• Journal of Korea Multimedia Society
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• v.24 no.2
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• pp.178-185
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• 2021

Three-dimensional high-resolution magnetic resonance imaging (MRI) provides fine-level anatomical information for disease diagnosis. However, there is a limitation in obtaining high resolution due to the long scan time for wide spatial coverage. Therefore, in order to obtain a clear high-resolution(HR) image in a wide spatial coverage, a super-resolution technology that converts a low-resolution(LR) MRI image into a high-resolution is required. In this paper, we propose a super-resolution technique through filter learning based on information on the surrounding gradient information in 3D space from 3D MRI images. In the learning step, the gradient features of each voxel are computed through eigen-decomposition from 3D patch. Based on these features, we get the learned filters that minimize the difference of intensity between pairs of LR and HR images for similar features. In test step, the gradient feature of the patch is obtained for each voxel, and the filter is applied by selecting a filter corresponding to the feature closest to it. As a result of learning 100 T1 brain MRI images of HCP which is publicly opened, we showed that the performance improved by up to about 11% compared to the traditional interpolation method.

• Journal of Korean Neurosurgical Society
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• v.66 no.2
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• pp.172-182
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• 2023

Objective : The blood-brain barrier (BBB) is an obstacle for molecules to pass through from blood to the brain. Focused ultrasound is a new method which temporarily opens the BBB, which makes pharmaceutical delivery or removal of neurodegenerative proteins possible. This study was demonstrated to review our BBB opening procedure with magnetic resonance guided images and find specific patterns in the BBB opening. Methods : In this study, we reviewed the procedures and results of two clinical studies on BBB opening using focused ultrasound regarding its safety and clinical efficacy. Magnetic resonance images were also reviewed to discover any specific findings. Results : Two clinical trials showed clinical benefits. All clinical trials demonstrated safe BBB opening, with no specific side effects. Magnetic resonance imaging showed temporary T1 contrast enhancement in the sonication area, verifying the BBB opening. Several low-signal intensity spots were observed in the T2 susceptibility-weighted angiography images, which were also reversible and temporary. Although these spots can be considered as microbleeding, evidence suggests these are not ordinary microbleeding but an indicator for adequate BBB opening. Conclusion : Magnetic resonance images proved safe and efficient BBB opening in humans, using focused ultrasound.

• Physical Therapy Rehabilitation Science
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• v.11 no.4
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• pp.553-564
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• 2022

Objective: The purpose of this studyaimed to investigate the effects of scapular stabilization training using the different exercise prop for impingement syndrome of factory workers. Design: A randomized controlled trial Methods: Twenty shoulder impingement syndrome subjects were randomly divided into two groups of ten subjects each. Inclusion criteria was presence of positive sign in at least two of Neer test, Hawkins test, Yocum test, Jobe test and Speeds test. Andexclusion criteria, those with surgical history of rotator cuff, those with disease in upper limb other than shoulder impingement syndrome, those who took anti-inflammatory drugs over the past 12 months were excluded from the sample. One group was performed scapula stabilization exercise using elastic bands, while dumbbell group performed the exercise using dumbbell. Both groups performed the exercise after applying the general physical therapy. After applying five days a week for a total of six weeks, range of motion of shoulder joint, muscle strength and pain and function level were evaluated. Results: After the intervention, in both groups, all dependent variables at the 6-week post-test significantly improved compared with the pre-test (p<0.05). In addition, elastic band exercise group showed a significant differences in SPADI function score and SPADI total score compared to the dumbbell group(p<0.05). Conclusions: The elastic band training may be effective methodology using low-to-moderate intensity resistance for SPADI scores.

• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.97-106
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• 2023

Objective: This study addressed the case of a cerebral infarction patient with recurring aspiration pneumonia. Methods: A patient diagnosed with cerebral infarction with recurring aspiration pneumonia was treated with Korean medicine therapies, including herbal medication (Shigyungbanha-tang-gami), acupuncture, electro-acupuncture, and moxibustion combined with antibiotics for 31 days. To evaluate the therapeutic effect, we checked chest X-rays, lab evaluations, the number of night suctions, and body temperature. Results: After treatment, chest X-rays and inflammation markers improved. In addition, the number of night suctions decreased, and the body temperature was normalized. Aspiration pneumonia recurred. However, the intensity of the symptoms gradually weakened, and the recovery speed increased. Conclusion: These results suggest that Korean medicine therapies, including Shigyungbanha-tang-gami combined with antibiotics, have a beneficial effect on recurring aspiration pneumonia, an additional disease related to cerebral infarction.

• Journal of The Korean Society of Agricultural Engineers
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• v.65 no.1
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• pp.61-72
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• 2023

The increase in the rearing intensity of pigs has caused deterioration in the pig house's internal environment such as temperature, humidity, ammonia gas, and so on. Traditionally, the widely used method to control the internal environment was through the manipulation of the ventilation system. However, the conventional ventilation system had a limitation to control the internal environment, prevent livestock disease, save energy, and reduce odor emission. To overcome this problem, the air-recirculated ventilation system was suggested. This system has a semi-closed loop ventilation type. For designing this system, it was essential to evaluate the ventilation rates considering the pressure loss of ducts. Therefore, in this study, pressure loss calculation and experiment were conducted for the quantitative ventilation design of a semi-closed loop system. The results of the experiment showed that the inlet through which external air flows should always be opened. In addition, it was also found that for the optimum design of the semi-closed loop ventilation system, it was appropriate to install a damper or a backflow prevention device rather than a ventilation fan.

• Journal of Animal Reproduction and Biotechnology
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• v.38 no.4
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• pp.209-214
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• 2023

Background: Single nucleotide polymorphisms (SNPs) are widely used genetic markers with applications in human disease diagnostics, animal breeding, and evolutionary studies, but existing genotyping methods can be labor-intensive and costly. The aim of this study is to develop a simple and rapid method for identification of a single nucleotide change. Methods: A modified Polymerase Chain Reaction Amplification of Multiple Specific Alleles (PAMSA) and high resolution melt (HRM) analysis was performed to discriminate a bovine polymorphism in the NCAPG gene (rs109570900, 1326T > G). Results: The inclusion of tails in the primers enabled allele discrimination based on PCR product lengths, detected through agarose gel electrophoresis, successfully determining various genotypes, albeit with some time and labor intensity due to the use of relatively costly high-resolution agarose gels. Additionally, high-resolution melt (HRM) analysis with tailed primers effectively distinguished the GG genotype from the TT genotype in bovine muscle cell lines, offering a reliable way to distinguish SNP polymorphisms without the need for time-consuming AS-PCR. Conclusions: Our experiments demonstrated the importance of incorporating unique mismatched bases in the allele-specific primers to prevent cross-amplification by fragmented primers. This efficient and cost-effective method, as presented here, enables genotyping laboratories to analyze SNPs using standard real-time PCR.

• The Journal of the Korea institute of electronic communication sciences
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• v.19 no.1
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• pp.127-136
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• 2024

Because the hazardous working environments and high labor intensity of the root industry can potentially impact the health of workers, current regulations have focused on measuring and controlling environmental factors, on a semi-annual basis. However, there is a lack of quantitative criteria addressing workers' health conditions other than the physical work environment. This gap makes it challenging to prevent occupational diseases resulting from continuous exposure to harmful substances below regulatory thresholds. Therefore, this paper proposes a machine learning-based method for determining the peak level of risk in root industry work environments and enables real-time safety assessment in workplaces utilizing this approach.

• Tuberculosis and Respiratory Diseases
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• v.47 no.5
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• pp.669-680
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• 1999

Background: Pulmonary thromboembolism(PTE) is a life threatening disease that needs early diagnosis. Spiral CT angiography depict thromboemboli in the central pulmonary vessels with greater than 90% sensitivity and specificity, which approaches the results of pulmonary angiography in the Prospective Investigation of Pulmonary Embolism Diagnosis(PIOPED) study. This study was performed to evaluate the findings and the diagnostic value(clinical utility) of the spiral CT angiography with 2D image(multiplanar reformation) and 3D images(Shaded surface display, Minimal intensity projection) in the pulmonary thromboembolism. Methods: We retrospectively analysed spiral CT angiography and pulmonary angiography, lung scan and clinical recordings of 20 patients who had PTE diagnosed by spiral CT angiography(n=19 cases) or pulmonary angiography(n=l case) from September 1997 to August 1998. Among 20 patients who had underwent spiral CT angiography, 14 patients could be performed lung perfusion scan at the same time. We analyzed the vascular and parenchymal change in spiral CT angiogram. Results: Anatomical distribution of PTE was as follows: 1) left lung(n= 103)

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.1
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• pp.18-23
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• 2010

Purpose: PET/CT combines functional and morphologic data and increases diagnostic accuracy in a variety of malignancies. Especially reconstructed Fusion PET/CT images or MIP (Maximum Intensity Projection) images from a 2-dimensional image to a 3-dimensional one are useful in visualization of the lesion. But in Fusion & MIP 3D reconstruction image, due to hot uptake by urine or urostomy bag, lesion is overlapped so it is difficult that we can distinguish the lesion with the naked eye. This research tries to improve a distinction by removing parts of hot uptake. Materials and Methods: This research has been conducted the object of patients who have went to our hospital from September 2008 to March 2009 and have a lot of urine of remaining volume as disease of uterus, bladder, rectum in the result of PET/CT examination. We used GE Company's Advantage Workstation AW4.3 05 Version Volume Viewer program. As an analysis method, set up ROI in region of removal in axial volume image, select Cut Outside and apply same method in coronal volume image. Next, adjust minimum value in Threshold of 3D Tools, select subtraction in Advanced Processing. It makes Fusion & MIP images and compares them with the image no using Region Cut Definition. Results: In Fusion & MIP 3D reconstruction image, it makes Fusion & MIP images and compares them by using Advantage Workstation AW4.3 05's Region Cut Subtraction, parts of hot uptake according to patient's urine can be removed. Distinction of lesion was clearly reconstructed in image using Region Cut Definition. Conclusion: After examining the patients showing hot uptake on account of volume of urine intake in bladder, in process of reconstruction image, if parts of hot uptake would be removed, it could contribute to offering much better diagnostic information than image subtraction of conventional method. Especially in case of disease of uterus, bladder and rectum, it will be helpful for qualitative improvement of image.

• Journal of radiological science and technology
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• v.32 no.3
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• pp.313-323
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• 2009

Diffusion-weighted imaging (DWI) has been demonstrated to be a practical method for the diagnosis of various brain diseases such as acute infarction, brain tumor, and white matter disease. In this study, we used two techniques to examine the average signal intensity (SI) and apparent diffusion coefficient (ADC) of the brains of patients who ranged in age from 10 to 60 years. Our results indicated that the average SI was the highest in amygdala (as derived from DWI), whereas that in the cerebrospinal fluid was the lowest. The average ADC was the highest in the cerebrospinal fluid, whereas the lowest measurement was derived from the pons. The average SI and ADC were higher in $T_2^*$-DW-EPI than in FLAIR-DW-EPI. The higher the b-value, the smaller the average difference in both imaging techniques; the lower the b-value, the greater the average difference. Also, comparative analysis of the brains of patients who had experienced cerebral infarction showed no distinct lesion in the general MR image over time. However, there was a high SI in apparent weighted images. Analysis of other brain diseases (e.g., bleeding, acute, subacute, chronic infarction) indicated SI variance in accordance with characteristics of the two techniques. The higher the SI, the lower the ADC. Taken together, the value of SI and ADC in accordance with frequently occurring areas and various brain disease varies based on the b-value and imaging technique. Because they provide additional useful information in the diagnosis and treatment of patients with various brain diseases through signal recognition, the proper imaging technique and b-value are important for the detection and interpretation of subacute stroke and other brain diseases.