• Title/Summary/Keyword: diluents

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Effect of Diluents on Disintegration Efficiency of Disintegrants in Enzyme Tablets (효소함유 정제에 있어서 붕해제의 효과에 미치는 부형제의 영향)

  • Kim, Jeong-Hoon;Kim, Seung-Hwan;Cha, Bong-Jin;Kwon, Jong-Won
    • YAKHAK HOEJI
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    • v.36 no.6
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    • pp.513-517
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    • 1992
  • The effect of solubility and hygroscopicity of some tablet diluents on the disintegration of enzyme tablets was investigated. Tablets were prepared by direct compression method using sodium starch glycolate, crospovidone, croscarmellose sodium and low-substituted hydroxypropyl cellulose as super disintegrants. Lactose, dextrose, sucrose, sorbitol and calcium phosphate dibasic were selected as typical diluents in this study. They were different in solubility (sucrose, sorbitol>dextrose>dextrose>lactose>calcium phosphate dibasic) and hygroscopicity (sorbitol>sucrose>dextrose>caicium phosphate dibasic, lactose). The disintegrants accelerated differently the disintegration of the tablets prepared with different diluents in the decreasing order of calcium phosphate dibasic>lactose>dextrose>sucrose and sorbitol. These results indicate highly soluble and/or hygroscopic diluents decrease the efficiencies of super disintegrants in the enzyme tablets.

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Changes of Sperm Motility in Black Seabream (Acanthopagrus schlegeli) by Osmolality of Diluents (희석액의 삼투질농도에 따른 감성돔 (Acanthopagrus schlegeli) 정자의 운동성 변화)

  • 장영진;임한규;장윤정
    • Journal of Aquaculture
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    • v.13 no.3
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    • pp.187-191
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    • 2000
  • The effects of osmolality on the sperm motility in black seabream (Acanthopagrus schlegeli) were studied. Sperm motility of black seabream was suppressed when the osmolality was equal to the seminal fluid. But sperm became motile when the osmolality increased in electrolyte solution (NaCl, KCl, $CaCl_2$, $MgCl_2$) and non-electrolyte solution (mannitol, glucose, fructose, sucrose). The changes of sperm motility index (SMI) by osmolality of diluents described a parabola. In all of the diluents, SMI was the highest at ca. 1,000 mOsm/kg, which is similar to the osmolality of seawater. Sperm motility was induced by osmolality of diluents, but exposure to hypotonic or hypertonic diluents was harmful to the sperm.

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Cold Storage of Sperm in Marbled Sole Limanda yokohamae (문치가자미, Limanda yokohamae 정자의 냉장보존)

  • 장영진;고강희;임한규
    • Journal of Aquaculture
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    • v.10 no.4
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    • pp.381-386
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    • 1997
  • A series of experiments were conducted to compare the effects of various diluents in cold storage on the marbled sole, Limanda yokohamae sperm. Various diluents of glucose, L. yokohamae serum, marine fish Ringer's solution, sodium citrate and Ca2+ free artificial seawater (ASM) (tris-HCI, pH 7.4) containing 3 mM ethylene glycol-bis (2-aminoethyl ether) tetraacetic acid (EGTA) were used to store the sperm at 4℃. The storage effect was evaluated using motility index and survival rate of sperm. Glucose and sodium citrate were found to be better diluents which maintained high motility and survival rate of sperm for a storage period of 10 days. Some morphological changes of spermatozoa were observed during the cold storage with diluents. In particular, a detachment of the nuclear enveloped and of the plasma membrane from the nucleus in spermatozoa was observed. Morphological normality of the stored spermatozoa diluted with 0.3 M glucose was better than that of the stored spermatozoa undiluted or diluted with Ca2+ free ASW containing 3 mM EGTA.

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EFFECT OF HEMA AND TEGDMA ON THE PROPERTIES OF EXPERIMENTAL COMPOSITE RESINS (Hydroxyethyl methacrylate (HEMA)와 Triethylene glycol dimethacrylate (TEGDMA)가 실험적 복합레진의 특성에 미치는 영향)

  • Han Man-Hyun;Choi Boo-Byung;Woo Yi-Hyung
    • The Journal of Korean Academy of Prosthodontics
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    • v.41 no.4
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    • pp.476-492
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    • 2003
  • Purpose : The purpose of this study was to compare HEMA and TEGDMA as diluents for the composite resin. Material and methods : Eight kinds of experimental light curable composite resins were prepared and used. Concentrations of monomer and filler were same for all experimental composites, except, the diluent's ratios to the monomer. The ratio of diluents to Bis-GMA were 15%, 20%, 25%, and 30%, and two kinds of diluents were used, so total experimental groups were eight including one control group of 25% TEGDMA. Results : Depth of cure, flexural strength, shear bond strength to bovine enamel, shear bond strength to bovine dentin, water absorption and solubility of composites in water were measured. Sample size for each groups were 10. Arithmetic means were used as each groups representative values, and regression test for two diluents and low concentrations, Duncan's multiple range test, and Two-way ANOVA test were done for kinds of diluents and its concentrations at level of 0.05. Conclusion : Following results were obtained ; 1. There were not significant differences in effects of HEMA and TEGDMA to depth of cure, flexural strength of composites and shear bond strength to bovine enamel (p>0.05). 2. Increase of the concentrations of the diluents made the depth of cure (p<0.001) and flexural strength (p<0.05) a little higher. 3. Shear bond strength to dentin was higher on HEMA containing composites than TEGDMA containing composites (p<0.001). 4. Water absorption was higher on HEMA containing composites than TEGDMA containing composites (p<0.01).

Studies on the Characteristics of Mineral Diluents Affecting the Decomposition of Sumithion in the Dust formulations (Sumithion 분제의 성분 변화에 영향을 미치는 증량제의 특성에 관한 연구)

  • Wuh K. D.;Han S. S.;Keum S. S.;Ahn S. H.;Lee C. N.
    • Korean journal of applied entomology
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    • v.10 no.2
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    • pp.77-83
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    • 1971
  • In order to find out the decomposing factors of Sumithion in mineral diluents, the physical and chemical properties of the diluents such as talcs, bentonites, diatomaceous earth and other clay minerals was studied in relation to the decomposition rate of Sumithion in dust formulations. The total base, moisture adsorption capacity, pH, specific surface, water contents, active $Fe^{++}$, ignition loss and cation exchange capacity were analysed as the properties of mineral diluents, and these properties were correlated with the stability of Sumithion in dust formulations. And in hope of finding out the main factors among those properties of diluents, the decomposed products of Sumithion in dust formulations prepared with standard Sumithion were separated by the methods of column chromatography and investigated by thin layer chromatography. The following results were otbained; 1. The total base, moisture adsorption capacity, specific surface, water contents, active $Fe^{++}$ and cation exchange capacity of mineral diluents were found to be highly effective on the rate of decomposition of Sumithion in dust formulations. 2. Decomposed products of Sumithion in dust formulations were found to be dimethylphosphorothionate, 3-methyl-4-nitro phenol and its derivatives. And one fraction was not dissolved in n-hexane and ethylether, but was soluble in methylalcohol and ethylalcohol. 3. The moat highly correlated properties of diluents with the decomposition rate of Sumithion in dust were found to be the total base and water contents. 4. In regard to the kind of diluents, it was found that the rate of decomposition of Sumithion in dust formulations was higher in order of bentonite, diatomaceous earth, kaolin and talc.

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Effect of Diluents on the Cold Storage of Sperm in Sea Urchin, Hemicentrotus pulcherrimus (말똥성게, Hemicentrotus pulcherrimus 정자의 냉장보존에 미치는 희석액의 효과)

  • Kho Kang-Hee;Kang Kyoung Ho;Kim Jae-Min
    • Development and Reproduction
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    • v.7 no.1
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    • pp.9-13
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    • 2003
  • A series of experiments were conducted to compare the effects of various diluents in cold storage on the sea urchin, Hemicentrotus pulcherimus sperm. Various diluents of glucose solutions, artificial sea water(ASW) and 50% ASW were used to store the sperm at 4$^{\circ}C$. The storage effect was evaluated using sperm activity index(SAI), survival rate of sperm and fertilization rate to egg. ASW and 1.2 M glucose were found to be better diluents which maintained high motility and survival rate of sperm f3r a storage period of 30 days. Optimal pH of diluent to store the sperm at 4$^{\circ}C$ is 7.0∼8.0. In order to keep high SAI and survival rate of sperm, addition of 400 ppm neomycin into the diluent revealed the best storage results.

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Effect of MgO Diluents in Combustion Synthesis of TiB2 Nano Particles (TiB2 나노 입자의 연소합성 시 MgO 희석제가 미치는 영향)

  • Lee, Byung-Ki;Lee, Jong-Moo;Park, Je-Hyeong;Kang, Eul-Son;Baek, Seung-Soo;Kim, Do-Kyung
    • Journal of the Korean Ceramic Society
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    • v.42 no.9 s.280
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    • pp.607-612
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    • 2005
  • The effect of MgO diluents in combustion synthesis of $TiB_2$ nano particles was investigated. The reaction $TiO_2\;+\;B_2O_3\;+\;xMg\;{\rightarrow}\;TiB_2\;+\;5MgO$ was used to synthesize $TiB_2$ nano particles. The combustion velocity was measured to examine the relation between the reaction temperature and the morphologies of particles. The diluent MgO did not react with the reactants and played a role to decrease combustion temperature. As the MgO diluents contents increased, the particles with the smaller size and the narrower size distribution were synthesized. At the condition of 6 mole of MgO, the combustion wave velocity was about 5 cm/see and the synthesized particles showed the size of 60 nm with narrow size distribution.

Effects of Thawing Conditions on the Viability and Acrosomal Morphology of Cryopreserved Boar Semen (동결보존한 돼지정액의 융해조건이 정자의 생존율과 첨체변화에 미치는 효과)

  • 정영호;서경덕;김광식;심금섭;이장희
    • Journal of Embryo Transfer
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    • v.14 no.2
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    • pp.131-137
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    • 1999
  • This experiment was carried out to investigate the effects of osmolarity of thawing diluents, seminal plasma added in thawing diluents on the sperm viability and the effects of thawing temperature, the temparature of the thawing diluents on the sperm viability and acrosomal morphology of boar spermatozoa by the straw method. The result obtained were summarized as follows: 1. The sperm viablilty after thawing of the frozen semen was shown greater in the high osmolarity(392~492mOsm) than low osmolarity(300mOsm) in thawing diluent. The added levels of seminal plasma in thawing diluent did not affect the viability of frozen-thawed boar semen. 2. In terms of thawing temperature, the sperm viability was shown higher in the frozen semen thawed at 5$0^{\circ}C$ for one min. (p<0.01) than those thawed at 2$0^{\circ}C$ or 37$^{\circ}C$ for one min. The sperm viability was not significant at the diluent temparature of 2$0^{\circ}C$or 37$^{\circ}C$ after thawing: but the sperm viability was higher in thawing diluent at 2$0^{\circ}C$ than in that at 37$^{\circ}C$. However, the effects of thawing temperature and diluent solution on normal acrosomal rate were not significant. 3. Cleavage rates of oocytes fertilized with frozen semen were 46.4% and 43.3%, respectively, which were thawed at 5$0^{\circ}C$ for one min. and then diluted in mBTS medium at 2$0^{\circ}C$or 37$^{\circ}C$. To sum up, the sperm viability was shown greater at the high of thawing diluents of frozen boar semen. In terms of thawing conditions, the sperm viability was shown greater, when semen was thawed at a high temperature for a short time and then diluted at the same temperature as that in the straw.

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Effects of Reactive Diluents on the Electrical Insulation Breakdown Strength and Mechanical Properties in an Epoxy System

  • Park, Jae-Jun
    • Transactions on Electrical and Electronic Materials
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    • v.14 no.4
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    • pp.199-202
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    • 2013
  • In order to study the effect of reactive diluents on the electrical insulation breakdown strength and mechanical properties of, a polyglycol and an aliphatic epoxy were individually introduced to an epoxy system. Reactive diluents were used in order to decrease the viscosity of the epoxy system; polyglycol acted as a flexibilizer and 1,4-butanediol diglycidyl ether (BDGE) acted as an aliphatic epoxy, which then acted as a chain extender after curing reaction. The ac electrical breakdown strength was estimated in sphere-to-sphere electrodes and the electrical breakdown strength was estimated by Weibull statistical analysis. The scale parameters of the electrical breakdown strengths for the epoxy resin, epoxy-polyglycol, and epoxy-BDGE were 45.0, 46.2, and 45.1 kV/mm, respectively. The flexural and tensile strengths for epoxy-BDGE were lower than those of the epoxy resin and those for epoxy-polyglycol were lower than those of the epoxy resin.

Study on the Polymorphism of Sulfa Drugs (설파제의 다형(多形)에 관한 연구)

  • Sohn, Young-Taek
    • Journal of Pharmaceutical Investigation
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    • v.20 no.1
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    • pp.35-42
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    • 1990
  • A new form of sulfabenzamide was characterized using X-ray diffraction patterns and differential scanning calorimetry. Solubility studies demonstrated that, of the sulfabenzamide polymorphs, the new form was more soluble than form I. Compression of the new form at compression force of 1000 $kg/cm{^2}$ didn't induce polymorphic change in the crystal. Similar patterns were also produced through grinding. The effects of some diluents on the polymorphic transformation from the new form into form I by grinding and compression were also studied. Three diluents, $Avicel^{\circledR}$, lactose and starch showed no influence on the polymorphic transformation. The new form seemed to be more suitable for the pharmaceutical preparation.

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