• The Journal of the Society of Korean Medicine Diagnostics
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• v.19 no.1
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• pp.1-10
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• 2015

Objectives The purpose of this study was to survey the status of clinical use of a computerized tongue diagnosis system (CTDS) Methods We searched domestic/international articles using the CTDS from online medical databases including OASIS, NDSL and pubmed. We selected articles on clinical application or reliability of CTDS but excluded articles on mechanical design or software programming for developing a new CTDS. Finally we found 15 articles and classified the articles according to the study purpose. Results Out of the 15 articles, 8 were focused on the clinical application including halitosis, cold/heat syndrome, lung cancer, xerostomia etc. Other 5 articles were aimed at evaluating and improving reliability of CTDS. The other 2 articles were studied for development of differential diagnostic criteria on tongue coating thickness. Conclusion We found out that until now the researches on clinical application of CTDS mainly had been performed for producing a variety of CTDSs. Considering the importance of the tongue color in the traditional Korean medicine, we suggest that at first standard operating procedure for CTDS be developed and researches to develop differential diagnostic criteria on tongue body/coating color be performed and then explore its applications.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.22 no.1
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• pp.1-10
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• 2018

Objectives The purpose of this study is to compare the representative differential diagnosis methods of blood stasis pattern used in Korea, China and Japan, and then to characterize each diagnostic method. Methods Through the journal databases, we have selected representative tools that were developed for differential diagnosis of blood stasis pattern in Korea, China and Japan. In order to characterize the selected check-lists or questionnaires, we investigated the number of items, contents, score calculation method, internal consistency, and accuracy of each selected tool. Results A total of four diagnostic tools were finally selected; quantitative diagnosis scale of blood stasis syndrome (QDSBSS), diagnostic criteria for blood stasis (DCBS), blood stasis questionnaire (BSQ), and blood stasis syndrome questionnaire (BSSQ). The key points in the differential diagnosis for blood stasis were different for each of the diagnostic tool. The key point was oral mucosa (including tongue) status in the QDSBSS. Meanwhile it was abdominal pain/resistance in the DCBS, and general pain in the BSQ. Accuracy of the QDSBSS, the BSQ and the BSSQ were powerful but all of them was not generalized. Conclusions Therefore, it is desirable to select and apply a plurality of appropriate tools according to the characteristics of the blood stasis patients.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.20 no.1
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• pp.1-13
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• 2016

Objectives The aim of this study is to develop diagnostic and assessable questionnaires for cervical movement system impairment syndromes. Methods We reviewed the previous study and literature, and organized various checkable items for differential diagnosis of four different cervical movement system impairment syndromes. Next, we selected items which can be developed as questionnaire items. Finally, we conducted a face validity study with twelve Korean medical doctors and carried out survey research to evaluate the importance score of the items with three experts. Results We developed a diagnostic and assessable questionnaire as follows: 9 items for cervical extension syndrome; 5 items for cervical flexion syndrome; 9 items for cervical rotation syndrome. By conducting 2 rounds of survey research, we were able to bridge the differences in the importance score of each item. Conclusions A questionnaire for the diagnosis and assessment of movement system impairment syndromes was developed. This questionnaire holds promising applications for objective diagnosis and assessment of cervical movement system impairment syndromes. This tool may also be used for detecting the sub-health status of musculoskeletal systems.

• CELLMED
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• v.14 no.2
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• pp.4.1-4.4
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• 2024

The development of clinical reasoning, which is the basis of medical education, is of great importance in medical universities. One of the founders of modern structural clinical reasoning, based on the knowledge of pathological physiology, is the inventor of the stethoscope Rene Laennec (1781-1826). He described the pioneering experience of clinical reasoning in the pages of his treatise A Treatise on the Diseases of the Chest and on Mediate Auscultation, which is of lasting value, since every rookie physicians in his professional development goes through the path of Laennec. Laennec's practice is of great importance for novice physicians since Laennec's treatise contains a diagnostic analysis of the most common clinical cases. Each such analysis demonstrates the algorithm of clinical reasoning. The purpose of this study was to analyze the approaches of clinical reasoning by René Laennec, which made it possible to identify two basic principles. Laennec's diagnostic reasoning involved two principles: pathogenetic analysis of clinical manifestations and a syndrome-based approach to differential diagnosis. These principles help distinguish between diseases with similar symptoms and physical findings are used to demonstrate the practical application of syndrome-based differential diagnosis. These principles can be easily mastered by understanding the pathogenesis of clinical manifestations. Thanks to the pathogenetic basis, the principles of clinical reasoning of Rene Laennec are universal and applicable to the analysis of any signs of the disease: not only physical but also laboratory and instrumental.

• Journal of Microbiology
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• v.44 no.1
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• pp.11-22
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• 2006

Escherichia coli protein Rho is required for the factor-dependent transcription termination by an RNA polymerase and is essential for the viability of the cell. It is a homohexameric protein that recognizes and binds preferably to C-rich sites in the transcribed RNA. Once bound to RNA, it utilizes RNA-dependent ATPase activity and subsequently ATPase-dependent helicase activity to unwind RNA-DNA hybrids and release RNA from a transcribing elongation complex. Studies over the past few decades have highlighted Rho as a molecule and have revealed much of its mechanistic properties. The recently solved crystal structure could explain many of its physiological functions in terms of its structure. Despite all these efforts, many of the fundamental questions pertaining to Rho recognition sites, differential ATPase activity in response to different RNAs, translocation of Rho along the nascent transcript, interactions with elongation complex and finally unwinding and release of RNA remain obscure. In the present review we have attempted to summarize 'the knowns' and 'the unknowns' of the Rho protein revealed by the recent developments in this field. An attempt has also been made to understand the physiology of Rho in the light of its phylogeny.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.2
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• pp.18-26
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• 2008

Purpose : To review studies about voice diagnosis in orieltal medicine Method : The papers reviewed in this study were searched through internet search engines. For chinese studies, China National Knowledge Infrastructure(www.cnki.net) was the main source of the information and the key words for Voice diagnosis studies were "(語聲)", "(聲診)", and (TCM). Conclusions : In Oriental Medicine, There are two ways to research about voices. One way is to research through philological consideration with subjectical and experimental diagnosis & studies as human bowel related in traditional studies. The other way is to research through Computerized Speech Lab(CSL), differential diagnosis for Sasang constitution and disease.

• Imaging Science in Dentistry
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• v.54 no.1
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• pp.109-113
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• 2024

A 54-year-old male patient presented for a periodic check-up at the dental clinic. A panoramic radiograph showed bilateral ossification of the stylohyoid ligament with an oval radiopacity on the right side. Cone-beam computed tomography revealed a well-defined, homogenous hyperdense entity from the lower third of the ossified stylohyoid ligament on the right side. The differential diagnosis of osteoma on the stylohyoid chain includes Eagle syndrome and benign tumors of the stylohyoid chain and adjacent structures. Osteoma rarely manifests in the neck. Even more infrequent are tumors originating from the stylohyoid chain, with only a single documented case of osteoma reported in the literature in 1993. Due to the asymptomatic status, no surgical intervention was advised, and the case would be monitored periodically. This case report describes the details of an osteoma that emerged from the stylohyoid chain, marking it as the second recorded occurrence of this highly rare condition.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.5
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• pp.621-629
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• 2012

This study aimed to examine the possibility of data from pulse diagnosis device to be used for diagnosis of Sasang constitution. Systematic searches of 5 major Korean medical database were conducted for articles published up to May 2012. Searching key word was "Sasang" or "Constitution". Studies dealt with correlation between Sasang constitution and the pulse wave data from pulse diagnosis machine were included. Totally 2886 studies are searched and 3 studies are added from references of evaluated articles. Among them, 12 studies were met our inclusion criteria (2 Xishu Mac, 2 Self-made pulse diagnosis machine, 8 3D-Mac). Three of the eight 3D-Mac studies intended to develop a formula of constitutional differential diagnosis, 2 studies compared variables by Sasang constitution in healthy group and 3 studies compared variables by Sasang constitution in healthy group and special disease group. They all reported some significant variables, however results are not consistent between studies. The accuracy of the formula of constitutional differential diagnosis using 3D-Mac pulse diagnosis devices is 46.0% by now. Improvements in measuring pulse are required to achieve more accurate result and be used for diagnosis of Sasang constitution. Compensating B.M.I. among Sasang constitutional groups and separating constitutional pulse factors from acquired characteristics are also needed in further study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.204-210
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• 2016

This paper presents an experimental analysis of the growth and oxidation processes of soot particles generated in an isooctane diffusive laminar flame due to incomplete combustion. The effects of iron-based diagnostics were employed to measure the elastic scattering light from soot particles in a flame at different flame heights, and the differential scattering coefficients were calculated through a calibration process. The growth and oxidation of soot particles in flame was investigated by comparing differential scattering coefficients, and the soot volume fraction was seen to decrease in the soot oxidation process. In the same manner, the differential scattering coefficients were calculated for iron-based fuel-additive seeded flame, and these coefficients were revealed to be smaller than those obtained in the fuel-additive unseeded flame. In addition, transmission through the radial direction of the flame was measured, and transmission in the soot oxidation regime was approximately 5% higher for the seeded flame. The propensity of the data coincided well with the differential scattering coefficients, and it can be concluded that the iron component of the fuel additive plays a crucial role as a catalyst, which eventually enhanced soot particle oxidation.

• Journal of Society of Preventive Korean Medicine
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• v.10 no.1
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• pp.141-153
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• 2006

In order to study the changes in hematology and serum chemistry of rats injected with glycerol, Sprague-Dawley albino rats weighing 240 to 260 gm were injected intramuscularly with a 50% solution of glycerol(8ml/kg). We measured the values of hematology and serum chemistry, and compared the measured values of S1 group(passed for 1day after injection of glycerol), S2 group(passed for 2days after injection of glycerol), S3 group(passed for 3days after injection of glycerol), S4 group(passed for 3days after injection of glycerol) and S5 group(passed for 4days after injection of glycerol) with those of Normal group(non-treated group). The results are summarized as follows : 1. In body temperature, S1, S2, S4 groups showed significantly higher compared with Normal group, especially S2 group was higher than S1 group(p<0.05). But S5 group was lower than Normal group(p<0.05). 2. In RBC, S1 group was lower than Normal group(p<0.05). And in Hct, S1, S2, S3 groups were lower than Normal group(p<0.05), in Hb, S1 and S3 groups were lower than Normal group(p<0.05). 3. In WBC, S1, S2 groups were higher than Normal group(p<0.05). and in WBC differential count, S2, S3, S5 groups were higher than N, S1, S4 groups in monocyte(p<0.05). 4. In GOT, S1 group was higher than Normal group(p<0.05), and S2, S3, S4, S5 groups were lower than S1 group(p<0.05). In GPT, S1 group was higher than Normal group(p<0.05), and S2, S3 groups were lower than S1 group(p<0.05), S4, S5 groups were lower than N, S1, S2, S3 groups(p<0.05). 5. In total cholesterol and creatinine, S4 group was higher than Normal group(p<0.05). According to the above experimental results, we could find the anemia, inflamation, damage of renal function for 4 days by intramuscularly injection with a 50% solution of glycerol(8ml/kg) in rat.