• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.7 no.4
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• pp.328-335
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• 1996

The numerical dispersive characteristics and the numerical stability confition of the Multi-Resolution Time-Domain(MRTD) method are calculated. A dispersion analysis of the MRTD schemes including a comparison to Yee's Finite-Difference Time-Domain(FDTD) method is given. The superiority of the MRTD method to the spatial discretization is shown. The required computational memory can be reduced by using the MRTD method. We expect that the MRTD method will be very useful method for numerical modelling of electromagnetics.

• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.185-190
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• 2002

To improve the solubility of poorly water-soluble drug and to develop a sustained release tablets, the need for the technique, the formation of solid dispersion with polymeric materials that can potentially enhance the dissolution rate and extent of drug absorption was considered in this study. The 1:1, 1:4, and 1:5 solid dispersions were prepared by spray drying method using PVP K30, ethanol and methylene chloride. The dissolution test was carried out at in phosphate buffer solution at $37^{\circ}C$ in 100 rpm. Solid dispersed drugs were examined using differential scanning calorimetry and scanning electron microscopy, wherein it was found that felodipine is amorphous in the PVP K30 solid dispersion. Felodifine SR tablets were prepared by direct compressing the powder mixture composed of solid dispersed felodipine, lactose, Eudragit and magnesium stearate using a single punch press. In order to develop a sustained-release preparation containing solid dispersed felodipine, a comparative dissolution study was done using commercially existing product as control. The dissolution rate of intact felodipine, solid dispersed felodipine and its physical mixture, respectively, were compared by the dissolution rates for 30 minutes. The dissolution rates of felodipine for 30 minutes from 1:1, 1:4, 1:5 PVP K30 solid dispersion were 70%, 78% and 90%. However, dissolution rate offelodipine from the physical mixture was 5% of drug for 30 minutes. Our developed product Felodipine SR Tablet showed dissolution of 17%, 50% and 89% for 1, 4, and 7 hours. This designed oral delivery system is easy to manufacture, and drug releases behavior is highly reproducible and offers advantages over the existing commercial product. The dissolution rate of felodipine was significantly enhanced, following the formation of solid dispersion. The solid dispersion technique with water-soluble polymer could be used to develop a solid dispersed felodipine SR tablet.

• Journal of the Korean Ceramic Society
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• v.42 no.8 s.279
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• pp.561-566
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• 2005

For the homogeneous dispersion of $ZrO_2$ particles in $Al_2O_3/ZrO_2$ceramics, Zr-precusors were mixed with oxide $Al_2O_3$powders by chemical routes such as partial precipitation or partial polymerization of Zr-nitrate solutions. In case of the mechanical mixing of ultrafine $Al_2O_3$ and $ZrO_2$ oxide powders, relatively homogeneous dispersion was difficult to achieve so that the particle size and distributions of $ZrO_2$ were relatively inhomogeneous after sintering at high temperature. But when the Zr-Y-hydroxide were co-precipitated to ultrafine $Al_2O_3$ oxide powders followed by calcinations, homogeneous dispersion of nano-sized $ZrO_2$ particles in $Al_2O_3/ZrO_2$ composite ceramics were obtained. But because of the coalescence of dispersed $ZrO_2$ particles, dispersed $ZrO_2$ was grown up to more than 0.2${mu}m$ (200 nm) when sintered at the temperature of higher than $1500^{\circ}C$ But when the sintering temperature was kept to lower than $1400^{\circ}C$ by using nano-sized $\alpha-alumina$, the particle size of dispersed $ZrO_2$ could be sustained below 0.1 ${\mu}m$. But the coalescence of dispersed $ZrO_2$ between $Al_2O_3$ particles could not be avoided so that the mechanical properties were not enhanced contrary to the expectations. So Zr-polyester precursors were precipitated and coated to the surface of ultrafine $\alpha-alumina$ powders by the polymerization of Ethylene Glycol with Citric Acid and Zirconium Nitrate. By this dispersion much more uniform dispersion of $ZrO_2$ was achieved at $1450\~1600^{\circ}C$ of sintering temperature ranges. And due to especially discrete dispersion of $ZrO_2$ between $Al_2O_3$ particles, their mechanical strength was more enhanced than mechanical mixing or hydroxide precipitation methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.5A
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• pp.473-483
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• 2004

In this paper, we numerically investigated the optimum pump light power best compensating for pulse distortion due to both chromatic dispersion and self phase modulation (SPM) as a function of channel input power in 8 channel ${\times}$ 40 Gbps wavelength division multiplexing (WDM systems. Also we investigated the allowable maximum channel input power dependence on modulation format and fiber dispersion coefficient in the various pump light power of OPC. The considered WDM transmission system is based on path-averaged intensity approximation (PAIA) mid-span spectral inversion (MSSI) compensation method, which has highly-nonlinear dispersion shifted fiber (HNL-SDF) as nonlinear medium of optical phase conjugator (OPC) in the mid-way of total transmission line. We confirmed that optimal pump light power of HNL-DSF OPC depend on modulation format, initial channel input power, total transmission length and fiber dispersion. But optimal pump light power of HNL-DSF OPC must be selected to make power conversion ratio to almost unity. And we confirmed that, if we allow a 1 dB eye opening penalty (EOP), the tolerable maximum channel input power is increased by using RZ than NRZ as modulation format when pump light power of HNL-DSF OPC is not optimal value but another values.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.11
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• pp.1065-1075
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• 2017

In this study, high velocity impact tests along with modeling of material behavior and numerical analyses were conducted to predict the dispersion behavior of the debris resulting from a high velocity impact fracture. For the impact tests, two different materials were employed for both the projectile and the target plate - the first setup employed aluminum alloy while the second employed steel. The projectile impacts the target plate with a velocity of approximately 1 km/s were enforced to generate the impact damages in the aluminum witness plate through the fracture debris. It was confirmed that, depending on the material employed, the debris dispersion behavior as well as the dispersion radii on the witness plate varied. A numerical analysis was conducted for the same impact test conditions. The smoothed particle hydrodynamics (SPH)-finite element (FE) coupled technique was then applied to model the fracture and damage upon the debris. The experimental and numerical results for the diameters of the perforation holes in the target plate and the debris dispersion radii on the witness plate were in agreement within a 5％ error. In addition, the impact test using steel was found to be more threatening as proven by the larger debris dispersion radius.

• Korean Journal of Soil Science and Fertilizer
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• v.13 no.2
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• pp.65-70
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• 1980

This experiment was aimed at selecting the most suitable dispersing agent to the Korean soils. The particle size distribution of 18 soil samples representing the great soil groups in Korea was analysed with 5 different dispersing agents by pipette-method. Passing percent of 0.05, 0.02 and 0.002mm in diameter was used for the comparision of the dispersion capacity of chemical agents. The results obtained are as follows; 1. The influence of chemical agents on dispersion seemed to be greater to finer soil particles. The passing percents of 0.002mm showed a great differences according to the chemical agents used, while little differences was observed in those of 0.05mm. 2. It was showed that sodium pyrophosphate had the highest dispersion capacity for the most of Korean soils, the dispersion capacity of sodium hexametaphosphate was also high enough except for volcanic ash soils. 3. It was recommendable that sodium hexametaphosphate could widely be used as a dispersing agent in the routine analysis of soil particle size distribution except for the Volcanic ash soils. 4. The dispersion of Volcanic ash soils was rather poor when chemical agents used. Therefore, special care should be taken for the dispersion of allophane soils.

• Journal of Pharmaceutical Investigation
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• v.29 no.3
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• pp.227-234
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• 1999

Solid dispersions were prepared to increase the dissolution rate of biphenyl dimethyl dicarboxylate (DDB) using water-soluble carriers such as povidone, copolyvidone, $2-hydroxypropyl-{\beta}-cyclodextrin (HPCD)$, sodium salicylate or sodium benzoate by solvent evaporation method. Solid dispersions were characterized by infrared spectrometry, differential scanning calorimetry (DSC) and powder X-ray diffractometry, dissolution and permeation studies. DDB tablets (7.5 mg) were prepared by compressing the powder mixtures composed of solid dispersions, lactose, com starch, crospovidone and magnesium stearate using a single-punch press. DDB capsules (7.5 mg) were also prepared by filling the mixtures in empty hard gelatin capsules (size No.1). From the DSC and powder x-ray diffractometric studies, it was found that DDB was amorphous in the HPCD or copolyvidone solid dispersions. Dissolution rates after 10 min of DDB alone and solid dispersions (1 : 10) in sodium benzoate, sodium salicylate and copolyvidone were 11.8, 23.5, 22.8 and 82.5%, respectively. Dissolution rates of DDB after 30 min from 1 : 10 and 1 : 20 copolyvidone solid dispersions were 80.5 and 95.0%, respectively. For the DDB tablets prepared using solid dispersions (1 : 20), the initial dissolution rate was dependent on carrier material, and was ranked in order, $Kollidon\;30\;{\ll}$ copolyvidone < HPCD. For the HPCD solid dispersion tablets, dissolution rate reached 97.4% after 15 min, but thereafter slowly decreased to 80.7% after 2 hr due to the precipitation of DDB. However, in the case of copolyvidone solid dispersion tablets, dissolution increased linearly and reached 93.4% after 2 hr. Reducing the volume of test medium from 900 to 300 ml markedly decreased the dissolution rate of the tablets containing 1 : 20 HPCD solid dispersions and 1 : 10 copolyvidone solid dispersion. For 1 : 20 copolyvidone solid dispersion tablets, there was no significant change in dissolution rate up to 1 hr with different volumes of test medium. Preparation of the copolyvidone solid dispersion (1 : 20) in capsules markedly delayed the dissolution (31.2 % after 2hr) due to the limited diffusion within capsules. The permeation rate $(13.4\;g/cm^2\;after\;8\;hr)$ of DDB through rabbit duodenal mucosa from copolyvidone solid dispersion (1 : 10) was markedly enhanced, when compared with drug alone or physical mixtures. From overall findings, DDB formulations containing copolyvidone solid dispersions (1 : 20) could be used to remarkably improve the dissolution rate in dosage form of powders and tablets.

• Applied Microscopy
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• v.45 no.4
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• pp.203-207
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• 2015

Sample preparation is very important for crystal structure analysis of novel nanostructured materials in electron microscopy. Generally, a grid dispersion method has been used as transmission electron microscope (TEM) sampling method of nano-powder samples. However, it is difficult to obtain the cross-sectional information for the tabular-structured materials. In order to solve this problem, we have attempted a new sample preparation method using focused ion beam. Base on this approach, it was possible to successfully obtain the electron diffraction patterns and high-resolution TEM images of the cross-section of tabular structure. Finally, we were able to obtain three-dimensional crystallographic information of novel zeolite nano-crystal of the tabular morphology by applying the new sample preparation technique.

• Journal of Food Hygiene and Safety
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• v.18 no.2
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• pp.43-50
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• 2003

A liquid chromatographic method, using matrix solid-phase dispersion (MSPD) is developed for the extraction of residual furazolidone in chicken eggs. Blank or fortified egg samples (0.5 g) were blended with Octadecylsilyl (Bulk $C_{18}$, 40${\mu}{\textrm}{m}$, 18%. load, endcapped. 2 g) derivatized silica. After homogenization, $C_{18}$/egg and Na$_2$S $O_4$matrix were transferred to a column made of 10 ml glass syringe and filter paper and compressed 4.0∼4.5 ml volume. The column was washed with 8 ml of hexane and dried under $N_2$ gas. Furazolidone was eluted with acetonitrile (8 ml) under gravity. The eluate containing furazolidone was free from interfering compounds when analyzed by HPLC with UV detection (365 nm, photodiode array). Calibration curves were linear (r = 0.99985) and inter- (1.47%) and intra-assay (5.29%) variabilities for the concentration range examined (7.8∼497 ng/g of eggs, 20 ${mu}ell$ injection volume) were indicative of an acceptable methodology for the analysis of furazolidone. Average recovery of furazolidone added to egg was 96.2%. The limit of detection for the proposed method was 1 ng/g for furazolidone. The method using MSPD is proposed as an alternative assay to the classical method which involves the use of large volumes of a harmful solvent and requires a long tedious separation and clean-up processes prior to its determination.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.10
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• pp.178-184
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• 2007

A new adaptive alternating-direction-implicit finite-difference time-domain (ADI-FDTD) method is proposed to obtain isotropic wave propagation for all directional angles. We add the square terms of time-step multiplied by the spatial derivatives of x and y as a perturbed term to the conventional ADI-FDTD and can find the optimization coefficient of square terms of time-step to generate the minimum anisotropy. The new ADI-FDTD is also stable, even when its time-step is greater than the Courant-Friedrich-Levy (CFL) limit. The characteristic equation of the dispersion relation governing the new method is derived and compared with the theoretical and numerical results for the conventional ADI-FDTD and perturbed ADI-FDTD methods.