• 제목/요약/키워드: dosage rate

검색결과 550건 처리시간 0.035초

Early Efficacy of Endostar Combined with Chemoradiotherapy for Advanced Cervical Cancers

  • Ke, Qing-Hua;Zhou, Shi-Qiong;Huang, Min;Lei, Yong;Du, Wei;Yang, Ji-Yuan
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권3호
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    • pp.923-926
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    • 2012
  • The aim of this study was to investigate the early outcome of Endostar combined with chemoradiotherapy for advanced cervical cancer. Fifty-two cases (FIGO IIb to IVa) were divided randomly into two groups, receiving chemoradiotherapy alone (CRT group) and Endostar combined with chemoradiotherapy (CRT+E group). For the patients in the CRT+E group, Endostar was administered daily with the dosage of 7.5 $mg/m^2$, and cisplatin was administered weekly with the dosage of 20 $mg/m^2$ during the radiation. The regimens lasted for 4 weeks with no difference in chemoradiotherapy between the two groups. The early outcome complete remission rate was 73.1%, partial remission rate was 23.1% and the total response rate was 96.2% in CRT+E group, a significant improvement on the 34.6%, 42.3% and 76.9%, respectively, in the CRT group. One year survive rates were 100% and 84.6% in the CRT+E group and CRT groups, the difference being significant. Endostar combined with chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and adverse effects were not encountered.

열적-알칼리성 전처리 유무에 따른 폴리하이드록시부티레이트의 고온 혐기성 소화 영향 연구 (Thermophilic Anaerobic Digestion of Polyhydroxybutyrate with and without Thermo-alkaline Pretreatment)

  • 이지현;이준엽
    • 한국환경과학회지
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    • 제33권2호
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    • pp.121-129
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    • 2024
  • The study investigated the effect of thermo-alkaline pretreatment on the solubilization of polyhydroxybutyrate (PHB) and its potential to enhance of thermophilic anaerobic digestion, focusing on biochemical methane potential (BMP) and methane production rate, using two different particle sizes of PHB (1500 ㎛ and 400 ㎛). Thermo-alkaline pretreatment tests were conducted at 90 ℃ for 24 hours with varying NaOH dosages from 0-80% (w/w). BMP tests with untreated PHB exhibited methane production ranging from 150.4~225.4 mL CH4/g COD and 21.5~24.2 mL CH4/g VSS/d, indicating higher methane production for smaller particle sizes of PHB, 400 ㎛. Thermo-alkaline pretreatment tests achieved a 95.3% PHB solubilization efficiency when 400 ㎛ PHB particles were treated with 80% NaOH dosage at 90 ℃ for 24 hours. BMP tests with pretreated PHB showed substantial improvement in thermophilic anaerobic digestion, with an increase of up to 112% in BMP and up to 168% in methane production rate. The results suggest that a combined pretreatment process, including physical (400 ㎛ PHB particles) and thermo-alkaline (90 ℃, 40-80% NaOH dosage, and 24 hours reaction time), is required for high-rate thermophilic anaerobic digestion of PHB with enhanced methane production.

슬러지 응집효율이 침강특성에 미치는 상관관계에 대한 연구 (Effective correlation between coagulation efficiency and the sludge settling characteristic)

  • 한기봉;윤지현
    • 유기물자원화
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    • 제14권1호
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    • pp.151-159
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    • 2006
  • 런던협약의 영향으로 슬러지 처리의 중요성이 대두되고 있는 실정이므로 본 연구는 슬러지 처리에 대한 개선방안의 제시를 목적으로 유기성 폐수 및 하수처리장 슬러지를 대상으로 JAR test 및 교반장치를 부착한 침강 column을 이용하여 응집효율이 침강특성에 미치는 영향에 대한 실험을 실시하였으며 다음과 같은 결과를 얻었다. 최적의 침강효율을 얻기 위한 최소의 응집제 투여농도는 200mg/L의 경우로 나타났으며. 200mg/L 이상으로 PAC가 투여될 경우 각각의 임계슬러지 영역의 크기에서는 큰 변화가 없는 것으로 나타났다. 따라서 200mg/L로 투여되었을 때의 Clarification Rate(CR)은 임계슬러지 침강높이 비율이 0.4로 나타났으므로 CR = (Ho-Ht) / Ho = 1-0.4=0.6 로 산정되었다. MLSS농도가 높아질수록 슬러지 계면 침강속도는 감소하였으나 MLSS농도가 1,000mg/l 이상으로 증가하면 오히려 침강속도는 증가하는 것으로 나타났다. 이는 슬러지 농도가 1,000mg/l 이상으로 증가하게 되면 압밀침전영역으로 전이되어 상호작용에 의한 응집에 영향을 미치게 됨으로써 오히려 floc 형성에 긍정적인 영향을 미치기 때문이다. 슬러지 응집계면의 침강속도는 유기폐수 활성슬러지의 평균 침강속도 $4.25{\times}10^{-3}/min$보다 하수처리장 슬러지의 평균 침강속도가 $28.66{\times}10^{-3}/min$로 6.7배 높은 것으로 나타났다. 유기성 폐수 활성슬러지는 PAC의 투여량이 200mg/l 이하일 때는 침강속도 증가율보다 CR의 증가율이 더 컸으나 200mg/l 이상일 때는 CR의 증가율보다 침강속도 증가율이 더 커졌음을 알 수 있었다. 그러나 하수슬러지의 경우는 PAC 투여량이 증가함에 따라 CR의 변화율에는 차이가 적었으나 침강속도는 200m/l 이상일 때 차이가 급격히 증가하였다. 따라서 응집제 투여효과는 상등수의 SS제거율 효과보다는 MLSS의 침강속도에 더 큰 영향을 미치는 것을 알 수 있다.

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상수처리시스템 응집제 주입공정 퍼지 모델링과 제어 (Fuzzy modeling and control for coagulant dosing process in water purification system)

  • 이수범;남의석;이봉국
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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    • pp.282-285
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    • 1996
  • In the water purification plant, the raw water is promptly purified by injecting chemicals. The amount of chemicals is directly related to water quality such as turbidity, temperature, pH and alkalinity. At present, however, the process of chemical reaction to the turbidity has not been clarified as yet. Since the process of coagulant dosage has no feedback signal, the amount of chemical can not be calculated from water quality data which were sensed from the plant. Accordingly, it has to be judged and determined by Jar-Test data which were made by skilled operators. In this paper, it is concerned to model and control the coagulant dosing process using jar-test results in order to predict optimum dosage of coagulant, PAC(Polymerized Aluminium Chloride). The considering relations to the reaction of coagulation and flocculation, the five independent variables(turbidity, temperature, pH, Alkalinity of the raw water, PAC feed rate) are selected out and they are put into calculation to develope a neural network model and a fuzzy model for coagulant dosing process in water purification system. These model are utilized to predict optimum coagulant dosage which can minimize the water turbidity in flocculator. The efficacy of the proposed control schemes was examined by the field test.

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Sensitivity of Lavender to Proton, Electron, and Gamma Radiation

  • Chen, Wensheng;Li, Hui;Shi, Lei;Bai, Hong Tong
    • 원예과학기술지
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    • 제34권1호
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    • pp.122-133
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    • 2016
  • While ion beams are widely used in plant breeding, little is known about the sensitivity of Lavandula angustifolia (lavender) to ionizing radiation. To compare the biological effects of different types of ionizing radiation on the germination and survival rates of lavender, we exposed lavender seeds to gamma rays, 3 MeV electron beams, and 1.89 MeV proton ion beams. We observed that the seed germination rate decreased with increasing dosages of all three types of ionizing radiation. The malformation rate of lavender seedlings exposed to electron beams and gamma rays increased with increasing radiation dosage. By contrast, the effect of the accelerated proton beams on the malformation rate was negatively correlated with the dosage used. The survival rate of lavender seedlings exposed to the three types of ionizing radiation decreased in a dose-dependent manner. In addition, the survival rate of seedlings irradiated with proton and electron beams decreased more slowly than did that of seedlings irradiated with gamma rays. The half-lethal dose of gamma rays, electron beams, and proton beams was determined to be 48.1 Gy, 134.3 Gy, and 277.8 Gy, respectively, and the most suitable proton-ion energy for lavender seeds in terms of penetration depth was determined to be 5 MeV. These findings provide valuable information for the breeding of lavender by radiation mutation.

세라믹 정밀여과막 공정을 위한 최적 응집조건 (Optimum Coagulation Conditions for Ceramic Microfiltration Membrane Process)

  • 임재림;이경혁;이영주;박종율
    • 멤브레인
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    • 제22권2호
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    • pp.135-141
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    • 2012
  • 본 연구는 Y 정수장의 세라믹 정밀여과막 공정을 위한 최적의 응집 조건을 도출하고자 수행되었다. 쟈테스트 결과 Y댐 원수의 pH를 7로 조정 시 응집효율이 가장 우수하였으며, 원수 탁도가 10 NTU 이하인 평상시 탁도 조건하에서 최적 응집제 주입량은 3 mg/L (as $Al_2O_3$)인 것으로 나타났다. 최적 응집제를 선정하기 위하여 응집제 종류(PAC, PACS (II), PAHCS)별로 미니모듈 실험장치를 이용하여 평가한 결과 PAC를 주입하고 원수 pH를 7로 조정한 경우 비여과유속 감소율이 가장 낮은 것으로 나타났다. 원수 탁도를 10~150 NTU로 변화시키며 미니모듈에서 비여과유속 감소율을 평가한 결과 원수탁도 10~30 NTU 조건에서는 응집제 주입량 증가에 따라 비여과유속 감소율이 크게 감소하였으나 원수탁도가 50 NTU 이상에서는 응집제 주입량을 증가시켜도 비여과유속 감소율에 큰 차이가 없는 것으로 나타났다. 따라서 Y 정수장을 위해서 는 원수탁도 10 NTU 이하에서는 PAC (11% as $Al_2O_3$) 30 mg/L, 10~50 NTU에서는 30~50 mg/L, 50 NTU 이상에서는 50 mg/L이 적절하다.

혐기성 소화조 오니의 탈수에 대한 요인분석 (A Study on Dewatering Characteristics of Anaerobic Digested Sludges)

  • 팽종인
    • 한국환경보건학회지
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    • 제8권2호
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    • pp.13-31
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    • 1982
  • Factors affecting on dewatering characteristics of anaerobically digested or/and elutriated sludges were examined from 15 January 1982 to 30 April 1982, results obtained were as follows 1. Sludges, either anaerobically digested or/and elutriated sludges, which were produced at the Joong Rang Cheon Sewage Treatment Plant wore found to be compressive in its nature, coefficient of compressibility ranged from 0.83 for unelutriated and 1.10 for elutriated. 2. Dosage of FeC13 for the anaerobically digested sludges were difficult to establish for the most favorable dosage rate, though the filterability indicated linear improvement with increased dosage from dosing rate excess of over 15% in terms of dry solids by weight, under the conditions of this examination. Optimum filterability were obtained with 9~11% of $FeCl_3$ for elutriated sludges, and required CaO, as aids, were appeared to be 2.5~3.5 times that of the $FeCl_3$ at that point by weight. 3. The specific resistances for anaerobically digested sludges showed higher value than the elutriated one, being $11 \times 10^{12} ~ 20 \times 10^{12}$ cm/g with no chemical conditioning, and $2 \times 10^{12} ~ 11 \times 10^{12}$ cm/g with conditioned ($FeCl_3$ + CaO) contrast to $0.5 \times 10^{12} ~ 2.0 \times 10cm/g$ for the elutriated. 4. The strength of the alkalinities before and after elutriation were measured to 10,000 ~ 15,000 mg/l and 1,500 ~ 2,000mg/l respectively. These alkalinities affected greatly on the filterabilities together with concentration of the organic matters in the sludges. 5. The yields with 11% $FeCl_3$, by weight to the DS, on the elutriated sludges averaged to $14.7 kg/m^2.hr$, and $3.2kg/m^2.hr$ for unelutriated sludges. Which was 4.6 times of not elutriated sludges. Elutriated sludges without chemical conditioner added showed much better filterabilities than with 15% of $FeCl_3$ added to the anaerobically digested and unelutriated sludges.

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염산에틸에프린의 마이크로캅셀에 관한 약제학적 연구 (Pharmaceutical Studies on Microencapsulated Etilefrine Hydrochloride)

  • 김종갑;최수일
    • Journal of Pharmaceutical Investigation
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    • 제16권1호
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    • pp.12-17
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    • 1986
  • Etilefrine hydrochloride was microencapsulated with ethylcellulose by phase separation method to develop a sustained release dosage form. The results of dissolution test carried out with various microcapsules showed that the drug release was decreased with increasing the particle size of microcapsules at a constant core to wall ratio, and with decreasing the core to wall ratio. Also ethylcellulose 50 cps and fast stirring rate (900 rpm) was better in decreasing the drug release than ethylcellulose 22 cps and slow stirring rate (300 rpm), respectively.

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시판 세제를 사용하여 세척 조건에 따른 인공오염포의 세척성 (The Soil Removal of Artificially Soiled Fabrics with Commercial Detergents at Various Washing Conditions)

  • 정혜원;김미경
    • 한국의류산업학회지
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    • 제9권6호
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    • pp.671-678
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    • 2007
  • Formulations of compact and supercompact heavy-duty detergents, which are being used widely around the world, differ from those of conventional heavy-duty detergents. Significant differences in composition exist between the compact detergents and the conventional detergents. The compact detergents have a higher content of surfactants, oxygen bleach and enzymes than the conventional detergents. We have studied to find the most effective washing conditions of artificially soiled cloths with a commercial, supercompact, heavy-duty detergent and a drum type washing machine which is becoming the preferred type in Korea. Moreover, we have studied the washing performance with an impeller type washing machine, which has heretofore been the most popular type in East Asia. With the drum-type washing machine, washing performances improved as the washing temperatures went up and the washing times were lengthened. Though the rate of soil removal with a double recommended dosage was higher than with the recommended amount at $20^{\circ}C$, the effects of the higher dosage decreased as the washing temperatures increased. Finally, the washing performances with the two different dosages were the same at $60^{\circ}C$. The washing performances at $40^{\circ}C$ with the recommended dosage for 90 minutes were the same as with the double recommended dosage for 45 minutes. The soil removal efficiencies with the impeller-type washing machine were much lower than those of the drum-type washing machine. The reasons for this were the higher bath ratio that led to the lower concentration of wash liquor, the shorter washing time, and the lower washing temperature.

MBR반응기의 막오염방지를 위한 활성탄과 응집제를 이용한 전처리에 관한 연구 (Using Coagulant and Activated Carbon as Pretreatment for Membrane Fouling Control in MBR (Membrane Bioreactor))

  • 김동하
    • 상하수도학회지
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    • 제20권1호
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    • pp.122-127
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    • 2006
  • The aim of this study was to investigate the characteristics of membrane fouling caused by soluble organic materials in a membrane bioreactor process. For the removal of filterable organic materials (FOC) smaller than $1{\mu}m$, coagulants and activated carbon were added. A membrane bioreactor using a submerged $17{\mu}m$ metal sieve was operated in laboratory scale to examine the possibility of membrane fouling control. As the dosage of GAC and coagulant increased, the residual FOC concentration decreased and the permeate flow rate increased markedly. The permeate flux increased with an increased PACl addition at the range from 0 to 50 mg/l. At coagulant dosage of 27mg/l, the removal of FOC was about 46% and the flux increased to 3.5 times compared to the case without PACl addition. The permeate flux increased gradually with an increase in GAC dosage. At GAC dosage of 50mg/L, the permeate flux was about 2 times higher compared that for raw water. The particle in the range of $0.1{\sim}1.0{\mu}m$ were removed effectively by the addition of GAC and coagulant. Higher osage of GAC and coagulant, led to higher removal of FOC. A different set of experiments was also performed to investigate the effect of pretreatment on the permeation ability of MBR system using the metal sieve membrane. After 40 hours of operation, the permeate flux was about 1,000 ($L/m^2-hr$), which is 20 times higher compared to the results in literature. It is likely that combined pretreatment using coagulant and activated carbon was the most effective to resolve membrane fouling problems. Moreover, the continuous operations could be successful by applying this pretreatment method.