• 한국통신학회논문지
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• 제14권4호
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• pp.398-404
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• 1989

광굴절 효과를 갖는 $BaTiO_2$단결정에서의 실시간 홀로그램을 이용한 광패턴인식 시스템을 해석하고 실험하였다. 시스템의 패턴 판별능력을 높이기 위해 edge enhancement 기법을 도입하였으며, 주파수 평면 상관기 구조로 구성된 시스템은 5.5mW의 저출력 광원으로도 8sec 이내에 패턴인식이 가능하였다.

• Communications for Statistical Applications and Methods
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• 제13권1호
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• pp.73-88
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• 2006

In this paper, we construct data-base for fetal heart rate (FHR) data and develop the FHR Monitering system to diagnose fetus, HYFM-III. For diagnostic system, a few statistical decision making mechanism are adopted, such as approximate entropy, neural networks, and logistic discrimination. Since FHR data is very chaotic, we mostly adopt nonlinear statistical methods. On the basis of this system, we expect to develop expert system for early detection of abnormal fetus.

• 한국어업기술학회:학술대회논문집
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• 한국어업기술학회 2003년도 춘계 수산관련학회 공동학술대회발표요지집
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• pp.369-369
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• 2003

Hemocytes in marine bivalves play important immunological roles in discrimination, opsonization and phagocytosis of foreign materials as a defense mechanism. In this study we report the flow cytometric implications to investigate the immune parameters such as the compositional and the functional characteristics of hemocytes isolated from the Manila clams, Ruditapes philippinarum. Heterogeneity of the hemocytic cell population was determined by the forward scatter (FSC) and side scatter (SSC) cytometric profile which showed three populations: granulocytes, hyalinocytes and small agranular cells. In addition, phagocytosis rate was measured after adding fluorescent-labeled particles. The data were initially analysed for two-parameters: FSC and SSC, then the fluorescent (FL 1) frequency distribution histogram of the hemocyte population was subsequently obtained.

• Bulletin of the Korean Chemical Society
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• 제24권1호
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• pp.95-98
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• 2003

Enantioselectivity of the propranolol on β-cyclodextrin was simulated by molecular modeling. Monte Carlo (MC) docking and molecular dynamics (MD) simulations were applied to investigate the molecular mechanism of enantioselective difference of both enantiomeric complexes. An energetic analysis of MC docking simulations coupled to the MD simulations successfully explains the experimental elution order of propranolol enantiomers. Molecular dynamics simulations indicate that average energy difference between the enantiomeric complexes, frequently used as a measure of chiral recognition, depends on the length of the simulation time. We found that, only in case of much longer MD simulations, noticeable chiral separation was observed.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2007년도 하계종합학술대회 논문집
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• pp.399-400
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• 2007

This paper proposes an regional analytic approach in image data space for radiographic image. Image is segmented into four regions, such as background, thickness, weld area and tube area, due to directional properties. Each region has its own gray level distribution, contrast range and noise property, originated from X-ray project mechanism and electric control system itself. Projection incorrectness and noise influence included on imaging quality is analyzed functionally and statistically. The experimental results shows not only segmental effects, but also visual edge evaluation.

• 기술혁신학회지
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• 제17권1호
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• pp.124-145
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• 2014

국가연구개발사업은 시장실패를 교정하기 위한 정부정책 구현에 있어서 매우 중요한 활동이며 최근 재정규모의 확대로 인해 성과평가에 대한 중요성과 더불어 효율적인 관리체계 구축에 대한 논의가 진행되는 분야이다. 본 연구는 이러한 국가연구개발사업에 대해 전주기 관리방안을 모색하기 위한 탐색 연구이다. 체계적인 논의에 있어서 관리체계에 대한 사항을 사전평가의 관점을 중심으로 살펴보았다. 국외 사례와 국내 제도의 비교를 통해 현행 국가연구개발사업의 수명주기 관리와 관련하여 제도차원의 고려사항을 도출했고 국가연구개발사업의 사전분석에 대한 사례 자료를 수집하고 분석을 수행하였다. 이를 통해 현재 제도상의 문제점을 구체화하였으며 향후 국가연구개발사업의 전주기적 관리를 효과적으로 적용하기 위해서 연구개발 정부지출의 범주화와 지출성격에 따른 관리체계 이원화가 필요함을 제시하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제14권5호
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• pp.265-272
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• 2010

Follicular cystic ovary (FCO) is one of the most frequently diagnosed ovarian diseases and is a major cause of reproductive failure in mammalian species. However, the mechanism by which FCO is induced remains unclear. Genetic alterations which affect the functioning of many kinds of cells and/or tissues could be present in cystic ovaries. In this study, we performed a comparison analysis of gene expression in order to identify new molecules useful in discrimination of bovine FCO with follicular cystic follicles (FCFs). Normal follicles and FCFs were classified based on their sizes (5 to 10 mm and $\geq25mm$). These follicles had granulosa cell layer and theca interna and the hormone $17{\beta}$-estradiol ($E_2$)/ progesterone ($P_4$) ratio in follicles was greater than one. Perifollicular regions including follicles were used for the preparation of RNA or protein. Differentially expressed genes (DEG) that showed greater than a 2-fold change in expression were screened by the annealing control primer (ACP)-based PCR method using $GeneFishing^{TM}$ DEG kits in bovine normal follicles and FCFs. We identified two DEGs in the FCFs: ribosomal protein L15 (RPL15) and microtubule-associated protein 1B (MAP1B) based on BLAST searches of the NCBI GenBank. Consistent with the ACP analysis, semi-quantitative PCR data and Western blot analyses revealed an up-regulation of RPL15 and a down-regulation of MAP1B in FCFs. These results suggest that RPL15 and MAP1B may be involved in the regulation of pathological processes in bovine FCOs and may help to establish a bovine gene data-base for the discrimination of FCOs from normal ovaries.

• 약학회지
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• 제42권1호
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• pp.101-107
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• 1998

The antiparkinsonian agent l-deprenyl, a selective monoamine oxidase (MAO)-B inhibitor, is metabolized in part to l-methamphetamine and l-amphetamine. l< /I>-Deprenyl was evaluated for amphetamine and methamphetamine-like discriminative stimulus effects in rats and its mechanism of action was investigated. Rats were trained under a 5-response, fixed ratio schedule of stimulus-shock termination or a 10-response. Fixed-ratio schedule of food-presentation which discriminate between d-amphetamine (1mg/kg, i.p.) and saline or d-methamphetamine (1mg/kg, i.p.) and saline in a two-lever, operant conditioning procedure. Full generalization was obtained to d-amphetamine (1~3mg/kg). d-methamphetamine (1~3mg/kg) and l-deprenyl (17~30mg/kg) under both the food presentation and stimulus shock termination schedule. l-Deprenyl has dose-dependent amphetamine-and methamphetamine-like discriminative stimulus properties in rats only at doses of 17 and 30mg/kg. Reversible MAO-B inhibitor, RO 16-6491 didn`t show any amphetamine-like discriminative properties. Aromatic amino acid decarboxylase inhibitor, NSD 1015 decreased % responding of l-deprenyl in the methamphetamine-trained rats under the stimulus-shock termination schedule. SKF-525A produced partial inhibition of methamphetamine-like discriminative effects of l-deprenyl under the food presentation schedule. These results suggest that l-deprenyl has no abuse liability at the therapeutic range but there needs some caution at high doses and furthermore, drug discrimination studies under the food presentation and shock termination schedule are useful for the assessment of abuse liability of psychostimulants.

• 미생물학회지
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• 제55권1호
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• pp.1-8
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• 2019

Due to the major role played by several species of Streptococcus in the etiology of periodontitis, it is important to assess the pattern of Streptococcus pathogenic pathways within the infected subgingival pockets using a bacterial specific 16S rRNA fragment. From the total of 50 patients with periodontitis included in the study, only 23 Streptococcal isolates were considered for further analyses, in which their 16S rRNA fragments were amplified and sequenced. Then, a comprehensive phylogenetic tree was constructed and in silico prediction was performed for the observed Streptococcal species. The phylogenetic analysis of the subgingival Streptococcal species revealed a high discrimination power of the 16S rRNA fragment to accurately identify three groups of Streptococcus on the species level, including S. salivarius (14 isolates), S. anginosus (5 isolates), and S. gordonii (4 isolates). The employment of state-of-art in silico tools indicated that each Streptococcal species group was characterized with particular transcription factors that bound exclusively with a different 16S rRNA-based secondary structure. In conclusion, the observed data of the present study provided in-depth insights into the mechanism of each Streptococcal species in its pathogenesis, which differ in each observed group, according to the differences in the 16S rRNA secondary structure it takes, and the consequent binding with its corresponding transcription factors. This study paves the way for further interventions of the in silico prediction, with the main conventional in vitro microbiota identification to present an interesting insight in terms of the gene expression pattern and the signaling pathway that each pathogenic species follows in the infected subgingival site.

• 한국융합학회논문지
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• 제8권3호
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• pp.49-61
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• 2017

안드로이드 플랫폼에서 다양한 모바일 애플리케이션이 개발/배포되면서 편리함과 유용성이 더욱 증가하고 있으나 지속적으로 악성 모바일 애플리케이션(Malicious Mobile Application) 또한 급증하고 있어 스마트폰 사용자도 모르게 단말 내 중요 정보 등이 외부로 유출되고 있다. 악성앱 검출을 위해 안드로이드 플랫폼을 대상으로 다양한 모바일 백신이 개발되었지만 최근에 발견된 서버 기반 다형상 모바일 악성앱인 경우 은닉 우회 기법을 포함하고 있으며, C&C 서버 기반 다형상 생성기에 의해서 각 사용자 단말에 매번 조금씩 다른 형태의 악성앱이 생성 및 설치되기 때문에 기존 모바일 백신에 손쉽게 검출되지 않는다는 문제점이 있다. 이에 본 논문에서는 서버 기반 다형상 모바일 악성앱에 대한 APK 역컴파일 과정을 통해 핵심 악성 코드를 구성하는 DEX 파일내 메소드에 대한 유사도와 접근권한 유사도 측정을 통해 상관관계를 분석하여 SSP 악성앱을 판별하는 기법을 제시하였다. DEX 메소드 유사도와 퍼미션 유사도 분석 결과 SSP 악성앱에 대한 동작 방식의 특징을 추출할 수 있었으며 정상앱과 구별 가능한 차이점을 발견할 수 있었다.