• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2004-2010
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• 2022

Quantification of sensitive material is of vital importance when it comes to the movement of nuclear fuel throughout its life cycle. Within the electrorefiner vessel of electrochemical separation facilities, the task of quantifying plutonium by neutron analysis is especially challenging due to it being in a constant mixture with curium. It is for this reason that current neutron multiplicity methods would prove ineffective as a safeguards measure. An alternative means of plutonium verification is investigated that utilizes the (𝛼,n) signature that comes as a result of the eutectic salt within the electrorefiner. This is done by utilizing the multiplicity variable a and breaking it down into its constituent components: spontaneous fission neutrons and (𝛼,n) yield. From there, the (𝛼,n) signature is related to the plutonium content of the fuel.

• 한국전산구조공학회논문집
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• 제22권1호
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• pp.1-13
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• 2009

이 논문에서는 복잡한 기하학적 형상과 비선형 특성들을 보이는 곡선 프리스트레스트 콘크리트(PSC) 사장교의 극한거동을 안정적으로 예측하기 위한 비선형 해법을 제시하였다. PSC 교량 구조물의 비선형 거동 및 극한거동을 예측하기 위한 해법으로서 하중제어법(load control strategy)과 변위제어법(displacement control strategy)을 적용하였다. 콘크리트의 과다한 균열과 재료상태 및 케이블 장력의 급격한 변화로 인해 불평형력(unbalanced load)이 크게 변화하여 이들 두 해법으로 해를 구할 수 없는 경우에 대한 대안으로서 불평형력을 적정한 비율로 감소시키면서 하중제어 법을 적용하여 해를 안정적으로 구해 나가는 불평형력 감쇠(scale-down of the unbalanced load)를 적용한 하중제어법을 제시하였다. PSC 거더교의 극한해석을 수행하여 불평형력 감쇠를 적용한 하중제어법의 정당성을 평가하였다. 또한 곡선 PSC 사장교의 극한해석에 이 논문에서 제시한 비선형 해법을 적용하여 복잡한 비선형성으로 인해 해가 수렴하기 어려운 해석에도 이 해법이 유용함을 확인하였다.

• 한국연극학
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• 제40호
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• pp.307-344
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• 2010

Cultural Studies built on the critical mind of New Left exposes the relationship between culture and power, and investigates how this relationship develops the cultural convention. It has achieved the new perspective that could make us to think culture and art in terms of political correctness. However, the critical voices against the theoretical premises of Cultural Studies have been increased as its heyday in 1980s was nearly over. For instance, Terry Eagleton, a former Marxist literary critic, declared in 2003 that the golden age of cultural theory is long past. This essay, therefore, intends to show the weak foundations on which the approaches of cultural studies to theatre rest and to clarify the general problem of their introduction to theatre studies. The approach of cultural studies to theatre takes the form of 'top-down inquiry' as it applies a theory to a particular play or historical period. In other word, from the theory the writer moves to the particular case. The result is not an inquiry but rather a demonstration. This circularity can destroy the point of serious intellectual investigation as the theory dictates answers. The goal-oriented narrow viewpoint as a logical consequence of 'top-down inquiry' makes the researcher to favor the plays or the parts of a play that are proper to test a theory. As a result it loses the fair judgment on the artistic value of a play, and brings about the misinterpretation. The interpreter-oriented reading is the other defect of cultural studies as it disregards the inherent meaning of the text, distorting a play. The approach of cultural studies also consists of a conventionality as it arrives at a stereotyped interpretation by using certain conventions of reasoning and rhetoric. The cultural theories are fundamentally the 'outside theories' that seek to explain not theatre but the very broad features of society and politics. Consequently their application to theatre risks the destructive criticism, disregarding the inherent experience of theatre. Most of, if not all, cultural theories, furthermore, are proven to be lack of empirical basis. The alternative method to them is a 'cognitive science' that proves scientifically our mind being influenced by bodily experience. The application of cultural materialism to Shakespeare's is one of the cases that reveal the limits of cultural studies. Jonathan Dollimore and Water Cohen provide a kind of 'canonical study' in this application that is imitated by the succeeding researchers. As a result the interpretation of has been flooded with repetitive critical remarks, revealing the problem of 'top-down inquiry' and conventional reasoning. Cultural Studies is antipodal to theatre in some respect. It is interested chiefly in the social and political reality while theatre aims to create the fiction world. The theatre studies, therefore, may have to risk the danger of destroying its own base when it adopts cultural studies uncritically. The different stance between theatre and cultural theories also occurs from the opposition of humanism vs. antihumanism. We have to introduce cultural theories selectively and properly not to destroy the inherent experience and domain of theatre.

• 기록학연구
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• 제38호
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• pp.225-264
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• 2013

이 글은 미국과 캐나다의 북미 국가들에서 활발하게 진행되고 있는 '참여 아카이브(participatory archives)'를 중심으로 한 공동체 아카이브의 '거버넌스' 논의를 분석하고, 이로부터 국내 공동체 아카이브의 발전에 긍정적 함의를 도출하는 데 목적이 있다. 이 글은 북미에서의 공동체 아카이브에 대한 주요 특징들, 즉 추진 주체로서 주류 문화기관, 수집기관 중심의 아카이브 정리 및 기술, 그리고, 평가 주체로서 아키비스트의 역할론을 제시함으로써, 이들 국가들이 역사적으로 관 주도형 하향식 모델을 지배적 아카이브 시스템으로 채택하고 있음을 재차 확인한다. 이 때문에 하향식 모델의 한계점을 극복하기 위한 방안으로 민 관의 협치에 기반하여 아카이빙 전 과정에 공동체 참여를 적극적으로 독려하는, 북미 국가들이 최근 시도하고 있는 참여 아카이브의 제안을 살핀다. 결론에서는, 북미 거버넌스 논의의 비판적 독해를 통해 한국적 함의를 살핀다. 즉 국가기록원을 비롯해 다양한 주류 문화기관들이 추진 주체가 되어 구축해 왔던 대부분의 공동체 아카이브가 여전히 관주도의 '공동체에 관한(about the community)' 기록에 머물러 있는 우리 상황에서, 북미 참여 아카이브에서 보여지는 타자화된 공동체 기억을 복원하려는 논의는 국내 공동체 아카이브가 재활력을 얻는 데 중요한 시사점을 준다고 판단한다.

• 동의생리병리학회지
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• 제28권1호
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• pp.35-44
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• 2014

This study was performed to investigate the anti-photoaging effects of Persimmon leaf tea(PLT) in hairless mice(SKH-1) exposed to UVB radiation. The animals were divided into non-treated group (normal, N) and UV-radiated groups. UV-radiated groups were divided into only UV-radiated group(control, C) and UV-radiated and PLT treated experimental groups[first extraction treated group(PLT-I), second extraction treated groupe(PLT-II), and third extraction treated group(PLT-III)]. Three PLT treated experimental groups of mice were treated with both oral administration(300mg/Kg B.W./day) and topical application (100 ul of 2% conc./mouse/day) for 4 weeks. Anti-photoaging effects of Persimmon leaf were evaluated by MTT assay, anti oxidative reaction, MMP immunohistochemistry, gelatin zymography assay and RT-PCR observations. Treatment with Persimmon leaf tea(PLT)-I, and -III groups decreased immunohistochemical density of matrix metalloproteinases(MMP)-3 and -9 related to degradation of extracellular matrix in skin. Especially, immunohistochemical density of MMP-2 decreased in PLT-I, -II and -III groups in skin. On the effects of antioxidant function on the treatment with Persimmon leaf tea(PLT), treatment of HaCaT cells with extracts of PLT-I and PLT-II had also significantly reduced intracellular ROS produced by UVB irradiation in a dose dependent manner(PLT-I, p<0.05, p<0.01, p<0.001; PLT-II, p<0.01, p<0.001). Gelatin zymography assay revealed that PLT-II and PLT-III (200 ug/ml) had inhibitory effect on MMP-9 expression in UVB-radiated HaCaT cells. Western blot analysis revealed that PLT-1, -II and -III groups down-regulates the expression of inflammatory associated genes(IL-$1{\beta}$) and PLT-1 and -II groups down-regulates the expression of TNF-${\alpha}$ in a dose dependent manner. Our study suggests that Persimmon leaf tea(PLT) extracts participates in inhibitory effects on the morphological and molecular experiments related to photoaging skin on UVB irradiated hairless mice.

• Natural Product Sciences
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• 제24권3호
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• pp.171-180
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• 2018

Artemisia capillaris has been widely used as an alternative therapy for treating obesity and atopic dermatitis. It has been used as a hepatoprotactant. It is also used for ameliorating inflammatory reactions. Although there are several investigations on other Artemisia species, there is no systematic study describing the role of A. capillaris MeOH extract, its solvent soluble fractions, or derived anti-inflammatory principal components in regulating inflammatory conditions. Therefore, the objective of this study was to elucidate anti-inflammatory mechanisms of A. capillaris. Results revealed that MeOH extract of A. capillaris could decrease LPS-stimulated NO secretion. Of tested fractions, $CH_2Cl_2$, EtOAc, and n-BuOH strongly inhibited NO release from RAW264.7 cells. Bioactive mediators derived from $CH_2Cl_2$ and n-BuOH fractions elicited potent anti-inflammatory actions and strikingly abrogated LPS-triggered NO accumulation in RAW264.7 cells. Of particular interest, capillin and isoscopoletin possessed the most potent NO suppressive effects. Western blot analysis validated the molecular mechanism of NO inhibition and showed that capillin and isoscopoletin significantly down-regulated iNOS and COX-2 protein expression. Taken together, our results provide the first evidence that MeOH extract, $CH_2Cl_2$, EtOAc, and n-BuOH fractions from A. capillaris and its derived lead candidates can potently suppress inflammatory responses in macrophages by hampering NO release and down-regulating iNOS and COX-2 signaling.

• Journal of Gastric Cancer
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• 제2권4호
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• pp.213-220
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• 2002

Purpose: The cDNA microarray provides a powerful alternative with an unprecedented view in monitoring geneexpression levels and leads to discoveries of regulatory pathways involved in complicated biological processes. Our aim is to explore the different gene-expression patterns in gastric adenocarcinomas. Materials and Methods: By using a cDNA microarray representing 4,600 cDNA clusters, we studied the expression profiling in 10 paired gastric adenocarcinoma samples and in adjacent noncancerous gastric tissues from the same patients. Alterations in the gene-expression levels were confirmed by Vsing Northern blots and reverse-transcription PCR (RT-PCR) in all of 4 randomly selected genes. Results: Genes those were expressed differently in cancer ous and noncancerous tissues were identified. 44 (of which 26 were known) and 92 (of which 43 were known) genes or cDNA were up- and down-regulated, respectively, in more than $80\%$ of the gastric adenocarcinoma samples. In cancer ous tissues, genes related to gene/protein expression, cellcycle regulation, and metabolism were mostly up-regulated whereas genes related to the oncogene/tumor suppressor gene, cell structure/motility, and immunology were mostly down-regulated. The semi-quantitative RT-PCR results for the four genes we tested were consistent with the array findings. Conclusions: These results provide not only a new molecular basis for understanding the biological properties of gastric adenocarcinomas but also a useful resource for future development of therapeutic targets and diagnostic markers for gastric adenocarcinomas.

• 한국정보처리학회논문지
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• 제7권5호
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• pp.1464-1473
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• 2000

본 논문에서는 최근 상호연결망 위상으로 관심을 받고 있는 (n,k)-스티 그래프에 대한 사이클 특성을 분석한다.(n,k)-스티 그래프의 그래프 이론적 특성을 바탕으로 (n,k)-스티 그래프가 다양한 종류의 사이클들을 보유하고있는 범사이클(pancyclic)특성을 지니고 있음을 밝히고 해당 사이클들을 찾을 수 있는 알고리즘을 제시한다. 본 논문에서제안하고 있는 기법은 그래프자체의 체귀적 성질을 이용한 하형식(top-down)방식으로써 부-그래프들로 구성된 확장된 개념의 사이클들에 "차원확장"이라는 연산을 연속적으로 적용함으로써 원하는 사이클로 구체화해 가는 과정으로 진행하게 된다. 이러한 기법의 적용 결과 구성되는 사이클은 최소한의 한정된 부-그래프들로 밀집되어 모이는 경향이 있어 노드 또는 예지심에 서로 중복이 없이 독립된(disjoint) 사이클을 찾는 문제 등의 응용분야로 확대적용의 가능성이 있다. 본 연구 결과는 (n,k)-스티 그래프에 대한 그래프 이론적 관점에서의 댐사이클 특성을 분석한 이론적 의미와 더불어 해당 상호연결망 구조를 갖는 다중컴퓨터시스템에서의 메시지 라우팅이나 자원 할당 및 스케쥴링과 관련된 분야로의 응용가능성을 함께 의미하고 있다.

• Clinical and Experimental Reproductive Medicine
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• 제29권4호
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• pp.251-258
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• 2002

Objective : The aim of this study was to evaluate the outcomes of the GnRH antagonist (Cetrotide) minimal stimulation protocol comparing with GnRH agonist combined long step down stimulation protocol in PCOS patients. Materials and Method: From Apr 2001 to May 2002, 22 patients (22 cycles) were performed in controlled ovarian hyperstimulation using by GnRH antagonist and GnRH agonist for PCOS patients. GnRH antagonist (Cetrotide) combined minimal stimulation protocol was administered in 10 patients (10 cycles, Study Group) and GnRH agonist long step down stimulation protocol was administered in 12 patients (12 cycles, Control Group). We compared the pregnancy rate/cycle, total FSH (A)/cycle, Retrieved oocyte/cycle, the incidence of ovarian hyperstimulation syndrome, multiple pregnancy rate between the two groups. Student-t test were used to determine statistical significance. Statistical significance was defined as p<0.05. Results: Group of GnRH antagonist (Cetrorelix) minimal stimulation protocol produced fewer oocytes (6.4 versus 16.3 oocytes/cycle) using a lower dose of FSH (22.2 versus 36.1 Ample/cycle) and none developed OHSS and multiple pregnancy. Although the trends were in favour of the GnRH antagonist (Cetrorelix) protocol, the differences did not reach statistical significance. This was probably due to small sample size. Conclusion: The use of GnRH antagonist reduce the risk of ovarian hyperstimulation and multiple pregnancy. We suggest that GnRH antagonist might be alternative controlled ovarian hyperstimulation method, especially in PCOS patients who will be ovarian high response.

• 대한인간공학회지
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• 제31권4호
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• pp.515-523
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• 2012

Objective: The aim of this study is to investigate users' intuitive stereotypes on non-touch gestures and establish the gesture dictionary that can be applied to gesture-based interaction designs. Background: Recently, the interaction based on non-touch gestures is emerging as an alternative for natural interactions between human and systems. However, in order for non-touch gestures to become a universe interaction method, the studies on what kinds of gestures are intuitive and effective should be prerequisite. Method: In this study, as applicable domains of non-touch gestures, four devices(i.e. TV, Audio, Computer, Car Navigation) and sixteen basic operations(i.e. power on/off, previous/next page, volume up/down, list up/down, zoom in/out, play, cancel, delete, search, mute, save) were drawn from both focus group interview and survey. Then, a user participatory design was performed. The participants were requested to design three gestures suitable to each operation in the devices, and they evaluated intuitiveness, memorability, convenience, and satisfaction of their derived gestures. Through the participatory design, agreement scores, frequencies and planning times of each distinguished gesture were measured. Results: The derived gestures were not different in terms of four devices. However, diverse but common gestures were derived in terms of kinds of operations. In special, manipulative gestures were suitable for all kinds of operations. On the contrary, semantic or descriptive gestures were proper to one-shot operations like power on/off, play, cancel or search. Conclusion: The touchless gesture dictionary was established by mapping intuitive and valuable gestures onto each operation. Application: The dictionary can be applied to interaction designs based on non-touch gestures. Moreover, it will be used as a basic reference for standardizing non-touch gestures.