• Molecules and Cells
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• v.39 no.11
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• pp.783-789
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• 2016

Afflicted neurons in various neurodegenerative diseases generally display diverse and complex pathological features before catastrophic occurrence of massive neuronal loss at the late stages of the diseases. This complex nature of neuronal pathophysiology inevitably implicates systemwide changes in basic cellular activities such as transcriptional controls and signal cascades, and so on, as a cause. Recently, as one of these systemwide cellular changes associated with neurodegenerative diseases, epigenetic changes caused by protein toxicity have begun to be highlighted. Notably, recent advances in related techniques including next-generation sequencing (NGS) and mass spectrometry enable us to monitor changes in the post-translational modifications (PTMs) of histone proteins and to link these changes in histone PTMs to the specific transcriptional changes. Indeed, epigenetic alterations and consequent changes in neuronal transcriptome are now begun to be extensively studied in neurodegenerative diseases including Alzheimer's disease (AD). In this review, we will discuss details of our current understandings on epigenetic changes associated with two representative neurodegenerative diseases [AD and polyglutamine (polyQ) diseases] and further discuss possible future development of pharmaceutical treatment of the diseases through modulating these epigenetic changes.

• Korean Journal of Health Education and Promotion
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• v.8 no.1
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• pp.5-13
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• 1991

While the threat from traditional communicable diseases have been decreasing non communicable chronic diseases are increasing due to the aging of population and change in life pattern of the people such as over intake of cholesterol and lack of physical exercise etc. On the other hand, since 1980s, AIDS is spreading rapidly throughout the globe and environmental pollution, accidents, addictive diseases such as drug abuse and alcoholism are becoming serious factors to hinder the health promotion of the people. In order to improve general public health and promote individual health status, existing program for communicable disease control by the government such as tuberculosis, leprosy, STD and acute communicable diseases should be effectively continued. In principle, effort should be placed on eradication of source of infection, reduction of communicability of source in infection, treatment of source of infection as well as increase of individual registance to the diseases through immunization and improvement of physical status. Since the pattern of illness is being shifted from communicable diseases to non communicable chronic diseases such as cancer, cerebral hemorrhage, heart disease and hypertention etc., special emphasis should be placed on the prevention and control of those adult diseases. Early detection of the patients, registration and treatment of patients and health education should be systematically developed for effective control of the diseases. In addition, program activities on MCH, nutrition, dentistry, mental health, environmental health, accident prevention. medical delivery system, health insurance. and all other health issues should be improved in order to achieve our goal of health promotion.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.19 no.1
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• pp.44-142
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• 2013

The main purpose of this thesis is the Korean version of Gwang On Yeok Ron(廣瘟疫論). Gwang On Yeok Ron is a specialized book about infectious diseases(瘟疫). The book was compiled by Dae Cheon jang(戴天章) in 1722 who was a medical man in the Qing dynasty. The book consists of four volumes and an appendix. "Gwang On Yeok Ron Vol. I(廣瘟疫論卷之一)" is for the demonstration of colds(傷寒) and infectious diseases through a patient's odor(氣), skin tone(色), tongue(舌), mental state(神) and pulse(脈). Also, it describes the complications(兼證, 夾證) of infectious diseases. "Gwang On Yeok Ron Vol. II(廣瘟疫論卷之二)" describes the external symptoms(表證) of infectious diseases and the remedies. "Gwang On Yeok Ron Vol. III(廣瘟疫論卷之三)" describes the internal symptoms(裏證) of infectious diseases and the remedies. "Gwang On Yeok Ron Vol. IV(廣瘟疫論卷之四)" presents principles for the remedy of infectious diseases, and describes the sequelae(遺證) after the recovery of infectious diseases. "Appendix of Gwang On Yeok Ron(廣瘟疫論方目)" presents 83 prescriptions for the remedy of infectious diseases.

• Korean Institute of Interior Design Journal
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• v.22 no.2
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• pp.140-148
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• 2013

The purpose of this study is to examine the current status of allergic diseases associated with the housing environment and the psychological attitude of residents towards relevant risk factors. This study surveyed 1,200 people. In the first round, 200 participants were questioned through direct survey methods, while 1,000 participants filled out an online survey in the second round. Selected study subjects consisted of allergic diseases known to be closely related to housing environment factors. With advice from medical experts, the analysis included the examination of the prevalence status regarding five types of allergy-related diseases-allergic conjunctivitis, allergic rhinitis, allergic dermatitis, asthma and headache-with the range of disease incidence set within the past ten years. The survey was conducted on all age groups except those nine years old and younger, and the findings are as follows. Allergic diseases were found to be more prevalent among women than men. Residents identified effective methods for the alleviation and treatment of allergic diseases as ventilation, use of environmentally-friendly finishing materials, maintenance of a clean living space through cleaning or washing, and sunlight exposure. Residents' understanding of allergic diseases varied depending on their experience with such diseases and residential characteristics.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.19 no.2
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• pp.39-55
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• 2013

The main purpose of this thesis is the Korean version of "Gwang On Yeok Ron(廣瘟疫論)". Gwang On Yeok Ron is a specialized book about infectious diseases(瘟疫). The book was compiled by Dae Cheon jang(戴天章) in 1722 who was a medical man in the Qing dynasty. The book consists of four volumes and an appendix. "Gwang On Yeok Ron Vol. I(廣瘟疫論卷之一)" is for the demonstration of colds(傷寒) and infectious diseases through a patient's odor(氣), skin tone(色), tongue(舌), mental state(神) and pulse(脈). Also, it describes the complications(兼證, 夾證) of infectious diseases. "Gwang On Yeok Ron Vol. II(廣瘟疫論卷之二)" describes the external symptoms(表證) of infectious diseases and the remedies. "Gwang On Yeok Ron Vol. III(廣瘟疫論卷之三)" describes the internal symptoms(裏證) of infectious diseases and the remedies. "Gwang On Yeok Ron Vol. IV(廣瘟疫論卷之四)" presents principles for the remedy of infectious diseases, and describes the sequelae(遺證) after the recovery of infectious diseases. "Appendix of Gwang On Yeok Ron(廣瘟疫論方目)" presents 83 prescriptions for the remedy of infectious diseases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.10
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• pp.4411-4417
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• 2011

Degenerative brain diseases including Alzheimer's diseases, Parkinson's diseases increase in frequency with age. They are amongst the most costly and devastating diseases to patients and their families. Therefore developing therapies for degenerative brain diseases is of the highest priority. Recently therapeutics for these diseases have undergone scrutiny by many clinical trials according to the advances of cellular and molecular neurobiology. This review is focused on studies investigating the current therapeutic strategies already undergone different stage of clinical trials and recent R&D trend by nations through patent analysis on treatments for degegerative brain diseases.

• Korean Journal of Veterinary Research
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• v.53 no.1
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• pp.65-68
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• 2013

Hepatitis E virus (HEV) can infect not only human but also several animals. This study has been conducted to evaluate the comprehensive anti-HEV seroprevalence in zoo animals in Korea. Anti-HEV antibodies were identified in 14 of 64 zoo animal species. HEV antibodies were detected for the first time in Eurasian Lynx, Setland Pony, Fallow Deer, Ezo Sika, Formosa Deer, East Wapitis, Barasingha, Corriedale, American Bison, Guanacos, Reticulated Giraffe, and Saanen. These results indicate that the several zoo animal species were exposed to HEV.

• Tuberculosis and Respiratory Diseases
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• v.83 no.2
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• pp.116-121
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• 2020

Particulate matter (PM) is suspended dust that has a diameter of <10 ㎛ and can be inhaled by humans and deposited in the lungs, particularly the alveoli. Recent studies have shown that PM has an adverse effect on respiratory diseases. The aim of this article is to review respiratory diseases associated with PM. According to existing studies, PM is associated with chronic obstructive pulmonary disease, bronchial asthma, and several other respiratory diseases and increases the mortality rates of these diseases. Moreover, increased exposure in the high concentration of atmospheric PM is associated with the development of lung cancer. The most simple and common way to protect an individual from airborne PM is to wear a face mask that filters out PM. In areas of high concentration PM, it is recommended to wear a face mask to minimize the exposure to PM. However, the use of N95 or KF94 masks can interfere with respiration in patients with chronic respiratory diseases who exhibit low pulmonary function, leading to an increased risk of respiratory failure. Conclusionally, reduction of the total amount of PM is considered to be important factor and strengthening the national warning notification system to vulnerable patients and proper early management of exacerbated patients will be needed in the future.

• Journal of Haehwa Medicine
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• v.8 no.1
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• pp.97-114
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• 1999

By studying disease classifications of oriental medicine from Nei-Ching, Chao's-Bing-Yuan, Dong-Yi-Bao-Jian and Korea-standard classification of causes of disease & death. The results were obtained as follows : 1. In Nei-Ching 181 kinds, Chao's-Bing-Yuan 1729 kinds, Dong-Yi-Bao-Jian 966 kinds, and Korea-standard classification of causes of disease & death 2519 kinds of diseases, which suggested more diseases as time flew. 2. In classical books such as Nei-Ching, Chao's-Bing-Yuan, and Dong-Yi-Bao-Jian most of diseases and their names were originated from six kinds of pathogenic factors, Zang-Fu, Jung-Qi-Blood-Fluid, soul, and outer-body-signs, while Korea-standard classification of causes of disease & death classified diseases according to oriental medical departments. 3. Symptoms of Cold-Heat-Excess-Deficiency and pathogenic factors, body parts, Zang-Fu were applied to names of diseases in oriental medicine. 4. In oriental medicine, some symtoms, many intermal diseases were used as disease name, but it is necessary for us to select exact name of diseases in modem clinical treatment. 5. We should consider disease names in Korea-standard classification of causes of disease & death in relations with western medical terms of diseases.

• Journal of the Korea Safety Management & Science
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• v.12 no.3
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• pp.61-72
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• 2010

Judgment of cerebral and cardiovascular diseases arising out of duty follows the legal judgment method for the purpose of investigation of medical causes based on the Industrial Accident Compensation Insurance Act, with the characteristics of the occurrence as personal factors etc. act as risk factors while work-related ones as triggers, in the case of disease due to occupational cases, as whether it arose out of duty must be judged including even the individual's personal risk factors, there are limitations securing fairness even with existing laws, regulations and guidelines. This study was carried out to suggest basic data for the preparation of standardized guidances for diseases arising out of duty by reviewing the standards for the acknowledgment of cerebral and cardiovascular diseases due to occupational cases, and it has a significance in that it suggests target diseases that may be judged as cerebral and cardiovascular diseases, legal criteria for the acknowledgment and standards for the judgment of cerebral and cardiovascular diseases arising out of duty.