• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 춘계학술대회논문집
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• pp.1038-1043
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• 2003

There are many industrial applications including thin-body structures such as fins. For the numerical modeling of radiation of sound from thin bodies, the conventional boundary element method (BEM) using the Helmholtz integral equation fails to yield a reliable solution. Therefore, many researchers have tried to solve the thin-body acoustic problems. In the area of the design sensitivity analysis (DSA) and optimization methods, however, there has been just a few study reported. Especially fur the thin-body acoustics, however, no further study in the DSA and optimization fields has been reported. In this research, the normal derivative integral equation is adopted as an analysis formulation in the thin-body acoustics, and then used for the sizing DSA and optimization. Since the gradient-based method is used for the optimization, it is important to have accurate gradients (design sensitivities) of the objective function and constraints with respect to the design variables. The DSA formulations are derived through chain-ruled derivatives using the finite element method (FEM) and BEM by using the direct differentiation and continuum variation concepts. The proposed approaches are implemented and validated using a numerical example.

• Tuberculosis and Respiratory Diseases
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• 제40권4호
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• pp.345-352
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• 1993

The role of magnetic resonance(MR) imaging in the evaluation of thoracic disease has been limited Nontheless, MR has inherent properties of better contrast resolution than CT allowing tissue-specific diagnosis. MR has capability of direct imaging in sagittal, coronal, and oblique planes which provide better anatomic information than axial images of CT such as lesions in the pulmonary apex, aorticopulmonary window, peridiaphragmatic region, and subcarinal region. MR is sensitive to blood flow making it an ideal imaging modality for the evaluation of cardiovascular system of the thorax without the need for intravenous contrast media. Technical developments and better control of motion artifacts have resulted in improved image quality, and clinical applications of MR imaging in thoracic diseases have been expanded. Although MR imaging is considered as a problem-solving tool in patients with equivocal CT findings, MR should be used as the primary imaging modality in the following situations: 1) Evaluation of the cardiovascular abnormalities of the thorax 2) Evaluation of the superior sulcus tumors 3) Evaluation of the chest wall invasion or mediastinal invasion by tumor 4) Evaluation of the posterior mediastinal mass, especially neurogenic tumor 5) Differentiation of fibrosis and residual or recurrent tumor, especially in lymphoma 6) Evaluation of brachial plexopathy With technical developments and fast scan capabilities, clinical indications for MR imaging in thorax will increase in the area of pulmonary parenchymal and pulmonary vascular imaging.

• 한국산림과학회지
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• 제3권1호
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• pp.28-31
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• 1963

Recognizing shortcomings and unreasonable points of the usual methods of measurement of the standing-tree volume, author contrived measurement formula of standing-tree volume which is based on stem-curve equation, $y^2=2px$, resulted from the analysises and experiments on stem-curve by differentiation & integration. The results of this study are as follows ; (1) The following is the formula. $V=1/2g_{1.2}$(h+1.2) V=volume of tree $g_{1.2}$ = sectional area at breast heigh h = height of tree (2) So plain is the form of this formula that this formula is more convenient than usual formulas in measuring. (3) The percentage error of this formula is negative and it is remarkably superior to usual formulas except Pressler's formula, in other words, the higher the tree that is measured is, the more inaccurate become pressler's formula, and the percentage error of the breast-height form factor method is direct proportion to the grossness of the tree that is measured, but the higher the tree that is measured, the lower become percentage error of this formula in geometrical progression.

• Structural Engineering and Mechanics
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• 제4권1호
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• pp.25-35
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• 1996

This paper describes a continuum variational formulation for design optimization of nonlinear structures in the elastic-plastic domain, where unloading and reloading of the structures are allowed to occur. The Total Lagrangian procedure is used for the description of the structural deformation. The direct differentiation approach is used to derive the sensitivities of the various structural response measures with respect to the design parameters. Since the material goes into the inelastic range and unloading and reloading of the structure are allowed to occur, the structural response is path dependent and an additional step is needed to integrate the constitutive equations. It can be shown, consequently, that design sensitivity analysis is also path-dependent. The theory has been discretized by the finite element technique and implemented in a structural analysis code. Mathematical programming approach is used for the optimization process. Numerical applications on trusses are performed, where cross-sectional areas and nodal point coordinates are treated as design variables. Optimal designs have been obtained and compared by using two different strategies: a two level strategy where the levels are defined accordingly the type of design variables, cross sectional areas or node coordinates, and optimizing simultaneously with respect to both types of design variables.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제49권5호
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• pp.327-337
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• 2000

In this paper, the design sensitivity formula for the control of the transient temperature distribution is developed using the direct differentiation method, and used for the optimal design of induction heating coil position. The temperature distribution is calculated using the heat source of the induced eddy current and heat diffusion equation. The physical property variations of the workpiece depending on the temperature are considered. The eddy current distribution and the temperature distribution are calculated with the 2D finite element procedure. The adjoint variable technique is employed in expressing the design sensitivity. The goal of the design is to have the desired distribution of the temperature on a specific region of the sensitivity. The goal of the design is to have the desired distribution of the temperature on a specific region sensitivity. The goal of the design is to have the desired distribution of the temperature on a specific region of the workpiece. The numerical example shows that the proposed design sensitivity analysis for the control of the transient temperature distribution is very useful and practical in the optimal design of induction heating coils.

• Structural Engineering and Mechanics
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• 제71권1호
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• pp.45-56
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• 2019

A modified mechanical model of pre-pressed spring self-centering energy dissipation (PS-SCED) brace is proposed, and the hysteresis band is distinguished by the indication of relevant state variables. The MDOF frame system equipped with the braces is formulated in an incremental form of linear acceleration method. A multi-objective genetic algorithm (GA) based brace parameter optimization method is developed to obtain an optimal solution from the primary design scheme. Parameter sensitivities derived by the direct differentiation method are used to modify the change rate of parameters in the GA operator. A case study is conducted on a steel braced frame to illustrate the effect of brace parameters on node displacements, and validate the feasibility of the modified mechanical model. The optimization results and computational process information are compared among three cases of different strategies of parameter change as well. The accuracy is also verified by the calculation results of finite element model. This work can help the applications of PS-SCED brace optimization related to parameter sensitivity, and fulfill the systematic design procedure of PS-SCED brace-structure system with completed and prospective consequences.

• Structural Engineering and Mechanics
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• 제85권3호
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• pp.369-379
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• 2023

Reliability-Based Design Optimization (RBDO) is an appropriate framework for obtaining optimal designs by taking uncertainties into account. Large-scale problems with implicit limit state functions and problems with discrete design variables are two significant challenges to traditional RBDO methods. To overcome these challenges, this paper proposes a hybrid method to perform RBDO of structures that links Firefly Algorithm (FA) as an optimization tool to advanced (finite element) reliability methods. Furthermore, the Genetic Algorithm (GA) and the FA are compared based on the design cost (objective function) they achieve. In the proposed method, Weighted Simulation Method (WSM) is utilized to assess reliability constraints in the RBDO problems with explicit limit state functions. WSM is selected to reduce computational costs. To performing RBDO of structures with finite element modeling and implicit limit state functions, a First-Order Reliability Method (FORM) based on the Direct Differentiation Method (DDM) is utilized. Four numerical examples are considered to assess the effectiveness of the proposed method. The findings illustrate that the proposed RBDO method is applicable and efficient for RBDO problems with discrete and continuous design variables and finite element modeling.

• 한국정밀공학회지
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• 제13권7호
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• pp.90-99
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• 1996

In the area of assembly process of micro-chips and electronic parts on the printed circuit board, surface mounting device(SMD) is used as a fundamental tool. Generally speaking, the motion of the SMD is based on the ball screw system operated by any type of actuators. The ball screw system is a mechanical transformed which converts the mechanical rotational motion to the translational one. Also, this system could be considered as an efficient motion device against mechanical backlash and friction. Therefore a dynamic modeling and state sensitivity analysis of the ball screw system in SMD have to be done in the initial design stage. In this paper, a simple mathematical dynamic model for this system and the sensit- ivity analysis are mentioned. Especially, the bond graph approach is used for graphical modeling of the dynamic system before analysis stage. And the direct differentiation method is used for the state sensit- ivity analysis of the system. Finally, some trends for the state variables with respect to the design variables could be suggested for the better design and faster operating based on the results of dynamic and state sensitivity.

• 대한본초학회지
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• 제38권4호
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• pp.31-43
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• 2023

Objectives : The objective of this study was to investigate the phytochemistry and pharmacological activities of Cirsium setidens. Methods : Domestic and international articles about Cirsium setidens were investigated. A review was perfoemed via DB searching engine such as Sci.Direct, Springer, DBpia, KISS, Google scholar, Kipris, and so on. Total 73 listed literature were classified by compound analysis and pharmacological efficacy. Results : C. setidens contains pectolinarin and its glycoside, pectolinarigenin as index compounds, and linarin, apigenin, diosmetin, scopoletin, acacetin, cirsimarin, cirsimaritin, setidenosides A and B, silymarin, hispidulin, 92 volatile compounds, and 15 fatty acids. The Pharmacological activities of C. setidens has been reported to inhibit of platelet aggregation and fat accumulation in the liver, inhibit to hepatitis, anti-cancer, antibacterial, skin improvement, hair growth, liver protection, anti-diabetic, anti-inflammatory, sedative. Also, It has been reported the effect of cholesterol-lowering and anti-obesity, neuroprotective effects, increasing human stem cell viability, inhibiting osteoclast formation and osteogenic differentiation. Conclusion : This reviews showed that C. setidens which has been traditionally used for the treatment of inflammation and hypertension, has anticancer and river protective effect, as well as hair loss and diet. In order to maximize the efficacy of C. setidens, research has also begun on the effect of processing processes such as fermentation or fine powdering and combining natural plant resources.

• IMMUNE NETWORK
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• 제22권5호
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• pp.38.1-38.24
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• 2022

Exosomes, which are well-known nanoscale extracellular vesicles, are multifunctional biomaterials derived from endosomes and perform various functions. The exosome is a critical material in cell-cell communication. In addition, it regulates the pathophysiological conditions of the tumor microenvironment in particular. In the tumor microenvironment, exosomes play a controversial role in supporting or killing cancer by conveying biomaterials derived from parent cells. Innate immunity is a crucial component of the host defense mechanism, as it prevents foreign substances, such as viruses and other microbes and tumorigenesis from invading the body. Early in the tumorigenesis process, the innate immunity explicitly recognizes the tumor via Ags and educates the adaptive immunity to eliminate it. Recent studies have revealed that exosomes regulate immunity in the tumor microenvironment. Tumor-derived exosomes regulate immunity against tumor progression and metastasis. Furthermore, tumor-derived exosomes regulate polarization, differentiation, proliferation, and activation of innate immune cells. Exosomes produced from innate immune cells can inhibit or support tumor progression and metastasis via immune cell activation and direct cancer inhibition. In this study, we investigated current knowledge regarding the communication between tumor-derived exosomes and innate immune cell-derived exosomes (from macrophages, dendritic cells, NK cells, and neutrophils) in the tumor microenvironment. In addition, we discussed the potential development of exosomal immunotherapy using native or engineered exosomes against cancer.