• The Journal of Internal Korean Medicine
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• v.19 no.2
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• pp.159-184
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• 1998

The aim of the study was the experiment of the effect that Kami-Daesihotang had on the essential hypertension and hyperlipidemia. Rats were orally administered with Kami-Daesihotang for 30days and the constituent of the plasma and serum were analysed at the 10th, 20th and 30th day from the first day of experiment, respectively. The heart rate, blood pressure, plasma renin activity, plasma level of aldosterone, catecholamine, sodium and angiotensin II were measured after an oral administration of Kami-Daesihotang in SHR. In addition, serum levels of total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and total lipid were measured with cholesterol-fed rats. The results were summarized as following ; 1. Single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang remarkably decreased the blood pressure in SHR. 2. Double-dosage Kami-Daesihotang were recognized as having the effect on the decreased of the pulse rate in SHR. 3. Plasma renin activity was significantly decreasd in SHR after single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang treatment. 4. Double-dosage Kami-Daesihotang considerably reduced the plasma angiotensin level in SHR. 5. Noticeable decreased of plasma norepinephrine level was showed in SHR, after single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang treatment. 6. Single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang noticeable reduced body weight in hyperlipidemia rats which had fed with 1% cholesterol. 7. Single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang had a significantly decreasing effect on serum total cholesterol in hyperlipidemia rats which had fed with 1% cholesterol. 8. Serum triglyceride level was importantly decreased in hyperlipidemia rats which had fed with 1% cholesterol, after single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang treatment. 9. Remarkable decreased of serum low density lipoprotein cholesterol level was found in hyperlipidemia rats which had fed with 1% cholesterol, after single-dosage Kami-Daesihotang & double-dosage Kami-Daesihotang treatment. 10. Double-dosage Kami-Daesihotang was showed a significantly decreasing effect on serum total lipid level in hyperlipidemia rats which had fed with 1% cholesterol. 11. Single-dosage Kami-Daesihotang noticeably reduced organ weight of liver, kidney, spleen and testis in hyperlipidemia rats which had fed with 1% cholesterol. Double-dosage Kami-Daesihotang significantly decreased organ weight of liver, kidney and spleen in hyperlipidemia rats. These Findings suggest a possible anti-hypertensive and hyperlipidemic effect of Kami-Daesihotang.

• Journal of Korean Society on Water Environment
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• v.27 no.2
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• pp.188-193
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• 2011

The effects of coagulants on the microorganisms when they are injected directly into the biological treatment facility for T-P removal have been easily observed from the results of past experiments. As such this study is set out to derive the effective plans for the coagulant dosage by analyzing the effects of the injected coagulant on the microbial activity during the chemical treatment for T-P removal. The research methods entailed the assessment of removal efficiency of T-P according to the coagulant dosage while changing the molar ration between Alum and influent phosphorus. At the same time Specific Oxygen Uptake Rate (SOUR) according to the coagulant dosage was measured. SOUR was used as a method for indirect assessment of the microbial activity according to the coagulant dosage. The results from the study showed that with the increase in the alum dosage, the removal efficiency T-P tended to increase. On the other hand, the increase in coagulant dosage resulted in the decrease in SOUR, which indicates the decrease in the microbial activity. Such reduction in the activity could be explained by the increase in the concentration of removal efficiency of $TBOD_5$. Based on experiment results from the study, it is determined that coagulant dosage affects the microbial activity. Moreover, the indirect assessment on the microbial activity using SOUR is considered possible.

• Journal of Korean Society of Water and Wastewater
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• v.27 no.1
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• pp.49-58
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• 2013

A selected halogenated organic contaminant, monochlorophenol was successfully degraded by photocatalytic reaction in a circulating batch system. The photocatalytic degradation in most cases follows first-order kinetics. The photocatalytic reaction rate increased in the $TiO_2$ dosage range of 0.1 g/L to 0.4 g/L, then decreased with further increase of the dosage. Also the degradation rate increased over the range of the retention time from 0.49 min. to 0.94 min., then decreased with further increase of the retention time in the circulating batch reactor. The photocatalytic activity was enhanced by addition of metal impurities, platinum(Pt) and palladium(Pd) onto the photocatalysts. The photocatalytic degradation rate increased with the increase of Pt and Pd in the content range of 0 to 2wt %, then decreased with further increase of the metal contents. Therefore the metal loading to $TiO_2$ influence the degradation rate of a halogenated organic compound by acting as electron traps, consequently reducing the electron/positive hole pair recombination rate.

• Journal of the Korean Institute of Intelligent Systems
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• v.25 no.4
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• pp.369-376
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• 2015

Chemicals are injected in order to remove a variety of organic substances contained in the water purification plant influent. It can be determined with measuring sedimentation turbidity 4~7 hours later, whether the chemical dosage rate is proper or not, which make the real-time feedback control impossible. In addition, manual operation in accordance with the Jar-Test carried out in the laboratory and the operator's experience may cause the experimental and human error by the changes of organic characteristics and water quality. Especially at night ad weekend, the rate have been determined only by the operator judgment owing to environment engineer's absence. Therefore, the decision of optimal chemical dosage rate using proposed intelligent control algorithm is expected to result in real-time injection and cost reduction.

• Journal of environmental and Sanitary engineering
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• v.15 no.2
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• pp.58-64
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• 2000

The photocatalytic removal of Ag(I) in water by $TiO_2$ at a various conditions, which are initial Ag(I) concentration, circulation flow rate, $TiO_2$ dosage and methanol concentration, was studied. A continuous flow system with a circular type reactor of the TiO2 suspensions with UV light through an photoreactor column was applied. The major results of this study were as follows; 1. First order kinetics was observed from the result at different initial concentration of Ag(I). As the initial Ag(I) concentration was incereased, the reaction rate was decreased. 2. The removal efficiency of Ag(I) increased with increasing the circulation flow rate and $TiO_2$ dosage. However, over $4{\ell}/min$ of circulation flow rate and $1.5g/{\ell}$ of $TiO_2$ dosage, increasing of the efficiency reached a plateau. 3. The addition of methanol as hole scavenger enhanced the removal efficiency of Ag(I) but the removal efficiency reached a plateau over some level of methanol. 4. It was found that $TiO_2$ photocatalysis was effective method to remove of Ag(I) from aqueous solution.

• Journal of Pharmacopuncture
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• v.13 no.3
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• pp.15-46
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• 2010

Objectives: This study was performed to analyse the effects of Sweet Bee Venom(Sweet BV) on cardiovascular system in the conscious telemetered Beagle Dogs. Methods: All experiments were conducted at Biotoxtech Company, a non-clinical studies authorized institution, under the regulations of Good Laboratory Practice (GLP). Male Beagle dogs of 13-19 months old were chosen for the pilot study and surgical implantation was performed for conscious telemetered Beagle dogs. And after confirming condition of Beagle dogs was stable, Sweet BV was administered 4 times(first: 0.0 mg/kg, 2nd: 0.01 mg/kg, 3rd: 0.1 mg/kg, and forth: 0.5 mg/kg, one time/week) in thigh muscle of Beagle dogs. And blood pressure, heart rate, electrocardiography and clinical responses were measured. Equal amount of normal saline to the Sweet BV experiment groups was administered to the control group. Results: 1. In the analysis of body weight and taking amount, Beagle dogs did not show significant changes. 2. In the clinical observation, responses of pain and edema were showed depend on dosage of Sweet BV. 3. In the analysis of blood pressure, treatment with Sweet BV did not show significant changes in the dosage of 0.01 mg/kg, but in the dosage of 0.1 mg/kg and 0.5 mg/kg, treatment with Sweet BV increased blood pressure significantly. 4. In the analysis of heart rate, treatment of Sweet BV did not show significant changes in all dosage and period. 5. In the analysis of electrocardiography, treatment of Sweet BV was not showed significant changes in all dosage and period. Conclusion: Above findings suggest that Sweet BV is relatively safe treatment in the cardiovascular system. But in the using of over dosage, Sweet BV may the cause of increasing blood pressure. Further studies on the subject should be conducted to yield more concrete evidences.

• Journal of Korean Academy of Nursing
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• v.42 no.5
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• pp.689-698
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• 2012

Purpose: This study was done to develop and evaluate a drug dosage calculation training program using cognitive loading theory based on a smartphone application. Calculation ability, dosage calculation related self-efficacy and anxiety were measured. Methods: A nonequivalent control group design was used. Smartphone application and a handout for self-study were developed and administered to the experimental group and only a handout was provided for control group. Intervention period was 4 weeks. Data were analyzed using descriptive analysis, ${\chi}^2$-test, t-test, and ANCOVA with the SPSS 18.0. Results: The experimental group showed more 'self-efficacy for drug dosage calculation' than the control group (t=3.82, p<.001). Experimental group students had higher ability to perform drug dosage calculations than control group students (t=3.98, p<.001), with regard to 'metric conversion' (t=2.25, p =.027), 'table dosage calculation' (t=2.20, p =.031) and 'drop rate calculation' (t=4.60, p<.001). There was no difference in improvement in 'anxiety for drug dosage calculation'. Mean satisfaction score for the program was 86.1. Conclusion: These results indicate that this drug dosage calculation training program using smartphone application is effective in improving dosage calculation related self-efficacy and calculation ability. Further study should be done to develop additional interventions for reducing anxiety.

• Journal of Environmental Health Sciences
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• v.19 no.2
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• pp.1-9
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• 1993

In public water supply systems, Alum and/or PAC being used as a coagulant. It is well known that their use increased frequently the concentration of residual aluminum in filtered water upon operating conditions. This study was conducted to find the optimum conditions that both the concentration of residual aluminum and turbidity are minimized by changing such factors as pH, temperature, alum dosage, mixing rate, alkalinity and hardness. The results can be summarized as follows: The pH values for the minimum concentration of residual aluminum and turbidity as a given experimental condition were found at pH 6 and pH 7 respectively, the apparent clarity was best at pH 8. The floc settling rate was the greatest at pH 6.5, but the turbidity was high at the same condition. The more alum dosage, the higher the concentration of residual aluminum. However the alum dosage less than 15 mg/l tend to decrease in turbidity. Restabilization and enmeshment occurred near 15 mg/l and 20 mg/l of alum dose respectively. With the increase of mixing rate (rapid and slow), the concentration of residual aluminum and turbidity are increased and the same trend was found in increment of mixing time. At low water temperature, the concentration of residual aluminum was decreased, but turbidity was increased. It was confirmed that alkalinity had an effect on the coagulation efficiency, but hardness did not.

• Korean Journal of Clinical Pharmacy
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• v.9 no.2
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• pp.92-96
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• 1999

The pharmacokinetics of carbamazepine(100 mg/kg, oral) in the folic acid-induced renal failure rabbits was studied. Renal failure was induced by the i.v. injection of folic acid (50, 100, and 200 mg/kg). At folic acid dose of 100 and 200 mg/kg, the serum creatinine concentration (Scr) and blood urea nitrogen (BUN) increased significantly compared with control rabbits. Plasma concentrations and area under the plasma level-time curve (AUC) of carbamazepine increased significantly at folic acid dose of 100 and 200 mg/kg. The elimination rate constant (Kel) of carbamazepine decreased significantly, and half-life $(t_{1/2})$ of carbamazepine increased significantly at folic acid dose of 100 and 200 mg/kg. The serum creatinine concentration (Scr) correlated well with AUC and elimination rate constant (Kel) of carbamazepine, as well as BUN with AUC and elimination rate constant (Kel) of carbamazepine. These results suggest that adjustment of the dosage regimen of carbamazepine is desirable, and serum creatinine concentration (Scr) as well as BUN can be used for adjusting the dosage regimen of carbamazepine in renal failure.

• Journal of Korean Society of Water and Wastewater
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• v.23 no.2
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• pp.207-214
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• 2009

This study examines the optimum filtration conditions in pretreatment of seawater desalination by reverse osmosis. For this purpose, Masan bay seawater is treated through a gravity filter column while $FeCl_3$ is added as coagulant. The conditions of coagulantd osage, media depth, filtration rate, and backwash time are evaluated. The study results show that the filtrate quality improved with increasing coagulant dosage, but head loss rapidly increased. After 4mg/L, the unit filter run volume reduced to less than $200m^3/m^2$. Considering the head loss development, 4mg/L is determined as the optimum dosage. The better filtrate qualities are obtained with depth of 100cm than that of 80cm. The two stage filtration, which outperformed the single stage filtration, is suggested for treatment of Masan bay. The filtration rate of 5m/h is decided as the optimum condition considering the head loss development. At 10m/h, the filtrate quality deteriorated even though the extent was minimal, and head loss increased rapidly. The backwash time of 10 min is decided appropriate.