.1
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• pp.265-293
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• 2005

This research examines the relationship between the characteristics of Government S&T Research Institutes (GRI) and their institutional performance evaluation system. First, based on Kaplan & Norton (1992) Balanced Scorecard Model, six perspectives suitable to Korean GRI are derived. Second, personnel who works on evaluation job classified current performance measures into the six perspectives. Analyzing comparative weights of individual perspectives, the characteristics of performance evaluation systems among institutes are derived and compared with their missions. The results are as follows: First, GRI evaluation systems put most weight on the customer perspective and least weight on the financial perspective. This result complies with Korean GRI's missions and strategies as well as findings of foreign cases. Second, Basic-technology GRI group relatively more priotizes long-term customer perspective, while Applied-technology GRI Group relatively more priotizes short-term customer perspective. Public-technology GRI Group is located in the middle in terms of priority of customer perspectives. Third, for three yews (2000-2002), performance measure weights of Basic-technology Group are changed much less than those of the other two groups. Further research are needed for reasons of drastic changes for Applied-technology and Public-technology groups and some abnormally high and low measure weights.

• Computers and Concrete
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• v.11 no.1
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• pp.39-49
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• 2013

The use of ground fly ash in concrete can increase the risk of slump loss due to the drastic surface change of the particles after the grinding treatment and the accelerated reaction compared to the untreated ash. This study is aimed at the early age hydration and time-dependent rheology changes of cement paste containing ground fly ash. An original fly ash is ground into different fineness and the hydration of cement paste containing the ground fly ash is monitored with the ultrasound propagation method. The zeta potentials of the solid particles are measured and the changes of rheological parameters of the cement pastes with time are analyzed with a rheometer. A particle packing model is used to probe packing of the solid particles. The results show that the early age hydration of the paste is strongly promoted by replacing Portland cement with fly ash up to 30 percent (by mass), causing increase of the yield stress of the paste. The viscosity of a paste containing ground fly ash is lower than that containing the untreated ash, which is explained by the denser packing of the solid particles.

• Structural Engineering and Mechanics
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• v.76 no.2
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• pp.207-222
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• 2020

Due to the rugged terrain, metro lines in mountain city across numerous wide rivers and deep valleys, resulting in instability of high-pier bridge and insecurity of metro train subjected to fluctuating crosswind. To ensure the safe operation in metro lines in mountain cities, running safety of the metro train over the high-pier bridge under crosswind is analyzed in this paper. Firstly, the dynamic model of the wind-train-bridge (WTB) system is built, in which the speed-up effect of crosswind is fully considered. On the basis of time domain analysis, the basic characteristics of the WTB system with high-pier are analyzed. Afterwards, the dynamic responses varies with train speed and wind speed are calculated, and the safety zone of metro train over a high-pier bridge subjected to fluctuating crosswind in mountain city is determined. The results indicate that, fluctuating crosswind triggers drastic vibration to the metro train and high-pier bridges, which in turn causes running instability of the train. For this reason, the corresponding safety zone for metro train running on the high-pier is proposed, and the metro traffic on the high-pier bridge should be closed as the mean wind speed of standard height reaches 9 m/s (15.6 m/s for the train).

• The Journal of Industrial Distribution & Business
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• v.7 no.1
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• pp.11-14
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• 2016

Purpose - The study aims to show the successful application of Six Sigma in software companies for process improvement. Research design, data and methodology - A mixed methodology has been used which include both qualitative and quantitative research. In the qualitative research methodology part, a detailed and comprehensive literature study have been carried out. The literature study consists of articles, books, web materials, discussion forms and others. In the quantitative research methodology part, interviews have been conducted. Results - Six sigma is the practical application of a theoretical statistical measurement that equates to 3.4 defects per million opportunities -a position of practically zero defects for any process or service. Initially originating in Motorola Inc. in 1985 as a response to drastic quality improvement pressures from the threat of Japanese competition, it quickly gained many followers particularly G.E., Allied Signal, Ford Motor Company etc. and more recently attentions have shifted to service environments. There are still some problems and misconceptions existed about the applicability of Six Sigma in software companies. Conclusions - The paper concludes that Six Sigma can bring large benefits for software companies too. Furthermore, software companies have already started to implement Six Sigma approach, like Ericsson, Tata Consultancy Service, etc.

• Bulletin of the Korean Chemical Society
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• v.34 no.12
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• pp.3602-3608
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• 2013

Saccharomyces cerevisiae, which is a common species of yeast, is by far the most extensively studied model of a eukaryote because although it is one of the simplest eukaryotes, its basic cellular processes resemble those of higher organisms. In addition, yeast is a commercially valuable organism for ethanol production. Since the yeast data can be extrapolated to the important aspects of higher organisms, many researchers have studied yeast metabolism under various conditions. In this report, we analyzed and compared metabolites of Saccharomyces cerevisiae under salt and pH stresses of various strengths by using two-dimensional NMR spectroscopy. A total of 31 metabolites were identified for most of the samples. The levels of many identified metabolites showed gradual or drastic increases or decreases depending on the severity of the stresses involved. The statistical analysis produced a holistic outline: pH stresses were clustered together, but salt stresses were spread out depending on the severity. This work could provide a link between the metabolite profiles and mRNA or protein profiles under representative and well studied stress conditions.