• Journal of Chest Surgery
• /
• v.54 no.4
• /
• pp.239-245
• /
• 2021

Video-assisted thoracoscopic surgery (VATS) has been established as the surgical approach of choice for lobectomy in patients with early-stage non-small cell lung cancer (NSCLC). Patients with clinical stage I NSCLC with no lymph node metastasis are considered candidates for VATS lobectomy. To rule out the presence of metastasis to lymph nodes or distant organs, patients should undergo meticulous clinical staging. Assessing patients' functional status is required to ensure that there are no medical contraindications, such as impaired pulmonary function or cardiac comorbidities. Although various combinations of the number, size, and location of ports are available, finding the best method of port placement for each surgeon is fundamental to maximize the efficiency of the surgical procedure. When conducting VATS lobectomy, it is always necessary to comply with the following oncological principles: (1) the vessels and bronchus of the target lobe should be individually divided, (2) systematic lymph node dissection is mandatory, and (3) touching the lymph node itself and rupturing the capsule of the lymph node should be minimized. Most surgeons conduct the procedure in the following sequence: (1) dissection along the hilar structure, (2) fissure division, (3) perivascular and peribronchial dissection, (4) individual division of the vessels and bronchus, (5) specimen retrieval, and (6) mediastinal lymph node dissection. Surgeons should obtain experience in enhancing the exposure of the dissection target and facilitating dissection. This review article provides the basic principles of the surgical techniques and practical maneuvers for performing VATS lobectomy easily, safely, and efficiently.

• Korean Journal of Head & Neck Oncology
• /
• v.16 no.2
• /
• pp.206-211
• /
• 2000

Objectives: Any uptake of I-131 after total thyroidectomy means the remant thyroid tissue or distant metastasis of the thyroid cancer. However diffuse hepatic uptake of I-131 without abnormal uptake was showen in many cases on I-131 whole body scan. The aim of this study was to classify the liver uptake after I-131 scan and to evaluate the analysis of this finding. Materials and Methods: Between 1982 and 1998, 104 patients(l4 males, 90 females) with normal liver function underwent I-131 scan after total thyroidectomy. Prospectively we reviewed the films of the whole body scan and analysed the correlations between results of radioiodine uptake, pathologic diagnosis, prognostic factors, lymphatic metastasis, and thyroid function test. Result: Diffuse hepatic uptake was found in 44 of 104(42%) patients. 10 of 39(26%) patients on I-131 100mCi, and 34 of 63(54%) on I-131 150mCi showed hepatic uptake. 52 of 104(50%) patients was locally invasive thyroid cancer. The rate of the hepatic uptake was no significant differences with the thyroid hormone levels(T3, Free T4) and thyroglobulin between uptake group and non-uptake group. Conclusion: The rate of I-131 uptake was high in high-dose radioiodine treatment group. However, we can not find any correlation among the thyroid functions, the extent of metastasis or the extent of local invasion. We need further study to find out the causes of the hepatic uptake of I-131 after total thyroidectomy, besides liver metabolism of I-131 attached thyroid hormones.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.47 no.3
• /
• pp.39-49
• /
• 2010

Ad hoc network is infrastructureless network, that the network topology is configured by each node. Each node capacity device function namely, accomplishes a network control and a function of management because not being Network device of the exclusively. Ad hoc networks what kind of node join or leave the network topology to facilitate the expansion of arbitrary topology, to the case which is the distance whose traffic is distant the place must overtake through the route of intermediate nodes, like these facts give an effect to performance fluctuation. Consequently, each node in order to maintain traffic of oneself stably there is a necessity which will consider traffic and congestion control from the node which traffic of a condition and oneself of traffic of the circumference and the route which compose the network will overtake through. This paper assumes the path of the band with a finite resource, and path traffic to occupy the competition and its impact on transmission performance of these competing arguments to configure the model factor to analyse the performance impact on the results presented. Like this result with the fact that from the study, it will contribute in network management policy and the technique.

• Archives of Plastic Surgery
• /
• v.40 no.3
• /
• pp.238-243
• /
• 2013

Background Primary malignant tumors of the hand, although unusual, may present varied and often complex clinical problems. The main treatment modality of skin cancer of the hand has changed. Methods We retrospectively reviewed the medical records of 43 patients who underwent surgery for malignant skin tumors of the hand during an 18-year period, from September 1994 to February 2012. The characteristics of the tumor, methods of reconstruction, and long-term results were reviewed. Results We had 43 patients with 27 melanomas, 14 squamous cell carcinomas, and 2 sarcomas. Their ages ranged from 19 to 74 years (mean, $53.4{\pm}14.5$ years), from 46 to 79 years (mean, $59.7{\pm}9.6$ years), and from 15 to 43 years (mean, $29{\pm}19.8$ years), respectively. Thirty-four cases occurred on the fingertip (16 of those cases on the thumb), 5 cases occurred on the palm, and 4 cases on the dorsum of the hand. Amputation was most frequently used in early cases, but recently, tissue-sparing excision has been performed frequently. The incidence of local recurrence was 3 cases and distant metastasis was 1 case, and the 5-year survival rate was 100%, except in 4 cases due to follow-up loss. Conclusions The principles of treatment-to be curative and to preserve function and appearance-are important points. "Preservative surgery" preserves function and cosmesis of the involved finger or hand dorsum or palm. Preservative surgery not only emphasizes less resection and surgery of a smaller scale, but also optimal reconstruction of the soft tissue defect of the digit.

• Radiation Oncology Journal
• /
• v.35 no.1
• /
• pp.55-64
• /
• 2017

Purpose: The outcomes and toxicities of locoregionally recurrent non-small-cell lung cancer (NSCLC) patients treated with curative radiotherapy were evaluated in the modern era. Materials and Methods: Fifty-seven patients receiving radical radiotherapy for locoregionally recurrent NSCLC without distant metastasis after surgery from 2004 to 2014 were reviewed. Forty-two patients were treated with concurrent chemoradiotherapy (CCRT), and 15 patients with radiotherapy alone. The median radiation dose was 66 Gy (range, 45 to 70 Gy). Lung function change after radiotherapy was evaluated by comparing pulmonary function tests before and at 1, 6, and 12 months after radiotherapy. Results: Median follow-up was 53.6 months (range, 12.0 to 107.5 months) among the survivors. The median overall survival (OS) and progression-free survival (PFS) were 54.8 months (range, 3.0 to 116.9 months) and 12.2 months (range, 0.8 to 100.2 months), respectively. Multivariate analyses revealed that single locoregional recurrence focus and use of concurrent chemotherapy were significant prognostic factors for OS (p = 0.048 and p = 0.001, respectively) and PFS (p = 0.002 and p = 0.026, respectively). There was no significant change in predicted forced expiratory volume in one second after radiotherapy. Although diffusing lung capacity for carbon monoxide decreased significantly at 1 month after radiotherapy (p < 0.001), it recovered to pretreatment levels within 12 months. Acute grade 3 radiation pneumonitis and esophagitis were observed in 3 and 2 patients, respectively. There was no chronic complication observed in all patients. Conclusion: Salvage radiotherapy showed good survival outcomes without severe complications in postoperative locoregionally recurrent NSCLC patients. A single locoregional recurrent focus and the use of CCRT chemotherapy were associated with improved survival. CCRT should be considered as a salvage treatment in patients with good prognostic factors.

• Journal of Korean Ophthalmic Optics Society
• /
• v.13 no.2
• /
• pp.59-62
• /
• 2008

Purpose: This study was designed to investigate the time-dependent changes of visual acuity after alcohol ingestion. Methods: Both the subjective and objective refraction, distant contrast sensitivity, and three needle tests were carried out at 1 and 3 hours after alcohol ingestion. Results: It was found that the degree of myoptization increased as the blood alcohol level increased in the range of average -0.25D ~ -0.35D when tested 1 and 3 hours after alcohol ingestion. Under the same test conditions the increase in blood alcohol resulted in the reduction in the function of dynamic stereopsis. However, the variation in contrast sensitivity was found to be insignificant for all spatial frequencies. Conclusions: The optician has to be well aware of the fact that alcohol could affect the visual acuity and functional tests, therefore inquiring of the alcohol ingestion prior to visual test can be necessary.

• The Bulletin of The Korean Astronomical Society
• /
• v.37 no.2
• /
• pp.98.2-98.2
• /
• 2012

We firstly present the unified Far-UV continuum map of the Taurus-Auriga-Perseus (TPA) complex, one of the largest local associations of dark cloud located in (l, b)=([154,180], [-28, -2]), by merging both FIMS and GALEX. The FUV continuum map shows that dust extinction correlate well with the FUV around the complex. It shows strong absorption in FUV toward the dense Taurus cloud while it does not in California cloud. It turned out that it is related to the relative location of each cloud and Perseus OB2 association. We also present some results of dust scattering simulation based on Monte Carlo Radiative Transfer technique (MCRT). Through this dust scattering simulation, we have derived the scattering parameter for this region, albedo(a)=$0.42^{+0.05}{_{-0.05}}$, asymmetry factor(g)=$0.47^{+0.11}{_{-0.27}}$. The optical parameters we obtained seem reasonable compared to the theoretical model values ~0.40 and ~0.65 for the albedo and the phase function though the phase function is rather small. Using the result of simulation, we figured out the geometries of each cloud in the complex region, especially their distances and thicknesses. Our predictions from the results are in good agreement with the previous studies related to the TPA complex. For example, the Taurus cloud is within ~200pc from the Sun and the Perseus seems to be multi-layered, at least two. The California cloud is more distant than the other cloud on average at ~350 pc and Auriga cloud seems to be between the Taurus cloud and the eastern end of the California cloud. We figured out that across the TPA complex region, there might be some correlation between the LSR velocity and the distance to each cloud in the complex.

• Journal of Microbiology and Biotechnology
• /
• v.29 no.1
• /
• pp.141-150
• /
• 2019

The spatial landmark protein Bud8 plays a crucial role in bipolar budding in the budding yeast Saccharomyces cerevisiae. The unconventional yeast Yarrowia lipolytica can also bud in a bipolar pattern, but is evolutionarily distant from S. cerevisiae. It encodes the protein YALI0F12738p, which shares the highest amino acid sequence homology with S. cerevisiae Bud8, sharing a conserved transmembrane domain at the C-terminus. Therefore, we named it YlBud8. Deletion of YlBud8 in Y. lipolytica causes cellular separation defects, resulting in budded cells remaining linked with one another as cell chains or multiple buds from a single cell, which suggests that YlBud8 may play an important role in cell separation, which is distinct from the function of Bud8 in S. cerevisiae. We also show that the YlBud8-GFP fusion protein is located at the cell membrane and enriched in the bud cortex, which would be consistent with a role in the regulation of cell separation. The coiled-coil domain at the N-terminus of YlBud8 is important to the correct localization and function of YlBud8, as truncated proteins that do not contain the coiled-coil domain cannot rescue the defects observed in $Ylbud8{\Delta}$. This finding suggests that a new signaling pathway controlled by YlBud8 via regulation of cell separation may exist in Y. lipolytica.

• The Journal of the Korean bone and joint tumor society
• /
• v.1 no.2
• /
• pp.154-163
• /
• 1995

With the development of anticancer chemotherapy and improved radiographic imaging studies, limb salvage operation became possible in the treatment of malignant and aggressive benign tumors. High grade sarcomas of the shoulder or the upper extremity can be surgically treated with a forequarter amputation, shoulder disarticulation or limb salvage surgery such as Tikhoff-Linberg procedure, segmental resection and replacement with endoprosthesis, segmental resection and replantation, or segmental resection and free vascularized bone graft. Among them the limb salvage surgery showed not only preservation of the remained upper extremity but also the excellent functional results. When comparing amputation and limb salvage operation while performing anticancer chemotherapy in both cases, 5 year survival rate, local recurrence, and distant metastasis did not show much difference. We studied 13 cases of limb salvage for the malignant and aggressive benign bone tumor of the upper extremity from March 1986 to December 1993 at Severance hospital. The summarized results were as follows. 1. There were 21 cases of malignant bone tumors and 5 cases of benign aggressive ones. 2. Of the 26 cases of malignant and benign aggressive bone tumors, limb salvage procedures such as Tikhoff-Linberg operation(8 cases), endoprosthetic replacement(2 cases), segmental resection and replantation(2 cases), and segmental resection and free vascularized fibular graft(l case) were done in 13 cases. 3. In 13 patient on whom the limb salvage procedure was performed, there were 3 osteosarcomas, 4 chondrosarcomas, 3 giant cell tumors, 1 Ewing's sarcoma, 1 leiomyosarcoma and 1 chondroblastoma. 4. In 13 patients, there was no local recurrence nor distant metastasis except one who had a segmental resection of the entire humerus part including glenoid and then postoperative anticancer chemotherapy for the treatment of the Ewing's sarcoma of the entire shaft of the humerus with pathological fracture. Local recurrence occurred 2 years and 6 months postoperatively in this Ewing's sarcoma patient, so forequarter amputation was performed and the irradiation and the anticancer chemontherapy were performed, but multiple bony metastasis developed and died of the disease 22 months after local recurrence. 5. The patients were followed-up for I year to 7 years and 5 months(average 4 years 5 months). 6. In 8 cases in which Tikhoff-Linberg procedure was performed, the function of the hand was almost normal. 7. Segmental resection and endoprosthetic replacement was performed in 2 cases, and the function of the remained upper extremity was good with no evidence of aseptic loosening or nerve palsy. 8. In 1 case of segmental resection and free vascularized fibular graft for the patient of the chon drosarcoma in the humerus, the function of the shoulder, elbow and hand was nearly normal. 9. In I case of leiomyosarcoma which involved both forearm muscles and bone near wrist joint, segmental resection and replantation was performed, and the patient has useful hand function.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.34 no.4
• /
• pp.1125-1138
• /
• 2014

In this study, we applied an advanced non-parametric low-flow frequency analysis using boundary kernel by Representative Concentration Pathways (RCPs) climate change scenarios through Arc-SWAT long-term runoff model simulation at the Gwangdong storage reservoir located in Taeback, Gangwondo. The results show that drought frequency under RCPs was expected to increase due to reduced runoff during the near future, and the variation of low-flow time series was appeared greatly under RCP8.5 scenario, respectively. The result from drought frequency of Median flow in the near future (2030s) compared historic period, the case of 30-year low-flow frequency was increased (the RCP4.5 shows +22.4% and the RCP8.5 shows +40.4%), but in the distant future (2080s) expected increase of drought frequency due to the reduction of low-flow (under RCP4.5: -4.7% and RCP8.5: -52.9%), respectively. In case of Quantile 25% flow time series data also expected that the severe drought frequency will be increased in the distant future by reducing low-flow (the RCP4.5 shows -20.8% to -60.0% and the RCP8.5 shows -30.4% to -96.0%). This non-parametric low-flow frequency analysis results according to the RCPs scenarios have expected to consider to take advantage of as a basis data for water resources management and countermeasures of climate change in the mid-watershed over the Korean Peninsula.