• 약학회지
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• 제59권2호
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• pp.70-76
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• 2015

A Softgel is an oral dosage form for medicine similar to capsules and softgel dosage form offers several advantages over other oral dosage forms, such as delivering a liquid matrix designed to solubilize and improve the oral bioavailability of a poorly soluble compound as a unit dose solid dosage form, delivering low and ultra-low doses of a compound. This study aimed to qualify a proprietary vegetable soft capsule which contains modified starch and carrageenan as capsule shell components compare to the conventional gelatin softgel. Four kinds of samples were prepared with vegetable and gelatin capsule shell, respectively. Morphology of capsule shell, mechanical strength of capsule, and hygroscopic properties were studied for comparing the quality attributes of softgel. Short-term stability against heat and moisture was also investigated in this study. Vegetable capsule shell showed better mechanical strength, physical stability and disintegration time for temperature and humidity than those of conventional gelatin capsule shell with four different filling materials used frequently as soft capsule form. Conclusively, this vegetable capsule shell polymer system can replace easily gelatin-shell systems and additionally allows encapsulation of lipid fills at high temperatures that are semisolid or solid-like at room temperature.

• 상하수도학회지
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• 제23권2호
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• pp.207-214
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• 2009

This study examines the optimum filtration conditions in pretreatment of seawater desalination by reverse osmosis. For this purpose, Masan bay seawater is treated through a gravity filter column while $FeCl_3$ is added as coagulant. The conditions of coagulantd osage, media depth, filtration rate, and backwash time are evaluated. The study results show that the filtrate quality improved with increasing coagulant dosage, but head loss rapidly increased. After 4mg/L, the unit filter run volume reduced to less than $200m^3/m^2$. Considering the head loss development, 4mg/L is determined as the optimum dosage. The better filtrate qualities are obtained with depth of 100cm than that of 80cm. The two stage filtration, which outperformed the single stage filtration, is suggested for treatment of Masan bay. The filtration rate of 5m/h is decided as the optimum condition considering the head loss development. At 10m/h, the filtrate quality deteriorated even though the extent was minimal, and head loss increased rapidly. The backwash time of 10 min is decided appropriate.

• 상하수도학회지
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• 제14권2호
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• pp.164-173
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• 2000

Fluoridation of drinking water to a level of about 0.8mg/l (below 1.5mg/l) for reducing the incidence of tooth decay is recommended. However, concerns about potential problems of unknown effects and overdosing hinders the fluoridation. This study describes the work performed to obtain information on the behavior of fluoride under various conditions in the process of water fluoridation. Effects of water treatment chemicals, water treatment unit, and water distribution on water fluoridation were investigated at both lab and an actual water treatment plant. Residual fluoride concentration was not affected by lime and chlorine dosage up to 20mg/l. Flocculation with PAC slightly decreased the residual fluoride concentration as PAC dosage increased. Average fluoride concentration of 0.87mg/l at an intake basin was decreased to 0.83mg/l by sedimentation, 0.81mg/l by dual media(sand+anthracite) filtration, and 0.79mg/l by granular activated carbon filtration in the water treatment plant.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2015년도 춘계 학술논문 발표대회
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• pp.55-56
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• 2015

This study is corroborated as a fundamental resource to develop structural lightweight paste containing silica fume as a part of cement. Paste using foaming agent is generated much foam and decreased density of paste. This study is measured at 0.8% of foaming agent dosage but over 0.8% of foaming agent dosage raise density of paste because of interconnection with foam. Also, FEM analysis using SEM image is confirmed correspondence of between Elastic modulus of experiment and FEM analysis.

• Imaging Science in Dentistry
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• 제37권2호
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• pp.65-68
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• 2007

Purpose: To compare the leakage and scattered radiation from hand-held dental X-ray unit with radiation from fixed dental X-ray unit. Materials and Methods: For evaluation we used one hand-held dental X-ray unit and Oramatic 558 (Trophy Radiologie, France), a fixed dental X-ray unit. Doses were measured with Unfors Multi-O-Meter 512L at the right and left hand levels of X-ray tube head part for the scattered and leakage radiation when human skull DXTTR III was exposed to both dental X-ray units. And for the leakage radiation only, doses were measured at the immediately right, left, superior and posterior side of the tube head part when air was exposed. Exposure parameters of handheld dental X-ray unit were 70 kVp, 3 mA, 0.1 second, and of fixed X-ray unit 70 kVp, 8 mA, 0.45 second. Results: The mean dose at the hand level when human skull DXTTR III was exposed with portable X-ray unit $6.39{\mu}Gy$, and the mean dose with fixed X-ray unit $3.03{\mu}Gy$ (p<0.001). The mean dose at the immediate side of the tube head part when air was exposed with portable X-ray unit was $2.97{\mu}Gy$ and with fixed X-ray unit the mean dose was $0.68{\mu}Gy$ (p<0.01). Conclusions: The leakage and scattered radiation from hand-held dental radiography was greater than from fixed dental radiography.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1996년도 가을 학술발표회 논문집
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• pp.232-238
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• 1996

In this paper, the properties of high-strength concrete are described with respect to materials and mix conditions(water-cement ratio, chemical admixture, replacement of fly ash). As primary purposes of this study, the optimum mix design method of high-strength concrete to decrease unit cement contents is investigated, and the properties of fresh and hardened concretes are tested in terms of slump, air content and compressive strength. As results of this study, workability and strength development of the high-strength concrete depend on the water-cement ratio, replacement ratio of fly ash and dosage of the chemical admixture. The conditions which are proposed optimum mix design of the high-strength concrete show W/C 37%, S/A 42~45% and unit cement content 470~480kg/$\textrm{m}^3$. Based on the results, the applicability of high-strength concrete in site is clearly proved.

• The Korean Journal of Pain
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• 제30권3호
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• pp.183-191
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• 2017

Background: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines. To test this hypothesis, a survey was conducted across speciality throughout the country to observe the prescription pattern of these drugs amongst the health care providers in India. Methods: Three hundred fifty survey forms were distributed of which 281 forms were included for analysis. Results: It was observed that the commonly used initiation and maintenance dose for amitriptyline, pregabalin, and gabapentin was 5-10 mg/day, 50-75 mg/day, and 100-300 mg/day, respectively. The reason to select the lower dosages was to have a balancing effect to achieve good efficacy with minimum side effects. Care-givers reported no side effects/not many side effects as a reason in 22.2%, 16.88%, and 23.86% patients with amitriptyline, pregabalin, and gabapentin, respectively. Sedation and giddiness were commonly reported with all three drugs. Conclusions: Commonly prescribed drugs for management of neuropathic pain, such as amitriptyline, pregabalin, and gabapentin are preferred at lower doses in Indian clinical settings. Acceptable efficacy and low tolerance to the standard dosage is believed to be the reason behind the prescribed dose.

• 한국식품과학회지
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• 제31권5호
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• pp.1401-1404
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• 1999

솔잎추출물의 rat에 대한 단기 급성경구독성을 평가하기 위하여 체중 kg당 최고 10g의 솔잎 추출물을 rat의 위에 직접 투입하여 14일간 관찰하였다. 실험 결과 모든 실험군에서 사망예가 관찰되지 않아 $LD_{50}$, 10g/kg B.W. 이상으로 계산되었으며 임상증상이나 체중, 부검에서도 유의할만한 소견이 관찰되지 않았다. 따라서 본 실험의 솔잎 추출물은 rat에 있어서 단기 급성경구독성이나 부작용을 유발하지 않는 소재로 평가되었다.

• 한국건축시공학회지
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• 제16권1호
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• pp.35-43
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• 2016

콘크리트는 대표적인 불균질 재료이며 콘크리트의 역학적 특성은 다양한 요인들에 의해 영향을 받는다. 그 중 콘크리트 내부에 존재하는 공극은 콘크리트의 강도를 결정하는데 많은 영향을 주고 있기 때문에 공극의 분포 및 크기를 파악하는 연구는 매우 중요하며 그 방법으로 화상이미지를 이용한 연구가 대두되고 있다. 경량 기포 콘크리트는 현재 비구조용에 관한 연구만 진행되고 있기 때문에, 구조용으로 사용하기 위한 경량 기포 콘크리트의 역학적 특성을 평가하고 화상 이미지를 기반으로 FEM 해석을 이용한 검증에 관한 연구는 미비하다. 그러므로 기포제 혼입률에 따른 시멘트 페이스트를 제작하여 역학적 성능 평가를 실시하고 화상 이미지를 이용하여 FEM 해석을 실시하여 역학적 성능 비교 및 검증을 실시하였다. 본 연구에서 기포제 혼입률에 따른 공극 분포를 확인하기 위해 7수준으로 하였으며 추 후 구조용 경량 기포 콘크리트에 대한 연구를 진행하기 위해 물-결합재비를 20%로 하였다. 기포제 혼입률이 0.8%에서 단위 용적 질량이 최소가 되었으며 그 이상 혼입했을 시 기포 간의 상호 연결로 인한 깨짐 현상이 발생하여 단위 용적 질량이 증가하였다. 공극 분포에 따른 FEM 해석을 위해 화상분석기(HF-MA C01)를 이용하여 시멘트 페이스트 단면을 촬영하였고 이를 토대로 OOF(Object Oriented Finite elements)를 이용한 FEM 해석을 실시한 결과 실험 탄성계수와 해석 탄성계수가 일치하였다.

• Environmental Engineering Research
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• 제25권2호
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• pp.163-170
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• 2020

Knowledge of organic micropollutant transfers in barrier seal materials from waste storage facilities is limited to volatile organic compounds and phenolic compounds at ambient temperature. This study focused on the sorption of chlorophenols (CPs) from various geotextiles from clay geosynthetics under the influence of temperature. Also to study the impact of the polarity or the amount of CPs adsorbed on geotextiles with the partition coefficient. The effect of various parameters such as contact time, effect of temperature, initial CPs concentration and adsorbent dosage has been carried out in this study. The result obtained is non-linear and the data was calculated for affinity with Freundlich isotherm model. An important observation is that the amount of CPs sorbed on geotextiles increases with a growing number of chlorine atoms, ie increases with the partition coefficient (log K_ow). During this study, a decrease in adsorbent properties was observed with the rise in temperature from 23℃ to 55℃. The partitioning coefficients for CPs examined range are from 2.4 (R² = 0.86) to 8.4 mL/g (R² = 0.90). Among the CPs studied, the highest adsorbed quantity was observed for pentachlorophenol with 0.052 g/g at 23℃, this quantity will decrease with the increase in temperature.