• 제목/요약/키워드: digestive disease

검색결과 415건 처리시간 0.022초

과립구집락자극인자 투여로 치료한 범혈구감소증과 피부 박리를 보인 붉은사슴뿔버섯 중독 1례 (A Case of Podostroma Cornu-Damae Intoxication Induced Pancytopenia and Skin Desquamation: Successful Treatment with Granulocyte Colony Stimulation Factor (G-CFS))

  • 김중석;김규원;정재일;심명기;윤기철;최용훈;이하람;최인주;심찬섭;한정호
    • 대한임상독성학회지
    • /
    • 제13권1호
    • /
    • pp.50-54
    • /
    • 2015
  • Podostroma cornu-damae is a rare species of fungus belonging to the Hyocreaceae family. Its fruit body is highly toxic, as it contains trichothecene mycotoxins. The morphology is similar to that of immature Ganoderma lucidum, making identification difficult for non-experts. We experienced such a case of a 56- year-old male who picked and consumed podostroma cornu-damae, and consumed. Later that day, he developed digestive system symptoms, including nausea, vomiting, and abdominal pain. He presented to the emergency room (ER), there were no abnormal physical findings, symptoms improved after gastric lavage, and the patient voluntarily discharged himself on the same day. The following day, as the symptoms gradually deteriorated, he was admitted via the ER. He was presented with severe pancytopenia, alopecia, desquamation of skin, and acute renal failure. He recovered without any complications after conservative care, antibiotics therapy, and granulocyte colony stimulating factor administration. The most commonly reported complications of podostroma cornu-damae intoxication were reported pancytopenia, infection, disseminated intravascular coagulation, acute renal failure, etc. since Prevention is especially important because its toxicity can be lethal and there is no particular treatment to date, prevention is especially important. Promotion and education for the public are needed.

  • PDF

대도시, 중소도시, 농촌 노인의 건강상태에 관한 연구 (A Study of the Health Status of Elderly Residing in Large city, Medium and Small city, Rural areas in Korea)

  • 최영희;신윤희
    • 대한간호학회지
    • /
    • 제21권3호
    • /
    • pp.365-382
    • /
    • 1991
  • This study was designed to measure the physical, mental-emotional and social health status of elderlies according to rural areas, medium - small cities, and large city environment. Data collection was done from July 18 to August 17 1990. The subjects were a convenience sample after their place of residence was stratified into large, medium- small cities and rural areas. Those who attended elderly centers in Seodaemun, Mapo, and Kangnam districts in Seoul were considered to be residents of a large city and interviewed by trained research assistants and student nurses. Elderlies living in Chungju, Jinju, Chuncheon, and Jeonju cities were coded as residents of medium-small cities and were interviewed by professors of nursing colleges. Rural residents were interviewed by the community health practioners working in community health clinics in North and South Kyongsang, North and South Jeolla, and Kyonggi provinces. The tool used in this study was the health assessment tool developed by Choi, Young Hee in 1990. This tool was organized into 20 physical health status, 17 mental - emotional health status, and 37 social health ststus items. Physical health status items consisted of six factors - personal hygiene activity ability, external activity utilizing traffic, mass media, and spare time ability, sexual ability, digestive system related ability, sexual ability, sensory ability, and elimination ability. Mental - emotional health status items consisted of two factors - mental health factor and emotional health factor. Social health status items consisted of seven factors -grandparental role ability, parental role ability, spoused role ability, friendship role ability, kinship role ability, group member role ability, and religious believer role ability. Data Analysis included frequencies, percentage, mean, standard deviation, ANOVA, and chi - square test. The results of the analysis are as follows : 1. The mean physical health status score for large city residents was 4.1132, for rural residents 4.0787, and for medium and small city residents 3.9565. There were significant differences according to residential area for personal hygiene activity ability, external activity ability, sexual ability, and digestive system related ability items 2. The mean mental -emotional health status score for rural residents was 3.8291, for medium and small city residents 3.7967, and for large city residents 3.7807. There was a significant difference according to residential area in the mental health ability item. 3. The mean social health status score for medium and small city residents was 3.0000, for rural residents 2.9362, and for large city residents 2.8960. There were significant differences according to residential area for kinship role ability and religious believer role ability items. The following conclusion was derived from the above results 1. The physical health status of elderlies residing in medium - small cities and in rural areas was lower than that of those residing in Seoul, a large urban area. Therefore, more medical facilities are needed in rural area so as to monitor their health, prevent disease, and promote their health. 2. The mental -emotional ststus and social health status of elderlies residing in the large city were lower than that of those residing in medium - small cities and rural areas. This may reflect weakening of the strong traditional family bond that may happen with urbanization. Continued support for elderly parents is essential and education should emphasize the traditional cultural norm and value of filial piety. 3. Facilities and programs for elderly are needed so that they may spend their time more valuably in their urban environment.

  • PDF

곰피추출물의 간기능 개선 효과 평가를 위한 12주, 무작위배정, 이중맹검, 위약-대조 인체적용시험 (The Effects of Ecklonia stolonifera Extracts on Improvement of Hepatic Function: a Double-Blind, Randomized, Placebo-Controlled Clinical Study)

  • 김정희;김은진;강다혜;김형빈;장재영;엄애선;김종욱
    • 한국식품위생안전성학회지
    • /
    • 제37권3호
    • /
    • pp.198-205
    • /
    • 2022
  • 본 연구에서는 경증 또는 중등도 간기능 이상 소견자를 대상으로 ESE의 간기능 개선 효과를 평가하기 위해 시험식품군과 대조식품군으로 나누어 단일기관, 위약대조, 무작위배정, 이중눈가림 평행 인체적용시험으로 연구를 수행하였다. 12주간 ESE 420 mg(210 mg/포, 1일 2회)을 함유한 시험식품 또는 대조식품을 섭취하였을 때 ESE의 간 기능 개선 유효성과 안전성을 평가하였다. 유효성 평가 결과, 섭취 후 시험식품군은 대조식품군과 비교하여 ALT, AST, γ-GT 수준이 유의하게 감소하였다. 반면, 지질대사 지표는 두 군간의 의미 있는 차이를 보이지 않았다. 또한, 비알콜성 시험대상자군을 대상으로 분석하였을 때도 ALT 및 AST 수준이 유의하게 감소하였으며 γ-GT의 경우 감소하는 경향성을 보였다. 안전성 평가로서 혈액, 소변, 활력 징후를 검사한 결과 대부분 항목에서 시험식품군과 대조식품군 군간 차이가 없었으며 몇몇 유의성이 나타난 지표도 임상적 의미는 없었다. 따라서 ESE는 간기능 개선에 도움을 줄 수 있을 것으로 보이며 안전한 식품 소재로 판단된다.

소음인(少陰人) 신수열표열병론(腎受熱表熱病論)의 병증(病證) 및 약리(藥理)에 대한 연구(硏究) (A Study on the Diseases and Pharmacy of the Soumin's Sinsooyul-Pyoyul-Byung theory)

  • 주종천;김경요
    • 사상체질의학회지
    • /
    • 제9권2호
    • /
    • pp.67-94
    • /
    • 1997
  • The main purpose of this study is to arrange the diseases, principal medicinal substances and the prescriptions for the Soumin's Sinsooyul-Pyoyul-Byung(少陽人 腎受熱表熱病) by historical examination in the viewpoint of the Constitutional Medicine(四象醫學). In this study, first I collected the original texts of the diseases and priscriptions in Dongyi-Soose-Bowon(東醫壽世保元), and described the development process of the Soumin(少陽人)'s diseases and priscriptions by comparing with the contents in Dongyi-Soose-Bowon(東醫壽世保元). Next, I collected the efficacy of the medicinal substances and priscriptions by the examination of successive literatures referred it, and tried to explain the efficacy of each medicinal substances in the viewpoint of the Constitutional Medicine(四象醫學) by the analysis of successive literatures. As a result, the conclusions could be summarized as follows. 1. The Differentiation of Syndromes(辦證) in the Existing Medicine(旣存醫學) was formed according to the Eight Principal Syndromes(八綱), the Five Elements(五行), the Merdian system(經絡), therefore there were many confusions with the changes of the times. The differentiation of Syndromes(辦證) in the Constitutional Medicine(四象醫學) was formed according to the pathological change of Ascending and Descending Yin Yang(陰陽升降) in the Four Internal Organs(四臟), therefore, there was the consistency in the recognition of diseases. 2. The classification of the Soumin's Pyoyul-Byung(少陽人 表熱病) was divided into Yukuang Disease(鬱狂證) and Mangyang Disease(亡陽證) according to sweating or not. The conception of these diseases was mostly achived in Shanhanlun(優寒論). The treatment of Shanhanlun(優寒論) was alike to that of Dongyi-Soose-Bowon(東醫壽世保元) in a part. 3. Je ma, Lee thinked that the cause of the Soumin's Pyoyul-Byung(少陽人 表熱病) is the breakdown of the balanced equilibrium in ascending and descending Yin Yang(陰陽升降) for a Large Sin and a Small Bi(腎大脾小), and it is treated by warming and ascending Yang(溫補升陽). 4. The medicinal substances composing prescriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is characterized with the efficacy of Ascending Yang and supplying Qi(升陽益氣) and regulating the digestive organs with the efficacy of warming it. 5. The medicinal substances composing the precriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is divided into four parts with the state of Yang Qi(陽氣) in the disease it used. 6. The purpose of prescriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is to strengthen the Soumin(少陰人)'s Yangnan Qi(陽暖之氣). Je ma, Lee kept the principle not to mix with another constitution's medicinal substances in the creation of the priscription.

  • PDF

Phase II Trial of Loubo® (Lobaplatin) and Pemetrexed for Patients with Metastatic Breast Cancer not Responding to Anthracycline or Taxanes

  • Deng, Qian-Qian;Huang, Xin-En;Ye, Li-Hong;Lu, Yan-Yan;Liang, Yong;Xiang, Jin
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제14권1호
    • /
    • pp.413-417
    • /
    • 2013
  • Purpose: This phase II study was undertaken to determine the efficacy and safety of Loubo$^{(R)}$ (Lobaplatin) in combination with pemetrexed in treating patients with metastatic breast cancer who failed to respond to anthracycline or taxanes. Patients and Methods: Metastatic breast cancer cases who had previously received an anthracycline and a taxane in either adjuvant or metastatic settings, were enrolled. All patients were recruited from Jiangsu Cancer Hospital and Research Institute, and were treated with Loubo$^{(R)}$ (Lobaplatin) 35 $mg/m^2$ (intravenous; on day 1) and pemetrexed 500 $mg/m^2$ (intravenous; on day 1) every 21 days. Efficacy and side effects were evaluated after at least two cycles of chemotherapy. Results: All eligible 19 patients completed at least 2 cycles of chemotherapy with pemetrexed and lobaplatin, and were evaluable. Overall, 3 (15.8%) patients achieved partial response, 11 (57.9%) stable disease, 5 (26.3%) progression of disease, with no complete remission. Response rate was 15.8%, disease control rate was 42.1%. The median survival time was 10.3 months. Neutrophil suppression occurred in 36.8% of patients who had grade 2 toxicity, and 26.3% had grade 3, 26.4% had grade 4. Thrombocytopenia was encountered as follows: 21.1% grade 2, 15.8% grade 3 and 5.5% grade 4. Incidences of anemia were 10.5% in grade 2, 5.3% grade 3 and 0% grade 4. Only 5.3% of patients required packed red blood cell transfusion. Grade 3 digestive tract toxicity occurred in 5.5% of patients. Other toxicities included elevated transaminase,oral mucositis and skin rashes. Conclusions: The regimen of lobaplatin and pemetrexed is modestly active in metastatic breast cancer patients who failed anthracycline or taxanes, and the toxicity profile suggesting that the doses of chemotherapy should be further modified.

재원환자의 질환군에 따른 가정간호 요구도 (Needs of Home Care Nursing Services for Hospital Patients)

  • 한성숙;김순례;이소영;권은하
    • 지역사회간호학회지
    • /
    • 제18권1호
    • /
    • pp.165-176
    • /
    • 2007
  • Purpose: The purpose of this study was to investigate the needs of home care nursing services in relation to the patients in hospital. Method: Subjects were 129 patients who admitted hospital and were selected through convenience sampling. Data were collected using the Home Health Care Need Assessment Questionnaire constructed by the Korea Health Industry Development Institute. Data were analyzed using SAS 8.12 program by applying percentage. Results: 1. According to the diagnosis of the subjects, the majority had cancer (25.0%), followed by musculoskeletal disease (15,6%), neuro/cerebral vascular disease (14.1%), digestive (10.9%) and respiratory disease (10.9%). 2. With regard to fundamental nursing service, subjects wanted to receive home care services for the following reasons: Problem identification and diagnosis (77.5%), vital sign check (49.6%); and intake and output measure (20.9%). 3. With regard to clinical laboratory tests, 62.8% wanted to receive blood tests, and followed by urine tests 26.4%, and wound drainage 26.4%. 4. With regard to medication and treatment service, 40.3% of the subjects wanted to receive intravenous fluid therapy, 26.4% intravenous antibiotics, and 26.4% the monitoring of fluid therapy. 5. With regard to therapeutic nursing service, 33.3% wanted to receive wound care, 26.4% ROM exercise, and 27.9% foley catheter change and care. 6. With regard to educational needs, 42.6% wanted education on infection monitoring, 41.4% on medication, and 34.9% on diet. 7. With regard to counseling needs, 65.9% wanted to receive telephone counseling about patient condition, 52.7% counseling about re-admission and 51.9% direct counseling about patient condition. In the group of injury and toxicity, and cardiovascular/circulatory diseases, 100% wanted telephone and direct counseling about the patient condition. Conclusion: Therefore, in order to improve the quality of hospital based home health care services, various factors that affect to the need of home health care should be analyzed and specified nursing care should be looked into.

  • PDF

알레르기 질환을 가진 초등학교 고학년의 식생활·환경적 요인 및 성장과의 관련성 분석 (Risk Factors for Allergic Diseases in School-Aged Children)

  • 민선애;조미진;박경
    • 한국식품영양과학회지
    • /
    • 제42권9호
    • /
    • pp.1387-1394
    • /
    • 2013
  • 본 연구는 대구 지역 초등학교 5~6학년 학생을 대상으로 알레르기 질환 환자군과 대조군으로 분류한 후, 알레르기 유병과 관련이 있는 환경적 요인을 분석하고 알레르기 유병여부에 따른 대상자의 성장 수준 및 영양 섭취 상태를 비교 분석하였다. 본 연구의 결과를 요약하면, 첫째, 대조군과 비교하여 환자군의 어머니 교육수준이 더 높았으며, 부모 및 형제의 알레르기 질환 유병 비율이 더 높은 경향을 보였다. 둘째, 환자군이 대조군보다 출생 순위가 더 낮은 경향을 보였고, 출생 당시 질병을 가지고 있는 경우와 이유식 섭취 후 부작용을 경험한 비율이 더 높았다. 셋째, 현재 대상자의 건강상태를 반영하는 최근 병원 진료 경험 빈도와 감기 및 소화질환 경험 빈도는 대조군과 비교하여 환자군에게서 더 높은 경향을 보였다. 넷째, 아동의 알레르기 질환 위험을 높이는 가장 강력한 요인은 부모 및 형제의 알레르기 질환력이었다. 전 세계적으로 알레르기 질환의 유병률이 증가하고 있는 가운데, 위와 같은 본 연구의 결과는 향후 알레르기 질환의 예방을 위한 기초 자료로 사용될 수 있을 것이다.

소아 다기관 염증 증후군 (Multisystem Inflammatory Syndrome in Children (MIS-C))

  • 이준기;조은영;이현주
    • Pediatric Infection and Vaccine
    • /
    • 제28권2호
    • /
    • pp.66-81
    • /
    • 2021
  • 코로나바이러스감염증-19는 전 세계적으로 유행하고 있으며, 2021년 7월 15일 기준으로 1.88억명 이상의 확진자와 406만명 이상의 사망자가 발생하였다. 소아청소년에서는 성인에 비해 비교적 중증 감염 발생이 낮으나, 일부에서는 SARS-CoV-2 감염 약 2-6주후소아다기관염증증후군(multisystem inflammatory syndrome in children, MIS-C)라는 합병증이 발생할 수 있다. MIS-C는 어린영아부터 청소년까지 다양한 연령에서 발생할 수 있으며, 발열을 포함하여 다양한 장기와 관련된 증상을 보일 수 있다. 소화기 및 신경계 증상이 흔하며, 많은 경우 가와사키병과 유사한 피부점막증상 등이 나타난다. 특히 심장관련 증상으로 좌심실 기능저하, 심근염 등이 나타날 수 있으며, 관상동맥확장 및 관상동맥류가 나타날 수 있다. 경우에 따라 저혈압, 쇼크를 동반하며, 중환자실 치료 및 기계환기요법을 요하나, 적절한 치료 후 대체로 회복을 보이는 것으로 보고된다. 이와 같이 MIS-C는 소아청소년에서 SARS-CoV-2 이후 드물게 발생하는 중요한 합병증으로, 임상증상을 잘 인지하고 조기에 적절한 치료를 하는 것이 중요하다. 이에 본 종설에서는 MIS-C의 역학 및 임상 증상, 추정되는 병태생리, 진단적 접근 및 치료에 대해 다루고자 한다.

위식도역류질환 변증도구의 신뢰도 및 타당도 평가 (A Study of the Reliability and Validity of Standard Tools for the Pattern Identification of Gastroesophageal Reflux Disease)

  • 조윤재;하나연;고석재;박재우;김진성
    • 대한한방내과학회지
    • /
    • 제43권1호
    • /
    • pp.1-21
    • /
    • 2022
  • Purpose: The standard tool for the pattern identification is used for identifying patterns in patients using a questionnaire. The purpose of this study is to reorganize the standard tool for the pattern identification of gastroesophageal reflux disease (GERD) developed in 2017 and to analyze the reliability and validity of the standard tool for pattern identification by applying it to GERD patients. Methods: To reorganize the standard tool for the pattern identification of GERD developed in the previous study, we searched the literature in the main databases, OASIS (Oriental Medicine Advanced Searching Integrated System) and CNKI (China National Knowledge Infrastructure). We added the search results to the data used in the previous study and went through the reorganizing courses, such as evaluating the validity of the translation, the Delphi technique, and a small survey. After reorganization, the patients who visited the Kyunghee University Korean Medicine Center for GERD symptoms were provided the questionnaire, including the reorganized standard tool for pattern identification. We analyzed the survey results to evaluate their reliability and validity. Results: Fifty patients completed the questionnaire. Reliability analysis results showed a pattern identification match rate of 86%, Cronbach's α coefficient of 0.834, and intraclass correlation coefficient of 0.907. The Mann - Whitney U test and logistic regression were implemented to check the relations between the survey questions and pattern identification results; the Pearson correlation, compared with other scales, showed a moderate score. Conclusion: We reorganized the standard tool for the pattern identification of GERD to be updated on current issues and so that it is easily used. The analysis results of the questionnaire showed that the reorganized standard tool had high reliability and moderate validity.

의약분업 실시 전후 보건소 내소환자 진료내용 변화 (The Changes in Patients and Medical Services by Separation of Prescribing and Dispensing Practice in Health Center)

  • 천재경;감신;한창현
    • 농촌의학ㆍ지역보건
    • /
    • 제27권2호
    • /
    • pp.75-86
    • /
    • 2002
  • 의약분업실시 전후 보건소 투약환자의 특성변화, 질병양상변화 그리고 진료내용변화를 알아보기 위해 의약분업 전인 2000년 3월과 의약분업 후인 2001년 3월 각각 한 달 동안 경상남북도에 소재한 4개 보건소(도농복합형 시보건소 2개소, 군보건소 2개소)를 의약분업 전과 후에 이용한 투약환자 5,890명(의약분업 전)과 3,496명(의약분업 후)을 대상으로 건강 보험 및 의료급여 청구서를 이용하여 투약환자의 성, 연령, 주 진단명, 의료보장종류, 내소일수, 투약일수를 조사하였다. 또한 의약품 처방의 변화를 알기 위해 급성 호홉기질환 및 근골격계 질환자에 처방한 약제 종류수, 주사제 사용률, 항생제 사용률, 고가소염제 사용률를 조사하였다. 투약환자의 질환별로는 분업 전에 비해 급성호흡기 질환자는 49.7%, 고혈압환자는 18.1%, 근골격계질환자는 70.5%, 당뇨병환자는 8.5%, 소화기계질환자는 71.2%, 만성호흡기질환자는 76.4% 감소하였으며, 요도감염질환자는 의약분업 전에 비해 66.7% 증가하였다. 의약분업 전후 평균 내소일수의 변화는, 성별로는 남녀 모두 의약분업 전 보다 후가 유의하게 감소하였고(p<0.01), 의료보장형태별도는 건강보험은 유의하게 감소하였으나(p<0.01), 의료급여는 유의한 변화가 없었다. 질환별로는 고혈압, 당뇨병, 근골격계질환에서 유의하게 감소하였다(p<0.01). 의약분업 전후 평균 투약일수는 유의하게 증가하였다(p<0.01). 질환별로는 요도감염을 제외한 다른 질환들은 유의하게 증가하였으며(p<0.01), 요도감염은 증가는 하였으나 통계적으로 유의하지는 않았다. 의약분업 전후 급성호흡기질환자에 대한 평균 처방 약제 종류수는 4.9개에서 4.7개로 유의하게 감소하였고, 주사제 사용률은 63.8%에서 7.7%로 유의하게 감소하였으며, 항생제 사용률은 33.7%에서 19.1%로 유의하게 감소하였 다(p<0.01). 의약분업 전후 근골격계질환자에 대한 평균 처방약제 종류수는 3.7개에서 3.2개로 유의하게 감소하였으며, 주사제 사용률은 64.9%에서 1.7%로 유의하게 감소하였고, 고가 소염제 사용률은 29.1%에서 39.7%로 유의하게 증가하였다(p<0.01). 이상의 결과 의약분업 후 내소환자의 평균 내소일수는 감소한 반면 평균 투약일수는 증가하였다. 의사의 처방형태의 변화로는 평균 약재 종류수는 감소하였고 주사제나 항생제 처방률은 급격히 감소하였으나, 고가 소염제의 처방률은 증가하였다.

  • PDF