• Parasites, Hosts and Diseases
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• 제61권3호
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• pp.272-281
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• 2023

Chigger mites are the vector of scrub typhus. This study estimates the infestation status and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019. Chiggers were identified under the microscope, and infestation indices were calculated. The Preston's log-normal model was used to fit the curve of species abundance distribution. A total of 6,557 chiggers were collected in 136 of 342 N. fulvescens rats, showing high overall infestation indices (prevalence=39.8%, mean abundance=19.2, mean intensity=48.2) and high species diversity (S=100, H'=3.0). Leptotrombidium cangjiangense, Neotrombicula japonica, and Ascoschoengastia sifanga were the three dominant chigger species (constituent ratio=42.9%; 2,736/6,384) and exhibited an aggregated distribution among different rat individuals. We identified 100 chigger species, with 3 of them (Leptotrombidium scutellare, Leptotrombidium wenense, and Leptotrombidium deliense) as the main vectors of scrub typhus in China and nine species as potential vectors of this disease. Disease vector occurrence on N. fulvescens may increase the risk of spreading scrub typhus from rats to humans. Chigger infestation on N. fulvescens varied significantly in different environments. The species abundance distribution showed a log-normal distribution pattern. The estimated number of chigger species on N. fulvescens was 126 species.

• Journal of Oral Medicine and Pain
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• 제34권2호
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• pp.123-132
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• 2009

다양한 전신질환으로 입원한 환자들 중에서 구강질환을 진료받기 위해 내원한 구강내과적인 문제가 있는 54명 환자의 전신질환 상태와 치과적인 주소 그리고 구강질환 진단명을 조사함으로써 입원한 전신질환자의 구강내과적인 진료의 실태를 파악하고자 본 연구를 시행하여 다음과 같은 결과를 얻었다. 1. 구강내과 질환이 있는 환자는 남자 24명(44%) 여자 30명(56%) 이었으며, 연령은 50대 20명(37%), 60대 14명(26%), 40대 12명(22%), 30대 4명(7%) 순 이었다. 2. 전신질환의 진단명은 내분비, 영양 그리고 대사장애 36%, 순환계질환 36%, 신경계질환 10% 순 이었다. 3. 구강질환의 주소는 정기검사 26%, 두개하악장애 18%, 연조직 문제 18% 순 이었다. 4. 구강질환의 진단명은 타액선질환 32%, 치은염 및 치주질환 23%, 치아안면 이상증 16% 순 이었다. 이상의 결과로 입원한 전신질환자를 통해서 전신질환이 있는 환자의 구강질환과 구강내과적인 질환의 특성을 일정부분 파악하였으나 향후 구강질환과 전신질환과의 상관관계에 대한 연구가 계속적으로 이루어져야 한다고 사료된다.

• BMB Reports
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• 제55권9호
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• pp.465-471
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• 2022

Understanding and monitoring virus-mediated infections has gained importance since the global outbreak of the coronavirus disease 2019 (COVID-19) pandemic. Studies of high-throughput omics-based immune profiling of COVID-19 patients can help manage the current pandemic and future virus-mediated pandemics. Although COVID-19 is being studied since past 2 years, detailed mechanisms of the initial induction of dynamic immune responses or the molecular mechanisms that characterize disease progression remains unclear. This study involved comprehensively collected biospecimens and longitudinal multi-omics data of 300 COVID-19 patients and 120 healthy controls, including whole genome sequencing (WGS), single-cell RNA sequencing combined with T cell receptor (TCR) and B cell receptor (BCR) sequencing (scRNA(+scTCR/BCR)-seq), bulk BCR and TCR sequencing (bulk TCR/BCR-seq), and cytokine profiling. Clinical data were also collected from hospitalized COVID-19 patients, and HLA typing, laboratory characteristics, and COVID-19 viral genome sequencing were performed during the initial diagnosis. The entire set of biospecimens and multi-omics data generated in this project can be accessed by researchers from the National Biobank of Korea with prior approval. This distribution of large-scale multi-omics data of COVID-19 patients can facilitate the understanding of biological crosstalk involved in COVID-19 infection and contribute to the development of potential methodologies for its diagnosis and treatment.

• Journal of Periodontal and Implant Science
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• 제26권3호
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• pp.655-668
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• 1996

The change in vascular adhesion molecule expression and number of infiltrating leukocytes were investigated irnmunohistochemically in clinically healthy and inflammed gingiva. Monoclonal antibodies to ICAM-1, VCAM-1 and E-cadherin were used to identify positive vessels and leukocyte within gingival biopsies. 10 healthy gingiva and 30 inflammed gingiva was resected by clinical crown lengthening and modified Widman flap operation, respectively. Leukocyte entry into tissues at sites of inflammation is controlled by the interaction between adhesion molecule and endothelium. Because of rapid and severe destructive periodontal disease that is remarkable leukocyte adhesion deficiency, it is very important to unerdstand the mechanism of host defence against periodontal disease. The purpose of this investigation was the characterization of the presence and distribution of the adhesion molecule(ICAM-1, VCAM-1 and Evcadherin) in inflammatory gingival tissues compared to clinically healthy gingiva. The results were as followed; 1. ICAM-1 was distributed on basal layer, endothelium and mononuclear cells 10 healthy gingiva but inflammed gingiva was observed stronger stain than healthy gingiva. 2. Rare expression was observed in both group but few positive VCAM-1 cells were investigated in inflammatory gingival tissues 3. E-cadherin was expressed in only epithelium and reduced expression was observed in inflammatory gingival tissues. ICAM-1, VCAM-1 showed more expression in inflammatory tissues compared to healthy gingiva. Conversely, E-cadherin revealed a opposite result. These finding demonstrate a characteristic distribution and degree of adhesion molecule in healthy and inflammatory gingival tissues. But it is suggested that more detail study be progressive associated with leukocyte adhesion molecule to determine characterization of periodontal disease.

• 대한치과기공학회지
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• 제34권2호
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• pp.179-199
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• 2012

Purpose: This study was conducted to prepare the fundamental data on oral hygiene of the elderly and to assess the behavior of oral hygiene, subjective oral health, oral health problem among the elderly, and to contribute to successful enhancement of life in their declining years. Methods: The author surveyed the behavior of oral hygiene, subjective oral health, oral health problem to 192 elderly at a health center of Busan using structured self- administered questionnaire from Nov. 2nd 2009 to Feb. 10th 2010. Collected data were analysed by SPSS WIN 18.0 statistical program for frequency, percentage production, ${\chi}^2$ (Chi-square) verification, t-test, One-way ANOVA, Logistic Regression. Results: The distribution of total subjects by oral health behaviors were 56.8% for "have ever trained how to tooth brushing", 76.6% for "correctly performed tooth brushing by himself ", 71.8% for "tooth brushing a day is two times and less", 87.5% for "it doesn't tooth brushing in meals and after" and 53.6% for "it doesn't use the facility for oral health", respectively. The distribution of total subjects by the state of perceived oral health were 51.0% for "feel the oral discomfort", 51.6% for "feel the comfortable chewing on starchy food", respectively. The mean point of perceived oral health by general characteristics of total subjects were statistically significant difference in sex, type of medical insurance, smoke, exercise, and chronic disease. The mean point of perceived oral health by oral health behaviors of total subjects were statistically significant difference in educational experience on tooth brushing, recognition for tooth brushing by himself, tooth brushing a day, and tongue cleaning. The risk factors of perceived oral health were type of medical insurance and chronic disease in general characteristics, tooth brushing in meals and after and tooth brushing a day, and tongue cleaning in oral health behaviors. Conclusion: The author recommend to the prevention of chronic disease, carry out the tooth brushing in meals and after, three times and over tooth brushing a day and tongue cleaning for oral health. and the author consider that it need to prepare the active countermeasure to oral health such as reeducation for oral health and supply to the tongue cleaner.

• 한방안이비인후피부과학회지
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• 제20권3호
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• pp.181-190
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• 2007

Objective : The purpose of this study is to understand preferences of patients who had visited the Dept. of Ophthalmology Otolaryngology & Dermatology Method : We conducted questionnaire survey on the patients who had visited the Dept. of Ophthalmology, Otolaryngology & Dermatology Hospital of Dong Shin University from March to September, 2007. Result : The result were as follows. 1. Distribution of sex: male 41 % female 59% 2. The age distribution of patients showed highest in 30-39 years(23%), followed by 20-29 years, 40-49 years in order. 3. The classification of patients according to disease: Skin disease (38%), Nose (23%), Face (10%), Eye (9%), Throat (8%), Ear (7%) 4. Other offices patients visited before coming to this clinic: Local clinic (41%). Hospital (18%), Oriental clinic or hospital (5%), None (22%) 5. The length of time the patient has had the disease: 2years (26%), more than 3years (15%), 2-4weeks (13%), 6months (11%), 1year (10%) in order 6. The expected length of treatment: 1week (21%), 2week (12%), 1month (21%) 7. 26% expected about 100,000 won as medical expenses. 8. 88% of the patients are willing to have a check-up when it needed and 40% expected about 50,000 won as check-up expenses. 9. 52% of the patients are not willing to withstand pain, and would rather heal slowly. 10. 69% of the patients said that treatment would be affected by company(44%), school(19%) and business(16%). 11. 73% of the respondants are positive about night-time treatment and 92% is positeve about making an appointment for the treatment. Conclusion : Through the research, we could understand preferences of patients who had visited Dept. of Ophthalmology, Otolaryngology & Dermatology

• 한국환경과학회지
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• 제26권7호
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• pp.803-815
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• 2017

In this study of the oak wilt disease that has occurred in a large scale in a protected area located near South Korea's metropolitan region, a detailed analysis has been conducted on the terrain, species and Diameters at Breast Height (DBH) of infected trees to identify the distribution of infection properties in the affected area. Taking into consideration the distribution of oak tree vegetation, a total of 4,640 quadrats in a size of 10 m by 10 m, have been set; and oak tree species, the DBH and infection damage per quadrat have been investigated. Geological properties have been analyzed according to elevation, slope, aspect and micro topography while a weighted value has been given according to the degree of infection in order to calculate an infection index. Through correlation analysis, the infection ratio of seriously-damaged and withered trees and the infection index have been analyzed with regards to the geological properties, tree species and DBH. The analysis shows that the disease tends to affect an area with medium elevation rather than those in the highest or lowest areas and that serious damage has been observed at rugged spots with a steep gradient (more than $30^{\circ}$). Although there has been no distinct tendency with regards to aspect, the infection ratio is relatively high in areas facing the north while the seriously-damaged and withered ratio are high in areas facing the south. In terms of micro topography, more damage has been spotted in valley terrain. Quercus mongolica has sustained more damage than other species. When it comes to the DBH, as seen in previous studies, large trees have suffered severe damage, but the analysis has also revealed conspicuous damage to medium trees with a DBH of 15-20 cm, which had not previously been considered at high risk.

• 한방안이비인후피부과학회지
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• 제11권1호
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• pp.269-283
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• 1998

Paranasal sinusitis, especially chronic is one of the most common diseases in the field of otolaryngology. It is similar to Bee Yeun(鼻淵) in oriental medicine. Most cases of sinusitis are due to anatomical abnormalities within ostiomeatal unit or disturbed mucocilliary flow. The ostiomeatal unit is the first place of contact with bacteria and allergens during aspiration, and it can be obstructed easily by minute mucosal swelling due to anatomical narrowness. Therefore the treatment of paranasal sinusitis is not easy and often leads to recurrences in spite of long term treatment or surgical therapy. We studied 83 patients who had visited our hospital with complaints of nasal symptoms; they had been diagnosed as having paranasal sinusitis through an endoscopy or CT scan in another hospital and were diagnosed as the paranasal sinusitis through a PNS series. The results were as follows: 1. Age and sex distribution: The most common occurence was found between 6-10 and 1-5 years old. The Males Were 52($62.7\%$) and Females were 31($37.3\%$). 2. By residence 58 cases lived in apts: 25 lived in houses. 3. The longest duration of disease varied from a lower of 13 to a higher of 36 months in 22 cases and from 7 to 12 months in 21 cases. 4. The most common complication & past history with otolaryngologic or allergic disease were adenoid or tonsil hypertrophy & tonsillectomy and adenoidectomy (21 cases). In decreasing order the others were atopic dematitis, otitis media with effusion and allergic rhinitis. 5. Distribution of paranasal sinus disease was most common in both maxillary sinuses in 52 cases. 12 cases showed a normal PNS X-ray series but these had been diagnosed as paranasal sinusitis with an endoscopy or CT scan in another hospital. 6. Common sinusitis - related symptoms were from highest incidence to lowest nasal obstruction, postnasal drip rhinorrhea, frontal headache, cough with sputum. 7. The most administered of prescription was Gamibangpoongtongsungsan and Sunbangpaedoksan extract. 8. In 26 cases the subjects showed significant improvement symptoms in PNS X-ray series : In 21 case showed partial improvement symptoms.

• 지능정보연구
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• 제13권1호
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• pp.81-90
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• 2007

본 논문에서는 전문적인 지식이 부족한 일반인들을 대상으로 자신의 건강 상태를 파악 할 수 있는 지능형 자가 진단 시스템을 제안한다. 제안된 자가 진단 시스템은 보건 복지부에 제출된 '한국인이 부담을 가지는 질병' 관련보고서를 참조하여 선정한 30가지의 질병과 각 질병에 대한 대표 증상을 이용하여 질병을 도출한다. 본 논문에서는 개선된 FCM 알고리즘을 적용하여 질병 종류를 군집화하고 각 질병의 증상과 관련된 질의 결과를 입력 벡터로 적용하여 사용자의 건강 상태를 진단한다. 기존의 방법에서는 입력 벡터와 군집 중심과의 거리를 측정한 후 거리가 가까운 5가지를 선택하기 때문에 선택된 질의와 관련 없는 질병을 도출하는 단점이 있었다. 이러한 단점을 개선하기 위해, 선택된 질의와 도출된 질병에 대한 퍼지 소속도를 이용하여 정렬한다. 정렬된 질병에서 상위 5가지를 도출한 결과, 선택된 질의와 관련된 질병만을 도출하는 것을 확인 할 수 있었다.

• 융합신호처리학회논문지
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• 제21권2호
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• pp.73-78
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• 2020

근골격 질환은 착석 자세로 업무 및 학업을 장시간 진행하거나 잘못된 자세 습관으로 발생하는 경우가 많다. 일상생활에서 근골격 질환을 예방하기 위해서는 실시간 착석자세 모니터링을 통해 잘못된 자세를 바른 자세로 유도하는 것이 가장 중요하다. 본 논문에서는 의자에 밀착된 착석 정보를 무 구속적으로 검출하기 위하여 다채널 압력센서 기반의 자세 측정 시스템과 사용자의 착석 자세 분류를 위한 CNN 모델을 제안한다. 제안된 CNN 모델은 착석 자세 정보를 기반으로 압력분포에 따른 사용자의 5가지 자세 분석이 가능하다. 필드테스트를 통한 자세 분류 신경망의 성능평가를 위하여 10명의 피실험자를 대상으로 분류결과에 대한 정확도, 재현율, 정밀도 및 조화 평균을 확인하였다. 실험 결과, 99.84%의 accuracy, 99.6%의 recall, 99.6%의 precision, 99.6%의 F1을 확인하였다.