• Clinical and Experimental Pediatrics
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• 제64권6호
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• pp.301-309
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• 2021

Background: Celiac disease (CD) is a chronic autoimmune enteropathy. It results from genetic predisposition and exposure to gluten-containing food. The prevalence and presentation of CD vary among populations. Purpose: This study aimed to describe the prevalence and clinical characteristics of CD in children in Bahrain. Methods: We retrospectively reviewed the medical records of children diagnosed with CD in the pediatric department, Salmaniya Medical Complex, Bahrain, in 1988-2018. Their clinical, biochemical, serological, and histopathological findings were documented. Adherence to the recommended gluten-free diet (GFD) was assessed. Results: Of 86 patients with CD, 67 were included. The CD prevalence was 0.02%. A significant increase in prevalence in the last decade was observed (P<0.0001). Thirty-eight patients (56.7%) were males. The median (interquartile range) age at presentation was 4.45 (1.5-7.3) years. A family history of CD was positive in 13 out of 43 patients (30.2%). Pallor and failure to thrive were the most common presentations. The most frequent associated disease was iron-deficiency anemia in 23 patients (69.7%). Positive serology was found in 32 of 45 patients (71.1%). Marsh-Oberhuber type III was found in 16 of 35 patients (45.7%). Seropositive patients were significantly older (P=0.025) and had more severe duodenal histology (P=0.002). Adherence to GFD was poor in 27 patients (64.3%). Conclusion: This study revealed a significant increase in CD prevalence over the last decade. Atypical presentations were frequent. Most patients had poor adherence to GFD.

• 문화기술의 융합
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• 제8권2호
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• pp.1-6
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• 2022

라이프로그는 다양한 디지털 센서로부터 수집되는 개인의 디지털 기록으로, 활동량, 수면 정보, 체중 변화, 체질량, 근육량, 지방량 등이 포함된다. 최근, 웨어러블 디바이스가 보편화되면서 양질의 라이프로그 데이터가 많이 생산되고 있다. 라이프로그 데이터는 개인의 신체의 상태를 보여주는 데이터로, 개개인의 건강관리 뿐만 아니라, 질병의 원인 및 치료에도 활용될 수 있다. 그러나, 현재는, AI/ML 기반의 상관관계 분석 및 개인화를 반영하지 못하고 있다. 단순 기록이나 단편적인 통계치를 제시하는 수준에 그치고 있다. 이에 본 논문에서는, 라이프로그 데이터와 질병과의 연관성 및 AI/ML 기술의 라이프로그 데이터의 적용 사례를 살펴보고, 더 나아가, AI/ML을 활용한 라이프로그 데이터 분석 프로세스를 제안하고, 실제 갤럭시워치에서 수집된 데이터를 사용하여, 분석 프로세스를 실증한다. 더불어, 미래의 헬스케어 서비스인, 라이프로그 데이터와 식단, 건강정보, 질병정보와의 융복합 서비스 로드맵을 제안한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제25권4호
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• pp.293-299
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• 2022

Purpose: Data on eosinophilic esophagitis (EoE) in South America is scarce. Moreover, no studies are available in Ecuador. We evaluated the clinical, endoscopic, and histological characteristics of Ecuadorian children with EoE. Methods: Medical records of 2,711 children who underwent upper gastrointestinal endoscopy (UGE) between 2009 and 2020 at Hospital Metropolitano de Quito, Ecuador were reviewed. Esophageal mucosal biopsies were obtained from 72 patients and the features of 35 children with EoE were described. EoE was diagnosed when there were more than 15 eosinophils in the esophagus, per high power field. Results: EoE was diagnosed in 35 children (9.4±4.5 years) with a male predominance (74%). Abdominal pain (51.4%) and vomiting (31.4%) were dominant symptoms. A history of allergic diseases was noted in 47.1% of the children, which mainly included allergic rhinitis (37.1%) and atopic dermatitis (11.4%). The most common endoscopic findings were furrowing (82.9%) and edema (74.3%). All patients were initially treated with proton-pump inhibitors (PPIs). Those who did not respond to PPIs received steroids (5.7%) and diet therapy (5.7%), and five patients were referred to an allergist. Clinical and histological resolution was observed in 65% of the patients who underwent a second UGE after 6-8 weeks of PPI. Conclusion: Our study describes the clinical features of pediatric EoE in Ecuador. This is the first retrospective study in Ecuador that describes the clinical, endoscopic, and histological manifestations of EoE in a small pediatric population. Almost half of the children who underwent a biopsy had EoE.

• 한방비만학회지
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• 제22권1호
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• pp.86-92
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• 2022

26명의 환자에게 8~12주동안 산삼복합약침과 한약을 병행한 식이요법을 시행하여 체성분 변화에 미치는 영향을 알아보았다. 체성분 검사 결과 체중, BMI, 골격근량, 체지방량, 복부지방률, 내장지방단면적, 체지방률이 유의하게 감소하였고, 체중이 감소하면서 골격근량이 감소하긴 하였으나 체지방량 위주의 감소로 골격근의 비율은 오히려 유의하게 증가하였다. 태음조위탕을 증례에 맞게 가감하고, 하루 한 시간 혹은 만 보 걷기의 운동지도를 통해 하루 400~800 kal의 초저열량 식이로 인해 야기될 수 있는 부작용 중 일시적인 현기증과 무기력감 외에 탈모, 부종, 설사, 월경 이상 등은 관찰되지 않았다. 향후 체성분 변화뿐만 아니라 생화학적 검사나 골밀도 검사를 통한 장기적인 탐색이 필요할 것으로 생각한다.

• Journal of Nutrition and Health
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• 제55권6호
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• pp.630-641
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• 2022

Purpose: In this study, we assessed the intake of nutrients and food groups and analyzed the nutrition quotient of obese children in South Korea. The hypothesis was that dietary quality and nutrient intake are related to the body mass index (BMI) of obese children. Methods: The participants included 48 children (20 boys and 28 girls). Based on the guidelines for the age-for-body mass index provided by the Korean National Growth Charts for children and adolescents, the participants were divided into 3 groups: overweight, BMI ≥ 85th percentile; obese, BMI ≥ 95th percentile; severely obese, BMI ≥ 99th percentile. Results: The energy distribution showed that the carbohydrate ratio was significantly higher in the overweight group (p < 0.01), whereas the fat ratio was significantly higher in the obese and severely obese groups (p < 0.05). Thus, in the overweight and obese groups, the percent body fat was negatively associated with the carbohydrate ratio (p < 0.05) but was positively associated with the fat ratio (p < 0.05). The Dietary Reference Intakes (DRI) data revealed that the intake levels of protein, vitamin B₁, vitamin B₁₂, and sodium were higher in all groups. Intakes of fiber, calcium, potassium, and magnesium were insufficient in all groups, and the DRI percent for protein was significantly higher in the obese and severely obese groups than in the overweight group. No significant differences were obtained in food group patterns or Nutrition Quotient (NQ) scores among the 3 groups. According to the evaluation results by food record and NQ, a significant difference was obtained in the dietary quality of obese children. Conclusion: We conclude that a higher intake of fat enhances weight gain. Based on the study results, we propose that the guidelines should consider the energy distribution of carbohydrate and fat intake to prevent and control obesity among Korean children.

• Journal of Oral Medicine and Pain
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• 제47권4호
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• pp.198-205
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• 2022

Purpose: The first-line treatment of temporomandibular joint disorders (TMDs) should include self-management and education. Self-management techniques include moist heat application, stretching, diet control, and mandibular rest position adjustment. Although the effectiveness of video educational resources has been studied in multiple sectors, their application in TMD management has not yet been explored. This study seeks to assess how effective media education was at motivating TMD patients to self-management and improve symptoms. Methods: Data were obtained from the hospital records of TMD patients who visited the Department of Oral Medicine, Yonsei University Dental Hospital, between May 2020 and December 2021. First, without any differences between groups, a significance analysis was conducted between the degree of self-management and symptom improvement over time. At the second visit, one group received media education (n=31) linked to TMD management, while the other received written-oriented education (n=45). At the third visit, the number of precautions taken by the patients was determined and contrasted to that recorded in the previous visit between the groups. Generalized estimated equation multivariate models were applied for statistical analysis. Results: In the media education group, the frequency of stretching and the number of patients on pain-free diets increased substantially. Taking precautions improved daily pain intensity, maximum mouth opening, and pain intensity during the maximum unassisted opening. Conclusions: Media education could be beneficial for TMD patients because it allows them to take self-management precautions. The symptoms of the media education group improved, with no considerable distinction between both groups.

• 임상간호연구
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• 제15권1호
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• pp.5-17
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• 2009

Purpose: This study was to develop a factor-type patient classification system for general nursing unit based on nursing needs (KPCS; Korean patient classification system for nurses). Method: We reviewed workload management system for nurses(WMSN) of Walter Reed Medical Center, Korean patient classification system for ICU, and nursing activities in nursing records and developed the first version of KPCS. The final version KPCS was evaluated via validity and reliability verifications based on panel discussions and data from 800 patient classifications. Content validity was performed by Delphi method and concurrent validity was verified by the correlation of two tools (r=.71). Construct validity was also tested by medical department (p<.001), patient type (p<.001), and nurse intuition (p<.001). These verifications were performed from April to October, 2008. Results: The KPCS has 75 items in classifying 50 nursing activities, and categorized into 12 different nursing area (measuring vital sign, monitoring, respiratory treatment, hygiene, diet, excretion, movement, examination, medication, treatment, special treatment, and education/emotional support). Conclusion: The findings of the study showed sound reliability and validity of KPCS based on nursing needs. Further study is mandated to refine the system and to develop index score to estimate the necessary number of nurses for adequate care.

• 대한지역사회영양학회지
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• 제9권2호
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• pp.173-182
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• 2004

We carried out a validation-calibration study of the food frequency questionnaire (FFQ) that we had previously developed for a community-based cohort of the Korean Genome and Health Study of the Korea National Genome Research Institute. We have collected a total of 254 3-day diet records (DRs) from 400 subjects, 200 each randomly selected from the two study cohorts of Ansung and Ansan. FFQ was administered at the time of cohort recruitment in 2001, and DRs were collected during a two month period from January through February of 2002. The mean age was 52.2 years. Farming for men and housewife for women were the most common occupations. The majority of the subjects had undergone 6∼12 years of education. The general characteristics including demographic and other data were not different from the total cohort subjects. Absolute levels of consumed nutrients including total energy (energy), protein, fat, carbohydrate, calcium, phosphorus, sodium, potassium, iron, retinol, carotene, vitamin A, thiamin, riboflavin, niacin and vitamin C were compared. The average of energy intake was not significantly different between the data collected by the 2 methods. However, consumptions of protein and fat were higher in data of DRs, whereas that of carbohydrate was higher in FFQ data. Significant correlation of each nutrient consumption between the data sets was observed (p ＜ 0.05) except in the case of iron, while the average correlation coefficient between them was 0.22 ranging from 0.33 for energy to 0.11 for iron. The results of cross classification by quantile for exact classification ranged from 25.2% (carotene) to 35.0% (phosphorus), and from 64.6% (vitamin A) to 76.4% (retinol) for adjacent classification. The proportion of completely opposite classification was 8.1% in average. Calibration slope was estimated by regression and calibration parameters ranged from 0.025 for carotene to 0.423 for niacin. We conclude that the FFQ we have developed is an appropriate tool for assessing the nutrient intakes as ranking exposures in epidemiology studies in view that amounts of consumed nutrients obtained by FFQ were similar to those collected by DRs, that correlations between consumed nutrients collected by these methods were significant, and that classification results were relatively fair. The correlation coefficients, however, were lower than expected, which may be mainly due to the survey season. In fact, any short-term dietary survey cannot accurately reflect the overall dietary intakes that change heavily depending on seasons. Further studies including the analysis of chemical indices would be helpful for the studies of causal relationship between the diet and disease.

• 동아시아식생활학회지
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• 제15권1호
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• pp.29-39
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• 2005

The obesity incidence rate of children in Korea has increased from 2 to 3% in 1970 to 15% in 2004. The purpose of this study was to evaluate the effect of diet on obesity, and serum cholesterol and triglyceride concentrations by obese index in Korean elementary school students. The subjects were three hundred and thirteen students(male 157, female 156). Height, weight and body fat were measured. Dietary records by the 24-hr recall method were taken for 3 days, and serum cholesterol and triglyceride concentrations were determined. The obesity index was calculated by the Korean of Pediatrics Association standards. Nutrient intakes were calculated by CAN PRO. Almost twenty percent(19.8%) of the subjects were underweight, 60.1 % were normal, 10.2% were overweight and 9.9% were obesity. The obesity incidence rate of the males was not different from the females. Energy and nutrients intakes containing fatty acids were not significantly different by the obesity index. All the subjects had 59.7%～61.1% of carbohydrate and 24.2%～25.6% of fat for energy. Serum cholesterol concentrations of the obesity group(177.3 mg/dl) was higher than those of the underweight group(161.8 mg/dl) and normal weight group(163.5 mg/dl) and overweight group(163.8 mg/dl). Twenty nine percent of the obesity group had serum cholesterol concentrations over 200mg/dl, as compared with 4.8% of the normal and underweight group. Serum triglyceride in the obesity group(103.0mg/dl) was higher than those of the underweight group(79.7 mg/dL), normal weight group(81.0 mg/dl) and overweight group(81.1 mg/dl). Serum total cholesterol concentrations were correlated with the obese index, PIBW, R hrer index at p<0.001, with BMI at p<0.01 and with waist/hip ratio at p<0.05. Serum triglyceride concentrations were correlated with the obese index, PIBW, R hrer index at p<0.01. It is concluded that obesity increases serum total cholesterol concentrations and triglyceride concentrations, and that the obesity preventive program for normal weight children, and weight reduction program for obese children are necessary for elementary school children's education.

• 대한지역사회영양학회지
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• 제20권5호
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• pp.351-361
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• 2015

Objectives: The purpose of this study was to investigate the relations between diabetic dietary compliance and dietary intake, physical activity and prevalence of metabolic syndrome (MS) in type 2 diabetic patients. Methods: Seventy five subjects diagnosed with type 2 diabetes visiting the D hospital in Dongducheon from May 2014 to Dec 2014 were included in this study. The subjects were divided into two groups according to their diabetic dietary compliance score (median 39); low diabetic dietary compliance (LDDC) group (n=44) and high diabetic dietary compliance (HDDC) group (n=31). Survey data collection was carried out by direct interview method. The nutrient intake, food intake and KDDS (Korean's dietary diversity score), DVS (dietary variety score) and GMVDF (grain, meat, vegetable, dairy and fruit) were analyzed using data from the 24-recall method. Metabolic parameters were obtained from the hospital records. Data was analyzed using Chi-square test and general linear model adjusted for sex. Results: The prevalence of MS was 59.7% in the participating diabetic patients. The prevalence of MS of the HDDC (39.3%) was significantly lower than that of the LDDC (72.7%). The distribution of physical activity showed a significant difference between the groups (p=0.006). The intakes of seeds and nuts of the HDDC were significantly lower than those of the LDDC. Fat and vegetable fat intakes and % fat of energy in the HDDC were significantly lower than those in the LDDC. But, carbohydrate (CHO) and potassium intake and %CHO of energy in the HDDC were significantly higher than those in the LDDC. KDDS and GMVDF showed significant differences between groups (p=0.033; p=0.012). Conclusions: Continuous intervention by specialized nutritionists for long-term self-regulation is needed for diabetic patients, and the high compliance to diabetic diet and increasing physical activity may be effective in the prevention of metabolic syndrome.