• The Journal of the Korea Contents Association
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• v.13 no.2
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• pp.498-504
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• 2013

Recently, the frequency of typhoons have increased due to the effects of climate change. As a result, in mountain streams, it has caused streamflow increase upstream and frequent water surface elevation downstream. This study analyzed the effects of the heavy rainfalls caused by Typhoon Sanba, which had a direct impact on Korea between September 17 and 18, on the water level variations downstream in mountainous streams. In addition, the drainage basin of Samcheok Oship stream was chosen as the object of this study. This study analyzed the flood level by applying HEC-RAS model. The observed water level measured in 2012 and the water level simulated by HEC-RAS model showed similar results. In addition, the simulation results showed the maximum flood level was 5.32m the mean flow velocity was 2.33m/sec and the maximum channel water depth was 7.51m. The analysis showed that the heavy rainfalls caused by Typhoon Sanba had an impact on the water surface elevation in Oship stream. The final results from this study will give a reasonable and important data to perform the Design of Hydraulic Structure.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.216-221
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• 2019

The c-Met protein is a receptor tyrosine kinase involved in cell growth, proliferation, survival, and angiogenesis of several human tumors. Overexpression of c-Met has been found in gastric cancers and correlated with a poor prognosis. Indirubin is the active component of Danggui Longhui Wan, which is a traditional Chinese antileukemic recipe. In the present study, we tested the anti-cancer effects of an indirubin derivative, LDD-1937, on human gastric cancer cells SNU-638. When we performed the in vitro kinase assay against the c-Met activity, LDD-1937 inhibited the activity of c-Met. This result was confirmed by immunoblot and immunofluorescence of phosphorylated c-Met. Immunoblot analysis showed that LDD-1937 decreased the expression of the Erk1/2, STAT3, STAT5, and Akt, downstream proteins of c-Met. In addition, LDD-1937 reduced the cell viability and suppressed colony formation and migration of SNU-638 cells. Furthermore, LDD-1937 induced $G_2/M$ phase arrest in the SNU-638 cells by decreasing the expression levels of cyclin B1 and CDC2. Cleaved-PARP, an apoptosis-related protein, was up-regulated in cells treated with LDD-1937. Overall, this study suggests that LDD-1937 may be a novel small-molecule with therapeutic potential for selectively inhibiting c-Met and c-Met downstream pathways in human gastric cancers overexpressing c-Met.

• Journal of Korea Water Resources Association
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• v.44 no.9
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• pp.753-763
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• 2011

Allocated water storage of dam at the planning and design stage does not seem to be maintained well at the operation stage because of unexpected critical reasons. A dam is likely to be subject to negative effects caused by changes of dam operation conditions and it is hardly avoidable. Therefore, it must be timely improved to recover its original functions and looked for better alternatives to keep its original roles. Specifically the improper management of river condition degrades flood control capability in a dam and river eco-system. The dam downstream river improvement work is needed for normalizing dam functions and its valuations. This study focuses on estimating water use benefits from recovering its own effective storage buffer restricted for flood control. As the results, the water supply and the hydropower benefits in Imha, Daechung and Youngdam Dam are recovered totally by 19.9 million $m^3$/year and 20.8 GWh/year respectively. Also those results are used for the basic information of the economic analysis in the dam downstream river improvement work.

• Journal of Distribution Science
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• v.14 no.12
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• pp.107-118
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• 2016

Purpose - In today's markets, new technologies such as social network systems and user generated contents have provided consumers with access to unlimited amounts of information and an ability to communicate with other consumers in the world. Specially, the massive of the internet and the development of online communities and interactive platforms offer the potential to cocreate with a large number of consumers. Significant changes in marketplace suggest that simply being consumer oriented is not enough, so firms must learn from and collaborate with consumers to create values that meet their individual and dynamic needs. In these sense, emergent perspectives in marketing highlight new opportunities for co-opting consumers as a means to define and cocreate value through their engagement. Although the importance of consumer co-creation with firms, the current literature lacks the respond to two questions: (1) who are the most competent consumers for creating the values with firm? and (2) what are the stimulaters to help the consumers engage for co-creation? To this answer the question, this research investigate how to structure consumer motivations to encourage consumers to be more engaged for co-creation and what drives a consumer to get involved to respond to a call for co-creation. Research design, data, and methodology - To empirically test the hypotheses, a survey was conducted among consumers who had experienced the co-creation including upstream, downstream, autonomous, and sponsored co-creation with the firms. We collected a total of 343 responses. After we excluded 37 questionnaire because of incomplete responses, a total of 306 questionnaire remained. Working with a sample of 306 responses in Seoul and Kwangju, hierarchical moderated regression is employed to test research hypotheses. Results - The results indicated that consumer creativity and emergent nature are positively related to engagement in co-creation including upstream, downstream, autonomous, and sponsored co-creation. Also, the relationships between consumer creativity/emergent nature and engagement in co-creation were moderated by intrinsic motivation in case of upstream and downstream co-creation. Finally, interaction effects between consumer creativity/emergent nature and extrinsic motivation were not significant. Conclusions - These results suggest that marketing managers have to consider the consumer personality such as creativity and emergent nature and stimulate the intrinsic motivation of consumer to achieve the co-creation project successfully.

• Korean Journal of Ecology and Environment
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• v.50 no.2
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• pp.238-253
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• 2017

The sewage and wastewater (SAW) are a well-known major source of eutrophication and greentide in freshwaters and also a potential source of thermal pollution; however, there were few approaches to thermal effluent of SAW in Korea. This study was performed to understand the behavioral dynamics of the thermal effluents and their effects on the water quality of the connected streams during winter season, considering domestic sewage, industrial wastewater and hot spring wastewater from December 2015 to February 2016. Sampling stations were selected the upstream, the outlet of SAW, and the downstream in each connected stream, and the water temperature change was monitored toward the downstream from the discharging point of SAW. The temperature effect and its range of SAW on the stream were dependent not only on the effluent temperature and quantity but also on the local air temperature, water temperature and stream discharge. The SAW effects on the stream water temperature were observed with temperature increase by $2.1{\sim}5.8^{\circ}C$ in the range of 1.0 to 5.5 km downstream. Temperature effect was the greatest in the hot spring wastewater despite of small amount of effluent. The SAW was not only related to temperature but also to the increase of organic matter and nutrients in the connected stream. The industrial wastewater effluent was discharged with high concentration of nitrogen, while the hot spring wastewater was high in both phosphorus and nitrogen. The difference between these cases was due to with and without chemical T-P treatment in the industrial and the hot spring wastewater, respectively. The chlorophyll-a content of the attached algae was high at the outlet of SAW and the downstream reach, mostly in eutrophic level. These ecological results were presumably due to the high water temperature and phosphorus concentration in the stream brought by the thermal effluents of SAW. These results suggest that high temperature of the SAW needs to be emphasized when evaluating its effects on the stream water quality (water temperature, fertility) through a systematized spatial and temporal investigation.

• Journal of Korea Water Resources Association
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• v.49 no.3
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• pp.241-252
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• 2016

In this study, the characteristics of flow and bed changes with variation of space and length of serial spur dikes were investigated with 2 dimensional numerical simulation. Upstream spur dike was affected by flow and made a role as a single spur dike. As time increased, local scouring was developed around outside of spur dike, and migrated upstream. The aggradation of the bed at the back of spur-dike was made at the initial stage of experiment and numerical modelling. However, the aggradation of the bed was increased in the downstream area. The scour whole around a spur dike upstream was not deep as the Dimensionless spur-dike interval (b) of the dike increased. The depth of scour hole was nearly constant at the dynamic equilibrium state. The dimensionless scour depth ($y_s/H$) increased with L/b. The spur dike downstream had the characteristics of single spur dike as the L/b was larger than 10. However, the spur dike downstream was affected by the dike upstream as the L/b was less than 4, and the bed of the upstream in the spur dike was aggradated and the effects of the serial spur dikes on the bed decreased.

• Korean Journal of Ecology and Environment
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• v.43 no.2
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• pp.232-241
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• 2010

Epilithic diatom communities and water quality were monitored to evaluate the ecological impact of the inflow of Wonju-stream passing through the urban area in the Seom River Watershed. We selected the 14 sampling stations (5 main stream sites and 9 tributary sites), and collected diatom and water samples between October 2007 and September 2008, on the seasonal basis. The results indicate that most water quality parameters showed the site-specific patterns over the study, except for water temperature and dissolved oxygen. The levels of water quality parameters were highest at the site of Wonju stream, whereas the lowest in the upstream sites, and intermediate or gradually decreased in the downstream sites of the Seom river. One species, Achnanthes convergens, showed the highest biomass and frequency over the sites, while three saprophilous species-Navicula goeppertiana, Navicula subminuscula, Nitzschia palea were appeared only in Wonju Stream and other polluted sites. According to trophic diatom index (TDI) values, which were highly correlated with nutrients and EC, the study sites were classified into three classes: upstream and tributary (Class A and B), Wonju Stream (Class D), and mixed zone and downstream (Class C). A cluster analysis supported the result of TDI classification. Therefore, Wonju-stream located in populated urban area exerted the adverse ecological effects on the epilithic diatom community and water quality of the lower Seom River System, although its severity gradually decreased downstream.

• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.972-974
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• 2005

The present work deals with the theoretical study of the effects of copper vapours resulting from the erosion of the electrodes on the properties of a SF6 arc in a Laval nozzle. Computations have been done for a DC arc of 1000A with upstream gas pressure of 3.75MPa. The arc plasma is assumed to be in local thermodynamic equilibrium(LTE). The sheath and non-equilibrium region around the electrodes are not considered in this model. However, its effects on the energy flux into the electrodes are estimated from some experimental and theoretical data. The turbulence effects are calculated using the Prandtl mixing length model. A conservation equation for the copper vapour concentration is solved together with the governing equations for mass, momentum and energy of the gas mixture. Comparisons were made between the results with and without electrodes erosion. It has been found that the presence of copper vapours cools down the arc temperature due to the combined effects of increased radiation and increased electrical conductivity. The copper vapour distribution is very sensitive to the turbulent parameter. The erosion of upstream electrode(cathode) has larger effects on the arc compared to the downstream electrode(anode) as the copper vapour eroded from the anode cannot diffuse against the high-speed axial flow.

• Biomedical Science Letters
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• v.18 no.3
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• pp.181-192
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• 2012

Toll-like receptors (TLRs) induce innate immune responses that are essential for host defense against invading microbial pathogens. In general, TLRs have two major downstream signaling pathways; myeloid differential factor 88 (MyD88) and Toll/IL-1R domain-containing adaptor inducing IFN-${\beta}$ (TRIF) leading to the activation of NF-${\kappa}B$ and IRF3. Numerous studies demonstrated that certain phytochemicals possessing anti-inflammatory effects inhibit NF-${\kappa}B$ activation induced by pro-inflammatory stimuli including lipopolysaccharide and tumor necrosis factor-${\alpha}$ ($TNF{\alpha}$). However, the direct molecular targets for such anti-inflammatory phytochemicals are not fully identified. In this paper, we will discuss about the molecular targets of phytochemicals in TLRs signaling pathways. These results present a novel anti-inflammatory mechanism of phytochemicals in TLRs signaling.

• Proceedings of the KSME Conference
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• 2001.06e
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• pp.661-667
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• 2001

This paper is concerned with the effects of periodically approaching upstream wakes on cascade-flow and loss. The reduced frequency of the periodic wakes was varied in the narrow range from 0.5 to 0.7. According to a wake-passing through the cascade, two velocity deficits appear near the boundary layer contour in the downstream from about 60% chord-length. The first velocity deficit is caused by a periodic wake and the second one appears after some delayed time. The second velocity deficit may be interpreted as the results of reattachment of flow-separation. The higher reduced frequency decreases the duration time of separation appearance and the lesser loss of aerofoil is resulted.