• Journal of Biomedical Engineering Research
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• v.42 no.6
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• pp.251-258
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• 2021

Hyaluronic acid (HA) microspheres (MSs) crosslinked with polyethylene glycol diglycidyl ether (PEGDE) are prepared using a simple fluidic device (SFD) to investigate the optimized parameters. A solution mixture of PEGDE in 2-methyl-1-propanol was prepared as a continuous phase in SFD. HA solutions of 1 wt% concentration were introduced into SFD as a discontinuous phase. The HA solution prepared by stirring for more than 48 h exhibited spherical MSs at the needle tip inside the ring cap. As the flow rate of the continuous phase increased from 0.7 to 1.9 mL/min, the diameter of the MS decreased from 173±36 ㎛ to 129±13 ㎛. Although the PEGDE concentration in the range of 0.2 to 1.8 vol% did not affect the diameter of the MS, the microstructure of MS, consisting of inner hollow void and wall, was changed. The inner void and wall size decreased and increased from 79.5 ㎛ to 57.2 ㎛ and from 10.3 ㎛ to 21.4 ㎛, respectively, with increasing PEGDE concentration from 0.2 vol% to 1.8 vol%. FT-IR peaks located around 2867 cm^-1 and 1088 cm^-1 indicated that the HA MS prepared at different PEGDE concentrations were chemically crosslinked. The HA MSs containing different PEGDE concentrations exhibited quantitative cell viability of more than 98%. L-929 cells adhered well to the HA MSs and proliferated continuously with increasing culture time to 48 h regardless of PEGDE concentration, implying that the HA MSs are clinically safe and effective.

• Steel and Composite Structures
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• v.49 no.5
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• pp.487-502
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• 2023

In the realm of nanotechnology, the nonlocal strain gradient theory takes center stage as it scrutinizes the behavior of spinning cantilever nanobeams and nanotubes, pivotal components supporting various mechanical movements in sport structures. The dynamics of these structures have sparked debates within the scientific community, with some contending that nonlocal cantilever models fail to predict dynamic softening, while others propose that they can indeed exhibit stiffness softening characteristics. To address these disparities, this paper investigates the dynamic response of a nonlocal cantilever cylindrical beam under the influence of external discontinuous dynamic loads. The study employs four distinct models: the Euler-Bernoulli beam model, Timoshenko beam model, higher-order beam model, and a novel higher-order tube model. These models account for the effects of functionally graded materials (FGMs) in the radial tube direction, giving rise to nanotubes with varying properties. The Hamilton principle is employed to formulate the governing differential equations and precise boundary conditions. These equations are subsequently solved using the generalized differential quadrature element technique (GDQEM). This research not only advances our understanding of the dynamic behavior of nanotubes but also reveals the intriguing phenomena of both hardening and softening in the nonlocal parameter within cantilever nanostructures. Moreover, the findings hold promise for practical applications, including drug delivery, where the controlled vibrations of nanotubes can enhance the precision and efficiency of medication transport within the human body. By exploring the multifaceted characteristics of nanotubes, this study not only contributes to the design and manufacturing of rotating nanostructures but also offers insights into their potential role in revolutionizing drug delivery systems.

• Journal of the Geological Society of Korea
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• v.54 no.5
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• pp.477-488
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• 2018

Fluid muds commonly occur in estuarine environments, but their ancient examples have rarely been studied in terms of depositional characteristics and processes. Cores of estuarine channel deposits of the Early Cretaceous McMurray Formation, Alberta, Canada show various mudstone layers that possess depositional characteristics of high clay-concentration flows. These mudstone layers are examined in detail through microscopic observation of thin sections and classified into three microfacies (<1 to 25 mm thick) on the basis of sedimentary texture and structures. Structureless mudstone (Microfacies 1) consists mainly of clay particles and contains randomly dispersed coarser grains (coarse silt to fine sand). This microfacies is interpreted as being deposited by cohesive mud flows, i.e., fluid muds, which possessed sufficient strength to support suspended coarser grains (quasi-laminar plug flow). Silt-streaked mudstone (Microfacies 2) mainly comprises mudstone with dispersed coarse grains and includes very thin, discontinuous silt streaks of coarse-silt to very-fine-sand grains. The texture similar to Microfacies 1 indicates that Microfacies 2 was also deposited by cohesive fluid muds. The silt streaks are, however, suggestive of the presence of intermittent weak turbulence under the plug (upper transitional plug flow). Heterolithic laminated mudstone (Microfacies 3) is characterized by alternation of relatively thick silt laminae and much thinner clay laminae. It is either parallel-laminated or low-angle cross-laminated, occasionally showing low-amplitude ripple forms. The heterolithic laminae are interpreted as the results of shear sorting in the basal turbulent zone under a cohesive plug. They may represent low-amplitude bed-waves formed under lower transitional plug flows. These three microfacies reflect a range of flow phases of fluid muds, which change with flow velocities and suspended mud concentrations. The results of this study provide important knowledge to recognize fluid-mud deposits in ancient sequences and to better understand depositional processes of mudstones.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.2
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• pp.235-253
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• 2018

Groundwater flow induced by cracks in a buried pipe causes ground loss in the vicinity of it which can lead to underground cavities and sinkhole problems. In this study, the ground collapse mechanism and the failure mode based on an aperture in the pipe located in cohesionless ground were investigated through a series of physical model studies. As the influence parameters, size of the crack, flow velocity in the pipe, groundwater level, ground cover depth and ground composition were adopted in order to examine how each of the parameters affected the behavior of the ground collapse. Influence of every experimental condition was evaluated by the final shape of ground failure (failure mode) and the amount of ground loss. According to the results, the failure mode appeared to be a 'Y' shape which featured a discontinuous change of the angle of erosion when a groundwater level was equal to the height of the ground depth. While in the case of a water table getting higher than the level of ground cover depth, the shape of the failure mode turned to be a 'V' shape that had a constant erosion angle. As the height of the ground depth increased, it was revealed that a mechanism where a vertically collapsed area which consisted of a width proportional to the ground height and a constant length occurred was repeated.

• Korean Journal of Agricultural Science
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• v.17 no.2
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• pp.102-114
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• 1990

This study was carried out to analyze the operation of the sluice gates by taking Sabkyo Reservoir as the model, and to examine the formulae of the design criteria for the Agricultural Land Improvement Project by hydraulic model experiments. The results were summarized as follows ; 1. According to the records of gate operation for 9 years, the mean height of the opened gates was 4.13 m, the mean number of operated gates were 4.04, the average annual number of operation were 67 times, the average annual operating time were 192.5 hours, and the average operating time were 2.88 hours. 2. The water supplied through Sabkyo Reservoir was 88.15 megatons per year, which was about 1.4 times the effective storage capacity. And the annual volume of pumping in May, which is the most water demanding season, was 29.56 megatons in average. 3. As the submerged orifice was transformed into the surface orifice, the suggested formulae for the orifice flow on the design criteria for the Agricultural Land Improvement Project showed a discontinuous line on the transition zone. It should be improved, because it is different from the real hydraulic phenomena. 4. The formulae for the orifice flow which are divided into the submerged and surface orifices are being used. However, these formulae could be substituted for the formular, $q=C{\cdot}W\sqrt{2gH_1}$, if the discharge coefficient considering the reservoir water level, the sea water level, and the gate opening height is used.

• Economic and Environmental Geology
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• v.45 no.5
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• pp.513-523
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• 2012

The upper sedimentary layer of the Ulleung Basin in the East Sea shows stacked mass-flow deposits such as slide/slump deposits in the upper slope, debris-flow deposits in the middle and lower slope, and turbidites in the basin plain. Shallow gases or gas hydrates are also reported in many area of the Ulleung Basin, which are very important in terms of marine resources, environmental changes, and geohazard. This paper aims at studying acoustic characteristics and distribution pattern of gas-related structures such as acoustic column, enhanced reflector, dome structure, pockmark, and gas seepage in the upper sedimentary layer, by analysing high-resolution chirp profiles. Acoustic column shows a transparent pillar shape in the sedimentary layer and mainly occurs in the basin plain. Enhanced reflector is characterized by an increased amplitude and laterally extended to several tens up kilometers. Dome structure is characterized by an upward convex feature at the seabed, and mainly occurs in the lower slope. The pockmark shows a small crater-like feature and usually occurs in the middle and lower slope. Gas seepage is commonly found in the middle slope of the southern Ulleung Basin. These gas-related structures seem to be mainly caused by gas migration and escape in the sedimentary layer. The distribution pattern of the gas-related structures indicates that formation of these structures in the Ulleung Basin is controlled not only by sedimentary facies in upper sedimentary layer but also by gas-solubility changes depending on water depth. Especially, it is interpreted that the chaotic and discontinuous sedimentary structures of debris-flow deposits cause the facilitation of gas migration, whereas the continuous sedimentary layers of turbidites restrict the vertical migration of gases.

• Korean Institute of Interior Design Journal
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• v.22 no.6
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• pp.108-118
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• 2013

This study has analyzed the process of space information perceived and recognized through the estimation of observation frequency and number according to the time range of observation data acquired from observation experiment with the object of hospital lobby. The followings are the results analyzed at this study. First, the continual observation of 3 and 6 times was attentive and conscious for probing to find an object rather than for acquiring exact information and that of 9 times could be regarded as the time for acquiring visual appreciation. However, the repetitive occurrence of high and low frequencies can be thought of repetitive acts for visual appreciation. Second, the continual observation of 3 and 6 times had the highest observation frequency of II, while that of 9 times had the highest observation frequency of III. In case of 3 and 6 times, the observation frequency had the tendency to become a little higher after being low since V, and in case of 9 times it had the repetition of becoming low and high and from IX it characteristically got higher. This feature can be thought to be the process that the subject repeats the fixation and movement of observation at a visual activity for perception and recognition. In the process of first observation, the observation frequency was the highest after 20 seconds or so, but since then, it gets lower and repeatedly gets higher and lower as time passes. After 90 seconds, the frequency showed the tendency of getting higher continuously. Third, the examination of changing features of frequency may show the characteristics of exploration for and attention to space but if the observation frequency is not associated with observation times for analysis there will a limitation that the features of observation frequency cannot be clarified. Accordingly, the simultaneous analysis of both is very effective for estimating the observation characteristics seen at the processes of perception and recognition. Fourth, the general analysis of the both revealed: with the progress of observation time the discontinuous space exploration decreased, and as the observation time got longer the fixed attention to a specific spot increased. Fifth, in order to estimate the observation characteristics by the change of time range the observation frequency and times by trend line was analyzed, which approach seems to be an appropriate technique that can comprehensively show the overall flow of time series data.

• Tunnel and Underground Space
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• v.18 no.1
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• pp.44-57
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• 2008

In this study, a 2D finite-element analysis, using the SEEP/W program, was carried out to estimate the amount of groundwater flawing into a tunnel, as well as the groundwater tables around wetland areas during and after a tunnel excavation through rock mass. Four sites along the Wonhyo-tunnel in Cheonseong Mountain (Gyeongnam, Korea) were analysed, where the model damain of the tunnel included both wetland and fault zone. The anisotropy of the hydraulic conductivities of the rock mass was calculated using the DFN model, and then used as an input parameter for the cantinuum model. Parametric study on the influencing factors was perofrmed to minimize uncertainties in the hydraulic properties. Moreover, the volumetric water content and hydraulic conductivity functions were applied ta the model to reflect the ability of a medium ta store and transport water under both saturated and unsaturated conditions. The conductivity of fault zone was assumed ta be $10^{-5}m/sec\;or\;10^{-6}m/sec$ and the conductivity of grouting zone was assumed as 1/10, 1/50 or 1/100 of the conductivity of rock mass. Totally $6{\sim}8$ cases of transient flow simulation were peformed at each site. The hydraulic conductivities of fault zone showed a significant influence on groundwater inflow when the fault zone crossed the tunnel. Also, groundwater table around wetland maintained in case that the hydraulic conductivity of grouting zone was reduced ta be less than 1/50 of the hydraulic conductivity of rock mass.

• Journal of the Korea Concrete Institute
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• v.14 no.1
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• pp.100-109
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• 2002

Significant damage to concrete results from the intrusion of corrosive solutions, for example, dissolved chlorides corrode reinforcing steel and cause spatting. Effectively blocks the penetration of these solutions will eliminate or greatly reduce this damage and lead to increased durability. This study is to investigate the effects of pozzolanic admixtures, fly ash and silica fume, and a blast furnace slag on the chloride ion penetration of concretes. The main experimental variables wore the water-cementitious material ratios, the types and amount of admixtures, and the curing time. And it is tested for the porosity and pore size distributions of cement paste, chloride ion permeability based on electrical conductance, and 180-day ponding test for chloride intrusion. The results show that the resistance of concrete to the penetration of chloride ions increases as the w/c was decreased, and the increasing of curing time. Also, concrete with pozzolans exhibited higher resistance to chloride ion penetration than the plain concrete. The significant reduction in chloride ion permeability(charge passed) of concrete with pozzolans due to formation of a discontinuous macro-pore system which inhibits flow. It is shown that there is a relationship between chloride ion permeability and depth of chloride ion penetration of concrete, based on the pore structure (porosity and pore size distributions) of cement paste.

• Tunnel and Underground Space
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• v.32 no.6
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• pp.373-385
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• 2022

The drum cutter, which is used in the form of an attachment of a excavator, is very useful in that it can be used in connection with a excavator that can perform various tasks in the field. This study estimated the load and torque acting on the drum cutter attachment by measuring the hydraulic pressure and strain that appear during excavation on the exposed rock slope using the drum cutter installed in the excavator. Working conditions such as the operation angle between the boom and arm of the excavator were divided into eight working modes. And as a result of analyzing the variations in hydraulic pressure and action force according to the working mode, it was confirmed that the hydraulic pressure and flow rate can be driven without any problems within the range considered in the manufacturing specifications of the drum cutter. The average load and torque acting on the drum cutter were within the range of the manufacturing specifications, but the maximum load was up to four times the specification. Because sumping was not properly performed due to the high ground strength and the ground included discontinuous surfaces in some locations, no trend of load and torque was found depending on the angle between the boom and arm of the excavator. However, it is believed that this result can be used to determine the range of loads and torques that appear on the drum cutter when excavating a high-intensity rock.