• Water Engineering Research
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• 제3권4호
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• pp.215-234
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• 2002

Uncertainty in dam breach flood routing results was analyzed in order to provide the basis fer the investigation of their effects on the flood damage assessments and dam safety risk assessments. The Monte Carlo simulation based on Latin Hypercube Sampling technique was used to generate random values for two uncertain input parameters (i.e., dam breach parameters and Manning's n roughness coefficients) of a dam breach flood routing analysis model. The flood routing results without considering the uncertainty in two input parameters were compared with those with considering the uncertainty. This paper showed that dam breach flood routing results heavily depend on the two uncertain input parameters. This study indicated that the flood damage assessments in the downstream areas can be critical if uncertainty in dam breach flood routing results are considered in a reasonable manner.

• Steel and Composite Structures
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• 제19권2호
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• pp.385-403
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• 2015

This paper presents the status improvement of an old damaged deck type rural road steel truss bridge through the modal parametric study after partial retrofitting. The dynamic and static tests on bridge were carried out as in damaged state and after partial retrofitting. The dynamic testing on the steel bridge was carried out using accelerometers under similar environmental conditions with same speed of the moving vehicle. The comparison of the modal parameters i.e., frequency, mode shape mode shape curvature, modal strain energy, along with the deflection parameter are studied with respect to structural analytical model parameters. The status up gradation for the upper and downstream truss obtained was different due to differential level of damage in the bridge. Also after retrofitting the structural elemental behavior obtained was not same as desired. The damage level obtained through static tests carried out using total station indicated further retrofitting requirement.

• 생태와환경
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• 제41권4호
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• pp.466-471
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• 2008

Little is known about DNA-level and physiological levels for health assessments of stream or river environments. Recently, comet assay, so called Single Cell Gel Electrophoresis (SCGE) is introduced for assessments of DNA damage in the medical science, food science and mammal toxicology. The comet assay is known as a biomarker which is one of the best barometers in assessing the DNA damage by oxidative stress. In this study, we conducted the comet assay using sentinel species, Zacco platypus, as one of the pre-warning alarm systems for the aquatic ecosystem health assessments and also applied it to Gap Stream as a model system. Tail extent moments in the S1 and S2 were 5.20 and 9.90 respectively and the moment was 19.89 in the S3. Statistical ANOVA in the tail moments showed a significant difference (n=75, p<0.05) between S1 and S3. Also, the proportions of DNA in the tail were 14.47, 23.64, and $30.04{\mu}m$ in the upstream (control site), midstream, downstream sites, respectively. Our results in the downstream were accord with previous studies of individual-level, population-level, and community-level in Gap Stream. Our results suggest that the comet assay may be used as an important tool for diagnosing ecological health of aquatic ecosystems in the level of DNA.

• 한국구조물진단유지관리공학회 논문집
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• 제23권3호
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• pp.51-55
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• 2019

저수지의 붕괴 발생 시 인명 및 재산피해의 예방 및 저감을 위하여 붕괴예보 시스템의 필요성은 대두되고 있는 상황이다. 붕괴 예보시스템의 효율적 활용을 위해서는 실시간 계측한 이상거동 및 붕괴징후에 따라 대응할 수 있는 관리기준은 가장 중요한 요소이다. 기 연구된 수위 관리기준의 검증을 위하여 저수량에 따라 10여개의 저수지를 선정하고 수위변화 자료를 분석하여 적정성을 검토하였다. 1년 동안의 수위계측 자료에서 가장 급격한 변화구간을 선정하여 가중치 및 추세선을 적용하여 분석한 결과 3분위로 수립된 관리기준값은 7%이내의 표준편차를 보여주었다. 이는 수립된 관리기준값은 적정하다고 판단된다.

• Animal cells and systems
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• 제6권3호
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• pp.263-269
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• 2002

The p53 tumor suppressor gene is among the most frequently mutated and studied genes in human cancer, but the mechanisms by which it sur presses tumor formation remain unclear. DNA damage regulates both the protein levels of p53 and its affinity for specific DNA sequences. Stabilization of p53 in response to DNA damage is caused by its dissociation from Mdm2, a downstream target gene of p53 and a protein that targets p53 for degradation in the proteosome. Recent studies have suggested that phosphorylation of human p53 at Ser20 is important for stabilizing p53 in response to DNA damage through disruption of the interaction between Mdm2 and p53. We generated mice with an allele encoding changes at Ser20, known to be essential for p53 accumulation following DNA damage, to enable analyses of p53 stabilization in vivo. Our data showed that the mutant p53 was clearly defective for full stabilization of p53 in response to DNA damage. We concluded that Ser20 phosphorylation is critical for modulating the negative regulation of p53 by Mdm2, probably through phosphorylation-dependent inhibition of p53-Mdm2 interaction in the physiological context.

• 한국환경과학회지
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• 제17권6호
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• pp.601-609
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• 2008

In this study for the development of area due to the increasing of industry, population and spreading of urbanization is rapidly increasing but about seventy percent of our nation's areas consists of the mountainous districts. In such case, when those areas have the heavy rains break, they are washed away by a fast-flowing stream of a valley and overflowed. Thus it could result on human life and property damage and also the widespread of flood damage in the downstream area. To decrease those damage, the construction of flood control reservoir is necessary. This research was aim to construct the flood runoff models of a mountainous small district and to determine the probability rainfall by analyzing precipitation. The study also examined the effects of location and size of flood control reservoir on flood reduction. The result showed that the construction of detention basin was an effective way to ensure the safety of flood control and multiple detention basin had superior result for reducing amount of runoff in the down stream area than the single detention basin.

• 한국농공학회지
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• 제38권5호
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• pp.64-73
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• 1996

When typhoon occurs, the meteorological conditions get worse and can cause a large damage from storm and flood . This damage, however, can be minimized if a precise analysis of the runoff characteristics by typhoon tracks is used in the flood contorl This paper aims at the analysis of storm occurrence and runoff characteristics by typhoon tracks in Nakdong river basin. Therefore, the data of 14 typhoons which invaded Nakdong river basin during the period from 1975 to 1991 were collected, analyzed, and studied. The major results of this study are as followings; 1) The frequency of the typhoon occurrence here in Korea was affected by the storms three times a year on the average. The highest-recorded frequency was during the months of July to September. 2) The survey of the track characteristics depending on the forms of the storm in the Nakdong river basin showed that typhoon storm advanced from the south of the basin to the north, while the frontal type storm was most likely to advanced from the west to the north. 3) Typhoon tracks are classified into three categories, 6 predictors with high correlation coefficient are finally selected, and stepwise multiple regression method are used to establish typhoon strom forecasting models. 4) The riview on the directions of progress of the storm made it clear that the storm moving downstream from upstream of the basin could develop into peak discharge for ca short time and lead to more flood damage than in any other direction.

• 한국환경과학회지
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• 제20권12호
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• pp.1635-1646
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• 2011

This April 5th dam and Hwanggang dam, which are located in Imjin river, North Korea, become the main causes of water shortages and damages in Imjin river downstream. April 5th dam is assumed a small or medium-sized dam, its total storage volume reaches about 88 million $m^3$. And Hwanggang dam, multi-purposed dam of total storage volume approximately 0.3 billion $m^3$ to 0.4 billion $m^3$ is used as source of residental or industrial water in Gaeseong Industrial Complex. North Korea, which has April 5th dam and Hwanggang dam in Imjin river, manages water of approximately 0.39 billion $m^3$ to 0.49 billion $m^3$ directly. As water is storaged or discharged through dam, it causes a severe damage to areas in Yeoncheon-gun and Paju city, South Korea. Therefore, this study intends to analyze and estimate runoff through dam construction by using hydrological observation data and artificial data such as service water supply and agricultural water in Imjin river, water shortage and damage correctly.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4879-4881
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• 2012

Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage induced by ionizing radiation, and non-homologous end joining is the predominant pathway for repair of radiation-induced DSBs. Some cell signaling pathways that respond to normal growth factors are abnormally activated in human cancer. These pathways also invoke the cell survival mechanisms that lead to resistance to radiation. The molecular connection between the EGFR and its control over DNA repair capacity appears to be mediated by one or more signaling pathways downstream of this receptor. The purpose of this mini-review was not only to highlight the relation of the EGFR signal as a regulatory mechanism to DNA repair and radiation resistance, but also to provide clues to improving existing radiation resistance through novel therapies based on the above-mentioned mechanism.

• 한국미생물·생명공학회지
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• 제50권4호
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• pp.441-456
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• 2022

Shiga toxins (Stxs) are major virulence factors from the enterohemorrhagic Escherichia coli (EHEC), a subset of Stx-producing Escherichia coli. Stxs are multi-functional, ribosome-inactivating proteins that underpin the development of hemolytic uremic syndrome (HUS) and central nervous system (CNS) damage. Currently, therapeutic options for the treatment of diseases caused by Stxs are limited and unsatisfactory. Furthermore, the pathophysiological mechanisms underpinning toxin-induced inflammation remain unclear. Numerous works have demonstrated that the various host ribotoxic stress-induced targets including p38 mitogen-activated protein kinase, its downstream substrate Mitogen-activated protein kinase-activated protein kinase 2, and apoptotic signaling via ER-stress sensors are activated in many different susceptible cell types following the regular retrograde transportation of the Stxs, eventually leading to disturbing intercellular communication. Therapeutic options targeting host cellular pathways induced by Stxs may represent a promising strategy for intervention in Stx-mediated acute renal dysfunction, retinal damage, and CNS damage. This review aims at fostering an in-depth understanding of EHEC Stxs-mediated pathogenesis through the toxin-host interactions.