• 한국지하수토양환경학회지:지하수토양환경
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• 제16권1호
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• pp.12-18
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• 2011

To investigate the natural reduction characteristics of radon with a short half-life (3.82 day) in drinking Qgroundwater, we analyzed the changes of radon concentrations of groundwater, waters in storage tanks, and tap waters from the small-scale groundwater-supply systems (N = 301) by LSC (Liquid Scintillation Counter). We also analyzed the concentrations of uranium (half-life 4.5 billion years) in the waters by ICP/MS to compare with natural reduction of radon concentration. The radon concentrations of 68 groundwater-supply systems occupying 22.6% of the total samples exceeded the US EPA's Alternative Maximum Contaminant Level (AMCL : 4,000 pCi/L), with the average radon concentration of 7,316 pCi/L (groundwaters), 3,833 pCi/L (tank waters) and 3,407 pCi/L (tap waters). Compared to the radon levels of pumped groundwaters, those of tank and tap waters naturally reduced significantly down to about 50%. Especially, in case of 29 groundwater-supply systems with the groundwater radon concentrations of 4,000~6,000 pCi/L, average radon concentrations of the tank and tap waters naturally decreased down to the AMCL. Therefore this study implies that radon concentrations of drinking groundwater can be effectively reduced by sufficient storage and residence in tanks.

• 마이크로전자및패키징학회지
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• 제30권3호
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• pp.83-87
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• 2023

전자 및 반도체 기술 분야에서는 Si를 대체할 혁신적인 반도체 소재 연구가 활발하게 진행 중이다. 그러나 대체 소재에 대한 연구는 진행 중이지만 2차원 물질을 채널로 사용하는 트랜지스터의 구성요소, 특히 기생 저항과 RF(고주파) 응용 프로그램과의 관계에 대한 연구는 매우 부족한 편이다. 본 연구는 이러한 부족한 부분을 메우기 위해 다양한 트랜지스터 구조에 중점을 두고 전기적 성능에 미치는 영향을 체계적으로 분석하였다. 연구 결과, Access 저항과 Contact 저항이 반도체 소자 성능 저하의 주요 요인 중 하나로 작용함을 확인하였으며, 특히 고도로 scaling down된 경우 그 영향이 더욱 두드러지는 것을 확인하였다. 고주파 RF 소자에 대한 수요가 계속해서 증가함에 따라 원하는 RF 성능을 달성하기 위한 소자 구조 및 구성 요소를 최적화하기 위한 가이드라인을 수립하는 것은 매우 중요하다. 본 연구는 2차원 물질을 채널로 사용하는 다음 세대 RF 트랜지스터의 설계 및 개발에 도움이 될 수 있는 구조적 가이드라인을 제공함으로써 이 목표에 기여할 수 있다.

• 대한약침학회지
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• 제17권2호
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• pp.7-17
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• 2014

Objectives: Condurango is widely used in various systems of complementary and alternative medicines (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats, in vivo to validate its use as traditional medicine. Methods: Fifteen male and 15 female Sprague-Dawley (SD) rats were treated with 0.28 mg/kg of Sweet Bee Venom (SBV) (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate reactive oxygen species (ROS), which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer cell-death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusion: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• 한국가구학회지
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• 제18권2호
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• pp.91-99
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• 2007

Modernity which is superficial phenomenon set off the mass scale for mass consumption and provide uniformly artificial environment. But natural destruction, environment pollution, resources exhaustion and so on has been caused by this and now ecology is threatened by destruction and damage beyond the limitation and human beings survival is even threatened. Accordingly furniture development for environment preservation considered environment problem is the urgent real situation. Recent paradigm is the concept of Eco-design which is the green design possible to live together in symbiosis, and new types of alternative furniture are needed in Korea as well. 'Furniture for disassembly' is presented as new method for alternative furniture. Furniture for disassembly can be presented by mainly two directions. The first main characteristic is what is assembled by the use of woodworking joints technique as an assembly structure system without any hardware. The second is what is presented as the structure possible to be assembled by simple manual tools with hardware without any glue. The advantages of furniture for disassembly are environment preservation, space application, transportation efficiency and shapeliness. In manufacture method which is different from present furniture, the application of traditional truss technique which uses various types of custom-made and connection technique in case of assemble structure system without hardware is the typical differences. This assembly method expects not only interest induction about assembly and disassembly of diagram per sub materials but also the development of emotion, the improvement of collaboration, space perception ability and shape sense, the improvement of solid body structure insight and so on, when it use in the furniture for children with the application to many kinds of structure with BANGDOOSANJ (Wedged), JUMUGJANGBU (Dovetail) or NABIEUNJANG (Dovetail Keys) and so on.

• 한국정보시스템학회지:정보시스템연구
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• 제23권4호
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• pp.197-219
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• 2014

Despite of continuous efforts to crack down on piracy using penalties and regulations, this unauthorized piracy market is still enormous. Since the moral hazard about this phenomenon is pervasive and continually upsets the major intellectual property markets, an alternative plan is required. The purpose of this study is to provide an objective insight for factors that affect people's digital video piracy behavior. The following two research propositions were the focus: what psychological factors affect piracy behavior and how are these factors related to one another? In order to accomplish the research aims, we reviewed literatures on the current state of piracy in South Korea, characteristics of digital contents, studies on criminal psychology and behavioral theories. Previous research in the fields of criminal theory indicated that neutralization, a form of rationalization, would help explain digital piracy intentions. Thus, this study developed a model that explains effects of neutralization techniques and tested the possibility of an integrated model with other behavioral theory such as TPB and TIB. Empirical results of the study(368 sample collected) showed that all the factors in TPB including Attitude to Piracy(+), Subjective Norm(-), Perceived Behavioral Control(+) had a significant impact on Piracy Intention. Moreover, two neutralization techniques, Condemn the Condemners(+) and Appeal to Higher Loyalties(+), had a significant effect on Piracy Intention. In addition, Past Behavior had strong impacts on Attitude(+), Perceived Behavioral Control(+) and Piracy Intention(+). In terms of Expected Profit, it had an impact on Attitude to Piracy positively. These findings suggest implications for protecting the current intellectual property markets, with many stakeholders in movies and media industries. There are some limitations as followed: first, the study did not consider other neutralization techniques, low level of deterrence and the other expected results despite the possibility of their effects. Second, the study needs improvements through longitudinal research because the cross-sectional research could not rule out the alternative explanations.

• International Journal of Railway
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• 제1권3호
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• pp.83-88
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• 2008

Since the 1990's the fleet of the Dutch Railways showed a dramatic decrease in wheel tyre life. This lifetime reduction led to an unacceptable increase in life cycle costs. Therefore Lloyd's Register Rail has proposed to NedTrain to investigate the possibilities of improving the wheel tyre life. Three improvements were determined as most promising and relatively easy to achieve: - Profile optimisation for Rolling Contact Fatigue (RCF) reduction - a new wheel profile has been developed with a better resistance against rolling contact fatigue of the wheel tread. The profile has been implemented on single deck intercity trains and shows an increase in wheel tyre life of 30%. - Selection of improved wheel tyre materials - combining information from literature and experiences of manufacturers five alternative wheel tyre materials have been selected and are now being tested in practice. - Optimisation of the maintenance strategy - an alternative, preventative maintenance regime has been developed. With this Scraping regime, during short term maintenance every wheel is reprofiled. Higher mileages are reached and savings on life cycle costs up to 50% and more have been achieved. Unplanned maintenance goes down with $30{\sim}60%$. The results from field tests, using a reference group for comparison, and preliminary results after implementation show that the increase in wheel tyre life that is achieved with this project is significant. The results will continue to be monitored using the asset management tool 'Wheel Watch', that was specially developed for this project and is also described in this paper.

• 동의생리병리학회지
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• 제23권6호
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• pp.1409-1415
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• 2009

Obesity is especially a serious health problem in industrialized countries, because it is considered to be a risk factor associated with the genesis or development of various metabolic diseases, including cardiovascular disease and type 2 diabetes mellitus. The purpose of this study was to investigate the effects of tanshinone IIA from Salvia miltiorrhiza Bunge on induction of apoptossis and inhibition of adipogenesis in in 3T3-L1 preadipocytes and adipocytes. The results demonstrated that tanshinone IIA decreased cell population growth of 3T3-L1 preadipocytes, assessed with the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and LDH (lactate dehydrogenase) assay. Flow cytometric analysis of 3T3-L1 preadipocytes exposed to tanshinone IIA showed that apoptotic cells increased in a timeand dose-dependent manner. Treatment with tanshinone IIA decreased the number of normal cells and increased the number of apoptotic cells in a dose-dependent manner. The induction of apoptosis in 3T3-L1 preadipocytes by tanshinone IIA was mediated through the activation of caspase-3 and Bax, and then through the cleavage of PARP and the down-regulation of Bcl-2. Moreover, tanshinone IIA significantly decreased the amount of intracellular triglycerides and GPDH (glycerol-3-phosphate dehydrogenase) activity in 3T3-L1 adipocytes. Our results suggest that tanshinone IIA efficiently induces apoptosis and inhibits adipogenesis in 3T3-L1 preadipocytes and adipocytes.

• 대한약침학회지
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• 제18권2호
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• pp.86-87
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• 2015

Objectives: Condurango is widely used in various systems of complementary and alternative medicine (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats in vivo to validate its use as a traditional medicine. Methods: After one month of scheduled BaP feeding (50 mg/kg body-weight), lung cancer developed after four months. BaP-intoxicated rats were then treated with Condurango (0.06 mL) twice daily starting at the end of the four months for an additional one, two and three months, respectively. Effects of Condurango were evaluated by analyzing lung histology, reactive oxygen species (ROS) and antioxidant biomarkers, DNA-fragmentation, RT-PCR (Reverese Transcriptase-Polymerase Chain Reaction), ELISA (Enzyme linked immunosorbent assay) and western blot of several apoptotic signalling markers and comparing the results against those obtained for controls. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate ROS, which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer-cell death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusions: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• 한국건축시공학회지
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• 제23권5호
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• pp.571-581
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• 2023

최근 국내 건설산업은 건설업체의 경영난과 물량 감소로 인해 위축되고 있다. 국내 건설사들은 건설시장에서의 경쟁 우위 확보를 위해 모든 공종에 대해 원가절감 및 품질향상을 위한 노력을 기울이고 있다. 가치공학(VE) 기법은 건축공사에서 원가절감뿐만 아니라 공기 단축과 품질향상을 위한 도구로 활용되는데, 골조 공사 분야에 적용되는 성과가 상대적으로 미미한 실정이다. 공장 건설에서 골조 공사는 전체 공정에 큰 영향을 미치는 주요 공정이므로 골조 공사 계획단계에서 VE 기법을 도입해 설계도서와 현장 여건을 분석하여 품질과 안전을 확보하면서 공사 기간 단축, 원가절감, 작업성을 높일 수 있는 대안을 개발할 필요가 있다. 본 연구는 공기 단축, 원가절감, 시공 안전성 확보를 위한 기초연구가 될 것으로 기대된다.

• 공학교육연구
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• 제6권2호
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• pp.22-29
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• 2003

하드웨어 설계 교육의 궁극적인 목표는 학생들로 하여금 시스템 설계능력을 갖추도록 배양하는 데에 있다. 그러나 상당수의 기존 교과과정은 설계 자체보다는 개별적인 빌딩 블록의 내부동작 원리의 이해를 중심으로 운영되는 것이 현실이다. 따라서, 학생들의 학습동기 유발에 실패할 뿐만 아니라 정작 현장에서 필요로 하는 시스템적 관점에서의 설계를 충분히 경험하지 못하는 것이 문제점으로 지적된다. 이러한 문제점들을 극복하기 위한 대안으로, 과목의 초기 도입부에 추상화의 수준을 높여서 시스템의 전체 설계를 조망할 수 있도록 하고, 점차로 추상화의 단계를 낮추어서 결국 소자의 동작 원리를 탐구하는데 이르도록 강의의 순서를 역전시킬 필요성이 있다. 본 논문에서는 하드웨어 설계의 입문 과목인 논리설계 교과목을 대상으로 하여, 시스템 수준의 설계표현 및 검증방식을 먼저 소개하고 소자에 대한 세부지식은 후반부에 소개하는 새로운 교육방식을 제안하고 이의 타당성을 검증하기 위해 교내의 동아리를 활용한 비정규 교육과정에 이를 도입한 사례를 소개한다.